Increased adiposity measures are associated with lung function, asthma severity, and atopy in Puerto Rican children

2013 ◽  
Vol 14 ◽  
pp. S59-S60
Author(s):  
E. Forno ◽  
E. Acosta-Perez ◽  
J.M. Brehm ◽  
Y.Y. Han ◽  
M. Alvarez ◽  
...  
2021 ◽  
Vol 147 (2) ◽  
pp. AB92
Author(s):  
Karyn Parsons ◽  
Katharine Guarnieri ◽  
Dawit Tadesse ◽  
Md Monir Hossain ◽  
Vincent Mukkada ◽  
...  

2016 ◽  
Vol 10 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Bruno Sposato

Background: Asthma may show an accelerated lung function decline. Asthmatics, although having FEV1 and FEV1/VC (and z-scores) higher than the lower limit of normality, may show a significant FEV1 decline when compared to previous measurements. We assessed how many asymptomatic long-standing asthmatics (LSA) with normal lung function showed a significant FEV1 decline when an older FEV1 was taken as reference point. Methods: 46 well-controlled LSA (age: 48.8±12.1; 23 females) with normal FEV1 and FEV1/VC according to GLI2012 references (FEV1: 94.8±10.1%, z-score:-0.38±0.79; FEV1/VC: 79.3±5.2, z-score:-0.15±0.77) were selected. We considered FEV1 decline, calculated by comparing the latest value to one at least five years older or to the highest predicted value measured at 21 years for females and 23 for males. A FEV1 decline >15% or 30 ml/years was regarded as pathological. Results: When comparing the latest FEV1 to an at least 5-year-older one (mean 8.1±1.4 years between 2 measurements), 14 subjects (30.4%) showed a FEV1 decline <5% (mean: -2.2±2.6%), 19 (41.3%) had a FEV1 5-15% change (mean: -9.2±2.5%) and 13 (28.3%) a FEV1 decrease>15% (mean: -18.3±2.4). Subjects with a FEV1 decline>30 ml/year were 28 (60.8%). When using the highest predicted FEV1 as reference point and declines were corrected by subtracting the physiological decrease, 6 (13%) patients showed a FEV1 decline higher than 15%, whereas asthmatics with a FEV1 loss>30 ml/year were 17 (37%). Conclusion: FEV1 decline calculation may show how severe asthma actually is, avoiding a bronchial obstruction underestimation and a possible under-treatment in lots of apparent “well-controlled” LSA with GLI2012-normal-range lung function values.


Author(s):  
Matthew Wong ◽  
Yueh-Ying Han ◽  
Franziska Rosser ◽  
Edna Acosta-Pérez ◽  
Glorisa Canino ◽  
...  

2020 ◽  
Vol 202 (7) ◽  
pp. 962-972
Author(s):  
Eunice Y. Lee ◽  
Angel C. Y. Mak ◽  
Donglei Hu ◽  
Satria Sajuthi ◽  
Marquitta J. White ◽  
...  

1999 ◽  
Vol 29 (1) ◽  
pp. 121-126 ◽  
Author(s):  
S. RIETVELD ◽  
W. EVERAERD ◽  
I. VANBEEST

Background. Breathlessness in asthma often cannot be explained with objective variables indicating airways obstruction. The hypothesis that unrealistic breathlessness results from false interpretation of sensations was tested.Methods. Sixty-four children and adolescents with asthma, aged 9–18 years, were randomly assigned to: (1) standardized physical exercise for induction of general symptoms; (2) equipment causing itching through skin irritation; or (3) physical exercise combined with equipment causing itching through skin irritation. Pre-test and post-test measures were: lung function; breathlessness; general symptoms; itching; state anxiety; and worry.Results. Lung function decreased within normal parameters (3·8%, 1·1%, 2·6%, respectively) and did not differ significantly between conditions. Breathlessness increased significantly after exercise, particularly in condition 3. Breathlessness correlated with general symptoms and worrying, but not with changes in lung function, age, or asthma severity.Conclusion. Biased symptom perception can explain unrealistic breathlessness. Prerequisites are situational cues triggering selective perception and ambiguous sensations associated with the anticipated (feared) physical state. Excessive breathlessness may often warrant objective confirmation by means of lung-function testing.


2018 ◽  
pp. 192-198 ◽  
Author(s):  
T. N. Surovenko ◽  
Е. F. Glushkova

This article discusses issues of clinical diagnosis and course of bronchial asthma in children. We discuss assessment of asthma severity and, accordingly, the extent of the step-by-step therapy according to updated recommendations (GINA 2018). Particular attention is paid to the possibility of improving the control of asthma with the help of the M-cholinolytic drug of long-acting tiotropium bromide, presented as a special inhalation form of tiotropium Respimat and registered in the Russian Federation for treatment of asthma in children of moderate and severe course from 6 years of age. Application tiotropium Respimat in children with insufficient control of asthma allows to improve lung function and asthma control.


PEDIATRICS ◽  
1989 ◽  
Vol 84 (3) ◽  
pp. 451-459 ◽  
Author(s):  
Andrew B. Murray ◽  
Brenda J. Morrison

In 415 nonsmoking asthmatic children who were seen consecutively, asthma symptoms were more severe if the mother was a smoker than if she was a nonsmoker. This applied to both sexes but was more marked in boys than in girls. There were also other indications that sons were the more severely affected: the forced expiratory volume at 1 second, the forced expiratory flow rate during the middle half of the forced vital capacity, and the provocation concentration of histamine needed to result in a 20% decrease in the forced expiratory volume at 1 second were significantly decreased only in the sons, and lung function test results were significantly less in sons than in daughters of mothers who smoked. When the 415 children were stratified according to age, lung function improved significantly with increasing age in the children of nonsmokers; in children of smokers, by contrast, symptoms and lung function test results became progressively worse. As well, there was a correlation between these indications of asthma severity and the number of years the child had been exposed to the mother's smoke. It appeared that, compared with girls, boys were more sensitive to passive smoking, and that its adverse effect increased with age and with duration of exposure.


PEDIATRICS ◽  
1989 ◽  
Vol 83 (4) ◽  
pp. 507-512
Author(s):  
Gerard J. Canny ◽  
Joseph Reisman ◽  
Rosalean Healy ◽  
Clive Schwartz ◽  
Constantine Petrou ◽  
...  

Because inadequate assessment and inappropriate treatment of acute asthma have been implicated as contributing factors in morbidity and even deaths, the management of acute asthma, as practiced in an emergency room, were reviewed. The study population comprised 1,864 children (mean age 5.6 years; 65% boys) who attended the emergency room with acute asthma on 3,358 occasions during a 16-month period. Visits occurred more commonly in winter and usually in the evenings; 93% were self-referred and the mean duration of symptoms was 41 hours. Most acute episodes were associated with infection. Although chest auscultation, heart rate, and respiratory rate were recorded during the majority of visits, evidence that pulsus paradoxus had been measured could be found for only 1% of visits. Results of lung function and blood gas values were rarely recorded, but chest radiographs were obtained in 18% of visits. Drugs used in the emergency room included β2-agonisth (93% of visits), theophylline (16%), and systemic steroids (4%), but no child received anticholinergic therapy. In 26% of patient visits, admission to hospital occurred; one patient died. The erratic fashion in which asthma severity appears to have been assessed and the failure to document whether lung function had been measured are causes for concern. The surprisingly high hospitalization rate may have been avoided if bronchodilators and corticosteroids had not been underused in the emergency room.


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