1P-0109 The relationship between oxidative stress in vivo and multiple risk factors clustering syndrome

2003 ◽  
Vol 4 (2) ◽  
pp. 43
Author(s):  
T. Iizuka ◽  
T. Hitsumoto ◽  
K. Yoshinaga ◽  
M. Takahashi ◽  
H. Ohsawa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Multiple Risk Factors ◽  
Multiple Risk ◽  
The Relationship

Abstract P672: Black White Disparity in Multiple Risk Factors is Increased in Older Young Adults

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Prachi Mehndiratta ◽  
Kathleen Ryan ◽  
Adeolu Morawo ◽  
Seemant Chaturvedi ◽  
Carolyn A Cronin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Stroke Risk ◽  
Reference Group ◽  
Population Based ◽  
Multiple Risk Factors ◽  
Stroke In Young Adults ◽  
Multiple Risk ◽  
The Relationship ◽  
Control Study

Background: Stroke in young adults constitutes 15-18% of all ischemic strokes. Vascular risk factors contribute to stroke risk in young adults particularly older young adults. Few studies have addressed Black White differences in risk, stratified by age. We evaluated the prevalence of risk factors in the younger young (less than 40 years) vs. the older young adults (40 and above). Methods: A population based case control study with 1034 cases and 1091 controls, ages 15-49 was used to investigate the relationship between risk factors (DM, HTN, Smoking and Obesity) and stroke. Groups were defined by the number of risk factors (RF) among cases and controls : no risk factors (ref group), one RF, two RF, three RF and four RF. Prevalence of risk factors was determined in the entire population and stratified by age, sex and race. Logistic regression was used to determine odds of stroke based on the number of risk factors compared to the reference group. Results: The percent of cases with three or more risk factors was compared in different subgroups: ages 15-39 vs. 40-49 was 8.4 vs. 21.6, women vs. men was 15.6 vs. 18.6 and White vs. Black was 12.3 vs. 22.7. Among cases 40 years and older, Blacks were 3 times more likely than Whites (5.9 vs. 2) to have four or more risk factors.Across all age, race and sex subgroups, the odds of having a stroke increased exponentially with an increase in the number of risk factors. Conclusion: Blacks are more likely to have multiple risk factors than Whites. This difference is accentuated in those 40 years and older. Targeting young adults with multiple risk factors for preventive interventions would address a root case of excess stroke risk especially among Blacks.

scholarly journals Effect of various cardiovascular risk factors on oxidative stress markers in post menopausal women

2017 ◽  
Vol 6 (7) ◽  
pp. 1768
Author(s):  
Subrat Kumar Tripathy ◽  
Pramila Kumari Mishra
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Vitamin E ◽  
Cardiovascular Risk Factors ◽  
Multiple Risk Factors ◽  
Single Risk Factor ◽  
Multiple Risk ◽  
Post Menopausal

Background: The objectives was to study the association between oxidative stress and various cardiovascular risk factors individually and also there cumulative effect in post-menopausal women.Methods: 50 postmenopausal women with cardiovascular risk factors like hyperglycemia, hypertension, high Body Mass Index and Hyperlipidaemia were selected and burden of various cardiovascular risk factors in them is noted and also compared with 50 age matched apparently healthy post menopausal controls. Malon-di-aldehyde (MDA), vitaminE and vitamin C were taken to assess oxidative stress status. ANOVA was applied to find the effect of individual risk factor on oxidative stress and Student’s t-test was applied to compare between cases with single risk factors and multiple risk factors.Results: It was found that though all cardiovascular risk factors increase oxidative stress significantly but none of them has significant association in comparison to others (F value 0.37, 0.88 and 0.62 for MDA, vitamin E and C respectively). However, MDA value found in cases with multiple risk factors when compared with that of cases with single risk factor was found to be statistically significant (P <0.001). Similarly, the decrease in vitamin E in cases with multiple risk factors when compared with single risk factor cases was found to be significant. (P <0.01) and vitamin C in women with multiple risk factors was decreased in comparison to women with a single risk factor and was significant (P <0.001).Conclusions: The study shows that all the risk factors are equally responsible for increase in oxidative stress and multiple risk factors increase the oxidative stress significantly in comparison to any single risk factor.

Effect of Aging on the Relationship Between Multiple Risk Factors and Waist Circumference

2000 ◽  
Vol 48 (7) ◽  
pp. 788-794 ◽  
Author(s):  
Satoshi Iwao ◽  
Nobuko Iwao ◽  
Denis C. Muller ◽  
Dariush Elahi ◽  
Hiroshi Shimokata ◽  
...  
Keyword(s):  
Risk Factors ◽  
Waist Circumference ◽  
Multiple Risk Factors ◽  
Multiple Risk ◽  
The Relationship

The relative and interactive impact of multiple risk factors in schizophrenia spectrum disorders: a combined register-based and clinical twin study

2021 ◽  
pp. 1-11
Author(s):  
C. Lemvigh ◽  
R. Brouwer ◽  
R. Hilker ◽  
S. Anhøj ◽  
L. Baandrup ◽  
...  
Keyword(s):  
Risk Factors ◽  
Environmental Factors ◽  
Childhood Trauma ◽  
Cannabis Use ◽  
Paternal Age ◽  
Interactive Effects ◽  
Polygenic Risk Score ◽  
Multiple Risk Factors ◽  
Schizophrenia Spectrum ◽  
Multiple Risk

Abstract Background Research has yielded evidence for genetic and environmental factors influencing the risk of schizophrenia. Numerous environmental factors have been identified; however, the individual effects are small. The additive and interactive effects of multiple risk factors are not well elucidated. Twin pairs discordant for schizophrenia offer a unique opportunity to identify factors that differ between patients and unaffected co-twins, who are perfectly matched for age, sex and genetic background. Methods Register data were combined with clinical data for 216 twins including monozygotic (MZ) and dizygotic (DZ) proband pairs (one or both twins having a schizophrenia spectrum diagnosis) and MZ/DZ healthy control (HC) pairs. Logistic regression models were applied to predict (1) illness vulnerability (being a proband v. HC pair) and (2) illness status (being the patient v. unaffected co-twin). Risk factors included: A polygenic risk score (PRS) for schizophrenia, birth complications, birth weight, Apgar scores, paternal age, maternal smoking, season of birth, parental socioeconomic status, urbanicity, childhood trauma, estimated premorbid intelligence and cannabis. Results The PRS [odds ratio (OR) 1.6 (1.1–2.3)], childhood trauma [OR 4.5 (2.3–8.8)], and regular cannabis use [OR 8.3 (2.1–32.7)] independently predicted illness vulnerability as did an interaction between childhood trauma and cannabis use [OR 0.17 (0.03–0.9)]. Only regular cannabis use predicted having a schizophrenia spectrum diagnosis between patients and unaffected co-twins [OR 3.3 (1.1–10.4)]. Conclusion The findings suggest that several risk factors contribute to increasing schizophrenia spectrum vulnerability. Moreover, cannabis, a potentially completely avoidable environmental risk factor, seems to play a substantial role in schizophrenia pathology.

Multiple Risk Factors Before Pediatric Cardiac Transplantation Are Associated With Increased Graft Loss

2011 ◽  
Vol 33 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Scott R. Auerbach ◽  
Marc E. Richmond ◽  
Jonathan M. Chen ◽  
Ralph S. Mosca ◽  
Jan M. Quaegebeur ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiac Transplantation ◽  
Graft Loss ◽  
Multiple Risk Factors ◽  
Multiple Risk
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