3P-0685 Serum amyloid A induces migration of human aortic smooth muscle cells (HASMC) and its migration is inhibited by statins and fibrates

2003 ◽  
Vol 4 (2) ◽  
pp. 212
Author(s):  
Y. Kumon ◽  
T. Suehiro ◽  
Y. Ikeda ◽  
K. Arii ◽  
J. Sipe ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Serum Amyloid A ◽  
Muscle Cells ◽  
Serum Amyloid ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Amyloid A

Acute-phase, but not constitutive serum amyloid A (SAA) is chemotactic for cultured human aortic smooth muscle cells

Amyloid ◽  
2002 ◽  
Vol 9 (4) ◽  
pp. 237-241 ◽  
Author(s):  
Yoshitaka Kumon ◽  
Takanori Hosokawa ◽  
Tadashi Suehiro ◽  
Yukio Ikeda ◽  
Jean D. Sipe ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Acute Phase ◽  
Serum Amyloid A ◽  
Muscle Cells ◽  
Serum Amyloid ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Amyloid A

scholarly journals Effects of Serum Amyloid A and Lysophosphatidylcholine on Intracellular Calcium Concentration in Human Coronary Artery Smooth Muscle Cells

2011 ◽  
Vol 52 (3) ◽  
pp. 185-193 ◽  
Author(s):  
Tomofumi Tanaka ◽  
Kenichi Ikeda ◽  
Yumiko Yamamoto ◽  
Haruko Iida ◽  
Hironobu Kikuchi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Smooth Muscle Cells ◽  
Intracellular Calcium ◽  
Calcium Concentration ◽  
Serum Amyloid A ◽  
Muscle Cells ◽  
Serum Amyloid ◽  
Human Coronary Artery ◽  
Amyloid A

Sorghum Fermented by Aspergillus oryzae NK Enhances Inhibition of Vascular Inflammation in TNF-α-stimulated Human Aortic Smooth Muscle Cells

2018 ◽  
Vol 88 (5-6) ◽  
pp. 309-318
Author(s):  
Hae Seong Song ◽  
Jung-Eun Kwon ◽  
Hyun Jin Baek ◽  
Chang Won Kim ◽  
Hyelin Jeon ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Inflammatory Response ◽  
Smooth Muscle Cells ◽  
Adhesion Molecule ◽  
Vascular Inflammation ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Tnf Α ◽  
Cox 2

Abstract. Sorghum bicolor L. Moench is widely grown all over the world for food and feed. The effects of sorghum extracts on general inflammation have been previously studied, but its anti-vascular inflammatory effects are unknown. Therefore, this study investigated the anti-vascular inflammation effects of sorghum extract (SBE) and fermented extract of sorghum (fSBE) on human aortic smooth muscle cells (HASMCs). After the cytotoxicity test of the sorghum extract, a series of experiments were conducted. The inhibition effects of SBE and fSBE on the inflammatory response and adhesion molecule expression were measured using treatment with tumor necrosis factor-α (TNF-α), a crucial promoter for the development of atherosclerotic lesions, on HASMCs. After TNF-α (10 ng/mL) treatment for 2 h, then SBE and fSBE (100 and 200 μg/mL) were applied for 12h. Western blotting analysis showed that the expression of vascular cell adhesion molecule-1 (VCAM-1) (2.4-fold) and cyclooxygenase-2 (COX-2) (6.7-fold) decreased, and heme oxygenase-1 (HO-1) (3.5-fold) increased compared to the TNF-α control when treated with 200 μg/mL fSBE (P<0.05). In addition, the fSBE significantly increased the expression of HO-1 and significantly decreased the expression of VCAM-1 and COX-2 compared to the TNF-α control in mRNA level (P<0.05). These reasons of results might be due to the increased concentrations of procyanidin B1 (about 6-fold) and C1 (about 30-fold) produced through fermentation with Aspergillus oryzae NK for 48 h, at 37 °C. Overall, the results demonstrated that fSBE enhanced the inhibition of the inflammatory response and adherent molecule expression in HASMCs.

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