Beyond lowering circulating LDL: Apheresis-induced changes of systemic oxidative stress markers by four different techniques

2009 ◽  
Vol 10 (5) ◽  
pp. 34-38 ◽  
Author(s):  
Steffi Kopprasch ◽  
Juergen Graessler ◽  
Stefan R. Bornstein ◽  
Peter E.H. Schwarz ◽  
Sergey Tselmin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Stress Markers ◽  
Ldl Apheresis ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Induced Changes

scholarly journals Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Rade Grbic ◽  
Dijana J Miric ◽  
Bojana Kisic ◽  
Ljiljana Popovic ◽  
Vojkan Nestorovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Sequential Analysis ◽  
Bone Cells ◽  
Redox Status ◽  
Oxidative Stress Markers ◽  
Total Vitamin ◽  
Baseline Serum ◽  
Stress Markers ◽  
Systemic Oxidative Stress

In bacterial bone infections, excessively formed oxidants may result in local and systemic oxidative stress. Vitamin C is the major extracellular nonenzymatic antioxidant, also implicated in bone cells metabolism and viability. The physiological functions of vitamin C largely depend on its redox status. We sequentially assessed oxidative stress markers, hydroperoxides and malondialdehyde (MDA), total antioxidant activity (AOA), total vitamin C, ascorbic acid (Asc), and oxidized/reduced vitamin C ratio in 137 patients with acute osteomyelitis (OM). Compared to 52 healthy controls, in OM group baseline serum hydroperoxides, MDA and oxidized/reduced vitamin C ratio were higher whilst Asc and AOA were lower (P < 0.05, resp.). On the other side, total vitamin C levels in patients and controls were similar(P > 0.05), thereby suggesting a relative rather than absolute vitamin C deficiency in OM. During the follow-up, oxidative stress markers, AOA, and oxidizedreduced vitamin C ratio were gradually returned to normal, while there was no apparent change of total vitamin C concentrations. Persistently high values of oxidized/reduced vitamin C ratio and serum MDA were found in subacute OM. In conclusion, acute OM was associated with enhanced systemic oxidative stress and the shift of vitamin C redox status towards oxidized forms.

scholarly journals Significance of Elevated Blood Metal Ion Levels in Patients with Metal-on-Metal Prostheses: An Evaluation of Oxidative Stress Markers

2010 ◽  
Vol 4 (1) ◽  
pp. 221-227 ◽  
Author(s):  
Cathy Tkaczyk ◽  
Alain Petit ◽  
John Antoniou ◽  
David J Zukor ◽  
Maryam Tabrizian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metal Ion ◽  
Biological Effects ◽  
Redox Status ◽  
Heme Oxygenase 1 ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Metal On Metal ◽  
Significant Difference

It is widely known that cobalt and chromium ions can enhance the production of reactive oxygen species, known to be damaging to cells by disturbing their redox status and then generating oxidative stress. The aim of the present study was to determine if increased metal ion levels induce a state of oxidative stress in patients with metal-on-metal (MM) hip arthroplasty. Results indicated that there was no significant difference in the concentration of oxidative stress markers (total antioxidants, peroxides, and nitrated proteins) in the patients with MM bearings compared to patients without prostheses. The activity antioxidant enzymes was stable (catalase and glutathione peroxidase) or slightly decreased (superoxide dismutase and heme oxygenase-1) over time. This work is the first to determine the biological effects of metal ions released from MM hip implants with regards to mid-term systemic oxidative stress and showed that the increased levels of Co and Cr ions are not associated with significant oxidative stress damage in the plasma of patients with these implants.

Treatment of hyperthyroidism reduces systemic oxidative stress, as measured by markers of RNA and DNA damages

2021 ◽  
Author(s):  
Camilla B Larsen ◽  
Kamilla Ryom Riis ◽  
Kristian Hillert Winther ◽  
Emil List Larsen ◽  
Christina Ellervik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Urinary Excretion ◽  
Geometric Mean ◽  
Nodular Goiter ◽  
Whole Body ◽  
Oxidative Stress Markers ◽  
Toxic Nodular Goiter ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Rna And Dna

Abstract Background Whole-body oxidative stress can be estimated by the urine excretion of oxidized guanosine species, 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These oxidative stress markers are not well explored in thyroid disorders. Methods Urinary excretion of 8-oxoGuo and 8-oxodG was measured in 51 hyperthyroid patients (toxic nodular goiter (TNG), n=30; Graves’ disease (GD), n=21) before or shortly after initiation of therapy and when stable euthyroidism had been achieved for at least 12 months. Results Adjusting for age, the baseline urinary excretion of oxidative stress markers correlated positively with plasma thyroxine (8-oxoGuo: p=0.002; 8-oxodG: p=0.021) and was significantly higher in GD than in TNG patients (p=0.001 for both oxidative stress markers). Restoration of euthyroidism significantly affected the excretion of the oxidative stress markers. In TNG, 8-oxoGuo decreased from geometric mean 2.11 nmol/mmol creatinine (95%CI:1.85-2.39) to 1.91 nmol/mmol (95%CI:1.67-2.19), p=0.001, while 8-oxodG decreased from 1.65 nmol/mmol (95%CI:1.41-1.93) to 1.48 nmol/mmol (95%CI:1.27-1.74), p=0.026. In GD, 8-oxoGuo decreased from 2.25 nmol/mmol (95%CI:1.95-2.59) to 1.79 nmol/mmol (95%CI:1.63-1.97), p=0.0003, while 8-oxodG decreased from 2.02 nmol/mmol (95%CI:1.73-2.38) to 1.54 nmol/mmol (95%CI:1.31-1.81), p=0.001. In the euthyroid state, there were no differences between groups. Conclusion Restoration of euthyroidism in patients with hyperthyroidism significantly decreased the systemic oxidative stress load by 10-25%. Our findings may help to explain the higher morbidity and mortality linked to hyperthyroid diseases, as shown in observational studies.

scholarly journals Association of Changes in Body Composition with Changes in Systemic Oxidative Stress Following Weight Loss Program in Obese Adults Attending Obesity Clinic, Hospital Universiti Sains Malaysia

2014 ◽  
Vol 6 (1) ◽  
pp. 60-64
Author(s):  
Md Rizman Md Lazin @ Md Lazim ◽  
Rahimah Zakaria ◽  
Rohana Abdul Jalil ◽  
Wan Suriati Wan Nik ◽  
Che Badariah Abdul Aziz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Weight Loss ◽  
Body Composition ◽  
Weight Loss Program ◽  
Oxidative Stress Markers ◽  
Obese Adults ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Clinic Hospital ◽  
Obesity Clinic

The main objective of the present study was to evaluate the association of changes in body composition with changes in systemic oxidative stress markers among obese adults participating in a weight loss program. Thirty four obese adults were recruited from the Obesity Clinic, Hospital Universiti Sains Malaysia (USM) to voluntarily participate in a weight loss program comprising of physical exercise and dietary modification. Levels/activities of oxidative stress markers were measured before and after the program. Mean body weight, body mass index (BMI), waist circumference (WC), hip circumference (HC) and percentage of body fat mass decreased significantly while mean body lean mass and body water increased significantly after the weight loss program. Plasma glutathione peroxidase (GPx) activity and 4- hydroxynonenal (4-HNE) concentration increased significantly while other enzymatic antioxidant activities such as catalase (CAT) and superoxide dismutase (SOD) were not significantly increased. The ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) was significantly decreased. There was no significant association between changes in body composition and changes in systemic oxidative stress markers among obese adults. In conclusion, changes in body composition were not associated with changes in systemic oxidative stress markers among obese adults.

scholarly journals Systemic Oxidative Stress Markers in Cirrhotic Patients with Hepatic Encephalopathy: Possible Connections with Systemic Ammoniemia

Medicina ◽  
2020 ◽  
Vol 56 (4) ◽  
pp. 196 ◽  
Author(s):  
Cătălin Sfarti ◽  
Alin Ciobica ◽  
Ioana-Miruna Balmus ◽  
Ovidiu-Dumitru Ilie ◽  
Anca Trifan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepatic Encephalopathy ◽  
Control Group ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Group A ◽  
Cirrhotic Patients ◽  
Group B ◽  
Control Study

Background and objectives: Oxidative stress shows evidence of dysregulation in cirrhotic patients with hepatic encephalopathy (HE), although there are still controversies regarding the connections between oxidative stress and ammonia in these patients. The aim of this study was to evaluate the oxidative stress implication in overt HE pathogenesis of cirrhotic patients. Materials and Methods: We performed a prospective case-control study, which included 40 patients divided into two groups: group A consisted of 20 cirrhotic patients with HE and increased systemic ammoniemia, and group B consisted of 20 cirrhotic patients with HE and normal systemic ammoniemia. The control group consisted of 21 healthy subjects matched by age and sex. The activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) levels (lipid peroxidation marker), and ammoniemia were evaluated. Results: We found a significant decrease in SOD and GPx activity and also a significant increase of MDA levels in cirrhotic patients with HE as compared to the healthy age-matched control group (1.35 ± 0.08 vs. 0.90 ± 0.08 U/mL, p = 0.002; 0.093 ± 0.06 vs. 0.006 ± 0.008 U/mL, p = 0.001; and 35.94 ± 1.37 vs. 68.90 ± 5.68 nmols/mL, p = 0.0001, respectively). Additionally, we found significant correlations between the main oxidative stress markers and the levels of systemic ammonia (r = 0.452, p = 0.005). Patients from group A had a significant increase of MDA as compared with those from group B (76.93 ± 5.48 vs. 50.06 ± 5.60 nmols/mL, p = 0.019). Also, there was a compensatory increase in the activity of both antioxidant enzymes (SOD and GPx) in patients with increased systemic ammoniemia (group A), as compared to HE patients from group B. Conclusions: Our results demonstrated a significant decrease in antioxidants enzymes activities (SOD and GPx), as well as a significant increase in MDA concentrations, adding new data regarding the influence of oxidative stress in HE pathogenesis in cirrhotic patients.

scholarly journals The effects of gasotransmitters inhibition on homocysteine acutely induced changes in oxidative stress markers in rat plasma

2019 ◽  
Vol 50 (1) ◽  
pp. 6-12
Author(s):  
Marko Đurić ◽  
Sanja Kostić ◽  
Dragana Lončar-Stojiljković ◽  
Slavica Mutavdžin ◽  
Mirjana Čolović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Plasma ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Induced Changes

Oxidative Stress Markers After a Race in Professional Cyclists

2015 ◽  
Vol 25 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Alfredo Córdova ◽  
Antoni Sureda ◽  
María L. Albina ◽  
Victoria Linares ◽  
Montse Bellés ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Acute Exercise ◽  
Oxidative Stress Markers ◽  
Glutathione Peroxidase Activity ◽  
Stress Markers ◽  
Exercise Induced ◽  
Induced Changes ◽  
Plasma Malondialdehyde

The aim was to determine the levels and activities of the oxidative stress markers in erythrocytes, plasma, and urine after a flat cyclist stage. Eight voluntary male professional trained-cyclists participated in the study. Exercise significantly increased erythrocyte, leukocyte, platelet, and reticulocyte counts. The exercise induced significant increases in the erythrocyte activities of catalase (19.8%) and glutathione reductase (19.2%), while glutathione peroxidase activity decreased significantly (29.3%). Erythrocyte GSSG concentration was significantly increased after exercise (21.4%), whereas GSH was significantly diminished (20.4%). Erythrocyte malondialdehyde levels evidenced a significant decrease 3 h after finishing the stage (44.3%). Plasma malondialdehyde, GSH and GSSG levels significantly decreased after 3 hr recovery (26.8%, 48.6%, and 31.1%, respectively). The exercise significantly increased the F2-isoprostane concentration in urine from 359 ± 71 pg/mg creatinine to 686 ± 139 pg/mg creatinine. In conclusion, a flat cycling stage induced changes in oxidative stress markers in erythrocytes, plasma, and urine of professional cyclists. Urine F2-isoprostane is a more useful biomarker for assessing the effects of acute exercise than the traditional malondialdehyde measurement.

scholarly journals The Impact of Senile Cataract Maturity on Blood Oxidative Stress Markers and Glutathione-Dependent Antioxidants: Relations with Lens Variables

2012 ◽  
Vol 31 (3) ◽  
pp. 184-192 ◽  
Author(s):  
Dijana Mirić ◽  
Bojana Kisić ◽  
Lepša Žorić ◽  
Zana Dolićanin ◽  
Radoslav Mitić ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multivariate Logistic Regression Analysis ◽  
Senile Cataract ◽  
Oxidative Stress Markers ◽  
Multivariate Logistic Regression ◽  
Glutathione S Transferase ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Antioxidant Enzymes Activities ◽  
The Impact

The Impact of Senile Cataract Maturity on Blood Oxidative Stress Markers and Glutathione-Dependent Antioxidants: Relations with Lens VariablesOxidative stress is implicated in senile cataract (SC) genesis, although the impact of SC maturity on blood oxidative stress markers is unclear. Total hydroperoxides, malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S-transferase (GST) were measured in the blood and lens samples of patients having either immature (n=31) or mature SC (n=50), and in 22 blood samples from noncataract controls. Compared to controls, SC patients had higher plasma MDA and serum GST, and decreased plasma GR and GSH levels. Plasma GPx as well as hydroperoxides differed from control values only in patients with mature SC. The multivariate logistic regression analysis showed that the fall of plasma GR activity (OR 5.14; CI 1.82-14.51;p=0.0020), as well as serum GST activity (OR 3.84; CI 1.36-10.83;p=0.0108) were independently associated with the maturity of SC. Lens hydroperoxides, MDA and GST, showed no correlation with correspondent blood values, in contrast to GPx (r=0.715; p<0.001) and GR (r=0.703; p<0.001). This study showed that the severity of SC is associated with increased systemic oxidative stress, which could be due to the fall of GSH-dependent antioxidant enzymes activities.

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