716 PIOGLITAZONE, PEROXISOME PROLIFERATORACTIVATED RECEPTOR GAMMA ACTIVATOR, POSSIBLE INHIBITION OF RENAL STONE FORMATION IN RATS

1. Anomalous transmembrane anion transport has been observed in erythrocytes of patients with idiopathic calcium nephrolithiasis. 2. To verify whether cation transport is also abnormal, we investigated the frusemide-sensitive Na+ efflux from Na+-loaded erythrocytes and the natriuretic response to acute intravenous frusemide administration in calcium oxalate renal stone formers. 3. Frusemide administration induced a statistically significant smaller increase in the fractional excretion of Na+ in patients than in control subjects. Abnormal kinetic properties of erythrocyte Na+-K+-2Cl− co-transport were observed in approximately 60% of stone formers. The Km for Na+ of Na+-K+-2Cl− co-transport correlated with urinary Ca2+ excretion. 4. The abnormal kinetic properties of Na+-K+-2Cl− co-transport may be relevant for stone formation, hampering renal Ca2+ reabsorption in the distal nephron and determining critical physicochemical conditions for calcium/oxalate crystallization.

Download Full-text

Artificial Simulation of Renal Stone Formation

Nephron ◽

10.1159/000187445 ◽

1993 ◽

Vol 65 (1) ◽

pp. 77-81 ◽

Cited By ~ 9

Author(s):

F. Grases ◽

A. Costa-Bauzá ◽

J.G. March ◽

O. Söhnel

Keyword(s):

Renal Stone ◽

Stone Formation

Download Full-text

Prophylaxis and therapeutic effects of raspberry (Rubus idaeus) on renal stone formation in Balb/c mice

International braz j urol ◽

10.1590/s1677-55382011000200013 ◽

2011 ◽

Vol 37 (2) ◽

pp. 259-267 ◽

Cited By ~ 27

Author(s):

Ibrahim F. Ghalayini ◽

Mohammed A. Al-Ghazo ◽

Mohammad N. A. Harfeil

Keyword(s):

Renal Stone ◽

Stone Formation ◽

Rubus Idaeus ◽

Therapeutic Effects

Download Full-text

MP012PROBABILITY OF RENAL STONE FORMATION (PSF) IN OBESE PATIENTS BEFORE AND AFTER GASTRIC BYPASS SURGERY; APPLICABILITY OF A PREVENTIVE STRATEGY

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfx160.mp012 ◽

2017 ◽

Vol 32 (suppl_3) ◽

pp. iii432-iii432

Author(s):

Thomas Ernandez ◽

Catherine Stoermann-Chopard ◽

Minoa Jung ◽

William Robertson ◽

Pierre-Yves Martin ◽

...

Keyword(s):

Gastric Bypass ◽

Bypass Surgery ◽

Renal Stone ◽

Stone Formation ◽

Gastric Bypass Surgery ◽

Preventive Strategy ◽

Obese Patients ◽

Before And After

Download Full-text

The Efficacy of Polyunsaturated Fatty Acids as Protectors against Calcium Oxalate Renal Stone Formation: A Review

Nutrients ◽

10.3390/nu12041069 ◽

2020 ◽

Vol 12 (4) ◽

pp. 1069

Author(s):

Allen L. Rodgers ◽

Roswitha Siener

Keyword(s):

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Fish Oil ◽

Calcium Oxalate ◽

Renal Stone ◽

Stone Formation ◽

Membrane Phospholipids ◽

Dietary Pufa ◽

Evening Primrose ◽

Different Types

In the pathogenesis of hypercalciuria and hyperoxaluria, n-6 polyunsaturated fatty acids (PUFAs) have been implicated by virtue of their metabolic links with arachidonic acid (AA) and prostaglandin PGE2. Studies have also shown that n-3 PUFAs, particularly those in fish oil—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—can serve as competitive substrates for AA in the n-6 series and can be incorporated into cell membrane phospholipids in the latter’s place, thereby reducing urinary excretions of calcium and oxalate. The present review interrogates several different types of study which address the question of the potential roles played by dietary PUFAs in modulating stone formation. Included among these are human trials that have investigated the effects of dietary PUFA interventions. We identified 16 such trials. Besides fish oil (EPA+DHA), other supplements such as evening primrose oil containing n-6 FAs linoleic acid (LA) and γ-linolenic acid (GLA) were tested. Urinary excretion of calcium or oxalate or both decreased in most trials. However, these decreases were most prominent in the fish oil trials. We recommend the administration of fish oil containing EPA and DHA in the management of calcium oxalate urolithiasis.

Download Full-text

High Incidence of Renal Stones in Severely Disabled Children with Epilepsy Treated with Topiramate

Neuropediatrics ◽

10.1055/s-0038-1676287 ◽

2019 ◽

Vol 50 (03) ◽

pp. 160-163 ◽

Cited By ~ 1

Author(s):

Nobutsune Ishikawa ◽

Hiroo Tani ◽

Yoshiyuki Kobayashi ◽

Akira Kato ◽

Masao Kobayashi

Keyword(s):

Medical Records ◽

Renal Stone ◽

Stone Formation ◽

Renal Stones ◽

Treated Group ◽

Urinary Stones ◽

Disabled Children ◽

High Incidence ◽

Diuretic Drugs ◽

History Of

Purpose This study was aimed to assess the accurate incidence of renal stones in severely disabled children treated with topiramate (TPM). Method We reviewed the medical records of severely disabled children with epilepsy under 15 years old who underwent radiological examinations to investigate urinary stones. The study enrolled 26 patients who were divided into two groups. One group had been treated with TPM for at least 1 year and the other had not been treated with TPM, zonisamide, acetazolamide, or other diuretic drugs. We collected parameters from the medical records and compared the groups. Results All participants were evaluated radiologically, with computed tomography (CT) in two patients, ultrasonography in 22 patients, and both in two. No patient had any morphological abnormality of the kidneys and history of urinary tract infection. There were no significant differences in sex, age, body weight, or feeding manner between the groups, while the incidence of renal stones or calcifications was significantly higher in the TPM-treated group (60 vs. 0%; p = 0.00241). Conclusion There is a high incidence of renal stone formation in severely disabled children treated with TPM.

Download Full-text