scholarly journals Helicobacter pylori-negative Low-grade Extranodal B-cell Primary Gastric Mucosa-associated Lymphoid Tissue Lymphoma

2007 ◽  
Vol 70 (3) ◽  
pp. 121-125 ◽  
Author(s):  
Ying-Ying Yang ◽  
Su-Shun Lo ◽  
Fen Yau Li ◽  
Han-Chieh Lin ◽  
Fa-Yauh Lee ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
B Cell ◽  
Lymphoid Tissue ◽  
Low Grade

Ongoing somatic mutations and clonal expansions after cure of Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue B-cell lymphoma.

1998 ◽  
Vol 16 (12) ◽  
pp. 3822-3831 ◽  
Author(s):  
C Thiede ◽  
B Alpen ◽  
A Morgner ◽  
M Schmidt ◽  
M Ritter ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
B Cells ◽  
Gastric Mucosa ◽  
B Cell ◽  
Lymphoid Tissue ◽  
Somatic Mutations ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Low Grade ◽  
H Pylori

PURPOSE Although most patients with primary gastric low-grade mucosa-associated lymphoid tissue (MALT) B-cell lymphoma experience complete endoscopic and histologic remission after the cure of Helicobacter pylori infection, in many patients, the polymerase chain reaction (PCR) still detects monoclonal B cells in the gastric mucosa. The present study asked whether the lymphoma immunoglobulin VH (IgVH) sequences remained stable in patients with gastric MALT lymphoma after H pylori eradication. PATIENTS AND METHODS Eight patients with stage EI disease treated with H pylori eradication were analyzed before and at different time points after the cure of the infection. After the amplification of IgVH genes from DNA extracted from gastric biopsy specimens, monoclonal PCR products were cloned and multiple clones (43 to 105) were sequenced per patient. RESULTS Mutations were detected in all lymphoma VH sequences, which suggested germinal center or postgerminal center origin of the lymphoma B cells. In five of the eight patients, clonal heterogeneity was observed at diagnosis or during follow-up. Genealogical analysis of shared and unshared mutations showed that the process of somatic mutations was ongoing after H pylori eradication in four of the five patients who showed clonal instability. Ongoing mutations were observed in three of the four patients who completely responded to H pylori eradication, but in only one of the four patients who did not respond or who partially responded. CONCLUSION In low-grade gastric MALT lymphomas, an ongoing process of somatic hypermutation and antigen selection can be detected after the therapeutic removal of the underlying stimulus H pylori. These data point to the relevance of yet unknown antigens that drive this disease. In addition, they challenge the view that these lymphomas may be cured solely by the eradication of H pylori.

Monochemotheray as treatment of low-grade B-cell gastric mucosa associated lymphoid tissue lymphoma

1995 ◽  
Vol 108 (4) ◽  
pp. A478
Author(s):  
P. Hammel ◽  
C. Haioun ◽  
MT Chaurnette ◽  
M. Divine ◽  
P. Gaulard ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
B Cell ◽  
Lymphoid Tissue ◽  
Low Grade

scholarly journals Frequency of vacA Genotypes and Cytotoxin Activity in Helicobacter pylori Associated with Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

1998 ◽  
Vol 36 (8) ◽  
pp. 2369-2370 ◽  
Author(s):  
Stephan Miehlke ◽  
Alexander Meining ◽  
Andrea Morgner ◽  
Ekkehard Bayerdörffer ◽  
Norbert Lehn ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Low Grade ◽  
Vacuolating Cytotoxin

The vacA genotypes s1,m1 and s1,m2 were detected in 44 and 30% of Helicobacter pylori isolates, respectively, from patients with gastric mucosa-associated lymphoid tissue lymphoma, compared to 26 and 56% of isolates, respectively, from individuals with gastritis. The vacA s1 genotype was significantly associated with, but not predictive of, the presence of vacuolating cytotoxin activity.

scholarly journals Immune response in Helicobacter pylori-induced low-grade gastric-mucosa-associated lymphoid tissue (MALT) lymphoma

2004 ◽  
Vol 53 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Rie Yamasaki ◽  
Kenji Yokota ◽  
Hiroyuki Okada ◽  
Shyunji Hayashi ◽  
Motowo Mizuno ◽  
...  
Keyword(s):  
Immune Response ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Low Grade

Endoscopic characteristics of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori

2000 ◽  
Vol 15 (10) ◽  
pp. 1113-1119 ◽  
Author(s):  
Yoshihito Urakami ◽  
Toshiaki Sano ◽  
Shahnaz Begum ◽  
Hideko Endo ◽  
Hitoshi Kawamata ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Low Grade ◽  
Endoscopic Characteristics

scholarly journals First-line antibiotic therapy in Helicobacter pylori-negative low-grade gastric mucosa-associated lymphoid tissue lymphoma

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Sung-Hsin Kuo ◽  
Kun-Huei Yeh ◽  
Ming-Shiang Wu ◽  
Chung-Wu Lin ◽  
Ming-Feng Wei ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Antibiotic Therapy ◽  
Lymphoid Tissue ◽  
Low Grade ◽  
First Line
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