Nitrate tolerance as a model of vascular dysfunction: Roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress

2009 ◽  
Vol 61 (1) ◽  
pp. 33-48 ◽  
Author(s):  
Andreas Daiber ◽  
Matthias Oelze ◽  
Philip Wenzel ◽  
Jennifer M. Dias Wickramanayake ◽  
Swenja Schuhmacher ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aldehyde Dehydrogenase ◽  
Vascular Dysfunction ◽  
Nitrate Tolerance ◽  
Mitochondrial Oxidative Stress

scholarly journals MnSOD and ALDH‐2 deficiency potentiate aging‐associated vascular dysfunction, mitochondrial oxidative stress and mtDNA strand breaks

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Andreas Daiber ◽  
Philip Wenzel ◽  
Swenja Schuhmacher ◽  
Joachim Kienhöfer ◽  
Matthias Oelze ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vascular Dysfunction ◽  
Mitochondrial Oxidative Stress ◽  
Strand Breaks

scholarly journals Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate

2010 ◽  
Vol 2010 ◽  
pp. 1-13 ◽  
Author(s):  
Matthias Oelze ◽  
Swenja Schuhmacher ◽  
Andreas Daiber
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Vascular Dysfunction ◽  
Antioxidant Properties ◽  
Nitrate Tolerance ◽  
Diabetic Patients ◽  
Organic Nitrates ◽  
Common Principle ◽  
No Bioavailability

Organic nitrates represent a class of drugs which are clinically used for treatment of ischemic symptoms of angina as well as for congestive heart failure based on the idea to overcome the impaired NO bioavailability by “NO” replacement therapy. The present paper is focused on parallels between diabetes mellitus and nitrate tolerance, and aims to discuss the mechanisms underlying nitrate resistance in the setting of diabetes. Since oxidative stress was identified as an important factor in the development of tolerance to organic nitrates, but also represents a hallmark of diabetic complications, this may represent a common principle for both disorders where therapeutic intervention should start. This paper examines the evidence supporting the hypothesis that pentaerithrityl tetranitrate may represent a nitrate for treatment of ischemia in diabetic patients. This evidence is based on the considerations of parallels between diabetes mellitus and nitrate tolerance as well as on preliminary data from experimental diabetes studies.

scholarly journals Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

2014 ◽  
Vol 36 (13) ◽  
pp. 817-828 ◽  
Author(s):  
Francesco Paneni ◽  
Sarah Costantino ◽  
Lorenzo Castello ◽  
Rodolfo Battista ◽  
Giuliana Capretti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vascular Dysfunction ◽  
Prolyl Isomerase ◽  
Mitochondrial Oxidative Stress ◽  
Patients With Diabetes

scholarly journals Mitochondrial oxidative stress and nitrate tolerance – comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD+/-mice

2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Hanke Mollnau ◽  
Philip Wenzel ◽  
Matthias Oelze ◽  
Nicolai Treiber ◽  
Andrea Pautz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitrate Tolerance ◽  
Mitochondrial Oxidative Stress

scholarly journals Serelaxin Treatment Reduces Oxidative Stress and Increases Aldehyde Dehydrogenase-2 to Attenuate Nitrate Tolerance

2017 ◽  
Vol 8 ◽  
Author(s):  
Chen Huei Leo ◽  
Dhanushke T. Fernando ◽  
Lillie Tran ◽  
Hooi Hooi Ng ◽  
Sarah A. Marshall ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aldehyde Dehydrogenase ◽  
Nitrate Tolerance ◽  
Aldehyde Dehydrogenase 2
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