The role of the brain noradrenergic system in the regulation of cytochrome P450 expression in rat liver

2010 ◽  
Vol 62 ◽  
pp. 98-99
Author(s):  
Anna Sadakierska-Chudy ◽  
Marta Kot ◽  
Anna Haduch ◽  
Krystyna Gołembiowska ◽  
Władysława A. Daniel
2013 ◽  
Vol 86 (6) ◽  
pp. 800-807 ◽  
Author(s):  
Anna Sadakierska-Chudy ◽  
Anna Haduch ◽  
Marta Rysz ◽  
Krystyna Gołembiowska ◽  
Władysława A. Daniel

2021 ◽  
Vol 22 (16) ◽  
pp. 8447
Author(s):  
Przemysław J. Danek ◽  
Wojciech Kuban ◽  
Władysława A. Daniel

In order to achieve a desired therapeutic effect in schizophrenia patients and to maintain their mental wellbeing, pharmacological therapy needs to be continued for a long time, usually from the onset of symptoms and for the rest of the patients’ lives. The aim of our present research is to find out the in vivo effect of chronic treatment with atypical neuroleptic iloperidone on the expression and activity of cytochrome P450 (CYP) in rat liver. Male Wistar rats received a once-daily intraperitoneal injection of iloperidone (1 mg/kg) for a period of two weeks. Twenty-four hours after the last dose, livers were excised to study cytochrome P450 expression (mRNA and protein) and activity, pituitaries were isolated to determine growth hormone-releasing hormone (GHRH), and blood was collected for measuring serum concentrations of hormones and interleukin. The results showed a broad spectrum of changes in the expression and activity of liver CYP enzymes, which are important for drug metabolism (CYP1A, CYP2B, CYP2C, and CYP3A) and xenobiotic toxicity (CYP2E1). Iloperidone decreased the expression and activity of CYP1A2, CP2B1/2, CYP2C11, and CYP3A1/2 enzymes but increased that of CYP2E1. The CYP2C6 enzyme remained unchanged. At the same time, the level of GHRH, GH, and corticosterone decreased while that of T3 increased, with no changes in IL-2 and IL-6. The presented results indicate neuroendocrine regulation of the investigated CYP enzymes during chronic iloperidone treatment and suggest a possibility of pharmacokinetic/metabolic interactions produced by the neuroleptic during prolonged combined treatment with drugs that are substrates of iloperidone-affected CYP enzymes.


2020 ◽  
pp. 1-29
Author(s):  
Wojciech Kuban ◽  
Władysława Anna Daniel

2003 ◽  
Vol 23 (17) ◽  
pp. 6103-6116 ◽  
Author(s):  
Diana M. E. Otto ◽  
Colin J. Henderson ◽  
Dianne Carrie ◽  
Megan Davey ◽  
Thomas E. Gundersen ◽  
...  

ABSTRACT The cytochrome P450-dependent monooxygenase system catalyzes the metabolism of xenobiotics and endogenous compounds, including hormones and retinoic acid. In order to establish the role of these enzymes in embryogenesis, we have inactivated the system through the deletion of the gene for the electron donor to all microsomal P450 proteins, cytochrome P450 reductase (Cpr). Mouse embryos homozygous for this deletion died in early to middle gestation (∼9.5 days postcoitum [dpc]) and exhibited a number of novel phenotypes, including the severe inhibition of vasculogenesis and hematopoiesis. In addition, defects in the brain, limbs, and cell types where CPR was shown to be expressed were observed. Some of the observed abnormalities have been associated with perturbations in retinoic acid homeostasis in later embryogenesis. Consistent with this possibility, embryos at 9.5 dpc had significantly elevated levels of retinoic acid and reduced levels of retinol. Further, some of the observed phenotypes could be either reversed or exacerbated by decreasing or increasing maternal retinoic acid exposure, respectively. Detailed analysis demonstrated a close relationship between the observed phenotype and the expression of genes controlling vasculogenesis. These data demonstrate that the cytochrome P450 system plays a key role in early embryonic development; this process appears to be, at least in part, controlled by regional concentrations of retinoic acid and has profound effects on blood vessel formation.


1998 ◽  
Vol 72 (4) ◽  
pp. 207-214 ◽  
Author(s):  
Alessandra Turini ◽  
Giada Amato ◽  
Vincenzo Longo ◽  
Pier Giovanni Gervasi

2015 ◽  
Vol 27 (11) ◽  
pp. 2126-2132 ◽  
Author(s):  
Roberta Sellaro ◽  
Jelle W. R. van Leusden ◽  
Klodiana-Daphne Tona ◽  
Bart Verkuil ◽  
Sander Nieuwenhuis ◽  
...  

People tend to slow down after they commit an error, a phenomenon known as post-error slowing (PES). It has been proposed that slowing after negative feedback or unforeseen errors is linked to the activity of the locus coeruleus–norepinephrine (LC–NE) system, but there is little direct evidence for this hypothesis. Here, we assessed the causal role of the noradrenergic system in modulating PES by applying transcutaneous vagus nerve stimulation (tVNS), a new noninvasive and safe method to stimulate the vagus nerve and to increase NE concentrations in the brain. A single-blind, sham-controlled, between-group design was used to assess the effect of tVNS in healthy young volunteers (n = 40) during two cognitive tasks designed to measure PES. Results showed increased PES during active tVNS, as compared with sham stimulation. This effect was of similar magnitude for the two tasks. These findings provide evidence for an important role of the noradrenergic system in PES.


2006 ◽  
Vol 38 (3) ◽  
pp. 353-369 ◽  
Author(s):  
Gen Murakami ◽  
Nobuaki Tanabe ◽  
Hiro-taka Ishii ◽  
Mari Ogiue-Ikeda ◽  
Tomokazu Tsurugizawa ◽  
...  

2006 ◽  
Vol 27 (3) ◽  
pp. 372-380 ◽  
Author(s):  
Hai-yan XU ◽  
Zhi-yong XIE ◽  
Peng ZHANG ◽  
Jin SUN ◽  
Feng-ming CHU ◽  
...  

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