Iron preparations for women of reproductive age with iron deficiency anaemia in pregnancy (FRIDA): a systematic review and network meta-analysis

Using a systematic review method, the prevalence of anaemia, iron deficiency (ID), and iron deficiency anaemia (IDA) in women of reproductive age (WRA) and children under 5 years of age was obtained to inform priorities in health planning and policy in South Africa. We searched electronic databases for articles published between 1997 and 2021. A total of 713 articles were identified, of which 14 articles comprising 9649 WRA and 4085 children were included. Since most of the included studies were of low quality, we did not pool data in a meta-analysis due to heterogeneity (I2 > 75%). In WRA, anaemia prevalence ranged from 22.0% to 44.0%; ID from 7.7% and 19.0%; and IDA from 10.5% to 9.7%. The prevalence of anaemia in pregnancy was 29.0% to 42.7%; and 60.6% to 71.3% in HIV-infected pregnant women. Three national surveys reported anaemia in children at 28.9%, 10.7%, and 61.3%, respectively. Overall, among the children under 5 years old, anaemia was more prevalent in 1-year-olds (52.0%) compared to the other age groups. Between 2005 and 2012, ID increased by 3.8% and IDA decreased by 83.2% in children. Anaemia in WRA and children under 5 years in South Africa was a moderate public health concern. Therefore, interventions addressing anaemia should be intensified, and policies on iron supplementation and food fortification need to be revised and aligned to the WHO multiple micronutrient supplementation recommendations.

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Hepcidin-Guided Screen-and-Treat Interventions Against Iron Deficiency Anaemia in Pregnancy: A Randomised Controlled Trial in Gambian Women

SSRN Electronic Journal ◽

10.2139/ssrn.3373846 ◽

2019 ◽

Author(s):

Amat Bah ◽

Abdul Khalie Muhammad ◽

Rita Wegmuller ◽

Hans Verhoef ◽

Morgan M. Goheen ◽

...

Keyword(s):

Randomised Controlled Trial ◽

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Controlled Trial ◽

Deficiency Anaemia ◽

Anaemia In Pregnancy ◽

Randomised Controlled ◽

In Pregnancy

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Safety and Efficacy of Intravenous Ferric Carboxymaltose for Treatment of Iron Deficiency Anaemia in Pregnancy - An Intervention Study Done in a Tertiary Care Hospital of Pune

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/340 ◽

2021 ◽

Vol 8 (22) ◽

pp. 1803-1807

Author(s):

Anish Kumar Vishal ◽

Dinesh Bhasin ◽

Vidhu Dhar Dangwal ◽

Anurakshat Bhasin

Keyword(s):

Iron Deficiency ◽

Blood Transfusion ◽

Serum Ferritin ◽

Iron Deficiency Anaemia ◽

Tertiary Care ◽

Ferric Carboxymaltose ◽

Third Trimester ◽

Deficiency Anaemia ◽

Anaemia In Pregnancy ◽

In Pregnancy

BACKGROUND Anaemia is one of the major public health problems in developing nations. Iron deficiency anaemia (IDA) is the commonest type of anaemia in pregnancy. Parenteral iron therapy is a recommended modality of treatment of IDA. Inj. Ferric Carboxymaltose (FCM) is a dextran free preparation which is safe, easy to deliver and better tolerated. A maximum of 1000 mg can be infused at a time. The present study was intended to assess the efficacy and safety of Inj. FCM in the treatment of iron deficiency anaemia in the second and third trimester. METHODS This prospective study was conducted at a tertiary care centre at Pune. Pregnant women with iron deficiency anaemia of moderate and severe grade were infused 1000 mg of Inj. FCM by longer infusion protocol. A total of 165 pregnant women were included in the study. The efficacy of Inj. FCM was monitored by the rise in the haemoglobin level at 03-, 06- and 08-weeks post infusion of FCM injection and serum Ferritin levels. The safety was assessed by analysing the adverse reactions. RESULTS No serious adverse reaction was recorded in any of the patients. The rise in haemoglobin (Hb) in second and third trimester of moderate and severe grade of anaemia was significant (P < 0.001). The target level of 10 g / dl was achieved in every patient. Only 03 patients received blood transfusion and that was for obstetric indications. No blood transfusion was because of anaemia per se. The rise in serum ferritin level was also statistically significant (P < 0.001). CONCLUSIONS Inj. FCM is an excellent modality to treat iron deficiency anaemia in pregnancy. It is safe and the rise of haemoglobin with correction of anaemia is satisfactory in a short span of time. In our country where only a handful of patients had regular antenatal check-up and non-compliancy and refractory anaemia is rampant, Inj. FCM is a big boon. KEYWORDS Iron Deficiency Anaemia, Inj. Ferric Carboxymaltose, Serum Ferritin, Blood Transfusion

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ROLE OF CBC WITH SPECIAL REFERENCE TO RDW-CV IN DETECTING EARLY IRON DEFICIENCY ANAEMIA IN PREGNANCY

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2018/152 ◽

2018 ◽

Vol 5 (9) ◽

pp. 744-748

Author(s):

Sumita Tripathy ◽

Bagmi Mishra

Keyword(s):

Iron Deficiency ◽

Special Reference ◽

Iron Deficiency Anaemia ◽

Deficiency Anaemia ◽

Anaemia In Pregnancy ◽

In Pregnancy

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Paroxysmal nocturnal haemoglobinuria presenting as iron deficiency anaemia in pregnancy

Journal of Obstetrics and Gynaecology ◽

10.3109/01443619109013529 ◽

1991 ◽

Vol 11 (2) ◽

pp. 112-112 ◽

Cited By ~ 1

Author(s):

C. Fitzpatrick ◽

M. Brassil ◽

J. Stronge ◽

B. Otridge

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Paroxysmal Nocturnal Haemoglobinuria ◽

Deficiency Anaemia ◽

Anaemia In Pregnancy ◽

In Pregnancy

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Iron stores in pregnant women with sickle cell disease: a protocol for a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2018-026497 ◽

2019 ◽

Vol 9 (9) ◽

pp. e026497 ◽

Cited By ~ 2

Author(s):

Desmond Aroke ◽

Benjamin Momo Kadia ◽

Tsi Njim

Keyword(s):

Systematic Review ◽

Sickle Cell Disease ◽

Iron Deficiency ◽

Pregnant Women ◽

Sickle Cell ◽

Iron Deficiency Anaemia ◽

Meta Analysis ◽

Cochrane Library ◽

Cell Disease ◽

Deficiency Anaemia

IntroductionSickle cell disease (SCD) is the most common inherited disease worldwide. The greatest disease burden is seen in sub-Saharan Africa. Early diagnosis and improved care of people living with SCD have led to an increase in the number of women with SCD reaching the reproductive age. Iron deficiency anaemia remains the most common cause of anaemia in pregnancy, affecting 51%–63% of pregnancies in Africa. However, the unavailability of guidelines on supplementation of iron in this pregnant subpopulation often leaves clinicians in a fix. We propose to conduct the first systematic review and possibly a meta-analysis on the prevalence, associated factors and maternal/fetal outcomes of iron deficiency anaemia among pregnant women with SCD.Methods and analysisWe will search the following electronic databases for studies on the iron status of pregnant women with SCD: PubMed, MEDLINE, EMBASE, Google Scholar, African Journals Online, African Index Medicus, Popline and the Cochrane Library. After the selection of eligible studies from the search output, review of full text, data extraction and data synthesis will be performed. Studies obtained from the review shall be evaluated for quality, risk of bias and heterogeneity. Appropriate statistical methods shall be used to pool prevalence estimates for matching studies globally and in subpopulations. This protocol has been reported as per the 2015 guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols.Ethics and disseminationThere is no requirement for ethical approval as the proposed study will use published data. The findings of this study will be published in a peer-reviewed journal and will be presented at conferences.Trial registration numberCRD42018109803.

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