Next Steps: Author Rejoinder to Commentaries on Brief Therapeutic Approaches for Personality Disorders

Although estimates as to the incidence of personality disorder in the elderly remain controversial, it is well known that such a disorder is prevalently ego-syntonic and capable of interfering with the onset and treatment of other somatic and psychic pathologies, especially in later life, when individuals tend to be particularly vulnerable. Misdiagnosis or failure to treat these disorders may greatly diminish the quality of life of older adults and their families. The aim of this work is to define the chief psychopharmacological and psychotherapeutic guidelines for treating personality disorders in the elderly. Pharmacologically, patients require treatment with molecules designed to rebalance neurotransmitter system alterations, which underlie the symptomatological picture. As regards psychotherapeutic treatment, although there are only a few validation studies, we believe that dialectical behavior therapy and interpersonal psychotherapy may constitute valid therapeutic approaches that meet both the needs and the individual characteristics of patients affected by personality disorder and those of elderly patients.

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What Knowledge Is Lacking on Brief Interventions for Personality Disorders and Why: Commentary on Brief Therapeutic Approaches for Personality Disorders

The Cambridge Handbook of Personality Disorders ◽

10.1017/9781108333931.084 ◽

2020 ◽

pp. 495-497

Author(s):

Lars Mehlum

Keyword(s):

Personality Disorders ◽

Brief Interventions ◽

Therapeutic Approaches

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Relation Entre Dépression, Tempérament Et Trouble De Personnalité: Quelques Implications Thérapeutiques

The Canadian Journal of Psychiatry ◽

10.1177/070674379403900911 ◽

1994 ◽

Vol 39 (9) ◽

pp. 572-576

Author(s):

Jean Leblanc ◽

Ursula Streit ◽

Yolande Tanguay

Keyword(s):

Personality Disorders ◽

Mood Disorders ◽

Clinical Signs ◽

Personality Types ◽

Psychiatric Diagnoses ◽

Dimensional Model ◽

Therapeutic Approaches ◽

Therapeutic Implications ◽

Normal Personality ◽

Treatment Of Depression

Certain personality traits or disorders in combination with clinical signs complicate the diagnosis and treatment of depression. The approaches to the relationships between personality and mood disorders vary. Some see important links between normal personality types (or temperaments) and depression, while others see certain temperaments as sub-syndromic variants of mood disorders. Finally, a third approach proposes an analysis, drawing on Robins and Guze's criteria, of the validity of psychiatric diagnoses for determining whether this frequent comorbidity of depression and personality disorders (DSM-III) is consistent with a nosologic relationship, or is merely some definitional or other artefact. A category-based diagnostic approach provides little clarification; in some studies, a dimensional model attempts to better define the links between depression, temperament and personality and clarify the content of the apparently heterogeneous notion of depression, with therapeutic implications. Research in this area should lead to the development of increasingly specific therapeutic approaches to depression.

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Nanotheranostic agents for neurodegenerative diseases

Emerging Topics in Life Sciences ◽

10.1042/etls20190141 ◽

2020 ◽

Vol 4 (6) ◽

pp. 645-675

Author(s):

Parasuraman Padmanabhan ◽

Mathangi Palanivel ◽

Ajay Kumar ◽

Domokos Máthé ◽

George K. Radda ◽

...

Keyword(s):

Drug Delivery ◽

Neurodegenerative Diseases ◽

Cell Types ◽

Specific Cell ◽

Ageing Population ◽

Target Tissue ◽

Therapeutic Approaches ◽

Surface Receptors ◽

Theranostic Agents ◽

Preclinical Animal Models

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to countries with progressively ageing populations. Parallel with the search for biomarkers for early detection and prediction, the pursuit for therapeutic approaches has become growingly intensive in recent years. Various prospective therapeutic approaches have been explored with an emphasis on early prevention and protection, including, but not limited to, gene therapy, stem cell therapy, immunotherapy and radiotherapy. Many pharmacological interventions have proved to be promising novel avenues, but successful applications are often hampered by the poor delivery of the therapeutics across the blood-brain-barrier (BBB). To overcome this challenge, nanoparticle (NP)-mediated drug delivery has been considered as a promising option, as NP-based drug delivery systems can be functionalized to target specific cell surface receptors and to achieve controlled and long-term release of therapeutics to the target tissue. The usefulness of NPs for loading and delivering of drugs has been extensively studied in the context of NDDs, and their biological efficacy has been demonstrated in numerous preclinical animal models. Efforts have also been made towards the development of NPs which can be used for targeting the BBB and various cell types in the brain. The main focus of this review is to briefly discuss the advantages of functionalized NPs as promising theranostic agents for the diagnosis and therapy of NDDs. We also summarize the results of diverse studies that specifically investigated the usage of different NPs for the treatment of NDDs, with a specific emphasis on AD and PD, and the associated pathophysiological changes. Finally, we offer perspectives on the existing challenges of using NPs as theranostic agents and possible futuristic approaches to improve them.

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Lessons From the Neural Bases of Speech and Voice

Perspectives on Speech Science and Orofacial Disorders ◽

10.1044/ssod21.1.5 ◽

2011 ◽

Vol 21 (1) ◽

pp. 5-14

Author(s):

Christy L. Ludlow

Keyword(s):

Brain Networks ◽

Neural Substrates ◽

Voice Behavior ◽

Therapeutic Approaches ◽

Neural Bases ◽

Sound Foundation ◽

The Brain ◽

Normal Speech

The premise of this article is that increased understanding of the brain bases for normal speech and voice behavior will provide a sound foundation for developing therapeutic approaches to establish or re-establish these functions. The neural substrates involved in speech/voice behaviors, the types of muscle patterning for speech and voice, the brain networks involved and their regulation, and how they can be externally modulated for improving function will be addressed.

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Physiologic Studies Provide New Perspectives on Early Speech Development

Perspectives on Speech Science and Orofacial Disorders ◽

10.1044/ssod20.2.29 ◽

2010 ◽

Vol 20 (2) ◽

pp. 29-36

Author(s):

Erin M. Wilson ◽

Ignatius S. B. Nip

Keyword(s):

Motor Control ◽

Motor Development ◽

Motion Tracking ◽

Speech Development ◽

Speech Motor Control ◽

Therapeutic Approaches ◽

Facial Motion ◽

Disordered Speech ◽

Speech Motor ◽

Physiologic Data

Abstract Although certain speech development milestones are readily observable, the developmental course of speech motor control is largely unknown. However, recent advances in facial motion tracking systems have been used to investigate articulator movements in children and the findings from these studies are being used to further our understanding of the physiologic basis of typical and disordered speech development. Physiologic work has revealed that the emergence of speech is highly dependent on the lack of flexibility in the early oromotor system. It also has been determined that the progression of speech motor development is non-linear, a finding that has motivated researchers to investigate how variables such as oromotor control, cognition, and linguistic factors affect speech development in the form of catalysts and constraints. Physiologic data are also being used to determine if non-speech oromotor behaviors play a role in the development of speech. This improved understanding of the physiology underlying speech, as well as the factors influencing its progression, helps inform our understanding of speech motor control in children with disordered speech and provide a framework for theory-driven therapeutic approaches to treatment.

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