Genetic interactions and network reliability

2015 ◽  
pp. 51-64
Author(s):  
Edgar Delgado-Eckert ◽  
Niko Beerenwinkel
2020 ◽  
Vol 9 (3) ◽  
pp. 177-191
Author(s):  
Sridharan Priya ◽  
Radha K. Manavalan

Background: The diseases in the heart and blood vessels such as heart attack, Coronary Artery Disease, Myocardial Infarction (MI), High Blood Pressure, and Obesity, are generally referred to as Cardiovascular Diseases (CVD). The risk factors of CVD include gender, age, cholesterol/ LDL, family history, hypertension, smoking, and genetic and environmental factors. Genome- Wide Association Studies (GWAS) focus on identifying the genetic interactions and genetic architectures of CVD. Objective: Genetic interactions or Epistasis infer the interactions between two or more genes where one gene masks the traits of another gene and increases the susceptibility of CVD. To identify the Epistasis relationship through biological or laboratory methods needs an enormous workforce and more cost. Hence, this paper presents the review of various statistical and Machine learning approaches so far proposed to detect genetic interaction effects for the identification of various Cardiovascular diseases such as Coronary Artery Disease (CAD), MI, Hypertension, HDL and Lipid phenotypes data, and Body Mass Index dataset. Conclusion: This study reveals that various computational models identified the candidate genes such as AGT, PAI-1, ACE, PTPN22, MTHR, FAM107B, ZNF107, PON1, PON2, GTF2E1, ADGRB3, and FTO, which play a major role in genetic interactions for the causes of CVDs. The benefits, limitations, and issues of the various computational techniques for the evolution of epistasis responsible for cardiovascular diseases are exhibited.


Energies ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3242
Author(s):  
Hamid Mirshekali ◽  
Rahman Dashti ◽  
Karsten Handrup ◽  
Hamid Reza Shaker

Distribution networks transmit electrical energy from an upstream network to customers. Undesirable circumstances such as faults in the distribution networks can cause hazardous conditions, equipment failure, and power outages. Therefore, to avoid financial loss, to maintain customer satisfaction, and network reliability, it is vital to restore the network as fast as possible. In this paper, a new fault location (FL) algorithm that uses the recorded data of smart meters (SMs) and smart feeder meters (SFMs) to locate the actual point of fault, is introduced. The method does not require high-resolution measurements, which is among the main advantages of the method. An impedance-based technique is utilized to detect all possible FL candidates in the distribution network. After the fault occurrence, the protection relay sends a signal to all SFMs, to collect the recorded active power of all connected lines after the fault. The higher value of active power represents the real faulty section due to the high-fault current. The effectiveness of the proposed method was investigated on an IEEE 11-node test feeder in MATLAB SIMULINK 2020b, under several situations, such as different fault resistances, distances, inception angles, and types. In some cases, the algorithm found two or three candidates for FL. In these cases, the section estimation helped to identify the real fault among all candidates. Section estimation method performs well for all simulated cases. The results showed that the proposed method was accurate and was able to precisely detect the real faulty section. To experimentally evaluate the proposed method’s powerfulness, a laboratory test and its simulation were carried out. The algorithm was precisely able to distinguish the real faulty section among all candidates in the experiment. The results revealed the robustness and effectiveness of the proposed method.


Electronics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 955
Author(s):  
Vasyl Teslyuk ◽  
Andriy Sydor ◽  
Vincent Karovič ◽  
Olena Pavliuk ◽  
Iryna Kazymyra

Technical systems in the modern global world are rapidly evolving and improving. In most cases, these are large-scale multi-level systems and one of the problems that arises in the design process of such systems is to determine their reliability. Accordingly, in the paper, a mathematical model based on the Weibull distribution has been developed for determining a computer network reliability. In order to simplify calculating the reliability characteristics, the system is considered to be a hierarchical one, ramified to level 2, with bypass through the level. The developed model allows us to define the following parameters: the probability distribution of the count of working output elements, the availability function of the system, the duration of the system’s stay in each of its working states, and the duration of the system’s stay in the prescribed availability condition. The accuracy of the developed model is high. It can be used to determine the reliability parameters of the large, hierarchical, ramified systems. The research results of modelling a local area computer network are presented. In particular, we obtained the following best option for connecting workstations: 4 of them are connected to the main hub, and the rest (16) are connected to the second level hub, with a time to failure of 4818 h.


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