scholarly journals C.05 Direct visualization of the human zona incerta region using ultra-high field imaging: implications for stereotactic neurosurgery

2019 ◽  
Vol 46 (s1) ◽  
pp. S13
Author(s):  
JC Lau ◽  
TM Peters ◽  
Y Xiao ◽  
G Gilmore ◽  
KW MacDougall ◽  
...  
Keyword(s):  
High Field ◽  
T1 Mapping ◽  
Imaging Study ◽  
Zona Incerta ◽  
7 Tesla ◽  
Patient Specific ◽  
Ultra High Field ◽  
Fusion Methods ◽  
Deep Brain

Background: The zona incerta (ZI) is a small structure in the deep brain first identified by Auguste Forel for which robust in vivo visualization has remained elusive. The increased inherent signal from ultra-high field (7-Tesla or greater; 7T) magnetic resonance imaging (MRI) presents an opportunity to see structures not previously visible. In this study, we investigated the possibility of using quantitative T1 mapping at 7T to visualize the ZI region. Methods: We recruited healthy participants (N=32) and patients being considered for deep brain stimulation therapy as part of a prospective imaging study at 7T. Computational methods were used to process and fuse images to produce a high-resolution group average from which ZI anatomy could be delineated. Results: We pooled 7T data using image fusion methods and found that the contrast from quantitative T1 mapping was strikingly similar to classic histological staining, permitting facile identification of the ZI and nearby structures in reference to conventional stereotactic atlases. Conclusions: Using computational neuroimaging techniques, we demonstrate for the first time that the ZI is visible in vivo. Furthermore, we determined that this nuclear region can be decoupled from surrounding fibre pathways. This work paves the way for more accurate patient-specific optimization of deep brain targets for neuromodulation.

scholarly journals P.063 Stereotactic targeting of hippocampal substructures using ultra-high field magnetic resonance imaging: Feasibility study in patients with epilepsy

2018 ◽  
Vol 45 (s2) ◽  
pp. S32-S33
Author(s):  
JC Lau ◽  
J DeKraker ◽  
KW MacDougall ◽  
H Joswig ◽  
AG Parrent ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Dentate Gyrus ◽  
High Field ◽  
Longitudinal Axis ◽  
The Body ◽  
7 Tesla ◽  
Resonance Imaging ◽  
Ultra High Field

Background: The hippocampus can be divided longitudinally into the head, body, and tail; and unfolded medial-to-laterally into the subiculum, cornu ammonis (CA) sectors, and the dentate gyrus. Ultra-high field (≥ 7 Tesla; 7T) magnetic resonance imaging (MRI) enables submillimetric visualization of these hippocampal substructures which could be valuable for surgical targeting. Here, we assess the feasibility of using 7T MRI in conjunction with a novel computational unfolding method for image-based stereotactic targeting of hippocampal substructures. Methods: 53 patients with drug-resistant epilepsy were identified undergoing first-time implantation of the hippocampus. An image processing pipeline was created for computationally transforming post-operative electrode contact locations into our hippocampal coordinate system. Results: Of 178 implanted hippocampal electrodes (88 left; 49.4%), 25 (14.0%) were predominantly in the subiculum, 85 (47.8%) were in CA1, 23 (12.9%) were in CA2, 18 (10.1%) were in CA3/CA4, and 27 (15.2%) were in dentate gyrus. Along the longitudinal axis, hippocampal electrodes were most commonly implanted in the body (92; 51.7%) followed by the head (86; 48.3%). Conclusions: 7T MRI enables high-resolution anatomical imaging on the submillimeter scale in in vivo subjects. Here, we demonstrate the utility of 7T imaging for identifying the relative location of SEEG electrode implantations within hippocampal substructures for the invasive investigation of epilepsy.

Defining the human hypothalamus in vivo by ultra-high field 7 Tesla MRI

2013 ◽  
Vol 44 (01) ◽  
Author(s):  
S Schindler ◽  
L Schmidt ◽  
M Strauß ◽  
A Anwander ◽  
PL Bazin ◽  
...  
Keyword(s):  
High Field ◽  
7 Tesla ◽  
Ultra High Field ◽  
Human Hypothalamus ◽  
7 Tesla Mri

scholarly journals Sub-millimeter variation in human locus coeruleus is associated with dimensional measures of psychopathology: An in vivo ultra-high field 7-Tesla MRI study

2020 ◽  
Vol 25 ◽  
pp. 102148 ◽  
Author(s):  
Laurel S. Morris ◽  
Aaron Tan ◽  
Derek A. Smith ◽  
Mora Grehl ◽  
Kuang Han-Huang ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
High Field ◽  
7 Tesla ◽  
Ultra High Field ◽  
7 Tesla Mri ◽  
Mri Study

scholarly journals Direct visualization and characterization of the human zona incerta and surrounding structures

2020 ◽  
Author(s):  
Jonathan C. Lau ◽  
Yiming Xiao ◽  
Roy A.M. Haast ◽  
Greydon Gilmore ◽  
Kamil Uludag ◽  
...  
Keyword(s):  
Zona Incerta ◽  
7 Tesla ◽  
Histological Evaluation ◽  
Medial Lemniscus ◽  
High Magnetic Field Strength ◽  
Deep Brain Region ◽  
Tissue Characteristics ◽  
The 19Th Century ◽  
Deep Brain

AbstractThe zona incerta (ZI) is a small gray matter region of the deep brain first identified in the 19th century, yet direct in vivo visualization and characterization has remained elusive. Noninvasive detection of the ZI and surrounding region could be critical to further our understanding of this widely connected but poorly understood deep brain region and could contribute to the development and optimization of neuromodulatory therapies. We demonstrate that high resolution (submillimetric) longitudinal (T1) relaxometry measurements at high magnetic field strength (7 Tesla) can be used to delineate the ZI from surrounding white matter structures, specifically the fasciculus cerebellothalamicus, fields of Forel (fasciculus lenticularis, fasciculus thalamicus, field H), and medial lemniscus. Using this approach, we successfully derived in vivo estimates of the size, shape, location, and tissue characteristics of substructures in the ZI region, confirming observations only previously possible through histological evaluation that this region is not just a space between structures but contains distinct morphological entities that should be considered separately. Our findings pave the way for increasingly detailed in vivo study and provide a structural foundation for precise functional and neuromodulatory investigation.

scholarly journals Ultra-high-field 7-T MRI in multiple sclerosis and other demyelinating diseases: from pathology to clinical practice

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Nicolo’ Bruschi ◽  
Giacomo Boffa ◽  
Matilde Inglese
Keyword(s):  
Multiple Sclerosis ◽  
High Field ◽  
Neurological Diseases ◽  
Lesion Detection ◽  
Demyelinating Diseases ◽  
Metabolic Imaging ◽  
Central Vein ◽  
Ultra High Field ◽  
Functional Features

Abstract Magnetic resonance imaging (MRI) is essential for the early diagnosis of multiple sclerosis (MS), for investigating the disease pathophysiology, and for discriminating MS from other neurological diseases. Ultra-high-field strength (7-T) MRI provides a new tool for studying MS and other demyelinating diseases both in research and in clinical settings. We present an overview of 7-T MRI application in MS focusing on increased sensitivity and specificity for lesion detection and characterisation in the brain and spinal cord, central vein sign identification, and leptomeningeal enhancement detection. We also discuss the role of 7-T MRI in improving our understanding of MS pathophysiology with the aid of metabolic imaging. In addition, we present 7-T MRI applications in other demyelinating diseases. 7-T MRI allows better detection of the anatomical, pathological, and functional features of MS, thus improving our understanding of MS pathology in vivo. 7-T MRI also represents a potential tool for earlier and more accurate diagnosis.

S8. Increased Locus Coeruleus Volume in Humans With Pathological Anxiety: An Ultra-High Field 7-Tesla MRI Study

2019 ◽  
Vol 85 (10) ◽  
pp. S299-S300
Author(s):  
Laurel Morris ◽  
Aaron Tan ◽  
Derek Smith ◽  
Mora Grehl ◽  
Kuang-Han Huang ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
High Field ◽  
7 Tesla ◽  
Ultra High Field ◽  
7 Tesla Mri ◽  
Mri Study ◽  
Pathological Anxiety

scholarly journals An Assessment of Current Brain Targets for Deep Brain Stimulation Surgery With Susceptibility-Weighted Imaging at 7 Tesla

Neurosurgery ◽  
2010 ◽  
Vol 67 (6) ◽  
pp. 1745-1756 ◽  
Author(s):  
Aviva Abosch ◽  
Essa Yacoub ◽  
Kamil Ugurbil ◽  
Noam Harel
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Image Resolution ◽  
7 Tesla ◽  
Patient Specific ◽  
Susceptibility Weighted Imaging ◽  
Target Area ◽  
Electrode Position ◽  
Microelectrode Recording ◽  
Deep Brain

Abstract BACKGROUND: Deep brain stimulation (DBS) surgery is used for treating movement disorders, including Parkinson disease, essential tremor, and dystonia. Successful DBS surgery is critically dependent on precise placement of DBS electrodes into target structures. Frequently, DBS surgery relies on normalized atlas-derived diagrams that are superimposed on patient brain magnetic resonance imaging (MRI) scans, followed by microelectrode recording and macrostimulation to refine the ultimate electrode position. Microelectrode recording carries a risk of hemorrhage and requires active patient participation during surgery. OBJECTIVE: To enhance anatomic imaging for DBS surgery using high-field MRI with the ultimate goal of improving the accuracy of anatomic target selection. METHODS: Using a 7-T MRI scanner combined with an array of acquisition schemes using multiple image contrasts, we obtained high-resolution images of human deep nuclei in healthy subjects. RESULTS: Superior image resolution and contrast obtained at 7 T in vivo using susceptibility-weighted imaging dramatically improved anatomic delineation of DBS targets and allowed the identification of internal architecture within these targets. A patient-specific, 3-dimensional model of each target area was generated on the basis of the acquired images. CONCLUSION: Technical developments in MRI at 7 T have yielded improved anatomic resolution of deep brain structures, thereby holding the promise of improving anatomic-based targeting for DBS surgery. Future study is needed to validate this technique in improving the accuracy of targeting in DBS surgery.

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