scholarly journals Situating dissemination and implementation sciences within and across the translational research spectrum

2019 ◽  
Vol 4 (3) ◽  
pp. 152-158 ◽  
Author(s):  
Aaron L. Leppin ◽  
Jane E. Mahoney ◽  
Kathleen R. Stevens ◽  
Stephen J. Bartels ◽  
Laura-Mae Baldwin ◽  
...  
Keyword(s):  
Translational Research ◽  
Return On Investment ◽  
Task Force ◽  
Healthcare Research ◽  
Research Translation ◽  
Dissemination And Implementation ◽  
Translational Science ◽  
Academic Health ◽  
Health Institutions

AbstractThe efficient and effective movement of research into practice is acknowledged as crucial to improving population health and assuring return on investment in healthcare research. The National Center for Advancing Translational Science which sponsors Clinical and Translational Science Awards (CTSA) recognizes that dissemination and implementation (D&I) sciences have matured over the last 15 years and are central to its goals to shift academic health institutions to better align with this reality. In 2016, the CTSA Collaboration and Engagement Domain Task Force chartered a D&I Science Workgroup to explore the role of D&I sciences across the translational research spectrum. This special communication discusses the conceptual distinctions and purposes of dissemination, implementation, and translational sciences. We propose an integrated framework and provide real-world examples for articulating the role of D&I sciences within and across all of the translational research spectrum. The framework’s major proposition is that it situates D&I sciences as targeted “sub-sciences” of translational science to be used by CTSAs, and others, to identify and investigate coherent strategies for more routinely and proactively accelerating research translation. The framework highlights the importance of D&I thought leaders in extending D&I principles to all research stages.

scholarly journals A team-based translational journal club: Understanding the translational research highway

2019 ◽  
Vol 3 (6) ◽  
pp. 291-294
Author(s):  
Carol Feghali-Bostwick ◽  
Jillian Harvey ◽  
Carissa Hasseler ◽  
Diana Lee-Chavarria ◽  
Perry Halushka
Keyword(s):  
Translational Research ◽  
Basic Science ◽  
Journal Club ◽  
Dissemination And Implementation ◽  
Translational Science ◽  
Innovative Methods ◽  
Pivotal Study ◽  
Wide Range ◽  
Science Paper ◽  
Training Grant

AbstractThe mission of the National Center for Advancing Translational Science (NCATS) is to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.1 NCATS funded a predoctoral TL1 training grant at our institution. We developed a novel team-based Translational Journal Club utilizing three-member teams to find a basic science paper and two clinical study papers that covered a single therapeutic, either a pivotal study or a dissemination and implementation study; one member of the team presented a paper on the above topics in successive weeks. In addition, the trainees attended lectures on: how to design a pivotal clinical trial, dissemination and implementation, and drug development from a basic science discovery through its approval. From these presentations, the trainees appreciated the T0 to T3/4 continuum and its challenges. They also attended sessions on how to present scientific concepts, making them better communicators. The trainees found the Translational Journal club to be very rewarding, illuminating, and providing a much better understanding of the translational research processes required to develop new therapies.

scholarly journals Dissemination and implementation science activities across the Clinical Translational Science Award (CTSA) Consortium: Report from a survey of CTSA leaders

2019 ◽  
Vol 4 (3) ◽  
pp. 188-194 ◽  
Author(s):  
Rowena J. Dolor ◽  
Enola Proctor ◽  
Kathleen R. Stevens ◽  
Leslie R. Boone ◽  
Paul Meissner ◽  
...  
Keyword(s):  
Knowledge Translation ◽  
Implementation Science ◽  
Working Group ◽  
Dissemination And Implementation ◽  
Translational Science ◽  
Formal Element ◽  
Dissemination And Implementation Science ◽  
Qualitative Analyses ◽  
Science Activities

AbstractIntroduction:Dissemination and implementation (D&I) science is not a formal element of the Clinical Translational Science Award (CTSA) Program, and D&I science activities across the CTSA Consortium are largely unknown.Methods:The CTSA Dissemination, Implementation, and Knowledge Translation Working Group surveyed CTSA leaders to explore D&I science-related activities, barriers, and needed supports, then conducted univariate and qualitative analyses of the data.Results:Out of 67 CTSA leaders, 55.2% responded. CTSAs reported directly funding D&I programs (54.1%), training (51.4%), and projects (59.5%). Indirect support (e.g., promoted by CTSA without direct funding) for D&I activities was higher – programs (70.3%), training (64.9%), and projects (54.1%). Top barriers included funding (39.4%), limited D&I science faculty (30.3%), and lack of D&I science understanding (27.3%). Respondents (63.4%) noted the importance of D&I training and recommended coordination of D&I activities across CTSAs hubs (33.3%).Conclusion:These findings should guide CTSA leadership in efforts to raise awareness and advance the role of D&I science in improving population health.

Impact of advanced clinical and translational research educational programs on oncology specialties and career development.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 11026-11026
Author(s):  
Aron Simkins ◽  
Michael Lee ◽  
Wencesley A. Paez ◽  
Cecilia Arana Yi ◽  
Heidi E. Kosiorek ◽  
...  
Keyword(s):  
Career Development ◽  
Translational Research ◽  
Research Productivity ◽  
Return On Investment ◽  
Career Advancement ◽  
Translational Science ◽  
Group A ◽  
Group B ◽  
The U.S ◽  
Clinical And Translational Research

11026 Background: The Clinical and Translational Science Award (CTSA) Program currently supports more than 50 leading medical research institutions in the U.S. with the aims of training, promoting and developing future translational science researchers, with particular emphasis on advanced Clinical and Translational Research (CTR) education. No prior studies have evaluated career development in oncologists who have completed CTR training. The objective of this study is to examine the impact of advanced CTR training on career development, return-on-investment and research productivity in Oncology specialties. Methods: With IRB approval, we conducted a survey study of U.S.-based Hematology/Oncology (H/O), Radiation Oncology (RO), and Surgical Oncology (SO) members of the American Society of Clinical Oncology who completed CTR training. Data was anonymized and collected through Research Electronic Data Capture (REDCap). Outcomes were compared using Chi-square test for frequency data. Results: We received 225 survey responses (62.1% H/O, 23.3% RO, 13.2% SO, 1.4% others). About 28.4% (n = 64) of the respondents had a PhD or Master's degree in CTR (Group A) compared to 71.6% (n = 161) with graduate certificates or non-degree granting courses in CTR (Group B). Specialty ratio was equally distributed between both groups. Overall, 79.7% vs 57.5%; P < 0.001 of respondents worked in academia, of which 55.2% had tenure track positions. Over 49 different CTSA Programs throughout the U.S. were represented. In terms of impact with new research projects, the ability to secure funding and opportunities for multidisciplinary collaboration, satisfaction with CTR training was higher among Group A compared with Group B (P < 0.001; P < 0.01; P < 0.01 respectively). In terms of research output, higher satisfaction was seen in Group A (67.2% vs 47.4%; P < 0.01), however total publications per year were not statistically significant (P = 0.135). Usefulness of a CTR degree on career advancement, a difference of 50.0% vs 19.1%; P < 0.001 was noted. Similarly, usefulness regarding new job opportunities and return-on-investment also favored Group A (P < 0.001). Overall satisfaction with training was significantly higher in Group A (73.4% vs 48.7%; P = 0.004). Conclusions: This study is the first to report satisfaction ratings for CTR training among oncology specialties. Although no significant difference was observed in terms of publication output, those with higher levels of advanced degrees were more satisfied with their CTR training, and viewed it as more impactful to career advancement and research productivity. The evidence presented is useful for informing career development for oncology residents and fellows offered CTR degrees during their training.

scholarly journals Linking dissemination and implementation science to Learning Health Systems: Opportunities for Clinical and Translational Science Award institutions

2020 ◽  
Vol 4 (3) ◽  
pp. 176-179 ◽  
Author(s):  
Nancy M. Bennett ◽  
Elissa Orlando ◽  
Paul Meissner
Keyword(s):  
Health Systems ◽  
Care Delivery ◽  
Health Improvement ◽  
Dissemination And Implementation ◽  
Translational Science ◽  
Evidence Based Practices ◽  
Dissemination And Implementation Science ◽  
Research Integration ◽  
Critical Components

AbstractLearning Health Systems (LHS) iteratively implement and evaluate health improvement projects. Dissemination and implementation (D&I) science is the study of evidence-based practices in real-world settings, a critical tool for LHS. This paper explores intersections between LHS and D&I science in Clinical and Translational Science Awards (CTSAs) institutions and identifies critical components of collaboration. We conducted website scans of 34 CTSAs and their home institutions that had Dissemination, Implementation, and Knowledge Translation (DIKT) Workgroup members. We identified linkages between CTSAs and their institutions’ LHS. We interviewed six CTSA leaders experienced in LHS and D&I sciences. Nearly half of CTSAs identified an LHS structure on their websites, but only one-third indicates CTSA involvement in these efforts. Interviewees identified key components for successful integration of LHS and D&I sciences: leadership, infrastructure, balance between rigor and efficiency, and aligned incentives. The need for research integration in LHS, to improve evaluation and increase knowledge, is an emerging opportunity for D&I scientists and CTSAs. CTSAs that are engaged in D&I science can introduce and/or expand the role of D&I science in LHS. Collaboration between CTSAs and clinical leaders could result in strengthened relationships between clinical and research enterprises, effective and efficient health care delivery, and improved health.

scholarly journals Advancing health equity through CTSA programs: Opportunities for interaction between health equity, dissemination and implementation, and translational science

2020 ◽  
Vol 4 (3) ◽  
pp. 168-175 ◽  
Author(s):  
Reza Yousefi Nooraie ◽  
Bethany M. Kwan ◽  
Elizabeth Cohn ◽  
Mona AuYoung ◽  
Megan Clarke Roberts ◽  
...  
Keyword(s):  
Translational Research ◽  
Health Equity ◽  
Health Inequities ◽  
Dissemination And Implementation ◽  
Evidence Based ◽  
Translational Science ◽  
Diverse Populations ◽  
Apply Research ◽  
Evidence Based Programs ◽  
Widespread Dissemination

AbstractDissemination and implementation (D&I) science is dedicated to studying how to effectively translate and apply research in real-world contexts. There has been increasing interest in health equity within the D&I field to ensure the equitable implementation of evidence-based programs/practices across a range of diverse populations and settings. At the same time, health equity researchers recognize the potential of D&I science to promote the more widespread dissemination, implementation, and sustainment of evidence-based interventions to address health inequities. The National Center for Accelerating Clinical and Translational Science Clinical and Translational Science Award (CTSA) Program has been a champion for community engagement and translational scholarship in its mission to improve individual and population health. The overall CTSA infrastructure and resources within and among CTSA hubs are well-equipped to facilitate a health equity focus to D&I across the phases of translational research. This paper proposes a framework that demonstrates the interaction and opportunities between health equity and D&I science and highlights how CTSAs can support and facilitate wider efforts in translational research with a focus on equitable D&I.

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