scholarly journals Rapid diagnostic testing for antimicrobial stewardship: Utility in Asia Pacific

2021 ◽  
pp. 1-5
Author(s):  
Anucha Apisarnthanarak ◽  
Hong Bin Kim ◽  
Luke Moore ◽  
Yonghong Xiao ◽  
Sanjeev Singh ◽  
...  
Keyword(s):  
Antimicrobial Stewardship ◽  
Viral Infections ◽  
Diagnostic Testing ◽  
Asia Pacific ◽  
Accurate Identification ◽  
Rapid Diagnostic Testing ◽  
Human Resource Capacity ◽  
Selective Approach ◽  
Consensus Statements ◽  
The Impact

Abstract Rapid diagnostic testing (RDT) can provide prompt, accurate identification of infectious organisms and be a key component of antimicrobial stewardship (AMS) programs. However, their use is less widespread in Asia Pacific than western countries. Cost can be prohibitive, particularly in less resource-replete settings. A selective approach is required, possibly focusing on the initiation of antimicrobials, for differentiating bacterial versus viral infections and identifying locally relevant tropical diseases. Across Asia Pacific, more data are needed on RDT use within AMS, focusing on the impact on antimicrobial usage, patient morbidity and mortality, and cost effectiveness. Moreover, in the absence of formal guidelines, regional consensus statements to guide clinical practice are warranted. These will provide a regionally relevant definition for RDT; greater consensus on its role in managing infections; advice on implementation and overcoming barriers; and guidance on optimizing human resource capacity. By addressing these issues, the outcomes of AMS programs should improve.

scholarly journals The Added Cost of Rapid Diagnostic Testing and Active Antimicrobial Stewardship: Is It Worth It?

2016 ◽  
Vol 55 (1) ◽  
pp. 20-23 ◽  
Author(s):  
Erin McElvania TeKippe
Keyword(s):  
Antimicrobial Stewardship ◽  
Diagnostic Testing ◽  
Hospital Costs ◽  
Turnaround Time ◽  
Clinical Microbiology Laboratory ◽  
Pathogen Identification ◽  
Ionization Time ◽  
Rapid Diagnostic Testing ◽  
Flight Mass Spectrometry ◽  
The Impact

ABSTRACT Rapid diagnostic testing reduces the turnaround time for pathogen identification in the clinical microbiology laboratory, but the impact on patient care and hospital costs is a matter of speculation. Patel et al. (J. Clin. Microbiol. 55:60–67, 2017, https://doi.org/10.1128/JCM.01452-16 ) investigate the impact of matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) in conjunction with active antimicrobial stewardship to determine if implementation is indeed worth the added costs.

scholarly journals The Confounding Role of Antimicrobial Stewardship Programs in Understanding the Impact of Technology on Patient Care: TABLE 1

2016 ◽  
Vol 54 (10) ◽  
pp. 2420-2423 ◽  
Author(s):  
Christopher D. Doern
Keyword(s):  
Patient Care ◽  
Antimicrobial Stewardship ◽  
Clinical Microbiology ◽  
Diagnostic Testing ◽  
Antimicrobial Stewardship Program ◽  
Rapid Diagnostic Testing ◽  
Stewardship Program ◽  
Impact Of Technology ◽  
The Impact

Numerous studies have demonstrated the benefit of the combination of antimicrobial stewardship program (ASP) intervention and rapid diagnostic testing (RDT). However, few studies have attempted to study the incremental benefit of ASP and RDT, making it difficult to understand the true benefits of each intervention. This issue is discussed in the context of an article by S. H. McVane and F. S. Nolte (J Clin Microbiol 54:2476–2484, 2016,http://dx.doi.org/doi:10.1128/JCM.00996-16), with suggestions about how the findings of this study can be applied to other areas of clinical microbiology.

scholarly journals Implementation of a Pharmacist-Directed Antimicrobial Stewardship Protocol Utilizing Rapid Diagnostic Testing

2016 ◽  
Vol 51 (10) ◽  
pp. 815-822 ◽  
Author(s):  
Angel Heyerly ◽  
Ron Jones ◽  
Gordon Bokhart ◽  
Mary Shoaff ◽  
Douglas Fisher
Keyword(s):  
Antimicrobial Stewardship ◽  
Diagnostic Testing ◽  
Rapid Diagnostic Testing

scholarly journals Predictors of Time to Effective and Optimal Antimicrobial Therapy in Patients With Positive Blood Cultures Identified via Molecular Rapid Diagnostic Testing

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Maya Beganovic ◽  
Tristan T Timbrook ◽  
Sarah M Wieczorkiewicz
Keyword(s):  
Patient Outcomes ◽  
Antimicrobial Stewardship ◽  
Antimicrobial Therapy ◽  
Diagnostic Tests ◽  
Diagnostic Testing ◽  
Rapid Diagnostic Tests ◽  
Blood Cultures ◽  
Effective Therapy ◽  
Rapid Diagnostic Testing ◽  
Optimal Therapy

Abstract Antimicrobial stewardship (AMS) programs integrated with rapid diagnostic tests optimize patient outcomes and reduce time to effective therapy (TTET) and time to optimal therapy (TTOT). This study identifies predictors of TTET and TTOT among patients with positive blood cultures and identifies limitations to current TTOT definitions and outcomes.

scholarly journals Antimicrobial Stewardship and Rapid Diagnostic Testing Bundle for Local Management of Gram-Negative Bloodstream Infections

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Elizabeth Nimmich ◽  
Thomas Smith ◽  
Julie Ann Justo ◽  
P. Brandon Bookstaver ◽  
Katie Hammer ◽  
...  
Keyword(s):  
Antimicrobial Stewardship ◽  
Diagnostic Testing ◽  
Bloodstream Infections ◽  
Local Management ◽  
Gram Negative ◽  
Rapid Diagnostic Testing

scholarly journals Identification and Antibiotic Susceptibility Patterns of Clinical Blood Culture Isolates Not Identified by a Rapid Microarray Diagnostic System

2021 ◽  
Author(s):  
Jeffrey A. Freiberg ◽  
Connor R. Deri ◽  
Whitney J. Nesbitt ◽  
Romney M. Humphries ◽  
George E. Nelson
Keyword(s):  
Blood Culture ◽  
Antimicrobial Stewardship ◽  
Antimicrobial Therapy ◽  
Antibiotic Susceptibility ◽  
Diagnostic Testing ◽  
Diagnostic System ◽  
Rapid Diagnostic Testing ◽  
Antibiotic Susceptibility Patterns ◽  
Susceptibility Patterns

Rapid diagnostic testing to identify bloodstream pathogens has arisen as an important tool both to ensure adequate antimicrobial therapy is given early and to aid in antimicrobial stewardship by allowing for more rapid deescalation of inappropriate antimicrobial therapy. However, there is a paucity of data regarding the significance of isolates that are not able to be identified by rapid diagnostic testing.

scholarly journals 2133. Clinical Impact of Implementation of Rapid Diagnostic Testing of Blood Cultures on Patient Outcomes

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S722-S722
Author(s):  
Anndee Gritte ◽  
Teri Hopkins ◽  
Kathleen Morneau ◽  
Christopher R Frei ◽  
Jose Cadena-Zuluaga ◽  
...  
Keyword(s):  
Antimicrobial Therapy ◽  
Diagnostic Testing ◽  
Positive Culture ◽  
Length Of Hospital Stay ◽  
Blood Cultures ◽  
Coagulase Negative Staphylococcus ◽  
Vancomycin Therapy ◽  
Rapid Diagnostic Testing ◽  
Diagnostic Technology ◽  
The Impact

Abstract Background Rapid diagnostic testing (RDT) in microbiology labs shortens the time to identification of bacteria in blood cultures. This study evaluates the impact of implementation of Cepheid® GeneXpert® to detect methicillin-resistant Staphylococcus aureus and S. aureus in Gram-positive blood cultures. Methods Patients with positive blood cultures for Staphylococcus spp. before (November 2015–August 2016) and after (November 2017–8/2018) implementation of a new rapid diagnostic technology were evaluated. RDT results were reviewed once daily by the antimicrobial stewardship team. The primary outcome was time to appropriate antimicrobial therapy. Secondary outcomes included the duration of antimicrobial therapy from time of positive culture, duration of vancomycin therapy, and length of hospital stay (LOS). Results A total of 113 patients were in the pre- and 73 patients were in the post-implementation cohort. Patients treated post-RDT demonstrated significantly shorter median time to appropriate therapy (20.6 hours vs. 49.8 hours, P = 0.03) and numerically shorter median duration of vancomycin therapy (3.0 days vs. 1.0 days, P = 0.32). These numerical differences were present despite the post-RDT cohort having significantly more MSSA and MRSA infections. Differences in duration of antimicrobial therapy were not statistically significant. Patients treated pre-RDT demonstrated a shorter median LOS than those treated post-implementation (7.0 days vs. 8.5 days, P = 0.03). Conclusion The use of RDT significantly decreased time to appropriate antimicrobial therapy. Patients in the post-RDT cohort had longer LOS, which may due to a higher incidence of S. aureus infections, compared with coagulase-negative Staphylococcus, in this cohort These results are promising for future RDT interventions. Disclosures All authors: No reported disclosures.

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