Effect on the reduction of bacterial load after surgical hand antisepsis with triclosan 0.5% compared to triclosan 0.5% followed by 70% alcoholic solution

2021 ◽  
pp. 1-3
Author(s):  
Luis Santé ◽  
María Luisa Gómez-Lus ◽  
Carlos Martin-Villa ◽  
Ricardo Becerro-de-Bengoa-Vallejo ◽  
Luis Alou ◽  
...  
Keyword(s):  
Bacterial Load ◽  
Alcoholic Solution ◽  
Hand Rubbing ◽  
Sustained Effect ◽  
Limited Effectiveness ◽  
Hand Antisepsis

Abstract Triclosan 0.5% by scrubbing does not meet the UNE-EN12791 criteria to be used in the surgical hand preparation (SHP). Triclosan 0.5% by scrubbing followed by ethanol 70% hand rubbing is suitable without the additional characteristic of sustained effect. This limited effectiveness implies that triclosan should be avoided in SHP given the restrictions on its use in consumer antiseptic products. The trial was registered at ClinicalTrials.gov (ID: NCT04538365).

scholarly journals Comparison of Disinfection Efficacy of Alcoholic Hand Rubbing Preparations (Surgical Hand Antisepsis) Against Bacteria on Hands of Nurses

2016 ◽  
Vol 31 (4) ◽  
pp. 235-240
Author(s):  
Tadashi NAKAMURA ◽  
Mie SAIJO ◽  
Misato TAGUCHI ◽  
Kenji MARUMO ◽  
Yoko YANAGAWA
Keyword(s):  
Hand Rubbing ◽  
Hand Antisepsis

scholarly journals Surgical Hand Antisepsis With Alcohol-Based Hand Rub Comparison of Effectiveness After 1.5 and 3 Minutes of Application

2009 ◽  
Vol 30 (5) ◽  
pp. 420-426 ◽  
Author(s):  
Walter P. Weber ◽  
Stefan Reck ◽  
Uschi Neff ◽  
Ramon Saccilotto ◽  
Marc Dangel ◽  
...  
Keyword(s):  
University Hospital ◽  
Bacterial Reduction ◽  
Experimental Conditions ◽  
Postdoctoral Training ◽  
Sustained Effect ◽  
Colony Forming Units ◽  
Significant Difference ◽  
Hand Antisepsis ◽  
European Norm ◽  
The Mean

Objective.Research has shown 1.5 minutes of surgical hand antisepsis with alcohol-based hand rub to be at least as effective under experimental conditions as the 3-minute reference disinfection recommended by European Norm 12791. The aim of the present study was to validate the effectiveness of 1.5 minutes of surgical hand antisepsis in a clinical setting by comparing the effectiveness of 1.5- and 3-minute applications of alcohol-based hand rub (45% vol/vol 2-propanol, 30% vol/vol 1-propanol, and 0.2% mecetronium ethylsulphate).Design.Prospective crossover trial in which each surgeon served as his or her own control, with individual randomization to the 1.5-or the 3-minute group during the first part of the trial.Setting.Basel University Hospital, Switzerland.Participants.Thirty-two surgeons with different levels of postdoctoral training.Methods.We measured the bactericidal effectiveness of 1.5 minutes and 3 minutes of surgical hand antisepsis with alcohol-based hand rub by assessing the mean (± SD) log10 number of colony-forming units before the application of hand rub (baseline), after the application of hand rub (immediate effect), and after surgery (sustained effect) so as to follow European Norm 12791 as closely as possible.Results.The immediate mean (± SD) log10 reduction in colony-forming units (cfu) was 2.66 ±1.13 log10 cfu for the 1.5-minute group and 3.01 ±1.06 log10 cfu for the 3-minute group (P = .204). Similarly, there was no statistically significant difference between the 2 groups with respect to the sustained effect; the mean ( ± SD) log10 increase in bacterial density during surgery was 1.08 ± 1.13 log10 cfu for the 1.5-minute group and 0.95 ± 1.27 log10 cfu for the 3-minute group (P = .708). No adverse effects were recorded.Conclusion.In this clinical trial, surgical hand antisepsis with alcohol-based hand rub resulted in a similar bacterial reduction, regardless of whether it was applied for 3 or 1.5 minutes, which confirms experimental data generated with healthy volunteers.

Comparing rubbing and scrubbing surgical hand antisepsis with propan-1-ol 60% in accordance with European regulation UNE-EN 12791:2016+A1:2018

2021 ◽  
pp. 1-3
Author(s):  
Carlos Martin-Villa ◽  
Ricardo Becerro-de-Bengoa-Vallejo ◽  
Luis Alou ◽  
Natalia González ◽  
Marta Losa-Iglesias ◽  
...  
Keyword(s):  
Crossover Trial ◽  
Bacterial Load ◽  
Load Reduction ◽  
European Regulation ◽  
Hand Antisepsis ◽  
European Regulations

Abstract A crossover trial was conducted to compare hand rub and hand scrub-brush methods for reducing bacterial loads when using propan-1-ol-60% according to European regulations. Both methods significantly reduced the bacterial load immediately after antisepsis, but only the hand rub method achieved significant bacterial load reduction 3 hours after the procedure.

scholarly journals Bactericidal Activity of Ready-To-Use Alcohol-Based Commercial Wipes According to EN 16615 Carrier Standard

2019 ◽  
Vol 16 (18) ◽  
pp. 3475
Author(s):  
Tarka ◽  
Chojecka ◽  
Paduch ◽  
Nitsch-Osuch ◽  
Kanecki ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Bactericidal Activity ◽  
Bacterial Load ◽  
Mechanical Action ◽  
Alcoholic Solution ◽  
Test Surface ◽  
Enterococcus Hirae ◽  
The Right ◽  
And Staphylococcus Aureus

Background: The effectiveness of ready-to-use disinfectant wipes was previously assessed in standardized suspension tests, which were inadequate because they ignored that the wipes are rubbed against a surface. Thus, we assessed the effectiveness of commercially available disinfectant wipes impregnated with an alcoholic solution according to the 16615 standard, which includes a test with mechanical action. Methods: According to the EN 16615 standard, under clean conditions, four squares (5cm x 5 cm), placed next to one another, were marked on a test surface. Enterococcus hirae, Pseudomonas aeruginosa, and Staphylococcus aureus were inoculated on the leftmost square, and a wipe impregnated with an alcoholic solution was placed to the left of that square. Then, the wipe was pressed with a 2.5 kg weight and moved to the right and back to the left. After contact times of 1, 5, 10, or 15 minutes, we measured the reduction in bacterial load. Results: Alcohol-based ready-to-use commercial wipes did not show sufficient bactericidal activity at the contact times of 1, 5, 10 and 15 minutes. Wipes containing propan-1-ol and a mixture of propan-1-ol and propan-2-ol were active against Pseudomonas aeruginosa at the contact times of 1 minute and 15 minutes. None of the examined wipes were active against Enterococcus hirae or Staphylococcus aureus. Conclusion: Bactericidal parameters of ready-to-use disinfectant wipes should be determined in surface tests, in addition to suspension tests, because suspension tests do not simulate the conditions under which disinfectant wipes are used in practice.

2379-PUB: Team-Based Diabetes Care Demonstrates Sustained Effect on A1C

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2379-PUB
Author(s):  
JANELLE VIOLAGO ◽  
PATRICIA BONONI
Keyword(s):  
Diabetes Care ◽  
Sustained Effect

5-Benzylidene-4-Oxazolidinones are Synergistic with Antibiotics for the Treatment of Staphylococcus Aureus Biofilms

2019 ◽  
Author(s):  
Bram Frohock ◽  
Jessica M. Gilbertie ◽  
Jennifer C. Daiker ◽  
Lauren V. Schnabel ◽  
Joshua Pierce
Keyword(s):  
Staphylococcus Aureus ◽  
Human Health ◽  
Matrix Model ◽  
Bacterial Load ◽  
Collagen Matrix ◽  
Resistance Mechanisms ◽  
Novel Therapeutics ◽  
Innovative Treatment ◽  
Antibiotic Action ◽  
Biofilm Infection

<div>The failure of frontline antibiotics in the clinic is one of the most serious threats to human health and requires a multitude of novel therapeutics and innovative treatment approaches to curtail the growing crisis. In addition to traditional resistance mechanisms resulting in the lack of efficacy of many antibiotics, most chronic and recurring infections are further made tolerant to antibiotic action by the presence of biofilms. Herein, we report an expanded set of 5-benzylidene-4-oxazolidinones that are able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilms and in combination with common antibiotics are able to significantly reduce the bacterial load in a robust collagen-matrix model of biofilm infection.</div>

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