Possible Role of the Cytoplasm in the Course of Morphogenesis, Namely, in the Case of Twinning

1975 ◽  
Vol 24 (3-4) ◽  
pp. 251-259 ◽  
Author(s):  
A. Giroud
Keyword(s):  
Congenital Malformations ◽  
Monozygotic Twins ◽  
Bilateral Symmetry ◽  
Nuclear Genes ◽  
Unequal Distribution

A number of facts that cannot be interpreted in terms of nuclear genes would seem to be interpretable in terms of cytoplasmic heredity. The hereditary role of the mitochondria has already been demonstrated in molds. The role of the cytoplasm (matrilineal heredity) has also been shown in some phanerogams, and analogous facts have been noted in insects and molluscs. In amphibians, the influence of an alteration of the egg cortical cytoplasm has been shown to reappear in the following generations. This cortical cytoplasm includes the morphological plan of the organism with its bilateral symmetry: mirror imaging in monozygotic twins would only be an extension of bilateral symmetry. In Tatusia novemcincta the twins may be morphologically or chemically different, which may only be explained by an unequal subdivision of a heterogenic cytoplasm. Similar facts are observed in human twinning. Monozygotic twins are usually discordant with respect to congenital malformations (especially symmelia and anencephaly), which may only be interpreted in terms of unequal distribution of cytoplasmic properties.

The Role of Negative Personality Traits in Psychological Adaptation

2019 ◽  
pp. 115-125
Author(s):  
Юлия Черткова ◽  
Yuliya Chertkova ◽  
Марина Егорова ◽  
Marina Yegorova
Keyword(s):  
Life Satisfaction ◽  
Personality Traits ◽  
Twin Study ◽  
Monozygotic Twins ◽  
Psychological Adaptation ◽  
Semantic Differential ◽  
Personal Traits ◽  
Only Children ◽  
Age Related

The paper reflects one of the aspects of the research carried out within the framework of the project “Nature of variability of negative personality traits: a twin study”. The research reviews the adaptive component of negative personal traits. The sample of the study consisted of 136 members of monozygotic twins and 401 only children in their families aged 18-78. Life satisfaction was a generalized metric of psychological adaptation. It is shown that a number of negative personality traits (in particular, narcissism, authoritarianism) positively correlate with life satisfaction. The biased value of various personality traits, which can also indirectly serve as an indicator of adaptability of these psychological properties, was assessed using a semantic differential. The age-related changes in the perfect image of the self, which are associated primarily with some more attractive negative personal traits, as well as the multidirectional desired changes in personality traits in themselves and the twin (more power and conflict in themselves and less of the same in the brother/sister) also indicate that a number of negative personal traits play a positive role in psychological adaptation. It is assumed that these traits can have a compensatory function during stress, and the destructiveness of these traits can have a greater impact on people around than on themselves.

Inequality of Opportunity in Mexico

2019 ◽  
pp. 134-158
Author(s):  
Roberto Vélez Grajales ◽  
Luis A. Monroy-Gómez-Franco ◽  
Gastón Yalonetzky
Keyword(s):  
Income Inequality ◽  
Lower Bound ◽  
Social Mobility ◽  
Wealth Inequality ◽  
Inequality Of Opportunity ◽  
Unequal Distribution ◽  
Variable Bias ◽  
Unequal Opportunities ◽  
Available Information

Mexico is a country with high levels of inequality and low intergenerational social-mobility rates for those located at the bottom extremes of the wealth distribution. Although such low rates suggest that at least a share of the observed income inequality may be due to an unequal distribution of opportunities, this conjecture has not been thoroughly tested in the literature. The present article fills this gap estimating the lower bound of the contribution of unequal opportunities to income and wealth inequality in Mexico, with an operationalization of the “ex-ante” approach to the measurement of inequality of opportunity. Relying on a national representative survey designed for the analysis of social mobility, namely, the ESRU Survey on Social Mobility in Mexico (2011), we are able to define a broad set of circumstance groups (“types”), encompassing the wealth of the household of origin. This available information reduces the omitted variable bias of previous estimations and allows for a better account of the role of inequality of opportunity in income inequality. Our results show that the lower bound of the contribution of unequal opportunities to total income inequality and total wealth inequality is around 30 per cent, which is substantially higher than previous estimations for Mexico and ranks among the highest values in Latin America.

Role of nuclear genes in expression of a mitochondrial tRNA gene in Saccharomyces cerevisiae

1983 ◽  
Vol 3 (3) ◽  
pp. 371-379
Author(s):  
M Wesolowski ◽  
C Palleschi ◽  
L Frontali ◽  
H Fukuhara
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Trna Gene ◽  
Mitochondrial Gene ◽  
Nuclear Genes ◽  
Yeast Mitochondria ◽  
Mitochondrial Trna ◽  
Genetic Crosses ◽  
Mitochondrial Trna Gene

In yeast mitochondria, most of the isoaccepting species of tyrosyl tRNA are coded by a mitochondrial gene, tyrA. A particular isoaccepting species is coded by a second mitochondrial gene, tyrB. This gene is not expressed in certain strains of yeast which show no deficient phenotype. Genetic crosses between strains expressing or not expressing the tyrB gene demonstrate that expression is controlled by specific nuclear genes and that a mutation of the tyrA gene can be bypassed when the tyrB gene is operative.

The PINHEAD/ZWILLE gene acts pleiotropically in Arabidopsis development and has overlapping functions with the ARGONAUTE1 gene

Development ◽  
1999 ◽  
Vol 126 (3) ◽  
pp. 469-481 ◽  
Author(s):  
K. Lynn ◽  
A. Fernandez ◽  
M. Aida ◽  
J. Sedbrook ◽  
M. Tasaka ◽  
...  
Keyword(s):  
Expression Patterns ◽  
Bilateral Symmetry ◽  
Floral Organ ◽  
Axillary Shoot ◽  
Apical Meristems ◽  
Shoot Apical Meristems ◽  
Positional Identity ◽  
Competence Factor ◽  
High Level

Several lines of evidence indicate that the adaxial leaf domain possesses a unique competence to form shoot apical meristems. Factors required for this competence are expected to cause a defect in shoot apical meristem formation when inactivated and to be expressed or active preferentially in the adaxial leaf domain. PINHEAD, a member of a family of proteins that includes the translation factor eIF2C, is required for reliable formation of primary and axillary shoot apical meristems. In addition to high-level expression in the vasculature, we find that low-level PINHEAD expression defines a novel domain of positional identity in the plant. This domain consists of adaxial leaf primordia and the meristem. These findings suggest that the PINHEAD gene product may be a component of a hypothetical meristem forming competence factor. We also describe defects in floral organ number and shape, as well as aberrant embryo and ovule development associated with pinhead mutants, thus elaborating on the role of PINHEAD in Arabidopsis development. In addition, we find that embryos doubly mutant for PINHEAD and ARGONAUTE1, a related, ubiquitously expressed family member, fail to progress to bilateral symmetry and do not accumulate the SHOOT MERISTEMLESS protein. Therefore PINHEAD and ARGONAUTE1 together act to allow wild-type growth and gene expression patterns during embryogenesis.

Doing Things with Legal History

2018 ◽  
pp. 922-940
Author(s):  
Alfred L. Brophy
Keyword(s):  
Property Rights ◽  
Historical Analysis ◽  
First Century ◽  
Unequal Distribution ◽  
Alternative Vision ◽  
Early Twenty ◽  
History Of ◽  
Support Property ◽  
Late Twentieth

This chapter discusses the role of historical analysis in property law. The history of property has been used to offer support for property rights. Their long history makes the distribution of property look normal, indeed natural and something that cannot or should not be challenged. However, historically in the U.S there have been competing visions of property. From the Progressive era onward especially, the history of property has been used to show the unequal distribution of property and to offer an alternative vision that expands the rights of non-owners of property. In the late twentieth and early twenty-first century, the history of opposition to feudalism and protection of the rights of non-owners was used to protect the rights of non-owners. Thus, the history of property has been a tool of judges and legislators to support property rights and it has also been, less frequently, a tool of critique.

Inequality in Globalization: An Extension of the Gini Index from the Perspective of National Competitiveness

2006 ◽  
Vol 7 (1) ◽  
pp. 119-140
Author(s):  
Min-young Kim
Keyword(s):  
International Business ◽  
Gini Index ◽  
Statistical Analyses ◽  
Inequality Index ◽  
Unequal Distribution ◽  
National Competitiveness ◽  
Double Diamond

This article studies the unequal distribution of the benefits a country enjoys from participating in globalization from the perspective of international business. As globalization is a set of mutually beneficial interactions between countries and MNCs to enhance competitiveness of each participant, benefits countries enjoy from globalization should be understood in terms of national competitiveness. In this light, this article applies the generalized double diamond (GDD) model to the analysis of national competitiveness and introduces the globalization inequality index (GII) as an extension of the Gini index to measure inequality in globalization. Statistical analyses of GIIs show that benefits from globalization are unequally distributed over countries and suggest a need for the strategic interpretation of the role of a location in the era of globalization.

scholarly journals Immune signatures of prodromal multiple sclerosis in monozygotic twins

2020 ◽  
Vol 117 (35) ◽  
pp. 21546-21556 ◽  
Author(s):  
Lisa Ann Gerdes ◽  
Claudia Janoschka ◽  
Maria Eveslage ◽  
Bianca Mannig ◽  
Timo Wirth ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Monozygotic Twins ◽  
Monozygotic Twin ◽  
T Cell Subsets ◽  
Effector T Cell ◽  
Immune Signatures ◽  
Relapsing Remitting ◽  
Immune Traits

The tremendous heterogeneity of the human population presents a major obstacle in understanding how autoimmune diseases like multiple sclerosis (MS) contribute to variations in human peripheral immune signatures. To minimize heterogeneity, we made use of a unique cohort of 43 monozygotic twin pairs clinically discordant for MS and searched for disease-related peripheral immune signatures in a systems biology approach covering a broad range of adaptive and innate immune populations on the protein level. Despite disease discordance, the immune signatures of MS-affected and unaffected cotwins were remarkably similar. Twinship alone contributed 56% of the immune variation, whereas MS explained 1 to 2% of the immune variance. Notably, distinct traits in CD4+effector T cell subsets emerged when we focused on a subgroup of twins with signs of subclinical, prodromal MS in the clinically healthy cotwin. Some of these early-disease immune traits were confirmed in a second independent cohort of untreated early relapsing-remitting MS patients. Early involvement of effector T cell subsets thus points to a key role of T cells in MS disease initiation.

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