scholarly journals Chronic intake of a high-cholesterol diet resulted in hepatic steatosis, focal nodular hyperplasia and fibrosis in non-obese mice

2009 ◽  
Vol 103 (3) ◽  
pp. 378-385 ◽  
Author(s):  
Maho Sumiyoshi ◽  
Masahiro Sakanaka ◽  
Yoshiyuki Kimura
Keyword(s):  
Hepatic Steatosis ◽  
Focal Nodular Hyperplasia ◽  
Milk Fat ◽  
Metabolic Disorders ◽  
Control Diet ◽  
High Cholesterol Diet ◽  
High Cholesterol ◽  
Monocyte Chemoattractant ◽  
Nodular Hyperplasia

We investigated the effects of a high-cholesterol (HC) diet administered long term (25 or 55 weeks) on metabolic disorders including hepatic damage in mice. The mice were fed the HC diet (15 % milk fat, 1·5 % cholesterol and 0·1 % cholic acid, w/w) for 25 or 55 weeks. Body and adipose tissue weights were similar to those of mice fed a control diet. Consumption of the HC diet long term resulted in hypercholesterolaemia, hepatic steatosis and gallstones. In addition, focal nodular hyperplasia (FNH) and mild fibrosis of the liver developed in all mice fed the HC diet for 55 weeks. Plasma levels of monocyte chemoattractant protein (MCP)-1 were elevated, and the level of hepatic platelet-derived growth factor (PDGF)-B protein was increased in mice fed the HC diet compared with those fed the control diet. Thus, it seems likely that the liver fibrosis and FNH caused by the long-term consumption of a HC diet may be partly due to an elevation of plasma MCP-1 and hepatic PDGF expression.

Natural course of hepatic focal nodular hyperplasia: A long-term follow-up study with sonography

2009 ◽  
Vol 37 (3) ◽  
pp. 132-137 ◽  
Author(s):  
Yuan-Hung Kuo ◽  
Jing-Houng Wang ◽  
Sheng-Nan Lu ◽  
Chao-Hung Hung ◽  
Yu-Ching Wei ◽  
...  
Keyword(s):  
Focal Nodular Hyperplasia ◽  
Natural Course ◽  
Follow Up Study ◽  
Nodular Hyperplasia ◽  
Long Term Follow Up

scholarly journals Hepatic focal nodular hyperplasia found in a patient of long-term intake of oral contraceptives.

1988 ◽  
Vol 21 (11) ◽  
pp. 2607-2610 ◽  
Author(s):  
Masaaki HANABATA ◽  
Harumasa OHYANAGI ◽  
Makoto USAMI ◽  
Eisei GU ◽  
Yoichi SAITOH
Keyword(s):  
Oral Contraceptives ◽  
Focal Nodular Hyperplasia ◽  
Nodular Hyperplasia

scholarly journals Mammary Nodular Hyperplasia in Intact Rhesus Monkeys

1973 ◽  
Vol 10 (2) ◽  
pp. 130-134 ◽  
Author(s):  
L. W. Nelson ◽  
L. D. Shott
Keyword(s):  
Focal Nodular Hyperplasia ◽  
Rhesus Monkeys ◽  
Clinical Change ◽  
Control Female ◽  
Subcutaneous Nodules ◽  
Female Rhesus ◽  
Nodular Hyperplasia ◽  
Well Differentiated

Two control female Rhesus monkeys in long-term toxicity studies had multiple, palpable nodules in the breast regions. These subcutaneous nodules were 2–7 mm in diameter, firm, and freely movable. No progressive clinical change was observed during a follow-up of 17 or 20 months. Microscopically, one excised nodule consisted of proliferated acinar epithelial cells arranged in lobular patterns. The cells were well differentiated and presented no features of neoplasia. A diagnosis of focal nodular hyperplasia was compatible with the microscopie findings and the clinical follow-up of similar nodules.

scholarly journals Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet

2009 ◽  
Vol 30 (11) ◽  
pp. 1505-1512 ◽  
Author(s):  
Hong-xia Guo ◽  
Dai-hua Liu ◽  
Ying Ma ◽  
Jin-feng Liu ◽  
Ying Wang ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat

scholarly journals Short and Long-Term Impact of Lipectomy on Expression Profile of Hepatic Anabolic Genes in Rats: A High Fat and High Cholesterol Diet-Induced Obese Model

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108717 ◽  
Author(s):  
Bey-Leei Ling ◽  
Chun-Tang Chiu ◽  
Hsiu-Chin Lu ◽  
Jin-Jin Lin ◽  
Chiung-Yin Kuo ◽  
...  
Keyword(s):  
Expression Profile ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Short And Long Term ◽  
Long Term Impact

scholarly journals Impact of SCP-2/SCP-x gene ablation and dietary cholesterol on hepatic lipid accumulation

2015 ◽  
Vol 309 (5) ◽  
pp. G387-G399 ◽  
Author(s):  
Devon Klipsic ◽  
Danilo Landrock ◽  
Gregory G. Martin ◽  
Avery L. McIntosh ◽  
Kerstin K. Landrock ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cholesteryl Ester ◽  
Hepatic Steatosis ◽  
Target Genes ◽  
High Cholesterol Diet ◽  
Carrier Protein ◽  
Sterol Carrier Protein ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Fatty Acid Binding

While a high-cholesterol diet induces hepatic steatosis, the role of intracellular sterol carrier protein-2/sterol carrier protein-x (SCP-2/SCP-x) proteins is unknown. We hypothesized that ablating SCP-2/SCP-x [double knockout (DKO)] would impact hepatic lipids (cholesterol and cholesteryl ester), especially in high-cholesterol-fed mice. DKO did not alter food consumption, and body weight (BW) gain decreased especially in females, concomitant with hepatic steatosis in females and less so in males. DKO-induced steatosis in control-fed wild-type (WT) mice was associated with 1) loss of SCP-2; 2) upregulation of liver fatty acid binding protein (L-FABP); 3) increased mRNA and/or protein levels of sterol regulatory element binding proteins (SREBP1 and SREBP2) as well as increased expression of target genes of cholesterol synthesis ( Hmgcs1 and Hmgcr) and fatty acid synthesis ( Acc1 and Fas); and 4) cholesteryl ester accumulation was also associated with increased acyl-CoA cholesterol acyltransferase-2 (ACAT2) in males. DKO exacerbated the high-cholesterol diet-induced hepatic cholesterol and glyceride accumulation, without further increasing SREBP1, SREBP2, or target genes. This exacerbation was associated both with loss of SCP-2 and concomitant downregulation of Ceh/Hsl, apolipoprotein B (ApoB), MTP, and/or L-FABP protein expression. DKO diminished the ability to secrete excess cholesterol into bile and oxidize cholesterol to bile acid for biliary excretion, especially in females. This suggested that SCP-2/SCP-x affects cholesterol transport to particular intracellular compartments, with ablation resulting in less to the endoplasmic reticulum for SREBP regulation, making more available for cholesteryl ester synthesis, for cholesteryl-ester storage in lipid droplets, and for bile salt synthesis and/or secretion. These alterations are significant findings, since they affect key processes in regulation of sterol metabolism.

Impact of Long-term, High-fat, and High-cholesterol Diet on Murine Vertebrae Bones

2020 ◽  
Author(s):  
Frank Alexander Schildberg ◽  
Koroush Kabir ◽  
Jessica Bojko ◽  
Mona Khoury ◽  
Werner Masson ◽  
...  
Keyword(s):  
Bone Density ◽  
Genetic Factors ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Micro Ct ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
The Impact

AbstractAs the percentage of overweight individuals in the population rises, diseases associated with excess weight resulting from poor nutrition are becoming more and more widespread. So far, the influence of weight or nutrition on bone health has shown conflicting results. In the literature, the existing studies disagree about the effect of diet on bones. Therefore, this study investigated the impact of a long-term, high-fat, and high-cholesterol diet on the spine in a mouse model. Wild-type mice were randomly separated into two groups; one group received a high-fat and high-cholesterol diet, and a control group was fed with a regular diet since birth for a duration of 8 months. The first to fifth thoracic vertebrae were extracted and investigated using histology and micro-CT. Samples were analyzed regarding different parameters: percentage of bone structure compared to the whole vertebra and the amount and thickness of the trabeculae. Both methods of the analysis showed similar results. Diet did not have a significant impact on the bone density of the vertebrae. The micro-CT examination showed that the average bone percentage of the examined vertebra was 6% (p = 0.2330) higher in the control group compared to the diet group. The same tendency was demonstrated in histology even though with a smaller difference of only 5%. The results of both methods were comparable and showed trends for the influence of different diets but not significant impacts. In summary, this study showed that a high-fat and high-cholesterol diet has a slightly negative impact on bone density. In order to further analyze the effects of different diets on bone composition, structure, and density, additional long-term studies should be carried out, and more parameters such as movement and genetic factors should be analyzed. Furthermore, other parameters such as exercise and genetic factors that could have a secondary influence on obesity should be investigated.

Dietary fenugreek seed regresses preestablished cholesterol gallstones in mice

2009 ◽  
Vol 87 (9) ◽  
pp. 684-693 ◽  
Author(s):  
R.L.R. Reddy ◽  
K. Srinivasan
Keyword(s):  
Induction Period ◽  
Control Diet ◽  
Cholesterol Concentration ◽  
Control Group ◽  
High Cholesterol Diet ◽  
High Dose ◽  
High Cholesterol ◽  
Biliary Cholesterol ◽  
Cholesterol Gallstones ◽  
Fenugreek Seeds

An animal study was carried out to evaluate the influence of dietary fenugreek seeds on regression of preestablished cholesterol gallstones (CGS). CGS was induced by feeding a high-cholesterol diet for 10 weeks. After CGS induction, the animals were maintained for a further 10 weeks on experimental diets of high cholesterol, 6% fenugreek powder, 12% fenugreek powder, or basal control. Incidence of CGS and its severity were evaluated at the end of this feeding regimen. The incidence of CGS was significantly lowered as a result of dietary fenugreek seeds, the extent of regression being 61% and 64% in the low and high dose groups compared with 10% regression in the basal control group. The antilithogenic influence of dietary fenugreek was accompanied by significant reductions of more than 35% in serum cholesterol concentration. Hepatic cholesterol concentration was also profoundly lowered by dietary fenugreek, being 53%–63% lower than that of the basal control diet. Biliary cholesterol concentration was significantly lower as a result of dietary fenugreek during the post-CGS induction period, resulting in a decreased cholesterol:phospholipid ratio (0.44 and 0.40 compared with 0.79 in the basal control group). Biliary cholesterol : bile acid ratio was lowered by 67% and 73% upon feeding fenugreek, significantly lower than that in the basal control group. The cholesterol saturation index in the bile was also beneficially lowered by fenugreek treatment during the post-CGS induction period (the index was 0.90 and 0.42 compared with 1.86 in the basal control group). The present study provides evidence of the potency of hypolipidemic fenugreek seeds in regressing preestablished CGS, and this beneficial antilithogenic effect is attributable to its primary influence on cholesterol levels. This finding is significant in the context of evolving a dietary strategy to address CGS, which could help in preventing the incidence and regression of existing CGS and controlling possible recurrence.

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