The fat and protein fractions of freshwater clam (Corbicula fluminea) extract reduce serum cholesterol and enhance bile acid biosynthesis and sterol excretion in hypercholesterolaemic rats fed a high-cholesterol diet

We investigated whether the fat and protein fractions of freshwater clam (Corbicula fluminea) extract (FCE) could ameliorate hypercholesterolaemia in rats fed a high-cholesterol diet. We also explored the mechanism and the components that exert the hypocholesterolaemic effect of FCE. The doses of the fat and protein fractions were equivalent to those in 30 % FCE. The fat and protein fractions of FCE, two major components of FCE, significantly reduced the serum and hepatic cholesterol levels. The fat fraction more strongly reduced serum cholesterol levels than the same level of total FCE. The excretion of faecal neutral sterols increased in rats fed the total the FCE and the fat fraction of FCE. On the other hand, faecal bile acid levels were greater in rats fed the total FCE and the fat and protein fractions of FCE than in control animals. The hepatic gene expression of ATP-binding cassette transporter G5 and cholesterol 7α-hydroxylase was up-regulated by the administration of the total FCE and both the fat and protein fractions of FCE. These results showed that the fat and protein fractions of FCE had hypocholesterolaemic properties, and that these effects were greater with the fat fraction than with the protein fraction. The present study indicates that FCE exerts its hypocholesterolaemic effects through at least two different mechanisms, including enhanced excretion of neutral sterols and up-regulated biosynthesis of bile acids.

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The effect of diabetes mellitus on aortic prostanoid synthesis and serum cholesterol levels in the rat fed a high cholesterol diet

Life Sciences ◽

10.1016/0024-3205(90)90620-7 ◽

1990 ◽

Vol 47 (6) ◽

pp. 587-594 ◽

Cited By ~ 1

Author(s):

Stuart I. Myers ◽

Lori Bartula ◽

Mike Linzel ◽

Tam Phan ◽

Pa Jong Jung ◽

...

Keyword(s):

Diabetes Mellitus ◽

Serum Cholesterol ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

Cholesterol Levels ◽

Prostanoid Synthesis

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Lactobacillus plantarum 06CC2 reduces hepatic cholesterol levels and modulates bile acid deconjugation in Balb/c mice fed a high‐cholesterol diet

Food Science & Nutrition ◽

10.1002/fsn3.1909 ◽

2020 ◽

Vol 8 (11) ◽

pp. 6164-6173

Author(s):

Masao Yamasaki ◽

Mikako Minesaki ◽

Asuka Iwakiri ◽

Yuko Miyamoto ◽

Kenjiro Ogawa ◽

...

Keyword(s):

Bile Acid ◽

Lactobacillus Plantarum ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

Hepatic Cholesterol ◽

High Cholesterol ◽

Cholesterol Levels

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Increase of Serum Cholesterol Levels by Heat-Moisture-Treated High-Amylose Cornstarch in Rats Fed a High-Cholesterol Diet

Lipids ◽

10.1007/s11745-008-3191-4 ◽

2008 ◽

Vol 43 (8) ◽

pp. 695-702 ◽

Cited By ~ 1

Author(s):

Haruhide Udagawa ◽

Chika Kitaoka ◽

Tatsuaki Sakamoto ◽

Kazuo Kobayashi-Hattori ◽

Yuichi Oishi ◽

...

Keyword(s):

Serum Cholesterol ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

Cholesterol Levels ◽

High Amylose

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Tu-W23:7 Effect of high cholesterol diet on cholesterol and bile acid metabolism in A-IM and A-I transgenic mice

Atherosclerosis Supplements ◽

10.1016/s1567-5688(06)80654-9 ◽

2006 ◽

Vol 7 (3) ◽

pp. 167

Author(s):

C. Parolini ◽

S. Caligari ◽

D. Gilio ◽

M. Montagnani ◽

E.M. Rubin ◽

...

Keyword(s):

Bile Acid ◽

Transgenic Mice ◽

Acid Metabolism ◽

Bile Acid Metabolism ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol

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Effects of saponins on bile acids and plasma lipids in the rat

British Journal Of Nutrition ◽

10.1079/bjn19790108 ◽

1979 ◽

Vol 42 (2) ◽

pp. 209-216 ◽

Cited By ~ 71

Author(s):

D. G. Oakenfull ◽

Dorothy E. Fenwick ◽

R. L. Hood ◽

D. L. Topping ◽

R. L. Illman ◽

...

Keyword(s):

Bile Acids ◽

Plasma Lipids ◽

Plasma Lipid ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

Faecal Excretion ◽

Neutral Sterols ◽

Low Cholesterol ◽

Bile Acid Secretion

1. The effects of feeding isolated saponins on plasma lipid concentrations and on concentrations of biliary and faecal bile acids and neutral sterols were studied in the rat.2. The animals were given one of four diets, i.e. a standard low-cholesterol synthetic diet, the diet+10 g saponins/kg, the diet+10 g cholesterol/kg, the diet+10 g cholesterol+10 g saponins/kg.3. Saponins partially reversed the hypercholesterolaemia caused by the high-cholesterol diet and increased both the rate of bile acid secretion and the faecal excretion of bile acids and neutral sterols. The proportionate contribution of the primary bile acids (particularly chenodeoxycholic) to faecal excretion was also increased by saponins.4. The results are discussed in relation to the hypothesis that saponins act by inducing the adsorption of bile acids by dietary fibre.

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Soybean germ oil reduces blood cholesterol by inhibiting cholesterol absorption and enhancing bile acid excretion

Food & Function ◽

10.1039/c8fo02585a ◽

2019 ◽

Vol 10 (4) ◽

pp. 1836-1845 ◽

Cited By ~ 12

Author(s):

Hanyue Zhu ◽

Jingnan Chen ◽

Zouyan He ◽

Wangjun Hao ◽

Jianhui Liu ◽

...

Keyword(s):

Bile Acid ◽

Cholesterol Absorption ◽

Blood Cholesterol ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

Acid Excretion ◽

High Cholesterol ◽

Bile Acid Excretion

Soybean germ oil is beneficial in management of hypercholesterolemia in hamsters fed a high cholesterol diet.

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Effects of Soybean. Cheonggukjang and Doenjang on Serum Cholesterol Level and Weight Reduction in Rats Fed a High-Fat/High-Cholesterol Diet

Korean Journal of Food Preservation ◽

10.11002/kjfp.2011.18.2.226 ◽

2011 ◽

Vol 18 (2) ◽

pp. 226-235 ◽

Cited By ~ 10

Author(s):

Jae-Joon Lee ◽

Ah-Ra Kim ◽

Hwan Lee ◽

Cheol-Ho Kim ◽

Hae-Choon Chang ◽

...

Keyword(s):

Cholesterol Level ◽

Serum Cholesterol ◽

Weight Reduction ◽

Serum Cholesterol Level ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

High Fat

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Vitamin B12 Inhibits Progression of Hypercholesterolemia and Atherosclerosis in Rabbits Fed a High Cholesterol Diet

McGill Journal of Medicine ◽

10.26443/mjm.v3i1.584 ◽

2020 ◽

Vol 3 (1) ◽

Author(s):

Salim Abou-Khalil ◽

Ron Poulsen ◽

Michael B. Stemerman ◽

Sean Moore ◽

Misbahuddin Zafar Alavi

Keyword(s):

Vitamin B12 ◽

Cholesterol Level ◽

Serum Cholesterol ◽

Serum Cholesterol Level ◽

Pharmacological Intervention ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

Baseline Serum ◽

Group 4

The present study was undertaken to examine the effect of vitamin B12 on serum cholesterol levels and development of aortic atherosclerosis in New Zealand White male rabbits fed a high cholesterol diet. Twenty rabbits were divided into 4 groups matched for their baseline serum cholesterol values. Groups 1 and 2 received a normal diet, whereas groups 3 and 4 had cholesterol mixed with their chow. After 5 weeks, the serum cholesterol of groups 3 and 4 increased by approximately 12 fold compared to groups 1 and 2. At that point, vitamin B12 was administered in the drinking water (1000 micrograms/l) to rabbits in groups 2 and 4. At week 8, the Vitamin B12 dose was increased to 2400 micrograms/l for group 4. At 12 weeks into the study, rabbits in group 4 (high cholesterol diet plus vitamin B12) had a serum cholesterol level of 919 +/- 270 mg/dl while those of group 3 (high cholesterol diet) had a serum cholesterol level of 1417 +/- 250 mg/dl. At the end of the study, rabbit aortas were excised, fixed, and stained with fat-red-B, a dye for lipid. Comparison of the aortas of rabbits that received the lipid rich diet revealed that animals given additional vitamin B12 had significantly decreased surface area of fat deposition. These data suggest the potential role for vitamin B12 as a safe and inexpensive pharmacological intervention for the modification of the progression of human atherosclerosis.

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