Soybean germ oil reduces blood cholesterol by inhibiting cholesterol absorption and enhancing bile acid excretion

2019 ◽  
Vol 10 (4) ◽  
pp. 1836-1845 ◽  
Author(s):  
Hanyue Zhu ◽  
Jingnan Chen ◽  
Zouyan He ◽  
Wangjun Hao ◽  
Jianhui Liu ◽  
...  
Keyword(s):  
Bile Acid ◽  
Cholesterol Absorption ◽  
Blood Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
Acid Excretion ◽  
High Cholesterol ◽  
Bile Acid Excretion

Soybean germ oil is beneficial in management of hypercholesterolemia in hamsters fed a high cholesterol diet.

scholarly journals Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits.

1990 ◽  
Vol 31 (11) ◽  
pp. 2019-2027
Author(s):  
ML Overturf ◽  
SA Smith ◽  
AM Gotto ◽  
JD Morrisett ◽  
T Tewson ◽  
...  
Keyword(s):  
Bile Acid ◽  
Dietary Cholesterol ◽  
Cholesterol Absorption ◽  
Acid Excretion ◽  
Bile Acid Excretion

scholarly journals Efek Ekstrak Biji Labu Kuning Terhadap Glukosa, Kolesteroldan Gambaran Histopatologi Pankreas Tikus Hiperkolesterolemia-Diabetes

2018 ◽  
Vol 1 (3) ◽  
pp. 144-151
Author(s):  
Joni Tandi ◽  
Rahmawati Rahmawati ◽  
Rini Isminarti ◽  
Jerry Lapangoyu
Keyword(s):  
Ethanol Extract ◽  
Pancreatic Tissue ◽  
Blood Cholesterol ◽  
Maximum Effect ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cell Degeneration ◽  
Pumpkin Seed ◽  
Per Oral

Hiperkolesterolemia adalah peningkatan kadar kolesterol di dalam darah melebihi batas yang diperlukan oleh tubuh. Penelitan ini bertujuan menguji kandungan senyawa fitokimia ekstrak etanol biji labu kuning, efek pemberian ekstrak etanol biji labu kuning dan perbedaan efek ekstrak dengan dosis bertingkat terhadap penurunan degenerasi sel beta pankreas tikus putih jantan hiperkolesterolemia diabetes. Penelitian eksperimen laboratorium ini menggunakan hewan uji sebanyak 30 ekor tikus dibagi dalam enam kelompok perlakuan. Kelompok 1 (kontrol normal) diberikan Na-CMC 0,5% dan kelompok 2 (kontrol negatif) diberi pakan tinggi kolesterol, suspensi Streptozotocin 35 mg/kgBB dan Na-CMC 0,5% b/v; kelompok 3 diberi metformin 9 mg/kgBB per oral, pakan tinggi kolesterol dan suspensi streptozotocin 35 mg/kgBB; kelompok 4, 5 dan 6 masing-masing diberikan dosis 270, 360, dan 450 mg/kgBB per oral, pakan tinggi kolesterol dan suspensi streptozotocin 35 mg/kgBB. Gambaran tingkat kerusakan histopatologi pankreas diamati dengan pewarnaan HE menggunakan mikroskop Olympus BX-51 perbesaran 200x. Hasil penelitian menunjukkan: Terdapat senyawa alkaloid, flavonoid, polifenol, saponin,dan tannin pada ekstrak etanol biji labu kuning; ekstrak etanol biji labu kuning dosis 360 dan 450 mg/kgBB efektif menurunkan degenerasi jaringan pankreas tikus hiperkolesterolemia diabetes dan pemberian ekstrak etanol biji labu kuning dosis 270 mg/kgBB tidak memberikan efek maksimal jika dibandingkan dengan dosis 360 mg/kgBB dan dosis 450 mg/kgBB terhadap regenerasi sel organ pankreas tikus putih jantan hiperkolesterolemia diabetes.   Hypercholesterolemia is an abnormal increase in blood cholesterol levels.  This study aimed to identify the phytochemical content of pumpkin seed ethanol extract, the effect of pumpkin seed ethanol extract and the difference in the effect of various doses of extract in decreasing pancreatic beta cell degeneration in male diabetic hypercholesterolemia rat. The experimental research in laboratory used 30 rats as test animals, divided into six group. Group 1 (normal control administered with 0.5% Na CMC and group 2 (negative control) administered with high cholesterol diet, Streptozotocin 35 mg/kgBWand 0.5% Na-CMC b/v; Group 3 orally administered with metformin 9 mg/kgBW, high cholesterol diet,  streptozotocin 35 mg/kgBW; group 4,5 and 6 orally administered with extract at doses of 270, 360, dan 450 mg/kgBB, high cholesterol diet,  streptozotocin 35 mg/kgBW. Histopathology examination to determine pancreas damage was observed by HE staining using microscop Olympus BX-51 200x. The results showed the presence of alkaloids, flavonoids, poliphenol, saponins,andtanninsin phumpkin seeds ethanol extract; Ethanol extract of phumpkin seeds at doses of 360 dan 450 mg/kgBW effectively decreased degeneration of pancreatic tissue of diabetic hypercholesterolemia rat and ethanol extract of phumpkin seeds at the dose of 270 mg/kgBW did not show maximum effect as compared to the doses of 360 and 450 mg/kg BE on cell regeneration of pancreatic tissue of diabetic hypercholesterolemia rat

Tu-W23:7 Effect of high cholesterol diet on cholesterol and bile acid metabolism in A-IM and A-I transgenic mice

2006 ◽  
Vol 7 (3) ◽  
pp. 167
Author(s):  
C. Parolini ◽  
S. Caligari ◽  
D. Gilio ◽  
M. Montagnani ◽  
E.M. Rubin ◽  
...  
Keyword(s):  
Bile Acid ◽  
Transgenic Mice ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

scholarly journals Analisis ketersediaan kolesterol total, trigliserid, glukosa dan aktivitas enzim Alanine aminotransferase (ALT) dan Aspartate Aminotransferase (AST) pada ayam Broiler kolesterol tinggi pasca pemberian bawang putih (Allium sativum Iinn)

2018 ◽  
Vol 29 (2) ◽  
pp. 110
Author(s):  
Agustina Dwi Wijayanti ◽  
Rani Puspita Sari ◽  
Riyanto Riyanto
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Allium Sativum ◽  
Blood Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Total Blood ◽  
Total Blood Cholesterol

This study was to find out the effect of ethanolic garlic extrct of total blood cholesterol, trigliserid, glucone and the activities of alanine aminotransferase (ALT) dan Aspartate Aminotransferase (AST) of broiler fed with high cholesterol diet.

scholarly journals Early Effects of High Cholesterol Diet on the Kidney of an Animal Model

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Zenab B. Hamad Mohamed ◽  
Hamad Abdulsalam Hamad Alfarisi ◽  
Nor Zamzila Abdullah ◽  
Norra Harun ◽  
Naznin Muhammad ◽  
...  
Keyword(s):  
Animal Model ◽  
Serum Creatinine ◽  
Histological Examination ◽  
Blood Cholesterol ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Early Effect ◽  
The Impact

Introduction: Previous studies have proven the existence of a complex association between progressive kidney damage and hypercholesterolemia. Most studies focused on the impact of chronic high blood cholesterol levels on the kidney. Information on the early effect of hypercholesterolemia on the kidney is still lacking. The aim of this study was therefore to determine early effect of high cholesterol diet on the kidney in an animal model. Materials and method: Ten female Sprague-Dawley rats were divided into two groups. The control group was fed with commercial rat pellet while the high cholesterol diet (HCD) group was fed with 12% cholesterol diet and 0.3% cholic acid. Biochemical analysis (lipid profile and renal function) was performed at 48 hours, 7 days and 6 weeks of the experiment. The animals were sacrificed at 6 weeks and the kidneys were harvested for histological examination. Results: The HCD group rats had significantly higher levels of serum total cholesterol (at 7 days and 6 weeks). The HDL-cholesterol and triglyceride levels were however lower at 6 weeks. The mean serum creatinine level of the HCD group were increased after 48 hours and 7 days compared to the control group. Histological examination of the kidney tissue of the HCD group at 6 weeks revealed segmental mesangial hypercellularity and mesangial matrix expansion of the glomeruli. Conclusion: The 12% cholesterol diet induced dyslipidaemia in the animal model. It resulted in acute kidney injury based on the serum creatinine at 48 hours and 7 days. Kidney tissues examined at 6 weeks revealed changes confined to mesangial cells of the renal glomeruli.

scholarly journals Sericin ameliorated dysmorphic mitochondria in high-cholesterol diet/streptozotocin rat by antioxidative property

2016 ◽  
Vol 242 (4) ◽  
pp. 411-421 ◽  
Author(s):  
Sumate Ampawong ◽  
Duangnate Isarangkul ◽  
Pornanong Aramwit
Keyword(s):  
Endoplasmic Reticulum ◽  
Exocrine Pancreas ◽  
Protective Role ◽  
Blood Cholesterol ◽  
High Cholesterol Diet ◽  
Zymogen Granule ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Electron Microscopic ◽  
Antioxidative Property

Sericin has been implicated in lower cholesterolemic effect due to its properties with several mechanisms. Mitochondria are one of the most important targets to be affected in high blood cholesterol and glucose conditions. The protective role of sericin on mitochondria remains doubtful. To examine this role, electron microscopic, histopathologic, immunohistochemical, and biochemical studies were performed in a high-cholesterol diet/streptozotocin rat model. The results demonstrated that sericin reduced blood cholesterol without hypoglycemic effect. Sericin alleviated dysmorphic mitochondria in heart and liver but not in kidney and also decreased peculiar endoplasmic reticulum in the exocrine pancreas. In addition, sericin decreased hepatic steatosis and preserved zymogen granule referable to the decline of reactive oxygen species production in hepatic mitochondrial extraction and down-regulation of malondialdehyde expression in the liver and exocrine pancreas however irrelevant to lipase activity. This study suggests that sericin has antioxidative property to reduce blood cholesterol by means of diminishing fat deposit in hepatocyte and improves mitochondria and endoplasmic reticulum integrities. [Box: see text]

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