scholarly journals Short- and long-term effects of a maternal low-protein diet on ventilation, O2/CO2chemoreception and arterial blood pressure in male rat offspring

2013 ◽  
Vol 111 (4) ◽  
pp. 606-615 ◽  
Author(s):  
José Luiz de Brito Alves ◽  
Viviane Oliveira Nogueira ◽  
Gerliny Bezerra de Oliveira ◽  
Glauber Santos Ferreira da Silva ◽  
Almir Gonçalves Wanderley ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Respiratory Rhythm ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Long Term Effects ◽  
Low Protein ◽  
Arterial Blood ◽  
Short And Long Term

Maternal undernutrition increases the risk of adult arterial hypertension. The present study investigated the short- and long-term effects of a maternal low-protein diet on respiratory rhythm, O2/CO2chemosensitivity and arterial blood pressure (ABP) of the offspring. Male Wistar rats were divided into two groups according to their mothers' diets during gestation and lactation: control (NP, 17 % of casein) and low-protein (LP, 8 % of casein) groups. Direct measurements of ABP, respiratory frequency (RF), tidal volume (VT) and ventilation (VE), as well as hypercapnia (7 % CO2) and hypoxia (7 % O2) evoked respiratory responses were recorded from the awake male offspring at the 30th and 90th days of life. Blood samples were collected for the analyses of protein, creatinine and urea concentrations. The LP offspring had impaired body weight and length throughout the experiment. At 30 d of age, the LP rats showed a reduction in the concentrations of total serum protein (approximately 24 %). ABP in the LP rats was similar to that in the NP rats at 30 d of age, but it was 20 % higher at 90 d of age. With respect to ventilatory parameters, the LP rats showed enhanced RF (approximately 34 %) and VE (approximately 34 %) at 30 d of age, which was associated with increased ventilatory responses to hypercapnia (approximately 21 % in VE) and hypoxia (approximately 82 % in VE). At 90 d of age, the VE values and CO2/O2chemosensitivity of the LP rats were restored to the control range, but the RF values remained elevated. The present data show that a perinatal LP diet alters respiratory rhythm and O2/CO2chemosensitivity at early ages, which may be a predisposing factor for increased ABP at adulthood.

scholarly journals Short- and long-term effects of a neonatal low-protein diet in rats on the morphology of the larynx

Nutrition ◽  
2009 ◽  
Vol 25 (7-8) ◽  
pp. 855-860 ◽  
Author(s):  
Iracema Hermes Pires-de-Mélo ◽  
Flávia Wanderley dos Reis ◽  
Lívia Silva Luz ◽  
Silvania Tavares Paz ◽  
Hilton Justino Silva ◽  
...  
Keyword(s):  
Protein Diet ◽  
Low Protein Diet ◽  
Long Term Effects ◽  
Low Protein ◽  
Short And Long Term

Long-term effects of a neonatal low-protein diet in rats on the number of macrophages in culture and the expression/production of fusion proteins

2012 ◽  
Vol 52 (5) ◽  
pp. 1475-1482 ◽  
Author(s):  
Juliana Félix de Melo ◽  
Thacianna Barreto da Costa ◽  
Tamara D. da Costa Lima ◽  
Maria E. C. Chaves ◽  
Muriel Vayssade ◽  
...  
Keyword(s):  
Fusion Proteins ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Long Term Effects ◽  
Low Protein

scholarly journals Long-Term Effects of Ketoanalogues on Mortality and Renal Outcomes in Advanced Chronic Kidney Disease Patients Receiving a Low-Protein Diet

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2708
Author(s):  
Yi-Chun Wang ◽  
Shu-Hui Juan ◽  
Chu-Lin Chou ◽  
Tsung-Cheng Hsieh ◽  
Jung-Lun Wu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Research Database ◽  
Long Term Effects ◽  
Low Protein ◽  
Significant Difference ◽  
Patients With Diabetes

The effects of ketoanalogues (KA) supplementation on mortality and progression to dialysis in patients with pre-dialysis stage 5 chronic kidney disease (CKD) receiving a low-protein diet (LPD) remain ambiguous. From Taiwan’s National Health Insurance Research Database during 1996–2011, 165 patients with pre-dialysis CKD on an LPD (0.6 g/kg/day) with KA supplementation were matched with 165 patients with pre-dialysis CKD on an LPD without KA supplementation. Of the 165 patients with advanced CKD receiving KA supplementation, 34 (20.6%) died, and 124 (75.2%) underwent long-term dialysis during the study period. There was no significant difference in mortality between the KA-user group and the KA-nonuser group (adjusted hazard ratio [HR], 1.41; 95% confidence interval [CI], 0.68–2.93; p = 0.355). KA supplementation significantly increased long-term dialysis risk (adjusted HR, 1.41; 95% CI, 1.04–1.90; p = 0.025) and combined outcome risk (defined as long-term dialysis and death; adjusted HR, 1.37; 95% CI, 1.02–1.83; p = 0.034). KA supplementation also increased long-term dialysis risk (adjusted HR, 1.49; 95% CI, 1.00–2.20; p = 0.048) in the subgroup of pre-dialysis patients with diabetes mellitus (DM), but not in those patients without DM. In conclusion, KA supplementation might increase long-term dialysis risk in patients with advanced CKD receiving an LPD, but it did not increase mortality.

Long-term effects of intracerebroventricular insulin microinjection on renal sodium handling and arterial blood pressure in rats

2008 ◽  
Vol 76 (4) ◽  
pp. 344-348 ◽  
Author(s):  
Leonardo F. Menegon ◽  
Adriana Zaparolli ◽  
Patrícia A. Boer ◽  
Amanda R. de Almeida ◽  
José A.R. Gontijo
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Long Term Effects ◽  
Arterial Blood ◽  
Renal Sodium Handling ◽  
Sodium Handling

scholarly journals Long-Term Effects of Carotid Sinus Denervation on Arterial Blood Pressure in Humans

Circulation ◽  
2002 ◽  
Vol 105 (11) ◽  
pp. 1329-1335 ◽  
Author(s):  
Arthur A.J. Smit ◽  
Henri J.L.M. Timmers ◽  
Wouter Wieling ◽  
Mariette Wagenaar ◽  
Henri A.M. Marres ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Carotid Sinus ◽  
Long Term Effects ◽  
Arterial Blood

scholarly journals Altered adipocyte properties in the offspring of protein malnourished rats

1997 ◽  
Vol 78 (1) ◽  
pp. 121-129 ◽  
Author(s):  
P.R Shepherd ◽  
N.J Crowther ◽  
M Desai ◽  
C.N Hales ◽  
S.E Ozanne
Keyword(s):  
Glucose Tolerance ◽  
G Protein ◽  
Critical Time ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Dependent Diabetes Mellitus ◽  
Long Term Effects ◽  
Low Protein ◽  
Pregnancy And Lactation

It is becoming well established that poor fetal and early postnatal growth can have long-term effects on adult health, including susceptibility to non-insulin-dependent diabetes mellitus, cardiovascular disease and hypertension. It is suggested that this results from poor nutrition during early life having permanent effects on the structure and metabolism of certain organs and tissues. In the present study we investigated the effect of a low-protein diet during pregnancy and lactation on adipocyte properties and glucose tolerance. Rat dams were fed on a diet containing either 200 (control) or 80 (low protein) g protein/kg during pregnancy and lactation. In addition cross-fostering techniques were employed to enable a separate evaluation of the prenatal and postnatal periods. All offspring were weaned onto a 200 g protein/kg diet at 21 d of age and then studied at 6 weeks of age. The mothers' protein supply during lactation appeared to be the most critical time window for longterm growth. In contrast, the offspring of mothers fed on a low-protein diet during pregnancy or lactation were significantly more glucose tolerant than controls, suggesting that both time windows can have long-term effects on glucose tolerance. In addition off spring of mothers fed on a lowprotein diet during pregnancy or lactation had significantly smaller adipocytes than controls. However the largest reduction in adipocyte size was observed when there was a low-protein diet during both pregnancy and lactation. The amount of insulin receptor present in adipocyte membranes was increased in the three animal groups that had been exposed to the low-protein diets while levels of the insulin responsive glucose transporter (GLUT 4) were similar in adipocyte membranes from all groups.

Effect of High-Salt, High-Carbohydrate, Low-Protein Diet on Hypertension in the Rat

1973 ◽  
Vol 45 (s1) ◽  
pp. 99s-102s
Author(s):  
Hideo Ueda
Keyword(s):  
Blood Pressure ◽  
High Protein Diet ◽  
Normal Diet ◽  
High Salt ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Heart Weight ◽  
Hypertensive Rats ◽  
High Carbohydrate ◽  
Low Protein

1. High-salt, high-carbohydrate and low-protein diet induces remarkable elevation of blood pressure in spontaneous hypertensive rats (SHR). 2. These animals have low serum potassium, low blood urea nitrogen and high blood sugar. 3. Heart weight is increased in proportion to the elevation of blood pressure. 4. Kidney weight of rats receiving the high-salt, high-carbohydrate and low-protein diet was, by contrast, smaller than SHR receiving a normal diet. 5. The kidneys of SHR receiving a high-salt, high-protein diet were twice as heavy as the kidneys of normal rats. 6. Similar dietary modifications in Goldblatt hypertensive rats to those in SHR produced similar changes in blood pressure and heart weight.

scholarly journals Does a Supplemental Low-Protein Diet Decrease Mortality and Adverse Events After Commencing Dialysis? A Nationwide Cohort Study

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1035 ◽  
Author(s):  
Chieh-Li Yen ◽  
Kun-Hua Tu ◽  
Ming-Shyan Lin ◽  
Su-Wei Chang ◽  
Pei-Chun Fan ◽  
...  
Keyword(s):  
Protein Diet ◽  
Low Protein Diet ◽  
Research Database ◽  
Negative Consequences ◽  
Term Survival ◽  
Low Protein ◽  
All Cause Mortality ◽  
Stage Renal Disease ◽  
End Stage

Background: A beneficial effect of a ketoanalogue-supplemented low-protein diet (sLPD) in postponing dialysis has been demonstrated in numerous previous studies. However, evidence regarding its effect on long-term survival is limited. Our study assessed the long-term outcomes of patients on an sLPD after commencing dialysis. Methods: This retrospective study examined patients with new-onset end-stage renal disease with permanent dialysis between 2001 and 2013, extracted from Taiwan’s National Health Insurance Research Database. Patients who received more than 3 months of sLPD treatment in the year preceding the start of dialysis were extracted. The outcomes studied were all-cause mortality, infection rate, and major cardiac and cerebrovascular events (MACCEs). Results: After propensity score matching, the sLPD group (n = 2607) showed a lower risk of all-cause mortality (23.1% vs. 27.6%, hazard ratio (HR) 0.77, 95% confidence interval (CI) 0.70–0.84), MACCEs (19.2% vs. 21.5%, HR 0.86, 95% CI 0.78–0.94), and infection-related death (9.9% vs. 12.5%, HR 0.76, 95% CI 0.67–0.87) than the non-sLPD group did. Conclusion: We found that sLPD treatment might be safe without long-term negative consequences after dialysis treatment.

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