Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study

2020 ◽  
pp. 1-8
Author(s):  
Jing-An Long ◽  
Rong-Huan Zhong ◽  
Si Chen ◽  
Fan Wang ◽  
Yun Luo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Health Study ◽  
Middle Aged ◽  
Nutrition And Health ◽  
Skeletal Mass ◽  
Age Related ◽  
Middle Aged Adults

Abstract A higher dietary intake or serum concentration of betaine has been associated with greater lean body mass in middle-aged and older adults. However, it remains unknown whether betaine intake is associated with age-related loss of skeletal muscle mass (SMM). We assessed the association between dietary betaine intake and relative changes in SMM after 3 years in middle-aged adults. A total of 1242 participants aged 41–60 years from the Guangzhou Nutrition and Health Study 2011–2013 and 2014–2017 with body composition measurements by dual-energy X-ray absorptiometry were included. A face-to-face questionnaire was used to collect general baseline information. After adjustment for potential confounders, multiple linear regression found that energy-adjusted dietary betaine intake was significantly and positively associated with relative changes (i.e. percentage loss or increase) in SMM of legs, limbs and appendicular skeletal mass index (ASMI) over 3 years of follow-up (β 0·322 (se 0·157), 0·309 (se 0·142) and 0·303 (se 0·145), respectively; P < 0·05). The ANCOVA models revealed that participants in the highest betaine tertile had significantly less loss in SMM of limbs and ASMI and more increase in SMM of legs over 3 years of follow-up, compared with those in the bottom betaine tertile (all Ptrend < 0·05). In conclusion, our findings suggest that elevated higher dietary betaine intake may be associated with less loss of SMM of legs, limbs and ASMI in middle-aged adults.

scholarly journals Effect of Dairy Protein Intake on Muscle Mass among Korean Adults: A Prospective Cohort Study

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2537
Author(s):  
Eunjin So ◽  
Hyojee Joung
Keyword(s):  
Skeletal Muscle ◽  
Cohort Study ◽  
Muscle Mass ◽  
Protein Intake ◽  
Skeletal Muscle Mass ◽  
Cox Proportional Hazards ◽  
Middle Aged ◽  
Dairy Consumption ◽  
Dairy Protein

This cohort study aimed to identify the associations of dairy protein intake with the risk of developing a low muscle mass during a 12-year follow-up period, using data from 4412 middle-aged Korean Genome and Epidemiology Study participants with a normal baseline muscle mass. Dairy protein intake at baseline was assessed using a semi-quantitative Food Frequency Questionnaire. Skeletal muscle mass index (SMI), defined as the weight-adjusted skeletal muscle mass, was measured biennially using multi-frequency bioelectrical impedance analyses. Cox proportional hazards regression analysis was used to calculate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Overall, 395 subjects developed a low SMI (%) during an average follow-up of 141 (19–152) months. The average consumption of milk and other dairy products was 73.6 and 104.1 g/day, respectively. In men, a higher dairy protein intake was associated with a decreased risk of developing a low SMI (tertile 3 [T3] vs. T1, HR: 0.63; 95% CI: 0.42, 0.94; p for trend = 0.029). In a stratified analysis according to a total protein intake, this association was stronger in the lower-protein intake group (HR: 0.59; 95% CI: 0.35, 0.99; p for trend = 0.036) but not detected in the higher-protein intake group. Men who consumed milk ≥1 time/day had a significantly lower risk of developing a low SMI (HR: 0.62; 95% CI: 0.39, 0.98; p for trend = 0.023). No significant associations were observed in women. In summary, dairy consumption appears to be beneficial for decreasing the risk of developing a low muscle mass in middle-aged Korean men.

scholarly journals Molecular Mechanism and Pathogenesis of Sarcopenia: An Overview

2021 ◽  
Vol 22 (6) ◽  
pp. 3032
Author(s):  
Anna Picca ◽  
Riccardo Calvani
Keyword(s):  
Skeletal Muscle ◽  
Molecular Mechanism ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Strength Function ◽  
Age Related

Sarcopenia involves a progressive age‐related decline of skeletal muscle mass and strength/function [...]

scholarly journals Relationship between age-related decreases in serum 25-hydroxyvitamin D levels and skeletal muscle mass in Japanese women

2020 ◽  
Vol 67 (1.2) ◽  
pp. 151-157 ◽  
Author(s):  
Michiko Sato ◽  
Teruhiro Morishita ◽  
Takafumi Katayama ◽  
Shigeko Satomura ◽  
Hiroko Okuno ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Japanese Women ◽  
Hydroxyvitamin D ◽  
Age Related ◽  
25 Hydroxyvitamin D

scholarly journals Gender-Specific Associations between Low Skeletal Muscle Mass and Albuminuria in the Middle-Aged and Elderly Population

2017 ◽  
Vol 14 (11) ◽  
pp. 1054-1064 ◽  
Author(s):  
Hye Eun Yoon ◽  
Yunju Nam ◽  
Eunjin Kang ◽  
Hyeon Seok Hwang ◽  
Seok Joon Shin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Elderly Population ◽  
Middle Aged ◽  
Gender Specific

scholarly journals NEUROMUSCULAR CHANGES WITH AGING AND SARCOPENIA

2018 ◽  
pp. 1-3
Author(s):  
B.C. Clark
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Muscle Function ◽  
Skeletal Muscle Mass ◽  
The Past ◽  
Conceptual Definition ◽  
Age Related ◽  
Per Se ◽  
Definition Of ◽  
And Function

Sarcopenia was originally conceptualized as the age-related loss of skeletal muscle mass. Over the ensuing decades, the conceptual definition of sarcopenia has changed to represent a condition in older adults that is characterized by declining muscle mass and function, with “function” most commonly conceived as muscle weakness and/or impaired physical performance (e.g., slow gait speed). Findings over the past 15-years, however, have demonstrated that changes in grip and leg extensor strength are not primarily due to muscle atrophy per se, and that to a large extent, are reflective of declines in the integrity of the nervous system. This article briefly summarizes findings relating to the complex neuromuscular mechanisms that contribute to reductions in muscle function associated with advancing age, and the implications of these findings on the development of effective therapies.

Hurrah for the increasing longevity: feasible strategies to counteract age-related loss of skeletal muscle mass

2015 ◽  
Vol 25 (1) ◽  
pp. 1-2 ◽  
Author(s):  
L. Holm ◽  
A. P. Jespersen ◽  
D. S. Nielsen ◽  
M. B. Frøst ◽  
S. Reitelseder ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Age Related

scholarly journals Protein intake per day and at each daily meal and skeletal muscle mass declines among older community dwellers in Japan

2019 ◽  
Vol 23 (6) ◽  
pp. 1090-1097 ◽  
Author(s):  
Rei Otsuka ◽  
Yuki Kato ◽  
Chikako Tange ◽  
Yukiko Nishita ◽  
Makiko Tomida ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Total Protein ◽  
Protein Intake ◽  
Skeletal Muscle Mass ◽  
Total Protein Intake ◽  
Dietary Records ◽  
Logistic Modelling ◽  
Community Dwellers

AbstractObjective:To examine associations between protein intake per day and at different meals and skeletal muscle mass declines.Design:Two-year prospective cohort study among older community dwellers.Setting:National Institute for Longevity Sciences–Longitudinal Study of Aging (NILS-LSA) in Japan.Participants:Older men (n 292) and women (n 363) aged 60–87 years who participated in the baseline (2006–2008) and follow-up studies (2008–2010) of NILS-LSA and did not exhibit low skeletal muscle mass at baseline. Muscle mass was assessed using dual-energy X-ray absorptiometry at baseline and follow-up. Low muscle mass was defined as skeletal muscle mass index <7·0 kg/m2 for men and <5·4 kg/m2 for women at follow-up. Daily protein intake and protein intake at each meal were calculated from 3 d dietary records at baseline and sex-stratified tertiles were determined.Results:Mean (sd) protein intake at breakfast, lunch and dinner was 22·7 (7·8), 26·7 (9·3) and 37·4 (10·5) g for men and 19·3 (6·3), 23·2 (7·3) and 28·5 (7·0) g for women, respectively. After adjusting for age, baseline skeletal muscle mass and other confounders in logistic modelling, greater total protein intake was associated with lower prevalence of skeletal muscle mass decline among men at follow-up (P = 0·024). Particularly, the OR (95 % CI) for high lunchtime protein intake was low (0·11 (0·02, 0·61); P = 0·01). No significant association between total protein intake and prevalence of skeletal muscle mass decline was found among women.Conclusions:High total protein intake, particularly at lunchtime, is associated with retention of skeletal muscle mass in men.

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