Combined anthocyanins and bromelain supplement improves endothelial function and skeletal muscle oxygenation status in adults: a double-blind placebo-controlled randomised crossover clinical trial

2020 ◽  
Vol 125 (2) ◽  
pp. 161-171
Author(s):  
Elizabeth J. Pekas ◽  
Jeonghwa Shin ◽  
Ronald J. Headid ◽  
Won-Mok Son ◽  
Gwenael Layec ◽  
...  
Keyword(s):  
Heart Rate ◽  
Endothelial Function ◽  
Nutritional Therapy ◽  
Healthy Adults ◽  
Resting Heart Rate ◽  
Double Blind ◽  
Total Antioxidant ◽  
Skeletal Muscle Oxygenation ◽  
Oxygenation Status ◽  
Artery Flow

AbstractAnthocyanins and bromelain have gained significant attention due to their antioxidative and anti-inflammatory properties. Both have been shown to improve endothelial function, blood pressure (BP) and oxygen utility capacity in humans; however, the combination of these two and the impacts on endothelial function, BP, total antioxidant capacity (TAC) and oxygen utility capacity have not been previously investigated. The purpose of this study was to investigate the impacts of a combined anthocyanins and bromelain supplement (BE) on endothelial function, BP, TAC, oxygen utility capacity and fatigability in healthy adults. Healthy adults (n 18, age 24 (sd 4) years) received BE or placebo in a randomised crossover design. Brachial artery flow-mediated dilation (FMD), BP, TAC, resting heart rate, oxygen utility capacity and fatigability were measured pre- and post-BE and placebo intake. The BE group showed significantly increased FMD, reduced systolic BP and improved oxygen utility capacity compared with the placebo group (P < 0·05). Tissue saturation and oxygenated Hb significantly increased following BE intake, while deoxygenated Hb significantly decreased (P < 0·05) during exercise. Additionally, TAC was significantly increased following BE intake (P < 0·05). There were no significant differences for resting heart rate, diastolic BP or fatigability index. These results suggest that BE intake is an effective nutritional therapy for improving endothelial function, BP, TAC and oxygen utility capacity, which may be beneficial to support vascular health in humans.

scholarly journals Association beween resting heart rate, shear and flow-mediated dilation in healthy adults

2014 ◽  
Vol 99 (10) ◽  
pp. 1439-1448 ◽  
Author(s):  
Brandon M. Fox ◽  
Lucy Brantley ◽  
Claire White ◽  
Nichole Seigler ◽  
Ryan A. Harris
Keyword(s):  
Heart Rate ◽  
Healthy Adults ◽  
Flow Mediated Dilation ◽  
Resting Heart Rate

Abstract 18257: Cardiovascular Response to Energy Drink Consumption in Healthy Adults

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Anna Svatikova ◽  
Naima Covassin ◽  
Krishen Somers ◽  
Filip Soucek ◽  
Tomas Kara ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cardiovascular Response ◽  
Energy Drinks ◽  
Energy Drink ◽  
Healthy Adults ◽  
Double Blind ◽  
Resting Blood Pressure ◽  
Energy Drink Consumption ◽  
Placebo Drink

Introduction: An increasing number of healthy adults consume energy drinks to enhance their physical and mental performance. Energy drinks contain caffeine and multiple other “natural” stimulants and their combined effects on cardiac hemodynamics in healthy individuals are unclear. Hypothesis: We hypothesized that drinking a commercially available energy drink, Rockstar , compared to a placebo drink, increases resting blood pressure and heart rate in healthy adults, and these increases would be further accentuated by stress conditions. Methods: We enrolled 25 healthy, normotensive subjects (14 males), aged 29±1 years, with body mass index 24.5±1 kg/m 2 , in a randomized, double-blind, placebo-controlled, crossover study. Each subject consumed a placebo drink and a commercially available Rockstar energy drink (473 ml), in random order on two separate study days. Blood pressure and heart rate responses were recorded and compared before and 30 minutes after drink consumption, both at rest and then in response to physical, mental and cold stressors. Results: The Rockstar energy drink induced a 6±1% increase in resting systolic blood pressure, compared to 3±1% with the placebo drink (P=0.0078). Diastolic blood pressure increased by 7±1% vs 0±1% with the placebo drink (P=0.0007; Figure 1). Heart rate increased similarly in both groups, by 5±2% in the energy drink group vs. 7±2% in the placebo group. Blood pressure and heart rate increases during the stress stimuli (sustained handgrip, mental stress and cold stress) did not differ between energy drink and placebo. Conclusions: Drinking a commercially available Rockstar energy drink significantly increases resting blood pressure in young healthy adults. Blood pressure increases are not further accentuated by exercise, mental or cold pressor stress stimuli. These hemodynamic changes induced by energy drink consumption could predispose to cardiovascular events.

scholarly journals Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jonathan M. Oliver ◽  
Lee Stoner ◽  
David S. Rowlands ◽  
Aaron R. Caldwell ◽  
Elizabeth Sanders ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Endothelial Function ◽  
Healthy Adults ◽  
Controlled Study ◽  
Flow Mediated Dilation ◽  
Double Blind ◽  
Meaningful Improvement ◽  
Randomized Controlled ◽  
Turmeric Extract ◽  
Apparently Healthy

Curcumin, a turmeric extract, may protect against cardiovascular diseases by enhancing endothelial function. In this randomized controlled double-blind parallel prospective study, fifty-nine healthy adults were assigned to placebo, 50 mg (50 mg), or 200 mg (200 mg) curcumin, for 8 weeks. The higher curcumin (200 mg) supplementation produced a dose-mediated improvement in endothelial function measured by flow-mediated dilation (FMD). The outcome was a clinically substantial 3.0% increase (90% CI 0.7 to 5.3%,p=0.032; benefit : harm odds ratio 546 : 1) with the 200 mg dose, relative to placebo. The 50 mg dose also increased FMD relative to placebo by 1.7% (−0.6 to 4.0%,p=0.23; 25 : 1), but the outcome was not clinically decisive. In apparently healthy adults, 8 weeks of 200 mg oral curcumin supplementation resulted in a clinically meaningful improvement in endothelial function as measured by FMD. Oral curcumin supplementation may present a simple lifestyle strategy for decreasing the risk of cardiovascular diseases. This trial was registered at ISRCTN registry (ISRCTN90184217).

scholarly journals Resting Heart Rate and the Risk of Heart Failure in Healthy Adults

2013 ◽  
Vol 6 (3) ◽  
pp. 403-410 ◽  
Author(s):  
David Nanchen ◽  
Maarten J.G. Leening ◽  
Isabella Locatelli ◽  
Jacques Cornuz ◽  
Jan A. Kors ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Healthy Adults ◽  
Resting Heart Rate

Regional Frontal Lobe Response Magnitudes During Affective Shifting Covary With Resting Heart Rate Variability in Healthy Volunteers

2016 ◽  
Vol 30 (4) ◽  
pp. 165-174 ◽  
Author(s):  
Ryan Smith ◽  
John J.B. Allen ◽  
Julian F. Thayer ◽  
Richard D. Lane
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Healthy Subjects ◽  
Emotional Reactivity ◽  
Bold Signal ◽  
Resting Heart Rate ◽  
Functional Magnetic Resonance ◽  
Absolute Value ◽  
Cardiac Vagal Control ◽  
Resting Heart Rate Variability

Abstract. We hypothesized that in healthy subjects differences in resting heart rate variability (rHRV) would be associated with differences in emotional reactivity within the medial visceromotor network (MVN). We also probed whether this MVN-rHRV relationship was diminished in depression. Eleven healthy adults and nine depressed subjects performed the emotional counting stroop task in alternating blocks of emotion and neutral words during functional magnetic resonance imaging (fMRI). The correlation between rHRV outside the scanner and BOLD signal reactivity (absolute value of change between adjacent blocks in the BOLD signal) was examined in specific MVN regions. Significant negative correlations were observed between rHRV and average BOLD shift magnitude (BSM) in several MVN regions in healthy subjects but not depressed subjects. This preliminary report provides novel evidence relating emotional reactivity in MVN regions to rHRV. It also provides preliminary suggestive evidence that depression may involve reduced interaction between the MVN and cardiac vagal control.

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