Abstract 18257: Cardiovascular Response to Energy Drink Consumption in Healthy Adults

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Anna Svatikova ◽  
Naima Covassin ◽  
Krishen Somers ◽  
Filip Soucek ◽  
Tomas Kara ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cardiovascular Response ◽  
Energy Drinks ◽  
Energy Drink ◽  
Healthy Adults ◽  
Double Blind ◽  
Resting Blood Pressure ◽  
Energy Drink Consumption ◽  
Placebo Drink

Introduction: An increasing number of healthy adults consume energy drinks to enhance their physical and mental performance. Energy drinks contain caffeine and multiple other “natural” stimulants and their combined effects on cardiac hemodynamics in healthy individuals are unclear. Hypothesis: We hypothesized that drinking a commercially available energy drink, Rockstar , compared to a placebo drink, increases resting blood pressure and heart rate in healthy adults, and these increases would be further accentuated by stress conditions. Methods: We enrolled 25 healthy, normotensive subjects (14 males), aged 29±1 years, with body mass index 24.5±1 kg/m 2 , in a randomized, double-blind, placebo-controlled, crossover study. Each subject consumed a placebo drink and a commercially available Rockstar energy drink (473 ml), in random order on two separate study days. Blood pressure and heart rate responses were recorded and compared before and 30 minutes after drink consumption, both at rest and then in response to physical, mental and cold stressors. Results: The Rockstar energy drink induced a 6±1% increase in resting systolic blood pressure, compared to 3±1% with the placebo drink (P=0.0078). Diastolic blood pressure increased by 7±1% vs 0±1% with the placebo drink (P=0.0007; Figure 1). Heart rate increased similarly in both groups, by 5±2% in the energy drink group vs. 7±2% in the placebo group. Blood pressure and heart rate increases during the stress stimuli (sustained handgrip, mental stress and cold stress) did not differ between energy drink and placebo. Conclusions: Drinking a commercially available Rockstar energy drink significantly increases resting blood pressure in young healthy adults. Blood pressure increases are not further accentuated by exercise, mental or cold pressor stress stimuli. These hemodynamic changes induced by energy drink consumption could predispose to cardiovascular events.

Abstract 3661: “Energy Drink” Consumption Causes Increases in Blood Pressure and Heart Rate

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Leah Steinke ◽  
James S Kalus ◽  
Vishnuprabha Dhanapal ◽  
David E Lanfear ◽  
Helen D Berlie
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Healthy Volunteers ◽  
Energy Drinks ◽  
Energy Drink ◽  
Direct Effects ◽  
Mean Values ◽  
Energy Drink Consumption ◽  
Clinically Significant ◽  
Observation Period

Introduction: “Energy drinks” are very popular and are used frequently, especially by young adults. Most marketed energy drinks contain high levels of caffeine and taurine. Both caffeine and taurine have been shown to have direct effects on cardiac function and hemodynamic status. Hypothesis: We assessed the hypothesis that a commonly used energy drink alters blood pressure, heart rate and EKG parameters in healthy volunteers. Methods: Healthy volunteers (n = 15, 53% female, 25.9 ± 5.9 years, 69.8 ± 14.8 kg) abstained from caffeine for 48 hours prior to and throughout the study period. On study day 1 (D1), blood pressure (BP), heart rate (HR) and an EKG were measured at baseline. Participants then consumed 500 mL (2 cans) of an energy drink containing caffeine (80 mg) and taurine (1000 mg) and BP, HR and EKG measurements were repeated at 30 minutes, 1, 2, 3, and 4 hours after consumption. Participants then consumed 2 cans of energy drink daily for the next 5 days (D2–D6). On day 7 (D7) the procedures followed on D1 were repeated. Average baseline measurements on days 1 and 7 were compared to maximum values during that observation period. Results: On both D1 and D7, maximum mean systolic BP, HR and corrected QT-interval (QTc) occurred at 4 hours. Maximum diastolic BP occurred at 2 hours on D1 and D7. Baseline and maximum mean values are presented in Table 1 . Within 4 hours of energy drink consumption on D1 and D7 respectively, systolic BP increased by 7.9% (p = 0.006) and 9.6% (p < 0.001), HR increased by 7.8% (p = 0.009) and 11.0% (p < 0.001) and QTc increased by 4.5% (p = 0.368) and 5.5% (p = 0.052). Diastolic BP increased by 7.0% (p = 0.046) and 7.8% (p = 0.063) within 2 hours of energy drink consumption. Conclusions: In conclusion, although no significant EKG changes were observed, subjects’ HR increased 5–7 bpm and systolic BP increased 10mmHg after consuming an “energy drink”. This level of change is likely clinically significant in patients with cardiac disease or those who consume such drinks regularly. Table 1. Baseline and Maximum Values (mean ± SD)

Abstract MP43: Electrocardiographic and Blood Pressure Effects of Energy Drinks and Panax Ginseng in Healthy Volunteers: A Randomized Clinical Trial

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Sachin A Shah ◽  
Tinh An (April) Nguyen ◽  
Andrew Occiano ◽  
Amanda Chan ◽  
Joseph C Sky ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Panax Ginseng ◽  
Qt Interval ◽  
Energy Drinks ◽  
Energy Drink ◽  
Qtc Interval ◽  
Energy Drink Consumption ◽  
Pr Interval

Introduction: Energy drink usage has been linked to emergency room visits and deaths. Cardiovascular and neurological adverse effects are among the most frequently reported, warranting further exploration of risk factors and cardiovascular outcomes. Hypothesis: We assessed the hypothesis that energy drinks and panax ginseng may contribute to significant electrocardiographic and blood pressure changes in healthy individuals. Methods: This was a randomized, double blinded, placebo controlled, crossover study where young healthy volunteers consumed 3 different study drinks on different days. The interventions included 32 ounces of an energy drink, control drink with 800 mg of panax ginseng or a matching placebo drink, all of which were consumed over a 45 minute period. Primary endpoints of interest were QTc interval and systolic blood pressure. Secondary endpoints included QT interval, PR interval, QRS duration, heart rate, and diastolic blood pressure. All endpoints were assessed at baseline, 1, 2, 3.5, and 5.5 hours post-study drink administration. Results: Twenty seven volunteers completed the study. A significant increase in QTc interval 2 hours post energy drink consumption was evident when compared to placebo (3.37±10.7 msec and -3.19±11.8 msec respectively; p=0.030). Similarly, systolic blood pressure 2 hours post energy drink consumption increased when compared to placebo (2.00±6.37 mmHg and -2.67±5.83 mmHg respectively; p=0.014). The PR interval significantly reduced over a 2 hour period post energy drink use in a clinically non-meaningful manner. Heart rate at 2 hours was not significantly higher in the energy drink group. The QT interval, QRS interval and diastolic blood pressure were not impacted at any time across groups. Conclusions: In conclusion, certain energy drinks consumed at a high volume can significantly increase the QTc interval and systolic blood pressure by over 6 msec and 4 mmHg respectively. Panax ginseng does not have a significant impact on ECG or blood pressure parameters. Future studies are warranted to delineate the electrophysiological and hemodynamic risks of certain energy drinks consumed at different concentrations and durations.

Abstract 12689: Cardiovascular Responses to Energy Drinks in a Healthy Population: The C-energy Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Teri M Kozik ◽  
Mouchumi Bhattacharyya ◽  
Teresa T Nguyen ◽  
Therese F Connolly ◽  
Walther Chien ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Vital Signs ◽  
Cardiovascular Responses ◽  
Energy Drinks ◽  
Energy Drink ◽  
Emergency Department Visits ◽  
Qtc Interval ◽  
Cardiac Responses ◽  
Energy Drink Consumption

Introduction: Energy drinks are presumed to enhance energy, physical endurance, mood, and boost metabolism. Serious health risks have been reported with energy drink consumption such as myocardial infarction, cardiac arrest, stroke, seizures, and arrhythmias. More than 20,000 emergency department visits related to energy drink consumption were reported in 2011. Little is known about the possible pathophysiological mechanisms and adverse events associated with energy drinks. Unlike the tobacco and alcohol industry, there are limited restrictions regulating the purchasing and marketing of these drinks. Purpose: To determine if consumption of energy drinks alter; vital signs (blood pressure, temperature), electrolytes (magnesium, potassium, calcium), activated bleeding time (ACT), or cardiac responses measured with a 12-lead electrocardiographic (ECG) Holter. Method: Subjects consumed two-16 ounce cans of an energy drink within one hour and remained in the lab where data was collected at base line (BL) and then during four hours post consumption (PC). Vital signs were taken every 30 minutes; blood samples were collected at BL, one, two and four hours PC and ECG data was collected throughout the entire study period. Paired students t-test and a corresponding non-parametric test (Wilcoxon signed rank) were used for analysis of the data. Results: Fourteen healthy young subjects were recruited (mean age 28.6 years). Systolic blood pressure (BL=132, ±7.83; PC= 151, ±11.21; p=.001); QTc interval (BL=423, ±22.74; PC=503, ±24.56; p<.001); magnesium level (BL 2.04, ± 0.09; PC=2.13, ±0.15; p=.05); and calcium level (BL=9.31, ±.28; PC=9.52, ±.22; p=.018) significantly increased from BL. While potassium and ACT fluctuated (increase and decrease) no significant changes were observed. Eight of the fourteen subjects (57%) developed a QTc >500 milliseconds PC. Conclusions: In our sample, consumption of energy drinks increased systolic blood pressure, serum magnesium and calcium, and resulted in repolarization abnormalities. Because these physiological responses can lead to arrhythmias and other abnormal cardiac responses, further study in a larger sample is needed to determine the effects and possible consequences of energy drink consumption.

scholarly journals Heart Rate Variability Behavior during Exercise and Short-Term Recovery Following Energy Drink Consumption in Men and Women

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2372
Author(s):  
Nicolas W. Clark ◽  
Chad H. Herring ◽  
Erica R. Goldstein ◽  
Jeffrey R. Stout ◽  
Adam J. Wells ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Repeated Measures ◽  
Energy Drink ◽  
Short Term ◽  
Double Blind ◽  
Warm Up ◽  
Autonomic Responses ◽  
Energy Drink Consumption ◽  
Graded Exercise

This study examined the cardiac autonomic responses, as measured by heart rate variability (HRV), during cycling exercise and short-term rest after energy drink consumption. Seventeen participants (seven males and 10 females; age: 22.8 ± 3.5 years; BMI: 24.3 ± 3.3 kg/m2) completed this double-blind, placebo-controlled, counterbalanced crossover design study. Participants received an energy drink formula containing 140 mg of caffeine and a placebo in a randomized order before completing a 10-min steady-state warm up (WUP) and a graded exercise test to exhaustion (GXT) followed by a 15-min short-term rest (STR) period. Heartbeat intervals were recorded using a heart rate monitor. Data were divided into WUP, GXT, and STR phases, and HRV parameters were averaged within each phase. Additionally, root mean square of the standard deviation of R–R intervals (RMSSD) during GXT was analyzed to determine the HRV threshold. Separate two-way (sex (male vs. female) x drink (energy drink vs. placebo)) repeated measures ANOVA were utilized. Significant increases in high frequency (HF) and RMSSD were shown during WUP after energy drink consumption, while interactions between drink and sex were observed for HRV threshold parameters (initial RMSSD and rate of RMSSD decline). No significant differences were noted during STR. Energy drink consumption may influence cardiac autonomic responses during low-intensity exercise, and sex-based differences in response to graded exercise to exhaustion may exist.

scholarly journals A randomized, placebo-controlled crossover trial of a decaffeinated energy drink shows no significant acute effect on mental energy

2020 ◽  
Vol 111 (3) ◽  
pp. 719-727
Author(s):  
Alicia Garcia-Alvarez ◽  
Corbin A Cunningham ◽  
Byron Mui ◽  
Lia Penn ◽  
Erin M Spaulding ◽  
...  
Keyword(s):  
Reaction Time ◽  
Visual Information ◽  
Crossover Trial ◽  
Flanker Task ◽  
Energy Levels ◽  
Energy Drinks ◽  
Energy Drink ◽  
Cognitive Measures ◽  
Double Blind ◽  
Placebo Drink

ABSTRACT Background “Energy drinks” are heavily marketed to the general public, across the age spectrum. The efficacy of decaffeinated energy drinks in enhancing subjective feelings of energy (s-energy) is controversial. Objective The authors sought to test the efficacy of the caffeine-free version of a popular energy drink compared with a placebo drink. Methods This study was a randomized, double-blind, placebo-controlled, crossover trial in 223 healthy men and women aged 18–70 y with intention-to-treat and completers analysis. Participants were randomly assigned to consumption of either the decaffeinated energy drink or a placebo drink on testing day 1, and the other drink a week later. A battery of computer-based mood and cognitive tests to assess s-energy was conducted at baseline and at 0.5, 2.5, and 5 h post-ingestion. The main outcome measures were 1) mood, which was assessed by using a General Status Check Scale and the Profile of Mood States 2nd edition brief form, and 2) cognitive measures, including the N-back task (reaction time and accuracy), Reaction Time test, Flanker task (distraction avoidance), and Rapid Visual Information Processing test. Results No statistically significant or meaningful benefits were observed for any outcome measure, including mood and cognitive measures. Analyses of mean differences, slopes, and median differences were consistent. Conclusions No differences were detected across a range of mood/cognitive/behavioral/s-energy–level tests after consumption of the energy drink compared with a placebo drink in this diverse sample of adults. Thus, we found strong evidence that the energy drink is not efficacious in enhancing s-energy levels, nor any related cognitive or behavioral variables measured. In light of federal regulations, these findings suggest that labeling and marketing of some products which claim to provide these benefits may be unsubstantiated. This trial was registered at www.clinicaltrials.gov as NCT02727920.

scholarly journals Effects of Acute Consumption of Noni and Chokeberry Juices vs. Energy Drinks on Blood Pressure, Heart Rate, and Blood Glucose in Young Adults

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Dariusz Nowak ◽  
Michał Gośliński ◽  
Anna Wesołowska ◽  
Karolina Berenda ◽  
Cezary Popławski
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Glucose ◽  
Energy Drinks ◽  
Energy Drink ◽  
Slight Reduction ◽  
Mild Reduction ◽  
Continue Research ◽  
Sugar Levels ◽  
Chokeberry Juice

The purpose of this study has been to determine the effect of acute consumption of noni and chokeberry juices vs. energy drinks on blood pressure, heart rate, and blood glucose. The subjects divided into 4 groups, which consumed three portions of noni or chokeberry juices (30 mL or 200 mL, respectively) and energy drink (ED) or water (200 mL) at one-hour intervals. All participants had their blood pressure (BP), both systolic and diastolic BP (SBP and DBP), as well as heart rate (HR) and blood glucose (BG), measured. Consumption of noni juice caused a significant decrease in SBP and DBP of 5.0% and 7.5%, respectively, while, the consumption of chokeberry juice slightly decreased only DBP by 3.6%. On the contrary, consumption of three portions of EDs caused a significant increase in DBP by 14.7%. The BG of participants consuming noni juice decreased by 7.3%, while the consumption of EDs increased BG by as much as 15.8%. Acute consumption of noni juice contributed to a significantly decreased SBP, DBP, and HR as well as a mild reduction of BG. Consumption of chokeberry juice caused only a slight reduction of DBP. Contrary to juices, EDs consumption resulted in an increase of blood pressure (especially DBP) and blood glucose. The results of the study showed that noni juice may be effective in lowering blood pressure and blood sugar levels, but there is a need to continue research on the long-term effect of this juice.

scholarly journals Does Energy Drink Provokes Gait Modifications in Young Healthy Adults?

2021 ◽  
Vol 8 (2) ◽  
pp. 82-92
Author(s):  
Martin G Rosario ◽  
Jason Hogle ◽  
Brooks Williams
Keyword(s):  
Young Adults ◽  
Informed Consent ◽  
Energy Drinks ◽  
Energy Drink ◽  
Healthy Adults ◽  
Milk Thistle ◽  
Psychoactive Substances ◽  
Positive Effects ◽  
Gait Parameters ◽  
Energy Drink Consumption

Energy drinks have become increasingly popular among young adults and athletes in the last few years. Despite their popularity, little research has substantiated the claims of the positive effects on physical performance of popular energy drinks. Most current research focuses on caffeine alone, but does not often look at how mixing it with other psychoactive substances might alter its effects. Purpose: This study aimed to determine the alterations of gait tasks after consumption of three popular energy drinks on young healthy adults. Methods: Fifteen women and five men were recruited, screened, and signed informed consent to participate in this study. All participants were healthy young adults with no apparent comorbidities that might have been impacted by the consumption of energy drinks. Motion analysis was conducted using Movement Lab TM sensors placed at key anatomical points. Subjects were asked for two bouts of gait tasks pre-energy drink consumption, and then repeat the same tasks after energy drink consumption. Results: There were no significant modifications in gait, however, observable trends were detected in postural gait parameters following the consumption of a Rockstar energy drink. Conclusion: We infer that the trends observed could be attributed to the specific key ingredients used in Rockstar and might have caused gait deviations post consumption. Further studies should focus on Rockstar alone and its specific key ingredients of caffeine, guarana, ginseng, and milk thistle to determine their influence on gait deviations.

Abstract P324: Impact of Energy Drinks on Electrocardiographic and Blood Pressure Parameters: A Meta-Analysis of Clinical Studies

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Sachin A Shah ◽  
Carolyn S Lacey ◽  
Ian C Riddock ◽  
Michael Lee ◽  
Anthony E Dargush
Keyword(s):  
Blood Pressure ◽  
Clinical Studies ◽  
English Language ◽  
Meta Analysis ◽  
Energy Drinks ◽  
Energy Drink ◽  
Sensitivity Analyses ◽  
Qtc Interval ◽  
Energy Drink Consumption ◽  
The Impact

Introduction: Energy drinks capture 47% of the beverage market share internationally. Several studies have tried to evaluate the health risks of energy drink consumption but a general consensus does not exist. We performed a meta-analysis to assess the cardiovascular effects of energy drinks on notable electrocardiographic and blood pressure parameters. Methods: A literature search in PubMed, CINAHL, Cochrane database and by hand searching of relevant references was performed. Human clinical studies published in the English language were included if evaluating the impact of an energy drink on the QT/QTc interval or systolic blood pressure (SBP). Diastolic blood pressure (DBP) and heart rate (HR) were also assessed. A weighted mean change from baseline was calculated using the DerSimonian and Laird random-effects model for all endpoints. Subgroup and sensitivity analyses were performed to assess heterogeneity. Results: Our initial search identified 351 studies of which 7 were ultimately included. A total of 93 and 132 individual subjects were incorporated for the QT/QTc interval and SBP analyses respectively. Compared to baseline, QT/QTc interval prolonged significantly by 10.0msec [95%CI 0.41 to 19.67; Cochrane Q p=0.505] and SBP increased significantly by 3.5mmHg [95%CI 0.92 to 6.11; Cochrane Q p=0.635]. DBP and HR increased non-significantly. These effects were maintained in most subgroup and sensitivity analyses. Conclusions: Energy drinks significantly prolong the QT/QTc interval and raise SBP. DBP and HR are increased non-significantly. Further safety evaluation of energy drink consumption is warranted to guide public health policy.

Abstract P394: Impact of Caffeinated Versus Decaffeinated Energy Shots on Blood Pressure

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Sachin A Shah ◽  
Abby Kurtz ◽  
Jessica Leong ◽  
Anthony E Dargush
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Energy Levels ◽  
Coffee Consumption ◽  
Energy Drinks ◽  
University Campus ◽  
Double Blind ◽  
Blood Pressures ◽  
Energy Shots ◽  
Double Blind Crossover Study

Introduction: Energy drinks are commonly used to boost cognitive performance. However, this is paralleled with a significant increase in systolic and diastolic blood pressures. No studies have evaluated these changes with energy “shots” and whether these effects are driven solely by the caffeine component in energy drinks or a multitude of ingredients remains unknown. The purpose of this study was to determine if the effects of regular (caffeinated) 5-Hour Energy® shot differ from that of decaffeinated 5-Hour Energy® (decaf) shot as assessed by changes in systolic (SBP) and diastolic blood pressure (DBP). Methods: This was a randomized, double-blind, crossover study conducted at a university campus. Healthy subjects, between 18-40 years of age with a blood pressure less than 140/90 and not on any medications were eligible for inclusion. Participants were randomized into either the regular 5-Hour Energy® drink or the decaf 5-Hour Energy® drink study arms with blood pressure recorded at baseline, 1, 3 and 5 hours. Following a washout period of at least 6 days, the same was performed giving the alternate study drink. Additionally, heart rate, adverse events and energy score (1-5 scale) were also assessed. Results: Ten males and 10 females were enrolled in the study with 90% (18 of 20) being of Asian race. Average age was 23.3±2.7 years, weighing 149.1±31.7 pounds with SBP of 114±11.3 mmHg and DBP of 69.5±7.6 mmHg. Baseline coffee consumption was less than 2 cups per week in 11 subjects and at least 1 cup per day in the remainder. The maximum SBP increase from baseline in the regular arm was 7.8±6.5 mmHg versus 2.8±5.6 mmHg in the decaf arm (p = 0.046). Maximum DBP increase was 6.3±3.7mmHg and 1.0±5.4 mmHg (p = 0.003) in the regular and decaf arms, respectively. Significant increases in systolic and diastolic pressures were evident at 1 and 3 hours post consumption (p ≤ 0.027) but not at 5 hours. Maximum heart rate or energy levels between the two groups were not significantly different (p ≥ 0.436). In subgroup analysis, regular energy drinks invoked a significantly higher increase in systolic and diastolic blood pressures (p ≤ 0.003) 1 hour post consumption in caffeine naïve subjects (n=11). Conclusion: Regular energy drinks available in the form of a “shot” increase both systolic and diastolic blood pressures by approximately 5mmHg. This effect appears to be exaggerated in caffeine naïve subjects.

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