Interaction between finger millet (Eleusine coracana) genotypes and drug-resistant mutants ofAzospirillum brasilensein calcareous soil

1984 ◽  
Vol 102 (3) ◽  
pp. 521-529 ◽  
Author(s):  
R. Rai ◽  
V. Prasad ◽  
I. C. Shukla
Keyword(s):  
Azospirillum Brasilense ◽  
Finger Millet ◽  
Nitrogenase Activity ◽  
Resistant Mutant ◽  
Eleusine Coracana ◽  
Drug Resistant ◽  
Mutant Strains ◽  
Drug Resistant Mutant ◽  
Uninoculated Control ◽  
Resistant Mutants

SummaryAzospirillum brasilensewas treated with nitrosoguanidine and five drug-resistant mutant strains isolated. The effects of acriflavin on pre- and post-irradiation with u.v. light and the level of antibiotic resistance were studied. Variations in factors were found between the strains. Inoculation of finger millet withA. brasilenseand mutant strains led to significant increases in grain yield and nitrogenase activity compared with the uninoculated control, with significant strain x genotype interactions. Differential response of genotype and strain was noted on the protein and amino acid concentration of seeds.

scholarly journals Baloxavir Marboxil Treatment of Nude Mice Infected With Influenza A Virus

2019 ◽  
Vol 221 (10) ◽  
pp. 1699-1702 ◽  
Author(s):  
Maki Kiso ◽  
Seiya Yamayoshi ◽  
Jurika Murakami ◽  
Yoshihiro Kawaoka
Keyword(s):  
Nude Mice ◽  
Influenza A ◽  
Body Weight Loss ◽  
Resistant Mutant ◽  
Prolonged Treatment ◽  
Drug Resistant ◽  
Neuraminidase Inhibitors ◽  
Drug Resistant Mutant ◽  
Suboptimal Dose ◽  
Resistant Mutants

Abstract Background Immunocompromised patients infected with influenza virus require prolonged treatment with neuraminidase inhibitors, because these patients are not able to eradicate the virus from the respiratory tract, leading to the emergence of drug-resistant mutant viruses. Methods In this study, we examined the efficacy of baloxavir marboxil in nude mice that were immunologically deficient. Results Daily treatment with a suboptimal dose of baloxavir marboxil increased the survival time of the virus-infected nude mice but did not clear the virus from their respiratory organs, resulting in gradual body weight loss after termination of treatment. Conclusions Despite the prolonged baloxavir marboxil treatment, few resistant mutants were detected.

Studies on associative nitrogen fixation by antibiotic-resistant mutants ofAzospirillum brasilensewith genotypes of lentil (Lens culinaris)Rhizobiumstrains in calcareous soil

1985 ◽  
Vol 104 (1) ◽  
pp. 207-215 ◽  
Author(s):  
R. Rai
Keyword(s):  
Nitrogen Fixation ◽  
Azospirillum Brasilense ◽  
Calcareous Soil ◽  
Lens Culinaris ◽  
Nitrogenase Activity ◽  
Dry Weight ◽  
Antibiotic Resistant ◽  
Uninoculated Control ◽  
Resistant Mutants ◽  
Antibiotic Resistant Mutants

SummaryNitrosoguanidine-induced mutation frequencies for resistance to streptomycin, spectinomycin, erythromycin and novomycin were studied inAzospirillum brasilense.Lentil inoculated withA. brasilenseand its mutants andRhizobiumstrains produced increased nodule dry weight, nitrogenase activity of nodules and roots and grain yield compared with an uninoculated control.

scholarly journals Molecular modeling of HIV-1 reverse transcriptase drug-resistant mutant strains: implications for the mechanism of polymerase action

1997 ◽  
Vol 10 (12) ◽  
pp. 1379-1383 ◽  
Author(s):  
M. B. Kroeger Smith ◽  
C. J. Michejda ◽  
S. H. Hughes ◽  
P. L. Boyer ◽  
P. A. Janssen ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Reverse Transcriptase ◽  
Resistant Mutant ◽  
Drug Resistant ◽  
Mutant Strains ◽  
Drug Resistant Mutant ◽  
Hiv 1

Isolation and characterization of Azotobacter vinelandii mutant strains with potential as bacterial fertilizer

1983 ◽  
Vol 29 (8) ◽  
pp. 973-978 ◽  
Author(s):  
Joyce K. Gordon ◽  
Marty R. Jacobson
Keyword(s):  
Azotobacter Vinelandii ◽  
Nitrogenase Activity ◽  
Resistant Mutant ◽  
Free Medium ◽  
Wild Type ◽  
Isolation And Characterization ◽  
Mutant Strains ◽  
Resistant Strains ◽  
Resistant Mutants

Mutant strains of Azotobacter vinelandii which might have potential for use as bacterial fertilizer have been isolated and fall into two categories: constitutive mutants that synthesize nitrogenase in the presence of ammonium and mutants that overproduce nitrogenase when grown in nitrogen-free medium. The constitutive mutants described in this paper were isolated from the wild type as methylalanine-resistant strains and express up to 23% of the fully derepressed nitrogenase level when grown in medium containing excess ammonium. By contrast, ammonium-grown cultures of wild type have less than 0.003% of the fully derepressed level. Strains which fix more N2 than the wild type in nitrogen-free medium were isolated as mefhylammonium-resistant mutants. Although the methylammonium-resistant mutant strains fix more N2 than the wild type, they grow no faster. The excess nitrogen produced by these mutants is excreted into the medium, resulting in up to 60% more nitrogen than in the medium of the wild type. Higher nitrogenase activity in the methylammonium-resistant mutant strains was found to be a result of increased levels of nitrogenase protein, suggesting that regulation of nitrogenase synthesis may be altered.

scholarly journals Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130022 ◽  
Author(s):  
Satoshi Yoshimi ◽  
Hidenori Ochi ◽  
Eisuke Murakami ◽  
Takuro Uchida ◽  
Hiromi Kan ◽  
...  
Keyword(s):  
Resistant Mutant ◽  
Drug Resistant ◽  
Accurate Evaluation ◽  
Genotype 1B ◽  
Invader Assay ◽  
Drug Resistant Mutant ◽  
Strain Frequency
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