scholarly journals Vaccination against Hong Kong influenza in Britain, 1968–9: A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines

1970 ◽  
Vol 68 (3) ◽  
pp. 359-368 ◽  
Author(s):  
D. A. J. Tyrrell ◽  
Rosemary Buckland ◽  
D. Rubenstein ◽  
D. M. Sharpe
Keyword(s):  
Hong Kong ◽  
Great Britain ◽  
Respiratory Virus ◽  
Medical Research Council ◽  
Serum Antibody ◽  
Polyvalent Vaccine ◽  
Antibody Titres ◽  
Adults And Children ◽  
Made In ◽  
Intranasal Spray

SUMMARYStudies of the effect of Hong Kong (HK) influenza vaccine were made in adults and children in Great Britain during 1968 and 1969. The vaccines were administered intramuscularly and also by intranasal spray. The serum antibody response was studied in 284 subjects. Most developed rising titres to vaccine given intramuscularly and few to vaccine given intranasally. Deoxycholate-split vaccine was as potent as conventional whole virus vaccine. Antibody titres were maintained for months. Over 4000 subjects in factories, offices and schools were observed during the epidemic. The incidence of disease was not significantly reduced by either form of vaccination. A survey was made of epidemics in boarding schools in which some of the pupils had been vaccinated, in six with commercial polyvalent vaccine and in five with HK; there was a lower incidence of influenza in two schools vaccinated 2 or 4 weeks earlier with HK vaccine.

scholarly journals Antibody responses and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant A2/Hong Kong/68 (H3N2) influenza vaccines A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines

1972 ◽  
Vol 70 (3) ◽  
pp. 531-543 ◽  
Author(s):  
D. S. Freestone ◽  
Stephanie Hamilton-Smith ◽  
G. C. Schild ◽  
Rosemary Buckland ◽  
Susan Chinn ◽  
...  
Keyword(s):  
Hong Kong ◽  
Respiratory Virus ◽  
Medical Research Council ◽  
Haemagglutination Inhibition ◽  
Antibody Responses ◽  
Influenza Vaccines ◽  
Influenza B ◽  
Antibody Titres ◽  
Adjuvant Vaccine ◽  
H3n2 Influenza

SUMMARYForty-nine subjects were vaccinated with either live attenuated, detergent split, or oil adjuvant A2/Hong Kong influenza vaccines, or a saline influenza B vaccine as control. Respiratory symptoms occurred more frequently in subjects who received the live vaccine but in total there was little difference between the symptoms in the four groups. Antibody titres hi nasal washings and serum were measured by haemagglutination inhibition, neuraminidase inhibition and virus neutralization tests. The oil adjuvant vaccine stimulated larger antibody responses than the other procedures. Six weeks after vaccination the volunteers were challenged with partially attenuated live A2/Hong Kong influenza virus administered intranasally. The live attenuated and oil adjuvant vaccines provided the best protection against challenge.

scholarly journals The efficacy of live and inactivated vaccines of Hong Kong influenza virus in an industrial community: A report to the Medical Research Council Committee on Influenza and other respiratory virus vaccines

1973 ◽  
Vol 71 (4) ◽  
pp. 641-647 ◽  
Author(s):  
D. Hobson ◽  
F. A. Baker ◽  
R. L. Curry ◽  
A. S. Beare ◽  
P. M. O. Massey
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Medical Research ◽  
Research Council ◽  
Respiratory Virus ◽  
Medical Research Council ◽  
Influenza Viruses ◽  
Protective Efficiency ◽  
Industrial Community ◽  
Inactivated Vaccines

Intranasal vaccines of inactivated or living attentuated A2/Hong Kong influenza viruses were compared for clinical acceptability, serological effects and protective efficiency against natural epidemic influenza in a large industrial and clerical population.

scholarly journals A graded-dose study of inactivated, surface antigen influenza B vaccine in volunteers: reactogenicity, antibody response and protection to challenge virus infection

1983 ◽  
Vol 90 (1) ◽  
pp. 107-115 ◽  
Author(s):  
A. Goodeve ◽  
C. W. Potter ◽  
A. Clark ◽  
R. Jennings ◽  
G. C. Schild ◽  
...  
Keyword(s):  
Hong Kong ◽  
Virus Infection ◽  
Antibody Response ◽  
Antibody Titre ◽  
Serum Antibody ◽  
Influenza B ◽  
Challenge Virus ◽  
Antibody Titres ◽  
Dose Study ◽  
Serum Antibody Titre

SUMMARYOne hundred and nineteen volunteers were divided into five groups, and each volunteer inoculated subcutaneously with an aqueous subunit B/Hong Kong/73 vaccine containing 40, 20, 10, or 5 μg of HA or saline alone in a 0·5 ml volume. The incidence of reactions was recorded 24 h after inoculation. One month following immunization the serum HI antibody to B/Hong Kong/73 virus was measured; each volunteer was inoculated intranasally with live, attenuated influenza B (RB77) virus; and the incidence of infection by the challenge virus was determined by HI antibody response.The results showed that the incidence of reactions to all doses of vaccine were relatively low, the severity mild, and the duration short. However, the incidence of reactions was highest for those given 40 μg HA and least for those given 5 μg HA. The serum HI antibody responses to vaccine showed a dose-response relationship. For volunteers given 40 μg HA, 22 (96%) showed a fourfold rise in antibody titre and all volunteers had antibody titres of > 40 following immunization: for volunteers given 5 μg HA the g.m.t. increased from 16·6 to 86·1; and for those given 10 and 20 μg HA the response was intermediate. Following challenge, the lowest incidence of infection was seen in volunteers given the highest dose of vaccine. However, all doses of vaccine induced some protection against challenge virus infection, and the incidence of infection was directly related to the serum antibody titre at the time of challenge. The 50% protection titre of serum HI antibody was estimated as 15 to 20.

scholarly journals Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
James A. Hutchinson ◽  
Katharina Kronenberg ◽  
Paloma Riquelme ◽  
Jürgen J. Wenzel ◽  
Gunther Glehr ◽  
...  
Keyword(s):  
Immune Checkpoint ◽  
Serum Antibody ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Effector Memory ◽  
Specific Memory ◽  
Immune Mediated ◽  
Antibody Titres ◽  
Pre Treatment ◽  
After Cancer

AbstractTreatment of advanced melanoma with combined PD-1/CTLA-4 blockade commonly causes serious immune-mediated complications. Here, we identify a subset of patients predisposed to immune checkpoint blockade-related hepatitis who are distinguished by chronic expansion of effector memory CD4+ T cells (TEM cells). Pre-therapy CD4+ TEM cell expansion occurs primarily during autumn or winter in patients with metastatic disease and high cytomegalovirus (CMV)-specific serum antibody titres. These clinical features implicate metastasis-dependent, compartmentalised CMV reactivation as the cause of CD4+ TEM expansion. Pre-therapy CD4+ TEM expansion predicts hepatitis in CMV-seropositive patients, opening possibilities for avoidance or prevention. 3 of 4 patients with pre-treatment CD4+ TEM expansion who received αPD-1 monotherapy instead of αPD-1/αCTLA-4 therapy remained hepatitis-free. 4 of 4 patients with baseline CD4+ TEM expansion given prophylactic valganciclovir and αPD-1/αCTLA-4 therapy remained hepatitis-free. Our findings exemplify how pathogen exposure can shape clinical reactions after cancer therapy and how this insight leads to therapeutic innovations.

England, Ireland, and Rome, 1847-1848

1989 ◽  
Vol 25 ◽  
pp. 259-277
Author(s):  
Donal A. Kerr
Keyword(s):  
Great Britain ◽  
Catholic Church ◽  
British Government ◽  
Catholic Priests ◽  
The Public ◽  
Northern District ◽  
Catholic Religion ◽  
Pius Ix ◽  
Public Papers ◽  
Made In

In the spring of 1848 a number of respected English vicars-general, William Bernard Ullathorne of the Western District, John Briggs of the Northern District, and Thomas Brown of Wales decided that one of them, together with Fr Luigi Gentili, the Rosminian missioner, should proceed immediately to Rome. Their object would be to support, by personal intervention with Pius IX, a memorial drawn up by Briggs, signed by twenty Irish and three or four bishops in Great Britain, which was solemnly presented to the Pope by Thomas Grant, President of the English College in Rome. This memorial ran: we most... solemnly declare to Your Holiness that British Diplomacy has everywhere been exerted to the injury of our Holy Religion. We read in the public Papers that Lord Minto is friendly received... by Your Holiness At this very time, however,... the first Minister of the British Government, the Son in Law of Lord Minto is publicly manifesting in England, together with his fellow Ministers, his marked opposition to the Catholic Religion and the Catholic Church. Another cause of our serious alarm is the very general hostile and calumnious outcry now made in both houses of our Parliament and throughout Protestant England against the Catholic Priests of Ireland, falsely charging them with being the abettors of the horrible crime of murder whilst as true Pastors they are striving t o . . . console their... perishing people and like good shepherds are in the midst of pestilence giving their lives for their flocks.

VI Non-Cancellable Disability Insurance

1971 ◽  
Vol 20 (01) ◽  
pp. 54-55
Author(s):  
J. Hamilton-Jones
Keyword(s):  
Great Britain ◽  
Disability Insurance ◽  
Sickness Insurance ◽  
Collective Method ◽  
Made In

There are two methods of dealing with the actuarial features of sickness insurance—the collective method and the reversionary method.Unfortunately, perhaps the two methods have developed quite independently of each other, for historical reasons.The collective method was used in Great Britain to investigate Friendly Society experience. The pattern for all subsequent investigations was set in the 1820s and brought to its culmination of refinement in Watson's Manchester Unity Experience still in the Institute's examination syllabus, 66 years after publication. No investigation of insured lives has yet been made in Great Britain. In the rest of this note the term ‘Manchester Unity method’ will be used to describe the collective method.

Persistent seropositivity in oophorectomy-resistant anti-NMDA receptor encephalitis

2021 ◽  
Vol 14 (9) ◽  
pp. e241878
Author(s):  
Susmit Tripathi ◽  
Nara M Michaelson ◽  
Alan Segal
Keyword(s):  
Clinical Decision Making ◽  
Serum Antibody ◽  
Disease Patient ◽  
Clinical Decision ◽  
High Serum ◽  
Nmda Receptor Encephalitis ◽  
Resistant Disease ◽  
Nmdar Encephalitis ◽  
Antibody Titres ◽  
Case Basis

To discuss (1) the significance of seropositivity in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and (2) clinical decision making in oophorectomy resistant disease. Patient A (a 35-year-old woman) had high CSF and serum anti-NMDA antibody titres, a complicated hospital course, little improvement with first and second-line therapies, and remained with high CSF and serum antibody titres despite unilateral oophorectomy, requiring a nearly 13-month long hospitalisation. Conversely, patient B (a 29-year-old woman) had low CSF titres, seronegative disease and quickly recovered to her baseline with first line therapies and oophorectomy. Anti-NMDAR antibodies are themselves pathological, causing signalling dysfunction and internalisation of the NMDAR. Seropositivity with anti-NMDAR antibodies likely reflects leakage from the blood–brain barrier, with high serum titres being a downstream effect of high CSF titres. Empiric bilateral oophorectomies is controversial but appropriate on a case-by-case basis in extremely treatment-resistant NMDAR encephalitis given the possibility of antigenic microteratomas, which may not be detected on imaging or even bilateral ovarian biopsies.

Anti-NMDAR encephalitis presenting after immature teratoma resection

2021 ◽  
Vol 14 (11) ◽  
pp. e244637
Author(s):  
Deandra Kimberly Chetram ◽  
Kelsey Pan ◽  
Aisha Elfasi ◽  
Merry Markham
Keyword(s):  
Cancer Diagnosis ◽  
Psychiatric Symptoms ◽  
Serum Antibody ◽  
Immature Teratoma ◽  
High Dose ◽  
Intravenous Methylprednisolone ◽  
Nmda Receptor Encephalitis ◽  
Positive Serum ◽  
Antibody Titres ◽  
Significant Clinical Improvement

This is a case of a young woman who developed neurological and psychiatric symptoms 3 days after resection of an immature teratoma. She was diagnosed with anti-NMDA receptor encephalitis via positive serum antibody titres, which was later confirmed with cerebrospinal fluid antibody titres. Given her cancer diagnosis, she underwent treatment with bleomycin, etoposide and cisplatin chemotherapy in addition to 5 days of high-dose steroids (1 g of intravenous methylprednisolone) for the encephalitis. This treatment regimen led to significant clinical improvement 3 weeks after completion of one cycle of chemotherapy.

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