scholarly journals Pen and field trials of flupropadine against the house mouse (Mus musculus L.)

1985 ◽  
Vol 95 (2) ◽  
pp. 513-518 ◽  
Author(s):  
F. P. Rowe ◽  
A. Bradfield ◽  
T. Swinney
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Second Generation ◽  
Treatment Success ◽  
Field Trials ◽  
Mortality Data ◽  
Wild Mice ◽  
Anticoagulant Rodenticides ◽  
Farm Buildings ◽  
Family Groups

SUMMARYLaboratory and field trials were conducted to determine the efficacy of the candidate rodenticide flupropadine against the house mouse (Mus musculus L.). In laboratory feeding tests, family groups of wild mice maintained in pens and conditioned to feeding on plain foods were offered flupropadine at either 0·10%, 0·15%, 0·18% or 0·20% in pinhead oatmeal bait. Overall mortalities in replicated 21-day treatments were 66/71 (93·0%), 71/79 (89·9%), 72/70 (94·7%) and 69/75 (92·0%) respectively.In 17 field trials carried out against mice infesting farm buildings, flupropadine was used at 0·10%, 0·15% and 0·18% in oatmeal bait. Mean treatment success, estimated from live-capture and mortality data, was 88·6%, 96·2% and 96·6% respectively.Flupropadine was found to be as near effective against mice as calciferol/warfarin and the second-generation anticoagulant rodenticides difenacoum, bromadiolone and brodifacoum. In further comparison with the anticoagulants, treatment with flupropadine bait achieved markedly quicker control.

scholarly journals Pen and field trials of a new anticoagulant rodenticide flocoumafen against the house mouse (Mus musculus L.)

1985 ◽  
Vol 95 (3) ◽  
pp. 623-627 ◽  
Author(s):  
F. P. Rowe ◽  
A. Bradfield ◽  
T. Swinney
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Treatment Success ◽  
Field Trials ◽  
Mortality Data ◽  
House Mice ◽  
Anticoagulant Rodenticide ◽  
Free Living ◽  
Wild Mice ◽  
Farm Buildings

SUMMARYThe efficacy of flocoumafen, a novel anticoagulant rodentide, was evaluated in feeding tests on confined and free-living populations of house mice (Mus musculus L.). In four pen trials, family groups of laboratory-reared wild mice were conditioned to feeding on plain foods and then offered flocoumafen at 0.005% in pinhead oatmeal bait. All 68 mice, comprising juvenile and adult animals, died within 10 days.Ten field trials were carried out, using the same formulated poison bait, against mice infesting farm buildings. Mean treatment success, estimated from live-capture and mortality data, ranged between 87–1 and 100%.The performance of flocoumafen is compared with that of difenacoum, bromadiolone and brodifacoum used at the same concentration in oatmeal bait. Flocoumafen gave an equally effective but quicker kill of mice. It is concluded that flocoumafen is a promising new rodenticide for the control of M. musculus.

scholarly journals Trials of the rodenticide pyriminil against wild house mice (Mus musculus L.)

1978 ◽  
Vol 80 (2) ◽  
pp. 315-319 ◽  
Author(s):  
F. P. Rowe ◽  
T. Swinney ◽  
A. Bradfield
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Corn Oil ◽  
Treatment Success ◽  
Field Trials ◽  
Zinc Phosphide ◽  
Post Treatment ◽  
House Mice ◽  
Wild House Mice ◽  
Family Groups

SUMMARYPen and field trials were conducted to assess the performance of the acute rodenticide pyriminil against the house mouse (Mus musculus L.). Four types of poison treatment were carried out using penned family groups of warfarin-resistant mice supplied with alternative plain foods. In each treatment pyriminil was included at 2% in a wholemeal flour/pinhead oatmeal/corn oil bait. Mortality was highest (46/54; 85·2%) when poison bait was offered for 4 days following 3 days of pre-baiting The same pre-baiting and poisoning technique was adopted in five field trials carried out against mice infesting farm building The efficacy of each poison treatment was estimated from the results of pre- and post-treatment census baitings; treatment success ranged between 53·7% and 96·7%, mean 80·5% It is concluded that pyriminil treatments are best carried out after a period of pre-baiting and that when pyriminil is used in this manner it is about as effective as zinc phosphide for the control of mice

scholarly journals Field trials of calciferol combined with warfarin against wild house-mice (Mus musculus L.)

1974 ◽  
Vol 73 (3) ◽  
pp. 353-360 ◽  
Author(s):  
F. P. Rowe ◽  
F. J. Smith ◽  
T. Swinney
Keyword(s):  
Vitamin D ◽  
House Mouse ◽  
Mus Musculus ◽  
Corn Oil ◽  
Field Trials ◽  
Post Treatment ◽  
House Mice ◽  
Effective Combination ◽  
Wild House Mice ◽  
Farm Buildings

SummaryA combination of calciferol (vitamin D2) and warfarin, each at 0·025% in medium oatmeal bait, failed to control six of seven house-mouse (Mus musculus L.) populations infesting urban and farm buildings. In three further treatments with both calciferol and warfarin at 0·05 % in dehusked canary seed bait plus 5% corn oil, mortality, estimated from the consumption of pre- and post-treatment census bait, ranged between 94·2 and 97·4%. Finally, among sixteen treatments done with calciferol at 0·1% and warfarin at 0·025% in various cereal baits, the best results (97·0–100%) were obtained in six treatments where the bait-base was whole canary seed; this was so whether the poison bait was applied directly or after a 3-day pre-baiting period. It is concluded that calciferol at 0·1 % plus warfarin at 0·025 % is an effective combination against house-mice, especially when used with whole canary seed. The role played by warfarin in the poison mixture needs to be investigated further.

scholarly journals Trials of the anticoagulant rodenticides bromadiolone and difenacoum against the house mouse (Mus musculus L.)

1981 ◽  
Vol 87 (2) ◽  
pp. 171-177 ◽  
Author(s):  
F. P. Rowe ◽  
C. J. Plant ◽  
A. Bradfield
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Treatment Success ◽  
Field Trials ◽  
Toxicity Tests ◽  
Laboratory Examination ◽  
Anticoagulant Rodenticide ◽  
Before And After ◽  
Equivalent Field ◽  
Overall Mortality

SummaryLaboratory and field trials were conducted to determine the efficacy of the anticoagulant rodenticide bromadiolone against the house mouse (Mus musculus). In laboratory feeding tests, family groups of warfarin-resistant mice maintained in pens and conditioned to feeding on plain foods were offered pinhead oatmeal bait containing bromadiolone at 0·005%. Overall mortality in replicated 21-day poison treatments was 55/58 or 94·8%. Six field trials were carried out, using the same poison bait, against mice infesting farm buildings. Treatment success, estimated from the results of census baitings conducted before and after treatment, ranged between 60·4% and 100%, mean 92·4%. In equivalent field trials using difenacoum, another newly developed anticoagulant rodenticide, the control achieved ranged between 70·2% and 100%, mean 96·0%.Five field trials, three involving bromadiolone and two difenacoum, were not completely successful and the surviving mice were removed for laboratory examination. In 21-day toxicity tests, each animal was fed the poison bait offered to it earlier in the field. Bromadiolone and difenacoum gave kills of 12/21 (57·1%) and 9/11 (81·8%) respectively. The possible emergence of mouse populations resistant to these anticoagulants is considered.

scholarly journals Field trials of the rodenticide 5-p-chlorophenyl silatrane against wild house mice (Mus musculus L.)

1974 ◽  
Vol 73 (1) ◽  
pp. 49-52 ◽  
Author(s):  
F. P. Rowe ◽  
T. Swinney ◽  
A. Bradfield
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Corn Oil ◽  
Treatment Success ◽  
Field Trials ◽  
Zinc Phosphide ◽  
House Mice ◽  
Before And After ◽  
Wild House Mice

SUMMARYThe performance of the rodenticide 5-p-chlorophenyl silatrane at 0.5% in a wholemeal flour/pinhead oatmeal/corn oil bait was compared with that of zinc phosphide at 3% in the same base in poison treatments carried out against urban infestations of the house mouse (Mus musculus L.). Each poison treatment was conducted for 1 day and after 3 days' pre-baiting. The success of the treatments was assessed from census baitings conducted before and after treatment. Treatment success varied considerably with both poisons used but in general 5-p-chlorophenyl silatrane proved to be at least as effective as zinc phosphide, a commonly used acute rodenticide for the control of mice.

scholarly journals Trials of the anticoagulant rodenticide WBA 8119 against confined colonies of warfarin-resistant house mice (Mus musculus L.)

1976 ◽  
Vol 77 (3) ◽  
pp. 427-431 ◽  
Author(s):  
F. P. Rowe ◽  
A. Bradfield
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Toxicity Tests ◽  
House Mice ◽  
Anticoagulant Rodenticide ◽  
Laboratory Findings ◽  
Anticoagulant Rodenticides ◽  
Choice Feeding ◽  
Better Than ◽  
Family Groups

SUMMARYThe efficacy of the newly developed anticoagulant rodenticide WBA 8119 was evaluated against the house mouse (Mus musculus L.) using individual and family groups of warfarin-resistant animals. WBA 8119 at 0·002 %, O % and 0.01 % in pinhead oatmeal bait gave complete kills of mice in ‘no-choice’ feeding tests carried out in cages and small pens. In replicated 21-day treatments on families of mice confined in larger pens and conditioned to feeding on plain foods, the overall mortalities obtained using the three formulated poison baits were 71/72, 62/63 and 57/57 respectively.The results of the WBA 8119 toxicity tests are considered in relation to previous findings on other anticoagulant rodenticides, particularly difenacoum. In equivalent tests, WBA 8119 performed better than difenacoum. The data thus support the laboratory findings that WBA 8119 is the most active anticoagulant so far tested for the control of warfarin-resistant house mice.

scholarly journals Field trials of brodifacoum (WBA 8119) against the house mouse (Mus musculus L.)

1978 ◽  
Vol 81 (2) ◽  
pp. 197-201 ◽  
Author(s):  
F. P. Rowe ◽  
T. Swinney ◽  
C. Plant
Keyword(s):  
Mus Musculus ◽  
Corn Oil ◽  
Treatment Success ◽  
Field Trials ◽  
The Other ◽  
House Mice ◽  
Anticoagulant Rodenticide ◽  
Seed Corn ◽  
Before And After ◽  
Farm Buildings

SummaryThe anticoagulant rodenticide brodifacoum was tested against house mice (Mus musculus L.) infesting farm buildings. In six trials, treatment success was assessed from the results of census baitings conducted before and after treatment. With 0·005% brodifacoum in canary seed/corn oil bait, the control achieved ranged between 92·7% and 100%, mean 98·8%. Two mouse populations were eradicated in 3 to 4 weeks but a few individuals survived each of the other four treatments which lasted 6 weeks. The effectiveness of brodifacoum against mice is compared with that of 0·1% calciferol and 0·025% warfarin in combination. It is concluded that brodifacoum and calciferol/warfarin are equally effective in controlling M. musculus but that brodifacoum treatments need to be conducted fora relatively longer period.

scholarly journals Field trials of the rodenticide gophacide against wild house mice (Mus musculus L.)

1975 ◽  
Vol 74 (1) ◽  
pp. 109-114 ◽  
Author(s):  
F. P. Rowe ◽  
T. Swinney ◽  
A. Bradfield
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Corn Oil ◽  
Treatment Success ◽  
Field Trials ◽  
Zinc Phosphide ◽  
House Mice ◽  
Complex Environments ◽  
Before And After ◽  
Wild House Mice

The acute rodenticide gophacide was tested against urban infestations of the house mouse (Mus musculus L.) and treatment success was assessed from the results of census baitings conducted before and after each treatment. Seven of eight populations of mice living in premises where alternative food supplies were limited were successfully controlled when medium oatmeal bait containing gophacide at 0.1% was laid directly for 4 days. In further treatments against mice inhabiting more complex environments and having greater access to other foods, the performance of gophacide at 0.1% and at 0.25% in a wholemeal flour/pinhead oatmeal/corn oil bait was compared with that of zinc phosphide at 3.0% in the same bait-base. The poison treatments were conducted for 1 or 4 days and always after 3 days pre-baiting. Treatment success varied considerably irrespective of the type of treatment or of the poison used. In general, however, gophacide proved to be as effective as zinc phosphide for the control of mice.

scholarly journals Insights into mammalian biology from the wild house mouse Mus musculus

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Megan Phifer-Rixey ◽  
Michael W Nachman
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Genetic Model ◽  
Inbred Strains ◽  
Mendelian Inheritance ◽  
Model Organisms ◽  
House Mice ◽  
Small Subset ◽  
Wild Mice ◽  
Wide Range

The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.

scholarly journals Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L.

Genetics ◽  
1991 ◽  
Vol 127 (1) ◽  
pp. 161-168
Author(s):  
A Ruvinsky ◽  
A Polyakov ◽  
A Agulnik ◽  
H Tichy ◽  
F Figueroa ◽  
...  
Keyword(s):  
Soviet Union ◽  
House Mouse ◽  
Mus Musculus ◽  
Complementation Test ◽  
Antigenic Determinants ◽  
Lethal Gene ◽  
Eastern Siberia ◽  
Wild Mice ◽  
Low Diversity ◽  
Lethal Genes

Abstract In previous studies, 13 different recessive embryonic lethal genes have been associated with t haplotypes in the wild mice of the species Mus domesticus. In this communication we have analyzed five populations of Mus musculus for the presence and identity of t haplotypes. The populations occupy geographically distant regions in the Soviet Union: Altai Mountains, western and eastern Siberia, Azerbaijan and Turkmenistan. No t haplotypes were found in mice from eastern Siberia. In the remaining four populations, t haplotypes occurred with frequencies ranging from 0.07 to 0.21. All the t haplotypes extracted from these populations and analyzed by the genetic complementation test were shown to carry the same lethal gene tcl-w73. In one population (that of western Siberia), another lethal gene (tcl-w5) was found to be present on the same chromosome as tcl-w73. This situation is in striking contrast to that found in the populations of the western form of the house mouse, M. domesticus. In the latter species, tcl-w73 has not been found at all and the different populations are characterized by the presence of several different lethal genes. The low diversity of t haplotypes in M. musculus is consistent with lower genetic variability of other traits and indicates a different origin and speciation mode compared to M. domesticus. Serological typing for H-2 antigenic determinants suggests that most, if not all, of the newly described t haplotypes might have arisen by recombination of tw73 from M. musculus with t haplotypes from M. domesticus either in the hybrid zone between the two species or in regions where the two species mixed accidentally.

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