Upper airway invasion by well-differentiated thyroid carcinoma

AbstractThe majority of well differentiated thyroid carcinoma are tumours of low grade malignancy. Laryngotracheal invasion by well differentiated thyroid carcinoma is an uncommon occurrence. The surgical management of patients with thyroid cancer invading the upper airway has primarily been by total laryngectomy. Other surgeons recommend in selected cases partial laryngeal and/or tracheal resection.A total of 122 patients with thyroid carcinoma were treated in our department between 1967 and 1982. Only seven patients with well differentiated tumours had airway invasion. In these seven patients we used a partial laryngeal and/or tracheal resection. In three of the patients with tracheal invasion a myoperichondrial flap was used for closing the tracheal defect. A partial resection of the larynx and trachea, and end to end anastomosis between the trachea and the remaining part of the larynx was performed in another four patients.

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The Role of Total Laryngectomy in the Management of Intraluminal Upper Airway Invasion by Well-Differentiated Thyroid Carcinoma

Ear Nose & Throat Journal ◽

10.1177/014556139407300908 ◽

1994 ◽

Vol 73 (9) ◽

pp. 659-662 ◽

Cited By ~ 14

Author(s):

Martin J. Donnelly ◽

Conrad I. Timon ◽

Donald P. McShane

Keyword(s):

Thyroid Carcinoma ◽

Total Laryngectomy ◽

Upper Airway ◽

Differentiated Thyroid Carcinoma ◽

Best Interest ◽

Laryngeal Function ◽

Airway Invasion ◽

Well Differentiated ◽

Voice Preservation

Intraluminal invasion of the upper airway by well differentiated thyroid carcinoma is very uncommon, and the management can be problematic. Many conservative, reconstructive-type surgical procedures have been advocated to maintain normal laryngeal function. Although voice preservation is desirable, it may not always be in the patient's best interest and radical surgery, including total laryngectomy, may be necessary. We describe three cases in which total laryngectomy was performed, and review the indicators for this procedure in the treatment of this difficult to manage condition.

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Laryngotracheal Invasion by Thyroid Carcinoma

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948209100407 ◽

1982 ◽

Vol 91 (4) ◽

pp. 363-369 ◽

Cited By ~ 31

Author(s):

Michael Friedman ◽

Vicki K. Shelton ◽

Frederick G. Berlinger ◽

Emanuel M. Skolnik ◽

Mohammad Arab

Keyword(s):

Experimental Study ◽

Thyroid Carcinoma ◽

Retrospective Analysis ◽

Total Laryngectomy ◽

Cricoid Cartilage ◽

Differentiated Thyroid Carcinoma ◽

Airway Narrowing ◽

Airway Invasion ◽

Well Differentiated ◽

Laryngotracheal Invasion

Laryngotracheal invasion by well-differentiated thyroid carcinoma is an uncommon occurrence. Recommendations for therapy have primarily included total laryngectomy or shaving of the tumor from laryngeal or tracheal cartilages. Clear guidelines have not been established for the applicability of partial laryngeal resections. In a retrospective analysis of patients with thyroid carcinoma, 13 patients had airway invasion. Of the five patients with laryngeal involvement, three were treated by a partial laryngeal resection. An experimental study was undertaken to determine more precisely the amount of cricoid cartilage which could be resected without reconstruction. Varying amounts of cricoid cartilage were resected. The results indicate that 25% of the cricoid cartilage may be resected without appreciable airway narrowing. On the basis of the retrospective analysis and experimental study, we feel a partial laryngeal resection is possible in most cases of airway invasion by thyroid carcinoma.

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Lymph node metastases location (central vs lateral neck) in well-differentiated thyroid carcinoma: Is it important?

Endocrine Abstracts ◽

10.1530/endoabs.49.ep1463 ◽

2017 ◽

Author(s):

Bernardo Marques ◽

Raquel Martins ◽

Joana Couto ◽

Jacinta Santos ◽

Teresa Martins ◽

...

Keyword(s):

Lymph Node ◽

Thyroid Carcinoma ◽

Lymph Node Metastases ◽

Differentiated Thyroid Carcinoma ◽

Lateral Neck ◽

Node Metastases ◽

Well Differentiated

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Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature

BMC Endocrine Disorders ◽

10.1186/s12902-021-00724-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Nadia De Falco ◽

Giuseppe Santangelo ◽

Fabrizio Chirico ◽

Angelo Cangiano ◽

Maria Giulia Sommella ◽

...

Keyword(s):

Literature Review ◽

Thyroid Carcinoma ◽

Papillary Carcinoma ◽

Parathyroid Carcinoma ◽

Malignant Tumors ◽

Gamma Probe ◽

Differentiated Thyroid Carcinoma ◽

Thyroid Carcinomas ◽

First Case ◽

Well Differentiated

Abstract Background Parathyroid carcinoma is a rare endocrine malignancy, rarer when synchronous with a non medullary well differentiated thyroid carcinoma. Parathyroid carcinoma accounts of 0.005% of all malignant tumors and it is responsible for less than 1% of primary hyperparathyroidism. The intrathyroidal localization of a parathyroid gland is not frequent with a reported prevalence of 0.2%. Carcinoma of parathyroids with intrathyroidal localization represents an even rarer finding, reported in only 16 cases described in literature. The rare constellation of synchronous parathyroid and thyroid carcinomas has prompted us to report our experience and perform literature review. Case presentation We herein report a case of a 63-years-old man with multinodular goiter and biochemical diagnosis of hyperparathyroidism. Total thyroidectomy with radio-guide technique using gamma probe after intraoperative sesta-MIBI administration and intraoperative PTH level was performed. The high radiation levels in the posterior thyroid lobe discovered an intrathyroidal parathyroid. Microscopic examination revealed a parathyroid main cell carcinoma at the posterior thyroidal left basal lobe, a classic papillary carcinoma at the same lobe and follicular variant of papillary carcinoma at the thyroidal right lobe. To the best of our knowledge, this is the first case documenting a synchronous multicentric non medullary thyroid carcinomas and intrathyroidal parathyroid carcinoma. Conclusions Our experience was reported and literature review underlining challenging difficulties in diagnostic workup and surgical management was carried out.

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Galectin-3, a marker of well-differentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia

Histopathology ◽

10.1046/j.1365-2559.2002.01304.x ◽

2002 ◽

Vol 40 (1) ◽

pp. 80-87 ◽

Cited By ~ 52

Author(s):

A Coli ◽

G Bigotti ◽

F Zucchetti ◽

F Negro ◽

G Massi

Keyword(s):

Thyroid Carcinoma ◽

Thyroid Nodules ◽

Differentiated Thyroid Carcinoma ◽

Cytological Atypia ◽

Galectin 3 ◽

Well Differentiated

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Prognostic Factors in Patients with Multiple Recurrences of Well-Differentiated Thyroid Carcinoma

Journal of Oncology ◽

10.1155/2009/650340 ◽

2009 ◽

Vol 2009 ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

Theresa Holler ◽

Jenna Theriault ◽

Richard J. Payne ◽

Jonathan Clark ◽

Spiro Eski ◽

...

Keyword(s):

Prognostic Factors ◽

Thyroid Carcinoma ◽

Univariate Analysis ◽

Mount Sinai Hospital ◽

Differentiated Thyroid Carcinoma ◽

Multiple Treatment ◽

Time To Recurrence ◽

Stage Disease ◽

Well Differentiated ◽

Multiple Recurrences

Introduction.Patients with multiple recurrences of well-differentiated thyroid carcinoma (WDTC) have markedly reduced overall survival when compared with those who have 1 recurrence of their disease. The purpose of this investigation is to identify prognostic factors for mortality in this subgroup.Methods.Patients with multiple recurrences of WDTC were retrospectively identified from the thyroid cancer database at Mount Sinai Hospital, Toronto (1963–2000). Data on patient, tumor, and recurrence characteristics were collected, and each patient was given aMACIS score.Results.A total of 31 patients were identified (11 male, 20 female; 16–83 years). Using univariate analysis, age 45, stage disease, distant metastasis, vascular invasion, MACIS score 6, and time to recurrence of 12 months were found to be significant predictors for mortality in this subgroup.Conclusions.Patients with multiple recurrences of WDTC follow a distinct clinical course, marked with multiple treatment failures and a substantial risk of mortality.

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