Undifferentiated carcinoma of the nasopharynx and leukemoid reaction: report of case with literature review

1997 ◽  
Vol 111 (1) ◽  
pp. 66-69 ◽  
Author(s):  
Sven Saussez ◽  
P. Heimann ◽  
Luc Vandevelde ◽  
Pierre Bisscnop ◽  
Albert Jortay ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Literature Review ◽  
Undifferentiated Carcinoma ◽  
Lymphoid Cells ◽  
Leukemoid Reaction ◽  
Cervical Mass ◽  
Epithelial Markers ◽  
Gm Csf ◽  
Reaction Report ◽  
Undifferentiated Nasopharyngeal Carcinoma

AbstractA case of undifferentiated carcinoma of the nasopharynx presenting as a cervical mass associated with a paraneoplastic neutrophilic leukemoid reaction is reported. The diagnosis of undifferentiated nasopharyngeal carcinoma of the Regaud type was established by the presence of aggregates of epithelial neoplastic cells separated by areas of reactive lymphoid cells; the epithelial nature being confirmed by the positivity for epithelial markers (AE1/AE3, EMA). Serum IL-la, GM-CSF and TNFα remained undetectable suggesting that these factors were not involved in the occurrence of the paraneoplastic leukemoid syndrome.

scholarly journals Update in pediatric nasopharyngeal undifferentiated carcinoma

2019 ◽  
Vol 92 (1102) ◽  
pp. 20190107 ◽  
Author(s):  
Line Claude ◽  
Emmanuel Jouglar ◽  
Loig Duverge ◽  
Daniel Orbach
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Systemic Treatment ◽  
Young Patients ◽  
Undifferentiated Carcinoma ◽  
Treatment Modalities ◽  
Long Term Effects ◽  
Chemotherapy Induction ◽  
Undifferentiated Nasopharyngeal Carcinoma

Many of the principles established in adults with undifferentiated nasopharyngeal carcinoma (NPC) apply to children, adolescents and young adults. However, NPC in young patients should be distinguished from the adult form by several points. This review focuses mainly on differences between adult and pediatric NPC. The role of biology and genetics in pediatric NPC is discussed. Systemic treatment modalities including type of chemotherapy induction, timing of treatment, role of immunotherapy as adjuvant treatment, or in relapsing/ metastatic diseases are reported. Radiation modalities (doses, techniques…) in children are also reviewed. Long-term effects including secondary cancers are finally be discussed in this young NPC population.

Nonkeratinizing Nasopharyngeal Carcinoma, Undifferentiated Type With Trisomy 2: A Case Report and Short Review of Cytogenetic and Molecular Literature

2020 ◽  
Vol 23 (6) ◽  
pp. 448-452
Author(s):  
Francesco Pontoriero ◽  
Ayaka M Silverman ◽  
Judy M Pascasio ◽  
Renu Bajaj
Keyword(s):  
Case Report ◽  
Nasopharyngeal Carcinoma ◽  
Xenograft Model ◽  
Short Review ◽  
Undifferentiated Carcinoma ◽  
World Health ◽  
Surface Epithelium ◽  
Barr Virus ◽  
Cytogenetic Aberration ◽  
Health Organization

Carcinoma originating from the surface epithelium of the nasopharynx is classified by the World Health Organization (WHO) as nasopharyngeal carcinoma (NPC) and has 3 main types: keratinizing squamous cell carcinoma (WHO type 1) and nonkeratinizing carcinoma, differentiated (WHO type II), and undifferentiated (WHO type III). Nonkeratinizing NPC is strongly associated with prior Epstein–Barr virus (EBV) infection. These tumors may be divided into differentiated and undifferentiated carcinoma. Histologically, the tumor is characterized by syncytia of large malignant cells with vesicular nuclei, conspicuous nucleoli, and easily observed mitotic figures. We report a case of a 14-year-old boy diagnosed with EBV and human papillomavirus (HPV)-positive NPC (WHO type 3) with cytogenetics showing the presence of mosaic trisomy 2. This case report brings to light a rare cytogenetic aberration to our knowledge only reported once before in the literature in a xenograft model.

scholarly journals High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?

Oncogene ◽  
2000 ◽  
Vol 19 (30) ◽  
pp. 3439-3444 ◽  
Author(s):  
Tim Crook ◽  
John M Nicholls ◽  
Louise Brooks ◽  
Jenny O'Nions ◽  
Martin J Allday
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
High Level Expression ◽  
High Level ◽  
Undifferentiated Nasopharyngeal Carcinoma

Carboplatin plus Taxol is an Effective Third-line Regimen in Recurrent Undifferentiated Nasopharyngeal Carcinoma

2002 ◽  
Vol 88 (4) ◽  
pp. 273-276 ◽  
Author(s):  
Mario Airoldi ◽  
Fulvia Pedani ◽  
Sara Marchionatti ◽  
Anna Maria Gabriele ◽  
Giovanni Succo ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Median Overall Survival ◽  
Low Dose ◽  
Recurrent Disease ◽  
Nasopharyngeal Cancer ◽  
First Line ◽  
Second Line Therapy ◽  
Previously Treated ◽  
Third Line ◽  
Undifferentiated Nasopharyngeal Carcinoma

Background Recurrent undifferentiated nasopharyngeal carcinoma is a chemosensitive disease. Few third-line treatments have been reported. Methods Twelve patients (9 males, 3 females; median age 50 years, range, 20-62) with recurrent undifferentiated nasopharyngeal carcinoma were treated with carboplatin AUC 5.5 + paclitaxel (175 mg/m2, 3-hr infusion) on day 1 every 3 weeks. All patients had been previously treated for recurrent disease with a first-line cisplatin-based chemotherapy and a second-line therapy with low-dose continous infusion 5-fluorouracil. Results Overall, 54 courses were given (median, 5; range, 2-6). Three patients (25%) obtained a partial response lasting 6, 10 and 26+ months, 1 (8.3%) a minimal response lasting 6 months, and 3 (25%) no change with a median duration of 5 months. The median survival time was 14 months for patients who had a partial or minimal response or no change, and 5 months for nonresponders. Median overall survival was 9.5 months (3-30+). The treatment was well tolerated, and toxicity was manageable. Conclusions The combination has a good pallitive role as third-line chemotherapy in recurrent undifferentiated nasopharyngeal cancer.

scholarly journals Aesthetic management of tooth discolouration: conservative treatment for a patient with undifferentiated nasopharyngeal carcinoma

2011 ◽  
Vol 26 (1) ◽  
pp. 84-87
Author(s):  
Ana Carolina Scarpelli ◽  
Cristiane Baccin Bendo ◽  
João Batista Novaes-Júnior ◽  
Ivan Doche Barreiros ◽  
Saul Martins Paiva
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Conservative Treatment ◽  
Undifferentiated Nasopharyngeal Carcinoma

Elevation of plasma osteopontin level in patients with undifferentiated nasopharyngeal carcinoma

2005 ◽  
Vol 31 (5) ◽  
pp. 555-558 ◽  
Author(s):  
T.S. Wong ◽  
D.L.-W. Kwong ◽  
J. Sham ◽  
W.I. Wei ◽  
Y.L. Kwong ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Undifferentiated Nasopharyngeal Carcinoma

scholarly journals Histological and Electron Microscopic Studies of Endemic Ethmoidal Carcinomas in Cattle

1979 ◽  
Vol 16 (2) ◽  
pp. 180-190 ◽  
Author(s):  
A. Pospischil ◽  
T. Haenichen ◽  
H. Schaeffler
Keyword(s):  
Epstein Barr Virus ◽  
Undifferentiated Carcinoma ◽  
Olfactory Mucosa ◽  
Lymphoid Cells ◽  
Electron Microscopic ◽  
Barr Virus ◽  
Human Nasopharyngeal Carcinoma ◽  
Microscopic Studies ◽  
Epstein Barr ◽  
Tumor Types

In five cases of endemic ethmoidal carcinoma in cattle from the Dominican Republic three tumor types could be classified: undifferentiated carcinoma (3), adenocarcinoma (1), and squamous cell carcinoma (1). Electron microscopy showed that the tumor cells in undifferentiated carcinomas closely resembled the cells of the normal olfactory mucosa. This was especially true for the dark cells of Bowman's gland. Ultrastructurally, the lymphoid cells of the undifferentiated bovine carcinoma resembled the lymphoid cells of human nasopharyngeal carcinoma being closely associated with Epstein-Barr Virus. This and epidemiological observations suggested a viral cause of endemic ethmoidal carcinoma.

Feasibility and long-term results of autologous PBSC transplantation in recurrent undifferentiated nasopharyngeal carcinoma

Head & Neck ◽  
2001 ◽  
Vol 23 (9) ◽  
pp. 799-803 ◽  
Author(s):  
Mario Airoldi ◽  
Alberto De Crescenzo ◽  
Fulvia Pedani ◽  
Sara Marchionatti ◽  
Anna Maria Gabriele ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Long Term Results ◽  
Undifferentiated Nasopharyngeal Carcinoma
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