scholarly journals The association between Vitamin D deficiency and risk of pre-diabetes among older adults

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Emily Trussler ◽  
Julia Navon ◽  
Rachele Pojednic ◽  
Elizabeth Metallinos-Katsaras
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Vitamin D ◽  
Glucose Tolerance ◽  
Vitamin D Deficiency ◽  
Vitamin D Status ◽  
Age And Gender ◽  
Final Sample ◽  
And Gender

AbstractIntroductionType 2 Diabetes Mellitus is one of the most common conditions affecting older adults, and is one of few diseases with a distinct liminal stage: prediabetes. Dietitians and healthcare practitioners currently recognize prediabetes as a lifestyle disease,and “reversing” it relies largely on dietary modifications and increased exercise.Some research suggests that vitamin D may also be a target since its deficiency has been tentatively linked to many chronic conditions,5 and a high prevalence has been observed among subjects with prediabetes and type 2 diabetes.6, 7 The purpose of this study was to examine the association between vitamin D deficiency and risk of pre-diabetes in people 50 + years of age living in the United States.Materials and MethodsThis was a cross-sectional analysis of the US National Health and Nutrition Examination Survey (2007–2012) subjects, ages 50 + years, free of kidney/liver diseases and diabetes. Outcome: Prediabetes, was defined as: HbA1c level 5.7–6.5%, or fasting plasma glucose level 100–125 mg/dL, or Oral Glucose Tolerance Test result 140–199 mg/dL, with no laboratory value in the diabetic range. Those with normal glucose tolerance (NGT) with no marker in the prediabetes/diabetes range were the comparison group. Exposure: subjects' vitamin D status was classified based on total serum 25(OH)D levels as follows: deficient = < 50 nmol/L, insufficient = 50–75 nmol/L, and sufficient = > 75 nmol/L. The final sample (n = 2,286) was sufficient to detect a 7% difference in odds of prediabetes (the average difference observed in the literature) with 80% power and 95% confidence. Multivariate logistic regression analysis included strata, cluster and weight variables. Models were adjusted for BMI, ethnicity, age and gender.ResultsThe final sample was 2,286 subjects, predominantly white (80.4%) and female (56.6%), with a mean age of 62.3 years; 1,387 had prediabetes (59.1%) and 899 were NGT (40.9%). Vitamin D status was associated with pre-diabetes (p = 0.03). Those with vitamin D deficiency were more likely to have prediabetes compared to vitamin D sufficient individuals (crude OR = 1.48 95%CI 1.15–1.91), which remained significant after adjustment for ethnicity, BMI, age and gender (aOR = 1.39 95%CI 1.02–1.89). There was no effect modification by BMI, gender or ethnicity.DiscussionOur results contributed to this existing literature by demonstrating that vitamin D status is associated with pre-diabetes in a nationally representative sample of older US adults.Vitamin D status was significantly associated with risk of prediabetes in Americans 50 + years of age. Prevention efforts should incorporate awareness of vitamin D.

scholarly journals Vitamin D Deficiency Is Associated with the Presence and Severity of Diabetic Retinopathy in Type 2 Diabetes Mellitus

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Nuria Alcubierre ◽  
Joan Valls ◽  
Esther Rubinat ◽  
Gonzalo Cao ◽  
Aureli Esquerda ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Diabetic Retinopathy ◽  
Vitamin D Deficiency ◽  
Vitamin D Status ◽  
25 Hydroxy Vitamin D ◽  
Advanced Stages

There is very few evidences on the role of vitamin D in the development of diabetic retinopathy. The aim of the current study was to explore whether there is an association of vitamin D status and diabetic retinopathy in type 2 diabetes. Two groups of patients were selected: 139 and 144 patients with and without retinopathy, respectively, as assessed by an experienced ophthalmologist. Subjects with advanced late diabetic complications were excluded to avoid confounding biases. 25-Hydroxy-vitamin D3(25(OH)D) concentrations and vitamin D deficiency were associated with the presence of diabetic retinopathy. Additionally, patients with more advanced stages of retinopathy (grades 2–4) had lower concentrations of 25(OH)D and were more frequently vitamin D deficient as compared with patients not carrying this eye complication. In conclusion, our study confirms the association of vitamin D deficiency with the presence and severity of diabetic retinopathy in type 2 diabetes. Further experimental and prospective studies on this issue are clearly warranted.

scholarly journals Diabetes Prevention: Vitamin D Supplementation May Not Provide Any Protection If There Is No Evidence of Deficiency!

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2651 ◽  
Author(s):  
Uwe Gröber ◽  
Michael F. Holick
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
The Metabolic Syndrome ◽  
Supplement Group ◽  
Increased Risk

The results of epidemiological and several interventional studies suggest an association between vitamin D deficiency and an increased risk of developing insulin resistance or type 2 diabetes. Various studies have indicated that a lack of vitamin D must be regarded as a pathogenic factor for type 2 diabetes and the metabolic syndrome, since a vitamin D deficiency (25(OH)D < 20 ng/mL) increases insulin resistance and reduces insulin secretion from beta cells in the pancreas. A recent study by Pittas et al. did not show a clear preventive effect of vitamin D supplementation with respect to the risk of developing type 2 diabetes. In terms of this study, it must be remembered that more than 70% of the participants in both the vitamin D supplement group and the placebo group did not have a vitamin D deficiency. In medical and pharmaceutical practice, more attention should be paid to vitamin D deficiency than has previously been accorded. Vitamin D status can be assessed objectively when necessary by laboratory testing of the serum 25(OH)D levels. Type 2 diabetes patients benefit from improving their vitamin D status with respect to their glucose metabolism and decreased mortality risk. Patients with insulin resistance who are vitamin D deficient should be treated with an appropriate amount of vitamin D to achieve circulating levels of 25(OH)D of 40–60 ng/mL.

scholarly journals Correlative Analysis of Vitamin D Status in People Suffering from Type-2 Diabetes Mellitus in Eastern Region of Nepal

2019 ◽  
Vol 3 (3) ◽  
pp. 565-569
Author(s):  
Rajneesh Jha ◽  
Meena Kumari Mishra ◽  
Amit Mishra ◽  
Raju Kumar Chaudhary
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Eastern Region ◽  
Vitamin D Status ◽  
Blood Samples ◽  
Type 2 Diabetics

Introduction: Vitamin D deficiency exists as a common problem among population worldwide. The deficient vitamin D level leads to direct impact on various normal functioning of human body systems. It has been observed in few studies that decreased circulating concentration of 25-hydroxyvitamin D is associated with type-2 diabetes mellitus. The possible reason behind such occurrence is due to the direct effect of vitamin D on glucose metabolism. Vitamin D exerts influences on activity of pancreatic β-cell function from where insulin is secreted. In addition, the patients suffering from low vitamin D status show insulin resistance. These affected individuals with low vitamin D status exhibits impaired markers of glucose metabolism such as glycosylated hemoglobin. So, researchers have found vitamin D deficiency to correlate with type-2 diabetes and 80 % of obese adults suffering from vitamin D insufficiency state. In spite of such crucial significance, the correlative studies related to vitamin D status and type-2 diabetes still remains obscure in eastern region of Nepal. Objective: We aimed to investigate status of vitamin D among type-2 diabetics and analyze its possible correlation. Methodology: In the present study which was hospital-based and cross sectional one, antecubital venous blood samples were collected from patients (n=100) in plain vials with informed written consent. Blood samples were allowed to clot and centrifuged for separation of serum. The separated sera were further processed for determination of glucose (fasting as well as post-prandial) by spectrophotometry and estimation of vitamin D with use of microwell Enzyme-linked immunosorbant assay (ELISA) technique. The data was interpreted by using SPSS software version 16. Results: We found that 75 % type-2 diabetics had suffered from “state of vitamin D deficiency”. Among them, females, in contrast, were predominating which was interesting in an analytical point of view. Conclusion: Our study reviews evidence on disorders related to type-2 diabetes mellitus and vitamin D status, especially in older people. The biological processes that lead to synthesis of vitamin D in human body tissues become less efficient when an individual's age advances with in additional occurrences of type-2 diabetes mellitus. We should therefore maintain the repletion of vitamin D in healthy older people via supplementary intakes and sensible sun-exposure. 

Pilot Study to Evaluate the Effect of Short-Term Improvement in Vitamin D Status on Glucose Tolerance in Patients with Type 2 Diabetes Mellitus

2010 ◽  
Vol 16 (4) ◽  
pp. 600-608 ◽  
Author(s):  
Deepal Parekh ◽  
Vijaya Sarathi ◽  
Vyankatesh Shivane ◽  
Tushar Bandgar ◽  
Padma Menon ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Pilot Study ◽  
Glucose Tolerance ◽  
Vitamin D Status ◽  
Short Term

scholarly journals Study of Vitamin D Status and its Correlation with Glycated Haemoglobinin Type 2 Diabetes Mellitus

2019 ◽  
pp. 12-16
Author(s):  
Khalid Aljabri
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Glycated Haemoglobin ◽  
Inverse Association ◽  
Age Group ◽  
Vitamin D Status

Introduction: Few published researches have surveyed the correlation between Vitamin D status and glycaemic control in type 2 diabetes mellitus (T2DM). The present study was conducted to investigate the status of vitamin D and its correlation with glycated haemoglobin in type 2 diabetes mellitus. Method: A cross-sectional single centre study was conducted in 2440 patients with T2DM attending the Diabetes Centre at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia between January 2018 and December 2018. Eligible patients were 20 years or older. Results: There were 2440 patients with T2DM. Vitamin D deficiency (25-OHD<50 nmol/l) was found 47.5%. Patients with HbA1c<7% were younger than patients with HbA1c 7%-9% and >9% (55.3 ±16.0 vs. 58.4 ±15.2 vs. 57.1 ±15.4 respectively, p<0.0001). The mean 25-OHD concentration was statistically significant lower in patients with Hba1c>9% compared to patients with Hba1c<7% and 7%-9% (49.7 ±27.0 vs. 61.8 ±31.4 vs. 56.9 ±28.8 respectively, p<0.0001). The frequency of vitamin D deficiency was statistically significant higher in patients with Hba1c>9% compared to patients with Hba1c<7% and 7%-9% (40% vs. 48% vs. 61% respectively, p<0.0001). The frequency of vitamin D deficiency was upward across HbA1c groups as age advanced with highest frequency of vitamin D deficiency was found to be statistically significant in HbA1c>9% compared to HbA1c< and 7%-9% groups in the age group 50-59 years and ≥60 years with males most frequently predominant than females in all age group associated with HbA1c 7%-9% and 9%. HbA1c was significantly positively correlated with age whereas 25-OHD concentration was significantly negatively correlated with age. Conclusions: We report vitamin D deficiency and its inverse association with Glycated Haemoglobin in type 2 Diabetes Mellitus.

588-P: Vitamin D Status in a Bulgarian Population with Type 2 Diabetes and Diabetic Foot Ulcers

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 588-P
Author(s):  
ANI S. TODOROVA ◽  
RUMYANA DIMOVA ◽  
NEVENA CHAKAROVA ◽  
MINA SERDAROVA ◽  
GRETA GROZEVA-DAMYANOVA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Vitamin D Status ◽  
Bulgarian Population
Sign in / Sign up

Export Citation Format

Share Document