Structural brain changes in patients with anorexia nervosa

SynopsisTwenty-five patients with anorexia nervosa were compared with 17 normal healthy control subjects in terms of their cerebral computed tomographic (CT) scan appearances. The patients displayed significantly greater ventricular and sulcal enlargement when compared to control subjects. There were no relationships between the CT scan appearance and clinical indices of illness severity or weight loss in the patient group. In 14 patients who had repeat scans after attaining normal body weight, no significant change was observed in the ventricular appearance, but there was a significant lessening in the degree of sulcal widening.

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Structural brain changes in severe and enduring anorexia nervosa: a multimodal magnetic resonance imaging study of gray matter volume, cortical thickness, and white matter integrity

Psychiatry Research Neuroimaging ◽

10.1016/j.pscychresns.2021.111393 ◽

2021 ◽

pp. 111393

Author(s):

Ryo Mishima ◽

Masanori Isobe ◽

Tomomi Noda ◽

Keima Tose ◽

Michiko Kawabata ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Anorexia Nervosa ◽

Gray Matter Volume ◽

Imaging Study ◽

White Matter Integrity ◽

Magnetic Resonance Imaging Study ◽

Resonance Imaging ◽

Matter Volume ◽

Brain Changes ◽

Structural Brain

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Su1569 Children With Functional Gastrointestinal Disorders Display Structural Brain Alterations Compared to Healthy Control Subjects

Gastroenterology ◽

10.1016/s0016-5085(16)31822-4 ◽

2016 ◽

Vol 150 (4) ◽

pp. S529

Author(s):

Kirsten Tillisch ◽

Jennie Tsao ◽

Jennifer S. Labus ◽

Alia C. Manetta ◽

Cody Ashe-McNalley ◽

...

Keyword(s):

Functional Gastrointestinal Disorders ◽

Gastrointestinal Disorders ◽

Control Subjects ◽

Healthy Control ◽

Structural Brain ◽

Structural Brain Alterations

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Structural Brain Changes and Malnutrition in Anorexia Nervosa

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1997.tb48238.x ◽

1997 ◽

Vol 817 (1 Adolescent Nu) ◽

pp. 398-399 ◽

Cited By ~ 12

Author(s):

M. R. KOHN ◽

M. ASHTARI ◽

N. H. GOLDEN ◽

J. SCHEBENDACH ◽

M. PATEL ◽

...

Keyword(s):

Anorexia Nervosa ◽

Brain Changes ◽

Structural Brain

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Cognitive and Physiologic Correlates of Subclinical Structural Brain Disease in Elderly Healthy Control Subjects

Archives of Neurology ◽

10.1001/archneur.59.10.1612 ◽

2002 ◽

Vol 59 (10) ◽

pp. 1612 ◽

Cited By ~ 46

Author(s):

Ian A. Cook ◽

Andrew F. Leuchter ◽

Melinda L. Morgan ◽

Elise Witte Conlee ◽

Steven David ◽

...

Keyword(s):

Brain Disease ◽

Control Subjects ◽

Healthy Control ◽

Structural Brain

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Hypothalamic BOLD response to glucose intake and hypothalamic volume are similar in anorexia nervosa and healthy control subjects

Frontiers in Neuroscience ◽

10.3389/fnins.2015.00159 ◽

2015 ◽

Vol 9 ◽

Cited By ~ 9

Author(s):

Anna M. van Opstal ◽

Anna M. Westerink ◽

Wouter M. Teeuwisse ◽

Mirjam A. M. van der Geest ◽

Eric F. van Furth ◽

...

Keyword(s):

Anorexia Nervosa ◽

Bold Response ◽

Control Subjects ◽

Glucose Intake ◽

Healthy Control

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Bone turnover during inpatient nutritional therapy and outpatient follow-up in patients with anorexia nervosa compared with that in healthy control subjects

American Journal of Clinical Nutrition ◽

10.1093/ajcn/80.3.774 ◽

2004 ◽

Vol 80 (3) ◽

pp. 774-781 ◽

Cited By ~ 42

Author(s):

Martina Heer ◽

Claudia Mika ◽

Ina Grzella ◽

Nicole Heussen ◽

Beate Herpertz-Dahlmann

Keyword(s):

Anorexia Nervosa ◽

Bone Turnover ◽

Nutritional Therapy ◽

Control Subjects ◽

Healthy Control

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Twenty-four-hour food intake in patients with anorexia nervosa and in healthy control subjects

Biological Psychiatry ◽

10.1016/0006-3223(94)91179-7 ◽

1994 ◽

Vol 36 (10) ◽

pp. 696-702 ◽

Cited By ~ 44

Author(s):

Madelyn H. Fernstrom ◽

Theodore E. Weltzin ◽

Shira Neuberger ◽

Nalini Srinivasagam ◽

Walter H. Kaye

Keyword(s):

Anorexia Nervosa ◽

Food Intake ◽

Control Subjects ◽

Healthy Control

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The effect of D-Trp6-LRH upon secretion of gonadotrophin – a possible therapeutic application in anorexia nervosa

Acta Endocrinologica ◽

10.1530/acta.0.1050161 ◽

1984 ◽

Vol 105 (2) ◽

pp. 161-166 ◽

Cited By ~ 6

Author(s):

S. Zgliczyński ◽

B. Baranowska ◽

W. Jeske ◽

A. Niewiadomska ◽

G. Rozbicka ◽

...

Keyword(s):

Weight Loss ◽

Body Weight ◽

Anorexia Nervosa ◽

Prolactin Secretion ◽

Control Group ◽

Female Patients ◽

Serum Lh ◽

Normal Body Weight ◽

Lh Release ◽

Lh Secretion

Abstract. The aim of this study was to evaluate the effect of the agonistic LRH analogue (D-Trp6-LRH) on LH, FSH and prolactin secretion, and its possible efficacy in female patients with anorexia nervosa. The study included 18 female patients with anorexia nervosa and 7 healthy women in the same age group. The patients with anorexia nervosa were divided into two groups of 9 women each. The first group consisted of patients in the weight loss phase of the disorder and the second of 9 women who had achieved normal body weight. Additionally, in 6 women with anorexia nervosa serum LH concentration was determined in response to native LRH before and 14 days after the treatment with D-Trp6-LRH. Serum LH, FSH, prolactin concentrations were determined before and 5, 10, 24 and 48 h after administration of D-Trp6-LRH in a dose of 5 μg. The serum LH response to D-Trp6-LRH in the second group did not differ from that of the control group. However, in women with anorexia nervosa in the weight loss phase, LH release in response to administration of the analogue was significantly lower. FSH release after LRH analogue administration in both groups of patients with anorexia nervosa did not differ from that in the control group. The increased LH secretion in response to native LRH after treatment indicates that D-Trp6-LRH in low doses did not inhibit pituitary responsiveness. A dose of 5 μg of D-Trp6-LRH was administered in a therapeutic regimen every 48 h from 1 to 3 months to 7 of 9 patients with anorexia nervosa who exhibited amenorrhoea in spite of normalization of body weight. All the patients treated with the analogue resumed menstruation. The results of this study suggest that D-Trp6-LRH may be of value in the treatment of amenorrhoea in women with anorexia nervosa.

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Morphological Changes in the Brain of Acutely Ill and Weight-Recovered Patients with Anorexia Nervosa

Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie ◽

10.1024/1422-4917/a000265 ◽

2014 ◽

Vol 42 (1) ◽

pp. 7-18 ◽

Cited By ~ 56

Author(s):

Jochen Seitz ◽

Katharina Bühren ◽

Georg G. von Polier ◽

Nicole Heussen ◽

Beate Herpertz-Dahlmann ◽

...

Keyword(s):

Anorexia Nervosa ◽

Cognitive Deficits ◽

Time Course ◽

Morphological Changes ◽

Meta Analysis ◽

Short Term ◽

Clinical Prognosis ◽

Qualitative Review ◽

Brain Changes ◽

The Brain

Objective: Acute anorexia nervosa (AN) leads to reduced gray (GM) and white matter (WM) volume in the brain, which however improves again upon restoration of weight. Yet little is known about the extent and clinical correlates of these brain changes, nor do we know much about the time-course and completeness of their recovery. Methods: We conducted a meta-analysis and a qualitative review of all magnetic resonance imaging studies involving volume analyses of the brain in both acute and recovered AN. Results: We identified structural neuroimaging studies with a total of 214 acute AN patients and 177 weight-recovered AN patients. In acute AN, GM was reduced by 5.6% and WM by 3.8% compared to healthy controls (HC). Short-term weight recovery 2–5 months after admission resulted in restitution of about half of the GM aberrations and almost full WM recovery. After 2–8 years of remission GM and WM were nearly normalized, and differences to HC (GM: –1.0%, WM: –0.7%) were no longer significant, although small residual changes could not be ruled out. In the qualitative review some studies found GM volume loss to be associated with cognitive deficits and clinical prognosis. Conclusions: GM and WM were strongly reduced in acute AN. The completeness of brain volume rehabilitation remained equivocal.

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