Genetic and environmental factors in the aetiology of menstrual, premenstrual and neurotic symptoms: a population-based twin study

1992 ◽  
Vol 22 (1) ◽  
pp. 85-100 ◽  
Author(s):  
K. S. Kendler ◽  
J. L. Silberg ◽  
M. C. Neale ◽  
R. C. Kessler ◽  
A. C. Heath ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Genetic Factors ◽  
Population Based ◽  
Self Report ◽  
Premenstrual Symptoms ◽  
Menstrual Symptoms ◽  
Multivariate Genetic Analysis ◽  
Genetic And Environmental Factors ◽  
Population Based Registry ◽  
Anxiety Depression

SYNOPSISSymptoms during the premenstrual and menstrual phases of the female reproductive cycle were assessed in 827 pairs of female same-sex twins from a population-based registry. By conventional factor analysis, premenstrual and menstrual symptoms were relatively independent of one another and of baseline ‘neurotic’ symptoms (i.e. anxiety, depression and somatization). Familial resemblance for menstrual and premenstrual symptoms was due solely to genetic factors with heritability estimates of 39·2% and 35·1%, respectively. Multivariate genetic analysis revealed distinct genetic and environmental factors for menstrual, premenstrual and neurotic symptoms. The genes and individual-specific experiences that predispose to premenstrual symptoms appear to be largely distinct from those which predispose either to menstrual or to neurotic symptoms. The generalizability of these results may be limited because only a modest number of premenstrual and menstrual symptoms were assessed, all by retrospective self-report.

Muscle Dissatisfaction and Muscle-Enhancing Substance Use: A Population-Based Twin Study in Young Adult Men

2006 ◽  
Vol 9 (3) ◽  
pp. 431-437 ◽  
Author(s):  
Anu Raevuori ◽  
Anna Keski-Rahkonen ◽  
Richard J. Rose ◽  
Aila Rissanen ◽  
Jaakko Kaprio
Keyword(s):  
Substance Use ◽  
Environmental Factors ◽  
Twin Study ◽  
Genetic Factors ◽  
Population Based ◽  
Tetrachoric Correlation ◽  
Polychoric Correlation ◽  
Adult Men ◽  
Genetic And Environmental Factors ◽  
Best Fit

AbstractIn the population-based FinnTwin16 study, proportions of genetic and environmental factors contributing to muscle dissatisfaction and muscle-enhancing substance use were assessed in 319 pairs of twin brothers: 141 monozygotic (MZ) and 178 dizygotic (DZ) pairs. In addition there were 86 twin individuals from pairs in which only one co-twin responded. Of all respondents, 30% experienced high muscle dissatisfaction. The corresponding proportion of muscle-enhancing substance use was 10%. The subjects were similar in age (23.8 years, 95% confidence interval [CI] 23.76–23.84), body mass index (23.7, 95% CI 23.5–23.9), and waist circumference (84.5 cm, 95% CI 83.7–85.2), independent of their muscle dissatisfaction or muscle-enhancing substance use status and independent of their zygosity. The MZ polychoric correlation for muscle dissatisfaction was .39 (95% CI .17–.58) and .27 for DZ pairs (95% CI .07–.46). The MZ tetrachoric correlation for muscle-enhancing substance use was .65 (95% CI .28–.87) and .56 for DZ pairs (95% CI .26–.78). The AE model, where additive genetic factors (A) accounted for 42% (95% CI .23–.59) and unique environmental factors (E) 58% (95% CI .41–.77) of the liability, provided the best fit for muscle dissatisfaction. The CE model, where common environmental factors (C) accounted for 60% (95% CI .37–.77) and unique environmental factors (E) 40% (95% CI .23–.63) of the liability, provided the best fit for muscle-enhancing substance use. Both genetic and unique (nonfamilial) environmental factors are involved in muscle dissatisfaction in the population. Nongenetic factors (both familial and non-familial) appear to best explain the use of muscle-enhancing substances.

scholarly journals Genetic Factors Underlie Stability of Obsessive–Compulsive Symptoms

2009 ◽  
Vol 12 (5) ◽  
pp. 411-419 ◽  
Author(s):  
Daniël S. van Grootheest ◽  
Daniëlle Cath ◽  
Jouke Jan Hottenga ◽  
Aartjan T. Beekman ◽  
Dorret I. Boomsma
Keyword(s):  
Genetic Factors ◽  
Adult Population ◽  
Genetic Correlations ◽  
Population Based ◽  
Self Report ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Genetic And Environmental Factors ◽  
The Stability ◽  
Time Point

AbstractThe contribution of genetic and environmental factors to the stability of obsessive–compulsive (OC) symptoms has not yet been established in adult population based samples. We obtained the Young Adult Self Report Obsessive–Compulsive Subscale in mono- and dizygotic twins from the population-based Netherlands Twin Register in 1991, 1995 and 1997 and the Padua Inventory Revised Abbreviated in 2002. Stability of OC symptoms was analyzed as a function of genetic and environmental components. Heritability of OC behavior was around 40% at each time-point, independent of the instrument used. OC behavior was moderately stable with correlations ranging between r = .2 (for 11-year intervals), .4 (for 4–5 year intervals) and .6 (for 2 year intervals). Genetic correlations across time were higher, varying between .4 and .9, indicating that the stability of OC symptoms is mainly due to stable genetic factors. This study showed a moderate heritability and stability for OC behavior in adults. Genetic stability across time is high.

A common genetic factor explains the association between psychopathic personality and antisocial behavior

2006 ◽  
Vol 37 (1) ◽  
pp. 15-26 ◽  
Author(s):  
HENRIK LARSSON ◽  
CATHERINE TUVBLAD ◽  
FRUHLING V. RIJSDIJK ◽  
HENRIK ANDERSHED ◽  
MARTIN GRANN ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Personality Traits ◽  
Antisocial Behavior ◽  
Genetic Factor ◽  
Population Based ◽  
Self Report ◽  
Psychopathic Personality ◽  
At Risk Children ◽  
Genetic And Environmental Factors ◽  
Common Genetic Factor

Background. Both psychopathic personality traits and antisocial behavior are influenced by genetic as well as environmental factors. However, little is known about how genetic and environmental factors contribute to the associations between the psychopathic personality traits and antisocial behavior.Method. Data were drawn from a longitudinal population-based twin sample including all 1480 twin pairs born in Sweden between May 1985 and December 1986. The twins responded to mailed self-report questionnaires at two occasions: 1999 (twins 13–14 years old), and 2002 (twins 16–17 years old).Results. A common genetic factor loaded substantially on both psychopathic personality traits and antisocial behavior, whereas a common shared environmental factor loaded exclusively on antisocial behavior.Conclusions. The genetic overlap between psychopathic personality traits and antisocial behavior may reflect a genetic vulnerability to externalizing psychopathology. The finding of shared environmental influences only in antisocial behavior suggests an etiological distinction between psychopathic personality dimensions and antisocial behavior. Knowledge about temperamental correlates to antisocial behavior is important for identification of susceptibility genes, as well as for possible prevention through identification of at-risk children early in life.

Cannabis use in the last year in a US national sample of twin and sibling pairs

2002 ◽  
Vol 32 (3) ◽  
pp. 551-554 ◽  
Author(s):  
K. S. KENDLER ◽  
M. C. NEALE ◽  
L. M. THORNTON ◽  
S. H. AGGEN ◽  
S. E. GILMAN ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Family Environment ◽  
Genetic Factors ◽  
Twin Studies ◽  
National Sample ◽  
Population Based ◽  
Cannabis Use ◽  
Self Report ◽  
Sibling Pairs ◽  
Sibling Resemblance

Background. Three prior population-based twin studies, none of which was nationally representative, suggested that both genetic and familial–environmental factors contribute to family resemblance for lifetime cannabis use. We seek to replicate these results in a US national probability sample of twin and sibling pairs examining only last year cannabis use.Methods. Cannabis use in the last year was assessed by self-report questionnaire. Biometrical twin analyses were performed.Results. Twin and sibling resemblance for last-year cannabis use was substantial, and much higher in monozygotic pairs than in dizygotic and sibling pairs, where levels of resemblance were similar. Modeling suggested that sibling resemblance was due to genetic factors – with a heritability of at least 60% – and probably family environmental factors. No evidence was found that cannabis use was influenced by a special twin environment.Conclusions. Consistent with prior studies, use of cannabis is substantially influenced by genetic factors but family–environment is also possibly of importance.

Cocaine use, abuse and dependence in a population-based sample of female twins

1998 ◽  
Vol 173 (4) ◽  
pp. 345-350 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Carol A. Prescott
Keyword(s):  
Cocaine Abuse ◽  
Genetic Factors ◽  
Model Fitting ◽  
Population Based ◽  
Cocaine Use ◽  
Past Half Century ◽  
History Of ◽  
Population Based Registry ◽  
Twin Resemblance

BackgroundAlthough cocaine use in women has increased substantially over the past half-century, we understand little about the aetiology in women of cocaine use and abuse, and know almost nothing about the role of genetic factors.MethodWe obtained by telephone interview a history of lifetime cocaine use, abuse and dependence from 1934 individual twins from female–female pairs ascertained through a population-based registry, including both members of 485 monozygotic (MZ) and 335 dizygotic (DZ) pairs.ResultsThe prevalence of lifetime cocaine use, abuse and dependence were 14.0%, 3.3% and 2.3%. Probandwise concordance rates, in MZ and DZ twins, respectively, were: cocaine use 54% and 42%; cocaine abuse 47% and 8% and cocaine dependence 35% and 0%. In MZ and DZ twins, odds ratios were: cocaine use 14.2 and 6.7 and cocaine abuse 40.8 and 2.7. Biometrical model-fitting suggested that twin resemblance for liability to cocaine use was due to both genetic and familial–environmental factors while twin resemblance for cocaine abuse and symptoms of dependence was due solely to genetic factors. Estimated heritabilities were: cocaine use 0.39, cocaine abuse 0.79 and symptoms of dependence 0.65.ConclusionsThe vulnerability to cocaine use and particularly cocaine abuse and dependence in women is substantially influenced by genetic factors.

scholarly journals interactions between genetic and environmental factors determine direction of population lateralization

2005 ◽  
Vol 28 (4) ◽  
pp. 598-598 ◽  
Author(s):  
chao deng
Keyword(s):  
Environmental Factors ◽  
Genetic Factors ◽  
Head Rotation ◽  
Head Turning ◽  
Genetic And Environmental Factors ◽  
Genetically Determined

direction of the embyro's head rotation is determined by asymmetrical expression of several genes (such as shh, nodal, lefty, and fgf8) in hensen's node. this genetically determined head-turning bias provides a base for light-aligned population lateralization in chicks, in which the direction of the lateralization is determined by genetic factors and the degree of the lateralization is determined by environmental factors.

scholarly journals Identification of Environmental Risk Factors Associated With the Development of Inflammatory Bowel Disease

2020 ◽  
Vol 14 (12) ◽  
pp. 1662-1671
Author(s):  
Kimberley W J van der Sloot ◽  
Rinse K Weersma ◽  
Behrooz Z Alizadeh ◽  
Gerard Dijkstra
Keyword(s):  
Inflammatory Bowel Disease ◽  
Environmental Factors ◽  
Bowel Disease ◽  
Multiple Testing ◽  
Stressful Life Events ◽  
Population Based ◽  
Factors Associated ◽  
Disease Aetiology ◽  
Inflammatory Bowel ◽  
Genetic And Environmental Factors

Abstract Background and Aims Multiple genetic and environmental factors are involved in the aetiology of inflammatory bowel disease [IBD] including Crohn’s disease [CD] and ulcerative colitis [UC], but data on these exposome factors are difficult to identify. Several exposome factors such as smoking have been shown to be involved; as for other environmental factors, eg stress, results have been conflicting. Methods We performed a case-control study including 674 IBD patients of the 1000IBD cohort, frequency-matched based on sex and age with 1348 controls from the population-based Lifelines Cohort Study. Exposome data were obtained using the validated Groningen IBD Environmental Questionnaire [GIEQ], capturing exposome factors through different stages of life using 844 items, of which 454 were applicable to study the role of 93 exposome factors in disease aetiology. Logistic regression [LR] modelling with Bonferroni correction for multiple testing was applied to estimate the multivariable-adjusted effect of each exposome factor. Results For IBD, we identified four novel factors: stressful life events (CD odds ratio [OR] 2.61/UC OR 2.92), high perceived stress [2.29/2.67], alcohol use [0.40/0.43], and bronchial hyper-reactivity [3.04/2.36]. Four novel factors were associated with only CD: prenatal smoke exposure [1.89], having a bed partner [0.53], allergies [2.66], and cow’s milk hypersensitivity [5.87]; and two solely with UC: carpet flooring [0.57] and neuroticism [1.32]. Nine factors were replicated. Conclusions In this study we identified 10 novel, and replicated nine previously reported, exposome factors associated with IBD. Identifying these factors is important for both understanding disease aetiology and future prevention strategies to decrease the development of IBD in genetically susceptible persons.

A longitudinal study of personality and major depression in a population-based sample of male twins

2007 ◽  
Vol 37 (8) ◽  
pp. 1163-1172 ◽  
Author(s):  
AYMAN H. FANOUS ◽  
MICHAEL C. NEALE ◽  
STEVEN H. AGGEN ◽  
KENNETH S. KENDLER
Keyword(s):  
Major Depression ◽  
Environmental Factors ◽  
Structural Equation ◽  
Causal Effect ◽  
Population Based ◽  
Twin Model ◽  
Genetic Overlap ◽  
Genetic And Environmental Factors ◽  
One Year ◽  
Time To Onset

ABSTRACTBackgroundThe relationship between personality and psychiatric illness is complex. It is not clear whether one directly causes the other.MethodIn a population-based sample of male twins (n=3030), we attempted to predict major depression (MD) from neuroticism (N) and extraversion (E) and vice versa, to evaluate the causal, scar, state, and prodromal hypotheses. In a longitudinal, structural equation twin model, we decomposed the covariation between N and MD into (a) genetic and environmental factors that are common to both traits, as well as specific to each one and (b) direct causal effects of N at time 1 on subsequent MD, as well as between MD and subsequent N.ResultsE was negatively correlated with lifetime and one-year prevalence of MD. N predicted the new onset of MD, and was predicted by both current and past MD. It did not predict the time to onset of MD. All of the covariation between N and MD was due to additive genetic and individual-specific environmental factors shared by both traits and a direct causal path between MD and N assessed later. No genetic factors were unique to either trait.ConclusionsIn men, N may be a vulnerability factor for MD but does not cause it directly. However, MD may have a direct causal effect on N. The genetic overlap between N and MD in men may be greater than in women.

scholarly journals Environmental and Genetic Contributions to Indicators of Oral Malodor in Twins

2011 ◽  
Vol 14 (6) ◽  
pp. 568-572 ◽  
Author(s):  
Walter A. Bretz ◽  
Aaron Biesbrock ◽  
Patricia M. Corby ◽  
Andrea L. Corby ◽  
Walter G. Bretz ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Genetic Factors ◽  
Sulfur Compounds ◽  
Exhaled Breath ◽  
Tongue Coating ◽  
Oral Malodor ◽  
Volatile Sulfur Compounds ◽  
Item Questionnaire ◽  
Genetic And Environmental Factors ◽  
Genetic Contributions

This study aimed to: (1) determine concordance rates of self-reported and subjectively determined indicators of oral malodor in twins; (2) determine the relative contributions of genetic and environmental factors to levels of volatile sulfur compounds (VSCs) in intraoral and exhaled breath. Fifty-one twin pairs participated in the study. Measurements of VSCs were obtained by a halimeter. The presence of tongue coatings was determined and twins filled out a 32-item questionnaire on oral malodor indicators independently of one another. Estimates of heritability (h2) for halimeter measurements were computed by SOLAR. The concordance rates for the presence of tongue coating among identical and fraternal twins were 67% and 11%, respectively. In the 10 most informative items, 70% exhibited higher concordance rates for identical than for fraternal twins. Of particular interest were the differences in concordance rates for dry mouth, sinus infection and unusual sweating. The h2 for intra-oral breath was 0.28 ± 0.17 (NS), whereas the h2 for exhaled breath was 0.50 ± 0.20 (p = .0207). The concordance rates of tongue coatings and malodor indicators were higher in identical twins than in fraternal twins. Intraoral breath VSC values were primarily attributable to environmental factors, whereas exhaled breath VSC values were partially explained by genetic factors.

scholarly journals The structure of genetic and environmental risk factors for phobias in women

2011 ◽  
Vol 41 (9) ◽  
pp. 1987-1995 ◽  
Author(s):  
N. Czajkowski ◽  
K. S. Kendler ◽  
K. Tambs ◽  
E. Røysamb ◽  
T. Reichborn-Kjennerud
Keyword(s):  
Environmental Factors ◽  
Social Phobia ◽  
Population Based ◽  
The Other ◽  
Twin Model ◽  
Co Morbidity ◽  
Twin Models ◽  
Best Fitting ◽  
Dsm Iv ◽  
Genetic And Environmental Factors

BackgroundTo explore the genetic and environmental factors underlying the co-occurrence of lifetime diagnoses of DSM-IV phobia.MethodFemale twins (n=1430) from the population-based Norwegian Institute of Public Health Twin Panel were assessed at personal interview for DSM-IV lifetime specific phobia, social phobia and agoraphobia. Comorbidity between the phobias were assessed by odds ratios (ORs) and polychoric correlations and multivariate twin models were fitted in Mx.ResultsPhenotypic correlations of lifetime phobia diagnoses ranged from 0.55 (agoraphobia and social phobia, OR 10.95) to 0.06 (animal phobia and social phobia, OR 1.21). In the best fitting twin model, which did not include shared environmental factors, heritability estimates for the phobias ranged from 0.43 to 0.63. Comorbidity between the phobias was accounted for by two common liability factors. The first loaded principally on animal phobia and did not influence the complex phobias (agoraphobia and social phobia). The second liability factor strongly influenced the complex phobias, but also loaded weak to moderate on all the other phobias. Blood phobia was mainly influenced by a specific genetic factor, which accounted for 51% of the total and 81% of the genetic variance.ConclusionsPhobias are highly co-morbid and heritable. Our results suggest that the co-morbidity between phobias is best explained by two distinct liability factors rather than a single factor, as has been assumed in most previous multivariate twin analyses. One of these factors was specific to the simple phobias, while the other was more general. Blood phobia was mainly influenced by disorder specific genetic factors.

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