Homeostasis and drinking

1979 ◽  
Vol 2 (1) ◽  
pp. 95-102 ◽  
Author(s):  
F. M. Toates

AbstractDrinking and thirst-motivated behaviour have traditionally been explained in terms of the rather simple concept of homeostasis. A homeostatic mechanism readily accounts for responses to acute changes in body-fluid levels. However, there are other factors regulating intake, for example, cues associated with eating, which interact with the time elapsed since last drinking and the availability of water. Future dehydration is avoided by behavioural hysteresis; a sudden reduction in fluid needs is not matched by an equivalent reduction in fluid intake. Another factor not explicable by traditional homeostasis is that, in general, drinking cannot be suppressed by water infusion. Nor are there rigid target values for body-fluid levels independent of the cost of obtaining water; when water is hard to get, a relatively low body fluid level is maintained, thus minimizing loss. On the basis of the results conflicting with traditional homeostatic theory, this paper tentatively suggests certain modifications toward a more realistic model of fluid ingestion.

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S315
Author(s):  
Hidenori Otani ◽  
Mitsuharu Kaya ◽  
Akira Tamaki ◽  
Junzo Tsujita ◽  
Seiki Hori
Keyword(s):  

2014 ◽  
Vol 21 (5) ◽  
pp. 734-755 ◽  
Author(s):  
Varun Mahajan ◽  
D.K. Nauriyal ◽  
S.P. Singh

Purpose – The purpose of this paper is to measure technical efficiencies, slacks and input/output targets for 50 large Indian pharmaceutical firms. Design/methodology/approach – The data are collected from Prowess of Centre for Monitoring of Indian Economy for the financial year 2010-2011. This study uses data envelopment analysis approach, taking raw material, salaries and wages, advertisement and marketing and capital usage cost as input variables and net sales revenue as output variable. Findings – The paper finds that out of 50 firms, nine firms were overall technical efficient while 19 firms pure technical efficient and thus defined the efficient frontier. The BCC model identified that the inefficiency is either due to inefficient managerial performance or scale utilization. Further, firms are classified as high, low and middle robust firms on the basis of peer count. The study also analysed the slacks which were found to be significant in regard of some inputs, especially advertisement and marketing. The targets setting results have shown that all the inputs have significant scope for reduction. Practical implications – The empirical results are useful in assessing the relative efficiency of the large Indian drug and pharmaceutical industry (ID&P) firms. The managers and owners can take corrective actions to reduce the cost of operations by optimizing advertising and marketing cost, capital usage cost and salary and wages so as to improve their efficiency. Originality/value – Unlike the previous studies on the efficiency of the ID&P industry, the paper have shown the significance of improvement in managerial performance and scale utilization. In addition to this, excess inputs used in the production process and also possible target values of inputs and outputs are shown in the study. The robustness and stability of efficiency scores is also checked.


2021 ◽  
Vol 17 (2) ◽  
pp. 161-177
Author(s):  
Ivan V. Zykin

Introduction. The timber processing complex became an important component of the project of “socialist industrialization” of the late 1920s – early 1940s in the Soviet Union. The first five-year plan was not implemented by the industry, despite a significant increase in indicators compared to the period of the “new economic policy”. The development of the forest industry in the second five-year plan should have become more balanced and not lose dynamism. During this period, the economic structure of the industry was relatively homogeneous. An analysis of the indicators of annual national economic plans in the context of the second five-year plan becomes relevant. Historiography of the period of “socialist industrialization” and, in particular, 1933–1937 consists mainly of studies of foreign and domestic scientists on the Soviet economy and works on the history of the forest industry of certain regions. Materials and Methods. The theoretical and methodological basis of the study is the concept of modernization. Based on the information of the second five-year plan and annual plans, series of data on the development of the timber processing complex of the Soviet Union were formed. Results. At the beginning of the second five-year plan, the industry experienced stagnation of production and financial indicators, failure to fulfill annual plans. Then, as capital investments increased, the construction of enterprises was completed, capacities were developed, new forms of socialist competition developed, the timber processing complex demonstrated a significant improvement in the results of activities. Labor productivity increased at a relatively high rate in the fields of machining and deep processing of wood, but slowly grew in the field of timber harvesting. Unsatisfactory tasks were performed to reduce the cost of production. Conclusions. The main volumes of work in the timber processing complex were carried out by the Narkomles (People’s Committee of Forest Industry) of the USSR. In 1935–1936 it became possible to approach the target values of the second five-year plan, which, however, was not fully implemented due to the beginning of mass repressions and the transfer of part of the enterprises to forced labor camps. Summing up the planned and actual results of the timber processing complex for 1933–1937 showed that the industry fulfilled the five-year plan by 80–90 %, and in some areas surpassed it.


Author(s):  
Shun Takai

At the end of a conceptual design phase, engineers choose a single (or a small set of) system concept from a large number of concept variants. In most cases, there is not enough design information to quantitatively evaluate how a final system developed from each concept would perform and cost. Thus engineers need to first perceptually evaluate and select a concept, and then design a system. On the other hand, if engineers know analytical relationships between system and part requirements, they can specify target values of part requirements such that a system achieves its target requirements. Furthermore, if engineers know how much it will cost to control part requirements within tolerances, they can minimize the cost of a system by optimizing tolerances of part requirements. This paper proposes and illustrates an approach to select a system concept when engineers know the relationship between system and part requirements, and how much it will cost to control part requirements within tolerances. Engineers choose a concept that minimizes cost.


2004 ◽  
Vol 36 (Supplement) ◽  
pp. S315
Author(s):  
Hidenori Otani ◽  
Mitsuharu Kaya ◽  
Akira Tamaki ◽  
Junzo Tsujita ◽  
Seiki Hori
Keyword(s):  

2007 ◽  
Vol 9 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Miyuki Satoh ◽  
Hiromi Sakuda ◽  
Toshio Kobayashi ◽  
Tsuyoshi Kataoka ◽  
Fujiko Nakao ◽  
...  

2007 ◽  
Vol 17 (3) ◽  
pp. 284-295 ◽  
Author(s):  
Dennis Passe ◽  
Mary Horn ◽  
John Stofan ◽  
Craig Horswill ◽  
Robert Murray

This study investigated the relationship between runners’ perceptions of fluid needs and drinking behavior under conditions of compensable heat stress (ambient temperature = 20.5 ± 0.7 °C, 68.9 °F; relative humidity = 76.6%). Eighteen experienced runners (15 men, 40.5 ± 2.5 y, and 3 women, 42 ± 2.3 y) were given ad libitum access to a sports drink (6% carbohydrate-electrolyte solution) at Miles 2, 4, 6, and 8. After the run (75.5 ± 8.0 min), subjects completed questionnaires that required them to estimate their individual fluid intake and sweat loss. Dehydration averaged 1.9% ± 0.8% of initial body weight (a mean sweat loss of 21.6 ± 5.1 mL·kg−1·h−1). Subjects replaced only 30.5% ± 18.1% of sweat loss and underestimated their sweat loss by 42.5% ± 36.6% (P ≤ 0.001). Subjects’ self-estimations of fluid intake (5.2 ± 3.2 mL·kg−1·h−1) were not significantly different from actual fluid intake (6.1 ± 3.4 mL·kg−1·h−1) and were significantly correlated (r = 0.63, P = 0.005). The data indicate that even under favorable conditions, experienced runners voluntarily dehydrate (P ≤ 0.001), possibly because they are unable to accurately estimate sweat loss and consequently cannot subjectively judge how much fluid to ingest to prevent dehydration. This conclusion suggests that runners should not depend on self-assessment to maintain adequate hydration, underscores the need for runners to enhance their ability to self-assess sweat losses, and suggests that a predetermined regimen of fluid ingestion might be necessary if they wish to maintain more optimal hydration.


Amino Acids ◽  
2016 ◽  
Vol 49 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Hui-Fei Zheng ◽  
Wen-Qiang Wang ◽  
Xin-Min Li ◽  
Gail Rauw ◽  
Glen B. Baker

2018 ◽  
Vol 315 (3) ◽  
pp. F653-F664 ◽  
Author(s):  
Takahiro Masuda ◽  
Yuko Watanabe ◽  
Keiko Fukuda ◽  
Minami Watanabe ◽  
Akira Onishi ◽  
...  

The chronic intrinsic diuretic and natriuretic tone of sodium-glucose cotransporter 2 (SGLT2) inhibitors is incompletely understood because their effect on body fluid volume (BFV) has not been fully evaluated and because they often increase food and fluid intake at the same time. Here we first compared the effect of the SGLT2 inhibitor ipragliflozin (Ipra, 0.01% in diet for 8 wk) and vehicle (Veh) in Spontaneously Diabetic Torii rat, a nonobese type 2 diabetic model, and nondiabetic Sprague-Dawley rats. In nondiabetic rats, Ipra increased urinary excretion of Na+ (UNaV) and fluid (UV) associated with increased food and fluid intake. Diabetes increased these four parameters, but Ipra had no further effect, probably because of its antihyperglycemic effect, such that glucosuria and, as a consequence, food and fluid intake were unchanged. Fluid balance and BFV, determined by bioimpedance spectroscopy, were similar among the four groups. To study the impact of food and fluid intake, nondiabetic rats were treated for 7 days with Veh, Ipra, or Ipra+pair feeding+pair drinking (Pair-Ipra). Pair-Ipra maintained a small increase in UV and UNaV versus Veh despite similar food and fluid intake. Pair-Ipra induced a negative fluid balance and decreased BFV, whereas Ipra or Veh had no significant effect compared with basal values. In conclusion, SGLT2 inhibition induces a sustained diuretic and natriuretic tone. Homeostatic mechanisms are activated to stabilize BFV, including compensatory increases in fluid and food intake.


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