Epigenetic regulation of brain-derived neurotrophic factor: Implications in neurodevelopment and behavior

2012 ◽  
Vol 35 (5) ◽  
pp. 377-378 ◽  
Author(s):  
Benjamin D. Schanker
Keyword(s):  
Epigenetic Regulation ◽  
Neurotrophic Factor ◽  
Neuronal Plasticity ◽  
Neural Circuits ◽  
Scientific Progress ◽  
Brain Derived Neurotrophic Factor ◽  
Research Findings ◽  
And Behavior

AbstractSeveral recent research findings have implicated brain-derived neurotrophic factor (BDNF) as a mediator of neuronal plasticity. The BDNF gene is under extensive epigenetic regulation, which modulates how much or how little environmental experiences become encoded within neurons and neural circuits. Future scientific progress within the postgenomic paradigm requires elucidation of the functional trajectory in neogenetic and environment interactions.

Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats

2019 ◽  
Vol 366 ◽  
pp. 36-44 ◽  
Author(s):  
Juliano Viana Borges ◽  
Betânia Souza de Freitas ◽  
Vinicius Antoniazzi ◽  
Cristophod de Souza dos Santos ◽  
Kelem Vedovelli ◽  
...  
Keyword(s):  
Social Support ◽  
Social Isolation ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Epigenetic Mechanisms ◽  
And Behavior

scholarly journals OLAHRAGA DAPAT MENINGKATKAN FUNGSI KOGNITIF MELALUI MODULASI EPIGENETIK EKSPRESI GEN BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)

2019 ◽  
Author(s):  
Nila Wahyuni ◽  
Made Hendra Satria Nugraha ◽  
Indira Vidiari Juhanna
Keyword(s):  
Cognitive Function ◽  
Epigenetic Regulation ◽  
Learning Process ◽  
Neural Plasticity ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Regulatory Change ◽  
Literature Study ◽  
Bdnf Expression ◽  
Bdnf Mrna

ABSTRACTExercise may improve cognitive function and slow the onset of neurodegeneration, but the underlying mechanism had not yet known certainly. The purpose of this paper is to know the mechanism of exercise in improving cognitive function in terms of biomolecular aspects. The method of this paper is literature study of articles about the benefits of exercise in improving cognitive function in terms of biomolecular aspects. Cognitive function is a function related to perception, learning process, concentration, memory and problem solving. Exercise is useful for improving cognitive function mediated by a neurotropin-brain brain-derived neurotrophic factor (BDNF). BDNF has important role in neural plasticity, nerve excitability, and especially in learning process and memory improving. Exercise can improve cognitive function by inducing increased BDNF expression that occurs through the mechanism of epigenetic regulatory change. The change in epigenetic regulation caused by exercise through DNA methylation, which increase the expression of BDNF mRNA in the hippocampus. The change in epigenetic regulation caused by exercise, which also increase the expression of BDNF mRNA is a histone modification. The increased expression of mRNA in the hippocampus is not only increase synapse plasticity in the hippocampus area but also synapse transmission, which lead to the increasing of molecules expression related to learning and memory.Keywords: Sport, Brain-derived neurotrophic factor (BDNF), Epigenetic.

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