Brain-Derived Neurotrophic Factor in Neuronal Survival and Behavior-Related Plasticity

2007 ◽  
Vol 1122 (1) ◽  
pp. 130-143 ◽  
Author(s):  
ROBERT H. LIPSKY ◽  
ANN M. MARINI
Keyword(s):  
Neurotrophic Factor ◽  
Neuronal Survival ◽  
Brain Derived Neurotrophic Factor ◽  
And Behavior

scholarly journals Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

1999 ◽  
Vol 189 (5) ◽  
pp. 865-870 ◽  
Author(s):  
Martin Kerschensteiner ◽  
Eike Gallmeier ◽  
Lüder Behrens ◽  
Vivian Vargas Leal ◽  
Thomas Misgeld ◽  
...  
Keyword(s):  
T Cells ◽  
Nervous System ◽  
B Cells ◽  
Neurotrophic Factor ◽  
Neuronal Survival ◽  
Neuroprotective Effect ◽  
Brain Derived Neurotrophic Factor ◽  
Human T Cells ◽  
Inflammatory Infiltrates

Brain-derived neurotrophic factor (BDNF) has potent effects on neuronal survival and plasticity during development and after injury. In the nervous system, neurons are considered the major cellular source of BDNF. We demonstrate here that in addition, activated human T cells, B cells, and monocytes secrete bioactive BDNF in vitro. Notably, in T helper (Th)1- and Th2-type CD4+ T cell lines specific for myelin autoantigens such as myelin basic protein or myelin oligodendrocyte glycoprotein, BDNF production is increased upon antigen stimulation. The BDNF secreted by immune cells is bioactive, as it supports neuronal survival in vitro. Using anti-BDNF monoclonal antibody and polyclonal antiserum, BDNF immunoreactivity is demonstrable in inflammatory infiltrates in the brain of patients with acute disseminated encephalitis and multiple sclerosis. The results raise the possibility that in the nervous system, inflammatory infiltrates have a neuroprotective effect, which may limit the success of nonselective immunotherapies.

Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats

2019 ◽  
Vol 366 ◽  
pp. 36-44 ◽  
Author(s):  
Juliano Viana Borges ◽  
Betânia Souza de Freitas ◽  
Vinicius Antoniazzi ◽  
Cristophod de Souza dos Santos ◽  
Kelem Vedovelli ◽  
...  
Keyword(s):  
Social Support ◽  
Social Isolation ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Epigenetic Mechanisms ◽  
And Behavior

Epigenetic regulation of brain-derived neurotrophic factor: Implications in neurodevelopment and behavior

2012 ◽  
Vol 35 (5) ◽  
pp. 377-378 ◽  
Author(s):  
Benjamin D. Schanker
Keyword(s):  
Epigenetic Regulation ◽  
Neurotrophic Factor ◽  
Neuronal Plasticity ◽  
Neural Circuits ◽  
Scientific Progress ◽  
Brain Derived Neurotrophic Factor ◽  
Research Findings ◽  
And Behavior

AbstractSeveral recent research findings have implicated brain-derived neurotrophic factor (BDNF) as a mediator of neuronal plasticity. The BDNF gene is under extensive epigenetic regulation, which modulates how much or how little environmental experiences become encoded within neurons and neural circuits. Future scientific progress within the postgenomic paradigm requires elucidation of the functional trajectory in neogenetic and environment interactions.

scholarly journals Prognostic Value and Therapeutic Potential of Brain-Derived Neurotrophic Factor (BDNF) in Brain Injuries (Review)

2019 ◽  
Vol 15 (1) ◽  
pp. 70-86 ◽  
Author(s):  
I. V. Ostrova ◽  
N. V. Golubeva ◽  
A. N. Kuzovlev ◽  
A. M. Golubev
Keyword(s):  
Neurotrophic Factor ◽  
Brain Injuries ◽  
Therapeutic Potential ◽  
Neuronal Survival ◽  
Brain Derived Neurotrophic Factor ◽  
Brain Dysfunction ◽  
Common Mechanism ◽  
Close Attention ◽  
System Functioning ◽  
The Brain

Neurotrophins are proteins that play an important role in the nervous system functioning by regulating cell proliferation, differentiation, processes of neuronal survival and death, and by participating in the mechanisms of neuronal plasticity. The brain-derived neurotrophic factor (BDNF) is one of the most well-described representatives of the neurotrophin family, which has received close attention over recent years. It is considered one of the key mediators of neuronal survival and recovery, and a drop of the BDNF level is considered a common mechanism underlying the development of various neurodegenerative diseases. The review discusses changes in BDNF levels in ischemic and traumatic brain damage, the prospects of its use in the clinical practice as a marker of brain dysfunction, as well as the possibility of its use for the treatment of post-ischemic encephalopathies.

scholarly journals BIT/SHPS-1 Enhances Brain-Derived Neurotrophic Factor-Promoted Neuronal Survival in Cultured Cerebral Cortical Neurons

2002 ◽  
Vol 75 (4) ◽  
pp. 1502-1510 ◽  
Author(s):  
Toshiyuki Araki ◽  
Masashi Yamada ◽  
Hiroshi Ohnishi ◽  
Shin-ichiro Sano ◽  
Hiroshi Hatanaka
Keyword(s):  
Neurotrophic Factor ◽  
Cortical Neurons ◽  
Neuronal Survival ◽  
Brain Derived Neurotrophic Factor ◽  
Cerebral Cortical Neurons
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