scholarly journals Giovanni Aldini: From Animal Electricity to Human Brain Stimulation

2004 ◽  
Vol 31 (4) ◽  
pp. 576-584 ◽  
Author(s):  
André Parent
Keyword(s):  
Electric Current ◽  
Brain Stimulation ◽  
Experimental Physics ◽  
Influential Book ◽  
The University ◽  
Luigi Galvani ◽  
The 19Th Century ◽  
First Time ◽  
Deep Brain ◽  
Crucial Experiments

Two hundred years ago, Giovanni Aldini published a highly influential book that reported experiments in which the principles of Luigi Galvani (animal electricity) and Alessandro Volta (bimetallic electricity) were used together for the first time. Aldini was born in Bologna in 1762 and graduated in physics at the University of his native town in 1782. As nephew and assistant of Galvani, he actively participated in a series of crucial experiments with frog's muscles that led to the idea that electricity was the long-sought vital force coursing from brain to muscles. Aldini became professor of experimental physics at the University of Bologna in 1798. He traveled extensively throughout Europe, spending much time defending the concept of his discreet uncle against the incessant attacks of Volta, who did not believe in animal electricity. Aldini used Volta's bimetallic pile to apply electric current to dismembered bodies of animals and humans; these spectacular galvanic reanimation experiments made a strong and enduring impression on his contemporaries. Aldini also treated patients with personality disorders and reported complete rehabilitation following transcranial administration of electric current. Aldini's work laid the ground for the development of various forms of electrotherapy that were heavily used later in the 19th century. Even today, deep brain stimulation, a procedure currently employed to relieve patients with motor or behavioral disorders, owes much to Aldini and galvanism. In recognition of his merits, Aldini was made a knight of the Iron Crown and a councillor of state at Milan, where he died in 1834.

scholarly journals Deep brain stimulation for obsessive compulsive disorder: A review of results by anatomical target

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Candace Borders ◽  
Frank Hsu ◽  
Alexander J. Sweidan ◽  
Emily S. Matei ◽  
Robert G. Bota
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Basolateral Amygdala ◽  
Accurate Determination ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Time ◽  
Deep Brain ◽  
Time Point

Studies suggest deep brain stimulation (DBS) as a treatment modality for the refractory obsessive-compulsive disorder (OCD). It is unclear where to place the DBS. Various sites are proposed for placement with the ventral capsule/ventral striatum (VC/VS) among the most studied. Herein, we aim to summarize both quantitative Yale-Brown Obsessive-Compulsive Scale (YBOCS) data and qualitative descriptions of the participants’ symptoms when given. A literature search conducted via PubMed yielded 32 articles. We sought to apply a standard based on the utilization of YBOCS. This yielded 153 distinct patients. The outcome measure we focused on in this review is the latest YBOCS score reported for each patient/cohort in comparison to the location of the DBS. A total of 32 articles were found in the search results. In total, 153 distinct patients’ results were reported in these studies. Across this collection of papers, a total of 9 anatomic structures were targeted. The majority of studies showed a better response at the last time point as compared to the first time point. Most patients had DBS at nucleus accumbens followed by VC/VS and the least patients had DBS at the bilateral superolateral branch of the median forebrain bundle and the bilateral basolateral amygdala. The average YBOCS improvement did not seem to directly correlate with the percentile of patients responding to the intervention. Well-controlled, randomized studies with larger sample sizes with close follow up are needed to provide a more accurate determination for placement of DBS for OCD.

Melchioris Cani Relectio de sacramentis in genere

2020 ◽  
Author(s):  
Boris Hogenmüller
Keyword(s):  
Early Summer ◽  
Sacramental Theology ◽  
Council Of Trent ◽  
General Introduction ◽  
German Translation ◽  
The Subject ◽  
The University ◽  
The 19Th Century ◽  
First Time ◽  
Academic Year

The third volume of the "Opera omnia Melchioris Cani" covers Cano's first "Relectio de sacramentis in genere". Melchor Cano held this important lecture in the early summer of 1547 as a professor at the University of Salamanca, as a ceremonial lecture at the end of the academic year. The subject itself offers a highly interesting example of sacramental theology, which was widely discussed in the 16th century, in particular at the Council of Trent. First printed in 1550, the lecture was intensively studied until the 19th century. In addition to a general introduction to the author and the topic, a text-critical Latin edition including a German translation is offered here for the first time.

scholarly journals Deep brain stimulation for obsessive compulsive disorder: A review of results by anatomical target

2018 ◽  
Vol 10 (2) ◽  
pp. 40-44 ◽  
Author(s):  
Candace Borders ◽  
Frank Hsu ◽  
Alexander J. Sweidan ◽  
Emily S. Matei ◽  
Robert G. Bota
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Basolateral Amygdala ◽  
Accurate Determination ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
First Time ◽  
Deep Brain ◽  
Time Point

Studies suggest deep brain stimulation (DBS) as a treatment modality for the refractory obsessive-compulsive disorder (OCD). It is unclear where to place the DBS. Various sites are proposed for placement with the ventral capsule/ventral striatum (VC/VS) among the most studied. Herein, we aim to summarize both quantitative Yale-Brown Obsessive-Compulsive Scale (YBOCS) data and qualitative descriptions of the participants' symptoms when given. A literature search conducted via PubMed yielded 32 articles. We sought to apply a standard based on the utilization of YBOCS. This yielded 153 distinct patients. The outcome measure we focused on in this review is the latest YBOCS score reported for each patient/cohort in comparison to the location of the DBS. A total of 32 articles were found in the search results. In total, 153 distinct patients' results were reported in these studies. Across this collection of papers, a total of 9 anatomic structures were targeted. The majority of studies showed a better response at the last time point as compared to the first time point. Most patients had DBS at nucleus accumbens followed by VC/VS and the least patients had DBS at the bilateral superolateral branch of the median forebrain bundle and the bilateral basolateral amygdala. The average YBOCS improvement did not seem to directly correlate with the percentile of patients responding to the intervention. Well-controlled, randomized studies with larger sample sizes with close follow up are needed to provide a more accurate determination for placement of DBS for OCD.

scholarly journals Deep brain stimulation for vocal tremor: a comprehensive, multidisciplinary methodology

2015 ◽  
Vol 38 (6) ◽  
pp. E6 ◽  
Author(s):  
Allen L. Ho ◽  
Elizabeth Erickson-Direnzo ◽  
Arjun V. Pendharkar ◽  
Chih-Kwang Sung ◽  
Casey H. Halpern
Keyword(s):  
Deep Brain Stimulation ◽  
Characteristic Feature ◽  
Brain Stimulation ◽  
Definitive Treatment ◽  
Medical Interventions ◽  
Ventral Intermediate Nucleus ◽  
Vocal Tremor ◽  
First Time ◽  
Therapeutic Avenue ◽  
Deep Brain

Tremulous voice is a characteristic feature of a multitude of movement disorders, but when it occurs in individuals diagnosed with essential tremor, it is referred to as essential vocal tremor (EVT). For individuals with EVT, their tremulous voice is associated with significant social embarrassment and in severe cases may result in the discontinuation of employment and hobbies. Management of EVT is extremely difficult, and current behavioral and medical interventions for vocal tremor result in suboptimal outcomes. Deep brain stimulation (DBS) has been proposed as a potential therapeutic avenue for EVT, but few studies can be identified that have systematically examined improvements in EVT following DBS. The authors describe a case of awake bilateral DBS targeting the ventral intermediate nucleus for a patient suffering from severe voice and arm tremor. They also present their comprehensive, multidisciplinary methodology for definitive treatment of EVT via DBS. To the authors’ knowledge, this is the first time comprehensive intraoperative voice evaluation has been used to guide microelectrode/stimulator placement, as well as the first time that standard pre- and post-DBS assessments have been conducted, demonstrating the efficacy of this tailored DBS approach.

scholarly journals The mycological collection of G. C. Girgensohn from the middle of the 19th century

2021 ◽  
Vol 58 ◽  
Author(s):  
Kadri Pärtel ◽  
Ave Suija ◽  
Iryna Yatsiuk
Keyword(s):  
Natural History ◽  
Life Sciences ◽  
Russian Empire ◽  
Lobaria Pulmonaria ◽  
History Museum ◽  
The Russian Empire ◽  
The University ◽  
The 19Th Century ◽  
First Time ◽  
Iucn Criteria

Since 1844, vouchers of mycological specimens collected from the territory of the historic Baltic provinces of the Russian Empire have been preserved in Estonian natural history collections. A pedagogue and an amateur bryologist, Gustav Carl Girgensohn (1786–1872) compiled a collection of 109 specimens of fungi and myxomycetes sampled from the Livonian Governorate, mostly from the vicinity of Tartu, in years 1844–1859. Girgensohn’s collection, which is kept in the fungarium of the Estonian University of Life Sciences, is introduced here for the first time. Among his specimens there are two notable ascomycetes—coprophilous Poronia punctata (Xylariaceae, Sordariomycetes), recently evaluated in Estonia as Critically Endangered according to IUCN criteria, and Microstoma protractum (Sarcoscyphaceae, Pezizomycetes), recently evaluated as Endangered. The collection’s eleven quite well-preserved specimens of myxomycetes represent six species, the least common of which is Diderma radiatum. In addition, the article introduces nine lichen specimens and one fungal specimen from Girgensohn’s bryophyte collection at the Natural History Museum of the University of Tartu. The most remarkable species among this collection is Lobaria pulmonaria (Lobariaceae, Lecanoromycetes), red-listed and protected in many countries.

The end of the European university?

1998 ◽  
Vol 6 (4) ◽  
pp. 441-457 ◽  
Author(s):  
Peter Scott
Keyword(s):  
Middle Ages ◽  
Industrial Revolution ◽  
Knowledge Society ◽  
Scientific Productivity ◽  
European Experience ◽  
Past Half Century ◽  
The University ◽  
The 19Th Century ◽  
First Time ◽  
European University

The past half-century has been perhaps the European university's greatest age, even compared with the earlier flourishing in the Middle Ages, the Renaissance and during the industrial revolution of the 19th century. More universities have been founded; student numbers have increased at an unprecedented rate; and the scholarly and scientific productivity of the universities has been unparalleled. But the university has become for the first time a truly global institution, cut off from its roots in Europe and Europe's colonial empires and open to other, non-European and non-élite, knowledge traditions. At the same time the tight relationship between the university and modernity, or ‘movement’, has been increasingly questioned. For more than a century that relationship has been axiomatic, relegating the university's other role as an agent of continuity and tradition into second place. But the dynamism of socio-economic and technological change in the so-called ‘Knowledge Society’ is now so great that the university's role as a force for stabilization may become more important. As a result the centrality of the university in the European experience could be diminished.

Delayed clinical improvement after deep brain stimulation–related subdural hematoma

2011 ◽  
Vol 115 (2) ◽  
pp. 289-294 ◽  
Author(s):  
Genko Oyama ◽  
Michael S. Okun ◽  
Theresa A. Zesiewicz ◽  
Tiffany Tamse ◽  
Janet Romrell ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Clinical Improvement ◽  
Brain Stimulation ◽  
Subdural Hematoma ◽  
Rating Scale ◽  
Chronic Phase ◽  
Imaging Studies ◽  
Excellent Outcome ◽  
The University ◽  
Deep Brain

Object The purpose of this paper is to present 4 cases that illustrate the management and outcome of subdural hematoma (SDH) following deep brain stimulation (DBS) lead implantation. Methods The authors identified 4 cases of SDH following DBS lead implantation from a pool of 500 consecutive lead implantations (incidence 0.08%) performed at the University of Florida. Cases were characterized by chart review, serial Unified Parkinson's Disease Rating Scale evaluations, and changes on serial postoperative imaging studies. Results Two of the 4 patients with DBS-related SDH were clinically symptomatic. In the other 2 cases the SDH was incidentally discovered on routine postoperative lead localization imaging studies. None of the patients required craniotomy for evacuation of the SDH in the acute phase. Three of the 4 cases were managed with bur hole drainage in the chronic phase, and one was successfully managed nonoperatively. In all 4 cases, thresholds for stimulationinduced side effects were lower during initial postoperative programming than during intraoperative macrostimulation. Expected clinical improvement from DBS was achieved without lead revision in all 4 cases, but only after a significant delay. Conclusions Subdural hematoma is a rare and potentially avoidable complication of DBS that does not typically mandate acute hematoma evacuation or hardware revision and does not preclude an excellent outcome from DBS therapy. The clinical picture and apparent lead position tend to improve with time, and it may be wise to delay repositioning of an ineffective DBS lead following a hemorrhage until the DBS lead and surrounding brain tissue have settled into their final position and the insulted brain has had sufficient time to recover.

scholarly journals The effect of the ventricular system on the electric current in deep brain stimulation

2009 ◽  
Vol 10 (S1) ◽  
Author(s):  
Nada Yousif ◽  
Dipankar Nandi ◽  
Alexander Green ◽  
Tipu Aziz ◽  
Xuguang Liu
Keyword(s):  
Deep Brain Stimulation ◽  
Electric Current ◽  
Brain Stimulation ◽  
Ventricular System ◽  
Deep Brain

scholarly journals Deep Brain Stimulation Utilizing Dexmedetomidine: A Clinical Report from the University of Miami Miller School of Medicine

2016 ◽  
Vol 03 (03) ◽  
pp. 233-238
Author(s):  
Derek Covington ◽  
Meredith Degnan ◽  
Yiliam Rodriguez-Blanco ◽  
Ankeet Choxi ◽  
Rupa Prasad ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Perioperative Complications ◽  
Anesthetic Management ◽  
Clinical Report ◽  
School Of Medicine ◽  
Perioperative Complication ◽  
Anaesthesia Care ◽  
The University ◽  
Deep Brain

Abstract Background: Deep brain stimulation (DBS) is an increasingly utilized technique to treat symptoms of neurological movement disorders, most commonly, Parkinson’s Disease. Patients and surgeons alike appreciate the minimally invasive nature of this procedure, as well as its reversibility. As these surgeries are being performed more often, it is becoming increasingly important to optimize our anesthetic management during these cases. Methods: We conducted a retrospective review of the DBS procedures that have been performed at our institution utilizing monitored anaesthesia care (MAC) via dexmedetomidine infusion to report on the frequency and type of perioperative complications as well as to assess the effectiveness of this technique. Results: A total of 150 patients and 174 lead placements were included in this study. Dexmedetomidine was the sole anaesthetic used in 85.6% of cases. The remaining cases used a combination of dexmedetomidine and adjuvant agents. A total of one perioperative complication was found in our series, resulting in a total complication rate percentage per patient of 0.6%.Conclusions: We found very few perioperative complications associated with the use of dexmedetomidine during these challenging cases. With its anxiolytic, sedative, and analgesic properties coupled with preservation of respiration and a short half-life, dexmedetomidine has ideal properties for DBS procedures.

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