Granular Cell Tumor (Myoblastoma) of RAT Brain

Granular cell myoblastoma is a rare tumor of which the nature and origin has been controversial. The cytogenesis of this tumor has been suggested as a neoplastic derivation from adult or embryonic muscle tissue, a histiocytic storage phenomenon, of neural origin and as a neoplasm derived from Schwann cells.This report presents the ultrastructure of a spontaneously occurring granular cell tumor from the brain of a 22 month old female Sprague- Dawley rat. Gross examination revealed an oval, gray external mass 3x4 mm in size and located on the cerebellar dorsal surface. This tumor was connected by a narrow stalk to a tumor mass located in the molecular layer of the cerebellum. The external tumor and the stalk were excised for electron microscopy (EM) and the remaining tumor mass, brain, and stalk were processed for light microscopy (LM).

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Malignant Clinical Presentation of a Benign Granular Cell Tumor of Breast in a Patient with Previously Treated Contralateral Invasive Ductal Carcinoma

Case Reports in Oncological Medicine ◽

10.1155/2012/974740 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3

Author(s):

Deniz Tural ◽

Emre Akar ◽

Tülin Öztürk ◽

Hande Turna ◽

Süheyla Serdengeçti

Keyword(s):

Invasive Ductal Carcinoma ◽

Granular Cell Tumor ◽

Ductal Carcinoma ◽

Subcutaneous Tissue ◽

Granular Cell ◽

Cell Tumor ◽

S 100 ◽

Neural Origin ◽

Benign Nature ◽

Previously Treated

GCT is a rare neoplasm and usually shows the benign character. GCT can occur in any body site and may be multifocal. The most common involved site is tongue which accounts for nearly 30% of all cases but skin and subcutaneous tissue are also affected frequently. Breast is an unusually involved site and accounts for 6% of all GCTs. The histiogenesis of GCT is still controversial but further investigations and immunohistochemical examinations were exposed to neural origin and the tumor is thought to be derived from Schwann cells of peripheral nerves. Generally used technique to diagnose GCT is the positivity of S-100 immunohistochemical staining. Despite its benign nature, GCT may mimic breast carsinoma clinically and radiologically and easily be misdiagnosed for breast cancer. We herein report a case of granular cell tumor that arose in a 56 year-old female patient who previously had been treated from an invasive ductal carcinoma in contralateral breast.

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Granular Cell Tumor over the Mons Pubis: An Uncommon Tumor

Case Reports in Obstetrics and Gynecology ◽

10.1155/2019/1279137 ◽

2019 ◽

Vol 2019 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

M. Patabendige ◽

D. J. Wickramasooriya ◽

L. Dasanayake

Keyword(s):

Soft Tissue ◽

Granular Cell Tumor ◽

Granular Cell ◽

Surgical Excision ◽

Cell Tumor ◽

The Body ◽

Complete Surgical Excision ◽

Neural Origin ◽

Labium Majus ◽

Uncommon Tumor

Granular cell tumors are uncommon, usually benign, soft tissue neoplasms of neural origin. They occur throughout the body; vulval involvement is uncommon and labium majus is the commonest site in vulva. Complete surgical excision is the preferred treatment of choice to prevent recurrence. Here, we present a benign granular cell tumor over the mons pubis of vulva in a 27-year-old woman.

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Uncommon Location for Granular Cell Tumor in a 10-year-old Caucasian Female

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.5.2.12 ◽

2021 ◽

Vol 5 (2) ◽

pp. 152-155

Author(s):

Joanna Trigg ◽

Stefanie Cubelli ◽

Graham Litchman ◽

Jason Cohen ◽

Suzanne Sirota Rozenberg

Keyword(s):

Granular Cell Tumor ◽

Neck Region ◽

Granular Cell ◽

Cell Tumor ◽

Histopathological Diagnosis ◽

Head And Neck Region ◽

Neural Origin ◽

Anatomic Variants ◽

Caucasian Female ◽

Uncommon Location

Granular cell tumors are uncommon soft-tissue neoplasms of confirmed neural origin and are typically found in females of African descent between 30 and 60 years old.1-3 Most cases are found in the head and neck region, specifically the tongue, although there have been reports of other anatomic variants in patients outside of the typical epidemiology. We report a case of a granular cell tumor in a 10-year-old Caucasian female located on the left ventral upper arm with a biopsy confirming the histopathological diagnosis.

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Granular Cell Tumor on the soft palate: a very rare location

Clinical and Laboratorial Research in Dentistry ◽

10.11606/issn.2357-8041.clrd.2015.96108 ◽

2015 ◽

Vol 21 (1) ◽

pp. 58

Author(s):

Willian Pecin Jacomacci

Keyword(s):

Soft Palate ◽

Granular Cell Tumor ◽

Benign Lesion ◽

Granular Cell ◽

Soft Tissue Tumors ◽

Cell Tumor ◽

Neural Origin ◽

Rare Location ◽

Rare Lesion ◽

Immunohistochemical Analyses

<p>Granular cell tumor (GCT) is a rare lesion of neural origin and uncertain nature. It can be a true neoplasm, a degenerative metabolic process or a proliferation trauma-induced. In general, it appears as a singular benign lesion, however, there are rare cases that are malignant multicentric forms. The most frequent orofacial localization is the tongue. The aim of this report was to describe a case of GCT occurring on the soft palate. Patient presented a discrete and asymptomatic nodule for approximately eight months. Definitive diagnosis of granular cell tumor was established by histological and immunohistochemical analyses. The case illustrates the occurrence of granular cell tumor in an unusual region and emphasizes the importance of including this entity in differential diagnosis of soft tissue tumors in otherwise locations besides the tongue. </p>

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Ultrastructural study of a granular cell tumor from forearm

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100113263 ◽

1984 ◽

Vol 42 ◽

pp. 676-677

Author(s):

C.N. Sun ◽

R. Shaefer

Keyword(s):

Tumor Cells ◽

Osmium Tetroxide ◽

Granular Cell Tumor ◽

White Male ◽

Mesenchymal Cell ◽

Granular Cell ◽

Cell Tumor ◽

Left Forearm ◽

Tumor Mass ◽

Fine Structures

Granular cell tumors are frequently reported in different body locations. Some authors believed it to be a neoplasm derived from skeletal muscle and others propose the origin of these lesions are from fibroblasts, histocytes, mesenchymal cell, neuron or Schwann cells. So far the tumor cells origin is still controversial. The purpose of this report is to present a case showing the cellular fine structures and to propose a possible origin of the tumor cells.A tumor mass (5 x 3 cm) from the left forearm of a 49 year old white male was removed, cut into small pieces (about 1 mm3), immediately fixed in 4 percent glutaraldehyde in phosphate buffer for 2 hours, and then post fixed in 1 percent buffered osmium tetroxide for 1 hour. After dehydration, tissues were embedded in Epon 812.

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Case for diagnosis

Anais Brasileiros de Dermatologia ◽

10.1590/abd1806-4841.20132772 ◽

2013 ◽

Vol 88 (6) ◽

pp. 1005-1007 ◽

Cited By ~ 2

Author(s):

Thaiane Lima Lage ◽

Mario Fernando Ribeiro de Miranda ◽

Maraya de Jesus Semblano Bittencourt ◽

Carolina Moraes Dias ◽

Amanda Magno de Parijós ◽

...

Keyword(s):

Granular Cell Tumor ◽

S100 Protein ◽

Benign Neoplasm ◽

Granular Cell ◽

Cell Tumor ◽

Pathological Examination ◽

S 100 ◽

Neural Origin ◽

The Right ◽

American Ethnicity

Granular cell tumor is a rare benign neoplasm of neural origin. We report the case of a female patient, 27 years old presenting a brown-red nodule in the right arm, which pathological examination showed to be formed by polygonal cells with eosinophilic granular cytoplasm and immunohistochemistry positive for S100 protein and CD68. Granular cell tumor is usually solitary and in half the cases located in the head and neck areas, 30% of these in the tongue. It is most frequent between the third and fifth decades of life in women and people of African-American ethnicity. Its origination is controversial, including the possible origins in muscle, fibroblasts, neural crest, neural sheath or histiocytes. The positivity for S-100 and CD68 suggest the neural origin.

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Oral Granular Cell Tumor: Report of Case Series and a Brief Review of the Literature

Balkan Journal of Dental Medicine ◽

10.1515/bjdm-2017-0018 ◽

2017 ◽

Vol 21 (2) ◽

pp. 116-118 ◽

Cited By ~ 1

Author(s):

Panayiotis Karakostas ◽

Apostolos Matiakis ◽

Eleftherios Anagnostou ◽

Alexandros Kolokotronis

Keyword(s):

Granular Cell Tumor ◽

Case Series ◽

Granular Cell ◽

Surgical Excision ◽

Cell Tumor ◽

Oral Disease ◽

Review Of The Literature ◽

Tumor Treatment ◽

Immunohistochemical Examination ◽

Neural Origin

Summary Background/Aim: The present analysis focuses on examining a case series of eight patients diagnosed with a granular cell tumor located in the oral cavity. Case series: The patients’ clinical states were thoroughly studied, along with the histopathological and immunohistochemical examinations findings. Their surgical treatment and postoperative course are also within the scope of this analysis. Numerous histogenesis theories and the appropriate tumor treatment are mentioned within the article being always in accordance with the relative literature. Conclusions: Oral granular cell tumor is a benign oral disease of possible neural origin commonly located on the tongue. Surgical excision is the treatment of choice. In any case, histological and immunohistochemical examination confirm both the clinical diagnosis and the differential diagnosis between oral squamous cell carcinoma.

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