scholarly journals Granular Cell Tumor on the soft palate: a very rare location

2015 ◽  
Vol 21 (1) ◽  
pp. 58
Author(s):  
Willian Pecin Jacomacci
Keyword(s):  
Soft Palate ◽  
Granular Cell Tumor ◽  
Benign Lesion ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Neural Origin ◽  
Rare Location ◽  
Rare Lesion ◽  
Immunohistochemical Analyses

<p>Granular cell tumor (GCT) is a rare lesion of neural origin and uncertain nature. It can be a true neoplasm, a degenerative metabolic process or a proliferation trauma-induced. In general, it appears as a singular benign lesion, however, there are rare cases that are malignant multicentric forms. The most frequent orofacial localization is the tongue.  The aim of this report was to describe a case of GCT occurring on  the soft palate. Patient presented a discrete and asymptomatic nodule for approximately eight months. Definitive diagnosis of granular cell tumor was established by histological and immunohistochemical analyses. The case illustrates the occurrence of granular cell tumor in an unusual region and emphasizes the importance of including this entity in differential diagnosis of soft tissue tumors in otherwise locations besides the tongue. </p>

scholarly journals Laryngeal Granular Cell Tumor; Rare Location

2011 ◽  
Vol 54 (1) ◽  
pp. 41-43
Author(s):  
Sedat Aydın ◽  
Arif Şanlı ◽  
Özlem Çelebi ◽  
Emin Ayduran ◽  
Gecer Melin
Keyword(s):  
Differential Diagnosis ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Complete Surgical Resection ◽  
Submucosal Lesions ◽  
Neurogenic Origin ◽  
Rare Location ◽  
Posterior Glottis

Granular cell tumors are benign subcutaneous or submucosal lesions of neurogenic origin. In this case study one patient was diagnosed and treated successfully with complete surgical resection of a laryngeal granular cell tumor that was originated from the left arytenoid region that very rare location. There is no evidence of recurrence 2 years after surgery. Granular cell tumors should be considered in the differential diagnosis of laryngeal masses, particularly in the posterior glottis.

Granular Cell Tumor (Myoblastoma) of RAT Brain

1982 ◽  
Vol 40 ◽  
pp. 230-231
Author(s):  
Yvonne White ◽  
Winslow Sheldon ◽  
Terrell Hoage ◽  
Robert West
Keyword(s):  
Granular Cell Tumor ◽  
Molecular Layer ◽  
Dorsal Surface ◽  
Granular Cell ◽  
Cell Tumor ◽  
Sprague Dawley ◽  
Tumor Mass ◽  
Neural Origin ◽  
The Brain ◽  
Gross Examination

Granular cell myoblastoma is a rare tumor of which the nature and origin has been controversial. The cytogenesis of this tumor has been suggested as a neoplastic derivation from adult or embryonic muscle tissue, a histiocytic storage phenomenon, of neural origin and as a neoplasm derived from Schwann cells.This report presents the ultrastructure of a spontaneously occurring granular cell tumor from the brain of a 22 month old female Sprague- Dawley rat. Gross examination revealed an oval, gray external mass 3x4 mm in size and located on the cerebellar dorsal surface. This tumor was connected by a narrow stalk to a tumor mass located in the molecular layer of the cerebellum. The external tumor and the stalk were excised for electron microscopy (EM) and the remaining tumor mass, brain, and stalk were processed for light microscopy (LM).

scholarly journals Malignant Clinical Presentation of a Benign Granular Cell Tumor of Breast in a Patient with Previously Treated Contralateral Invasive Ductal Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Deniz Tural ◽  
Emre Akar ◽  
Tülin Öztürk ◽  
Hande Turna ◽  
Süheyla Serdengeçti
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Granular Cell Tumor ◽  
Ductal Carcinoma ◽  
Subcutaneous Tissue ◽  
Granular Cell ◽  
Cell Tumor ◽  
S 100 ◽  
Neural Origin ◽  
Benign Nature ◽  
Previously Treated

GCT is a rare neoplasm and usually shows the benign character. GCT can occur in any body site and may be multifocal. The most common involved site is tongue which accounts for nearly 30% of all cases but skin and subcutaneous tissue are also affected frequently. Breast is an unusually involved site and accounts for 6% of all GCTs. The histiogenesis of GCT is still controversial but further investigations and immunohistochemical examinations were exposed to neural origin and the tumor is thought to be derived from Schwann cells of peripheral nerves. Generally used technique to diagnose GCT is the positivity of S-100 immunohistochemical staining. Despite its benign nature, GCT may mimic breast carsinoma clinically and radiologically and easily be misdiagnosed for breast cancer. We herein report a case of granular cell tumor that arose in a 56 year-old female patient who previously had been treated from an invasive ductal carcinoma in contralateral breast.

scholarly journals Granular Cell Tumor over the Mons Pubis: An Uncommon Tumor

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
M. Patabendige ◽  
D. J. Wickramasooriya ◽  
L. Dasanayake
Keyword(s):  
Soft Tissue ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Surgical Excision ◽  
Cell Tumor ◽  
The Body ◽  
Complete Surgical Excision ◽  
Neural Origin ◽  
Labium Majus ◽  
Uncommon Tumor

Granular cell tumors are uncommon, usually benign, soft tissue neoplasms of neural origin. They occur throughout the body; vulval involvement is uncommon and labium majus is the commonest site in vulva. Complete surgical excision is the preferred treatment of choice to prevent recurrence. Here, we present a benign granular cell tumor over the mons pubis of vulva in a 27-year-old woman.

scholarly journals Uncommon Location for Granular Cell Tumor in a 10-year-old Caucasian Female

2021 ◽  
Vol 5 (2) ◽  
pp. 152-155
Author(s):  
Joanna Trigg ◽  
Stefanie Cubelli ◽  
Graham Litchman ◽  
Jason Cohen ◽  
Suzanne Sirota Rozenberg
Keyword(s):  
Granular Cell Tumor ◽  
Neck Region ◽  
Granular Cell ◽  
Cell Tumor ◽  
Histopathological Diagnosis ◽  
Head And Neck Region ◽  
Neural Origin ◽  
Anatomic Variants ◽  
Caucasian Female ◽  
Uncommon Location

Granular cell tumors are uncommon soft-tissue neoplasms of confirmed neural origin and are typically found in females of African descent between 30 and 60 years old.1-3 Most cases are found in the head and neck region, specifically the tongue, although there have been reports of other anatomic variants in patients outside of the typical epidemiology. We report a case of a granular cell tumor in a 10-year-old Caucasian female located on the left ventral upper arm with a biopsy confirming the histopathological diagnosis.

scholarly journals Multifocal Abrikossoff's granular cell tumor of the oesophagus: Case report

2008 ◽  
Vol 136 (9-10) ◽  
pp. 533-537 ◽  
Author(s):  
Tomislav Randjelovic ◽  
Zorica Stojsic ◽  
Jasna Gacic ◽  
Darko Babic ◽  
Miodrag Stojiljkovic ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Granular Cell Tumor ◽  
Pathological Finding ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Posterior Mediastinum ◽  
Cell Tumor ◽  
Ki 67 ◽  
Luminal Narrowing ◽  
Operative Specimen

INTRODUCTION Granular cell tumors, relatively uncommon soft tissue tumors, have been a matter of debate among pathologists regarding histogenesis for a long time. Less common locations are in the aerodigestive tract including the oesophagus. CASE OUTLINE We have recently treated a rare case, a 37-year old male, who was admitted due to dysphagia and a painful swallow with occasional pharyngo-nasal regurgitation followed with a mild loss of weight. Standard clinical examination including X-ray chest, ECG and laboratory tests did not show pathological findings. Barium contrast oesophagography demonstrated multiple ovoid defects in the wall of the oesophagus. CT scan of the chest confirmed luminal narrowing owing to the tumor of the upper oesophagus. Upper endoscopy showed unusual multifocal nodular lesions alongside the oesophageal axis covered by smooth mucosa. A primary biopsy specimen taken from the largest nodules confirmed an unusual pathological finding of the granular cell tumor. Subtotal, transpleural oesophagectomy was performed and reconstruction was derived by long colon segment interposition through the posterior mediastinum. The postoperative course was uneventful. The operative specimen consisted of four ovoid tumors alongside the oesophagus (the greatest diameter 0.5-1.8, average 1.25). All verified tumors histologicaly consisted of a spindle-shaped or polygonal cells containing small and large eosinophilic granules and central nuclei. Most tumor cells showed strongly positive immunohistochemical staining for S-100 protein. These tumor cells were partially positive for p-53 and Ki-67. No lymph node metastases were detected histologically. CONCLUSION Multifocal granular cell tumor of the oesophagus is an unusual finding with low incidence, and rarely caused symptoms. Pathological features and multiplicity of such tumors emphasized malignant predisposition requiring surgical resection of the oesophagus.

scholarly journals Malignant granular cell tumor of the ulnar nerve: A case report of long-term follow-up and literature review

2021 ◽  
Vol 8 (1) ◽  
pp. 27
Author(s):  
Sei Morinaga ◽  
Norio Yamamoto ◽  
Katsuhiro Hayashi ◽  
Akihiko Takeuchi ◽  
Shinji Miwa ◽  
...  
Keyword(s):  
Ulnar Nerve ◽  
Poor Prognosis ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Ki 67 ◽  
S 100 ◽  
Long Term Follow Up ◽  
Malignant Granular Cell Tumor

Background: The incidence of malignant granular cell tumor, an extremely rare Schwann cell-derived tumor with a poor prognosis, is reported to be approximately 0.2% of malignant soft tissue tumors. We report a case of a malignant granular cell tumor originating from the ulnar nerve.Case presentation: A 71-year-old woman presented with a mass in her right forearm. Magnetic resonance imaging showed a tumor with homogenous intensity of T1 and heterogeneous hyperintensity of T2, continuous with the ulnar nerve. Incisional biopsy revealed a malignant granular cell tumor, and marginal excision of the tumor was performed. Histologically, the tumor size was 9.2 cm and consisted of eosinophilic, granular polygonal to round and spindle-shaped cells, with vesicular and prominent nucleoli, and increased mitosis. Immunohistochemically, the tumor cells were positive for S-100 protein, CD68, H3K27me3, TFE3, and SOX10 and negative for smooth muscle alpha-actin, desmin, cytokeratin AE1/3, epithelial membrane antigen, and synaptophysin. The Ki-67 positivity rate was 12%. These findings were consistent with those of malignant granular cell tumors. In addition, no metastasis or recurrence was observed 15 years after the excision.Conclusion: Surgical resection is the standard treatment option. In our case, the diagnostic criteria for malignant granular cell tumors were histologically met. Patients with malignant granular cell tumors have a poor prognosis. However, no metastasis or recurrence was observed in this case 15 years after the surgery.

scholarly journals A rare case of cutaneous granular cell tumour

2021 ◽  
Vol 9 (8) ◽  
pp. 2482
Author(s):  
Rohini Arumugam ◽  
Leena Dennis Joseph ◽  
Vidhya Venkatesan ◽  
C. D. Narayanan
Keyword(s):  
Soft Tissue ◽  
Female Patient ◽  
Rare Case ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Cell Tumour ◽  
Granular Cell Tumour ◽  
Uncertain Etiology

Granular cell tumors are uncommon tumors of uncertain etiology. It accounts for approximately 0.5% of all soft tissue tumors. However, the involvement of skin is rare. Only few cases of cutaneous granular cell tumor is reported till date. Here, we present a case of cutaneous granular cell tumor in a 48 years female patient.

scholarly journals A Single Case Report of Granular Cell Tumor of the Tongue Successfully Treated through 445 nm Diode Laser

Healthcare ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 267
Author(s):  
Maria Vittoria Viani ◽  
Luigi Corcione ◽  
Chiara Di Blasio ◽  
Ronell Bologna-Molina ◽  
Paolo Vescovi ◽  
...  
Keyword(s):  
Diode Laser ◽  
Laser Surgery ◽  
Granular Cell Tumor ◽  
Single Case ◽  
Benign Lesion ◽  
Granular Cell ◽  
Surgical Excision ◽  
Young Female ◽  
Complete Healing ◽  
Cell Tumor

Oral granular cell tumor (GCT) is a relatively rare, benign lesion that can easily be misdiagnosed. Particularly, the presence of pseudoepitheliomatous hyperplasia might, in some cases, lead to the hypothesis of squamous cell carcinoma. Surgical excision is the treatment of choice. Recurrence has been reported in up to 15% of cases treated with conventional surgery. Here, we reported a case of GCT of the tongue in a young female patient, which was successfully treated through 445 nm diode laser excision. Laser surgery might reduce bleeding and postoperative pain and may be associated with more rapid healing. Particularly, the vaporization effect on remnant tissues could eliminate GCT cells on the surgical bed, thus hypothetically leading to a lower rate of recurrence. In the present case, complete healing occurred in 1 week, and no recurrence was observed after 6 months. Laser surgery also allows the possibility to obtain second intention healing. Possible laser-induced histopathological artifacts should be carefully considered.

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