Pediatric mania: a developmental subtype of bipolar disorder?

Despite ongoing controversy, the view that pediatric mania is rare or non-existent has been increasingly challenged not only by case reports but also by systematic research. This research strongly suggests that pediatric mania may not be rare but that it may be difficult to diagnose. Since children with mania are likely to become adults with bipolar disorder, the recognition and characterization of childhood-onset mania may help identify a meaningful developmental subtype of bipolar disorder worthy of further investigation. The major difficulties that complicate the diagnosis of pediatric mania include:- its pattern of comorbidity may be unique by adult standards, especially its overlap with ADHD, aggression and conduct disorder;- its overlap with substance use disorders;- its association with trauma and adversity;- its response to treatment is atypical by adult standards.These issues will be reviewed in the presentation.

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Bipolar disorder and substance use disorders in a Tunisian sample

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.521 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S466-S466

Author(s):

S. Ben Mustapha ◽

W. Homri ◽

R. Labbane

Keyword(s):

Bipolar Disorder ◽

Substance Use ◽

Substance Use Disorders ◽

Family Cohesion ◽

Poor Quality ◽

Term Treatment ◽

Response To Treatment ◽

Criminal Records ◽

Long Term Treatment ◽

Bipolar Patients

AimsDescribe the sociodemographic and clinical profile of patients suffering from bipolar disorder and substance use disorders comorbidity and assess the consequences of this comorbidity on prognosis and evolution of bipolar disorder,MethodsA case-control study, 100 euthymic patients treated for bipolar disorder, recruited in the department of psychiatry C of Razi hospital. Two groups of 50 patients were individualized by the presence or not of substance use disorders comorbidity. The two groups were compared for sociodemographic, clinical, therapeutic and historical characteristics.ResultsCompared to bipolar patients without addictive comorbidity, those with this comorbidity had the following characteristics: we found more male, less family cohesion, more domestic violence, more criminal records, more time spent abroad, more personality disorders especially antisocial and borderline, fewer triggers of bipolar illness, more mood episodes, more psychotic features, higher impulsivity BIS-10 score, an increased need to put in a neuroleptic long term treatment, poor adherence to treatment, lower response to treatment, lower score of global assessment of functioning (GAF), more rapid cycles, shorter period of remission, longer duration of the last mood episode, poor socio-professional integration and poor quality of intervals between mood episodes.ConclusionsIt seems important to insist on the identification and the treatment of bipolar disorder or substance use disorders when one of them is diagnosed. This needs to set up urgently facilities and care structures for patients with substance use disorders and to create more addiction consultations.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Association of Bipolar and Substance Use Disorders in Parents of Adolescents With Bipolar Disorder

Biological Psychiatry ◽

10.1016/j.biopsych.2006.11.022 ◽

2007 ◽

Vol 62 (2) ◽

pp. 129-134 ◽

Cited By ~ 24

Author(s):

Timothy E. Wilens ◽

Joseph Biederman ◽

Joel Adamson ◽

Michael Monuteaux ◽

Aude Henin ◽

...

Keyword(s):

Bipolar Disorder ◽

Substance Use ◽

Substance Use Disorders

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Risk for Substance Use Disorders in Youths With Child- and Adolescent‐Onset Bipolar Disorder

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1097/00004583-199906000-00014 ◽

1999 ◽

Vol 38 (6) ◽

pp. 680-685 ◽

Cited By ~ 89

Author(s):

TIMOTHY E. WILENS ◽

JOSEPH BIEDERMAN ◽

RACHAEL B. MILLSTEIN ◽

JANET WOZNIAK ◽

AMY L. HAHESY ◽

...

Keyword(s):

Bipolar Disorder ◽

Substance Use ◽

Substance Use Disorders ◽

Child And Adolescent

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Tobacco smoking and other substance use disorders associated with recurrent suicide attempts in bipolar disorder

Journal of Affective Disorders ◽

10.1016/j.jad.2019.05.075 ◽

2019 ◽

Vol 256 ◽

pp. 348-357

Author(s):

R. Icick ◽

I. Melle ◽

B. Etain ◽

P.A. Ringen ◽

S.R. Aminoff ◽

...

Keyword(s):

Bipolar Disorder ◽

Substance Use ◽

Substance Use Disorders ◽

Tobacco Smoking ◽

Suicide Attempts

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The Duration of Undiagnosed Bipolar Disorder: Impact of Substance use Disorders co-morbidity

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.1950 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S132-S132

Author(s):

S. Ben Mustapha ◽

W. Homri ◽

L. Jouini ◽

R. Labbane

Keyword(s):

Bipolar Disorder ◽

Substance Use ◽

Standard Deviation ◽

Substance Use Disorders ◽

Mood Stabilizer ◽

Type I ◽

Addictive Behaviour ◽

Bipolar Disease ◽

Co Morbidity ◽

The Impact

AimsStudy the impact of substance use disorders (SUD) co-morbidity on the duration of undiagnosed bipolar disorder (DUBP).MethodsCase-control study during a period of six months from July 2015 to December 2015. One hundred euthymic patients with BD (type I, II or unspecified) were recruited in the department of psychiatry C Razi Hospital, during their follow-up. Two groups were individualized by the presence or not of a SUD co-morbidity. In our study DUBP was defined as the period between the first symptoms and the beginning of treatment by a mood stabilizer.ResultsThe beginning of addictive behaviour preceded the installation of bipolar disease in 32% of cases. Installation of bipolar disorder preceded the installation of addictive behaviour in 12% of cases. The beginning of addictive behaviour was concomitant with the installation of bipolar disease in 6% of cases. The average DUBP in the full sample was 4.80 years with a standard deviation of 8.04 and extremes ranging from 0.08 to 37.5.The average DUBP in patients with SUD co-morbidity was 5.91 years with a standard deviation of 8.16 and extremes ranging from 0.08 to 35, and 3.68 years with a standard deviation of 7.84 and extremes ranging from 0.08 to 37.5 in patients without SUD co-morbidity.ConclusionsAccording to studies over two thirds of patients with bipolar disorder received misdiagnoses before diagnosis of BD, and among the factors involved can report the presence of SUD co-morbidity. Hence, we should detect BD among patients with SUD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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