Chronic hepatitis B and C infections in the Netherlands: estimated prevalence in risk groups and the general population

AbstractChronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are usually asymptomatic for decades, thus targeted screening can prevent liver disease by timely diagnosis and linkage to care. More robust estimates of chronic HBV and HCV infections in the general population and risk groups are needed. Using a modified workbook method, the total number of ever chronically infected individuals in the Netherlands in 2016 was determined using population size and prevalence estimates from studies in the general and high-risk population. The estimated 2016 chronic HBV infection prevalence is 0.34% (low 0.22%, high 0.47%), corresponding to approximately 49 000 (low 31 000, high 66 000) HBV-infected individuals aged 15 years and older. The estimated ever-chronic HCV infection prevalence is 0.16% (low 0.06%, high 0.27%), corresponding to approximately 23 000 (low 8000, high 38 000) ever-chronic HCV-infected individuals. The prevalence of chronic HBV and HCV infections in the Netherlands is low. First-generation migrants account for most infections with 81% and 60% of chronic HBV and HCV infections, respectively. However, about one-fifth of HCV infections is found in the general population at low risk. This method can serve as an example for countries in need of more accurate prevalence estimates, to help the design and evaluation of prevention and control policies.

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Chronic hepatitis B and C infections in the Netherlands: estimated prevalence in risk groups and the general population

Journal of Hepatology ◽

10.1016/s0168-8278(18)30525-7 ◽

2018 ◽

Vol 68 ◽

pp. S156-S157 ◽

Cited By ~ 2

Author(s):

J. Koopsen ◽

J. van Steenbergen ◽

J.H. Richardus ◽

M. Prins ◽

E. Op de Coul ◽

...

Keyword(s):

Chronic Hepatitis ◽

General Population ◽

Hepatitis B ◽

The Netherlands ◽

Chronic Hepatitis B ◽

Risk Groups

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FoxP3, PD-1 and CTLA-4 are decreased significantly after a tenofovir therapy in patients with chronic hepatitis B

Future Virology ◽

10.2217/fvl-2019-0128 ◽

2020 ◽

Vol 15 (4) ◽

pp. 237-246

Author(s):

Hyosun Cho ◽

Hyojeung Kang ◽

Ji Y Kim ◽

Hee Y Kim ◽

Chang W Kim

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Mononuclear Cells ◽

Viral Infections ◽

Treatment Results ◽

Peripheral Blood Mononuclear ◽

Chronic Viral Infections ◽

Chronic Hbv ◽

Chronic Hcv

Background: FoxP3, PD-1 and CTLA-4 are upregulated in chronic viral infections, such as chronic HCV, chronic HBV and HIV infection. Materials & methods: During 1 year of tenofovir disoproxil fumarate (TDF) treatment in patients with chronic hepatitis B, we investigated the expression of FoxP3, PD-1 and CTLA-4. Peripheral blood mononuclear cells were isolated from the 30 study subjects at T0 (0 months), T3, T6 and T12 months after the commencement of TDF treatment. Results & conclusion: Expression of FoxP3, PD-1 and CTLA-4 was significantly decreased in T cells of patients with chronic hepatitis B under TDF treatment at T12, when compared with that at T0. A direct correlation was observed between FoxP3 and CTLA-4 expression in patients with chronic hepatitis B and the frequency of FoxP3 was positively associated with serum alanine aminotransferase levels.

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Example B: Using online respondent-driven sampling among Moroccan immigrants in the Netherlands

European Journal of Public Health ◽

10.1093/eurpub/ckz185.533 ◽

2019 ◽

Vol 29 (Supplement_4) ◽

Author(s):

N Hamdiui ◽

J E van Steenbergen ◽

A Thorson ◽

L E C Rocha ◽

A Urbanus ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B ◽

The Netherlands ◽

Chronic Hepatitis B ◽

Second Generation ◽

Monetary Incentive ◽

Respondent Driven Sampling ◽

Online Questionnaire ◽

Chronic Hbv ◽

Hbv Screening

Abstract The Dutch Health Council recommended chronic hepatitis B (HBV) screening for first-generation immigrants originating from intermediate/high HBV endemic countries. The Council proposed two screening strategies; individual case finding by general practitioners and local screening programmes. Our aim was to explore knowledge and information needs regarding chronic HBV and its screening among Moroccan immigrants in the Netherlands, in order to provide Dutch Municipal Health Services insights on how to inform immigrants. We also studied a randomized recruitment method using respondent-driven sampling (RDS) for a better understanding on how to reach and recruit immigrants for an online questionnaire. First- and second-generation Moroccan immigrants were asked to fill in an online questionnaire and forward this to four Moroccan contacts. Participants were randomized to one of three recruitment strategies; no incentive for filling in the questionnaire nor for successfully recruiting each contact, an incentive for filling in the questionnaire and for successfully recruiting each contact, and a gamified element as non-monetary incentive to stimulate peer-recruitment. Preliminary analyses show a sample of 59 Moroccans (17-59 years), of which 63% was second-generation and 76% was female. Of these, 46% would like to have information about chronic hepatitis B, while the average knowledge score was 5.02 (0-10). Over 60% of the participants intends to participate in chronic HBV screening, and would also recommend this to their (grand)parents. Using a monetary incentive seemed to be the best recruitment strategy in terms of the number of waves (max: 3). A gamified non-monetary incentive was least effective in stimulating peer-recruitment (max: 0). Despite the limited level of knowledge and information need, the majority of Moroccan immigrants had a positive screening intention. The next step is to determine whether our methodology could be applied to reach other immigrant groups.

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Prevalence of Chronic Hepatitis B and C in Malaysia- results from a community-based screening campaign.

10.21203/rs.3.rs-60491/v1 ◽

2020 ◽

Author(s):

Lim ZZ ◽

Teo JS ◽

Tan Soek Siam ◽

Rosmawati Mohamed ◽

Goh KL ◽

...

Keyword(s):

Young Adults ◽

Chronic Hepatitis ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Point Of Care ◽

Low Cost ◽

Point Of Care Test ◽

Hbv Vaccination ◽

Chronic Hbv ◽

Chronic Hcv

Abstract Introduction The epidemiology of hepatitis, which is apparently endemic in Asia, is still poorly documented in Malaysia. Available statistics are modelled estimates based on expert input or estimated from small studies on special populations. We therefore determined the prevalence of chronic hepatitis B and C in Malaysia based on a large sample data from a screening campaign. Methods A total of 10,914 subjects participated in the hepatitis screening campaign in 2018 and 2019. A low-cost Point-of-care test, which has previously been validated, was used to screen for HBsAg and anti-HCV. All screen positive subjects were recalled to undergo confirmatory serology tests and nucleic acid tests. Results We estimated 1.17% or 238,971 Malaysian adults aged 20 or older had chronic HBV, while only 0.74% or 151,144 adults had chronic HCV. Young adults below age 30 years had very low prevalence of HBV (0.09%). Women had lower prevalence of HBV and HCV, Chinese had the highest prevalence of HBV while Malay had the highest prevalence of HCV. Conclusion Young adults seems to be protected from HBV perhaps owing to the introduction of universal HBV vaccination since 1989. Chronic HBV however remains prevalent in older adults especially among the Chinese. Chronic HCV is uncommon in Malaysia.

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Prevalence of Chronic Hepatitis B and C in Malaysia- results from a community-based screening campaign

10.1101/2020.04.30.20085944 ◽

2020 ◽

Author(s):

ZZ Lim ◽

JS Teo ◽

AC Tan ◽

Tan Soek Siam ◽

Rosmawati Mohamed ◽

...

Keyword(s):

Young Adults ◽

Chronic Hepatitis ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Point Of Care ◽

Low Cost ◽

Point Of Care Test ◽

Hbv Vaccination ◽

Chronic Hbv ◽

Chronic Hcv

AbstractIntroductionThe epidemiology of hepatitis, which is apparently endemic in Asia, is still poorly documented in Malaysia. Available statistics are modelled estimates based on expert input or estimated from small studies on special populations. We therefore determined the prevalence of chronic hepatitis B and C in Malaysia based on a large sample data from a screening campaign.MethodsA total of 10,914 subjects participated in the hepatitis screening campaign in 2018 and 2019. A low-cost Point-of-care test, which has previously been validated, was used to screen for HBsAg and anti-HCV. All screen positive subjects were recalled to undergo confirmatory serology tests and nucleic acid tests.ResultsWe estimated 1.17% or 238,971 Malaysian adults aged 20 or older had chronic HBV, while only 0.74% or 151,144 adults had chronic HCV. Young adults below age 30 years had very low prevalence of HBV (0.09%). Women had lower prevalence of HBV and HCV, Chinese had the highest prevalence of HBV while Malay had the highest prevalence of HCV.ConclusionYoung adults seems to be protected from HBV perhaps owing to the introduction of universal HBV vaccination since 1989. Chronic HBV however remains prevalent in older adults especially among the Chinese. Chronic HCV is uncommon in Malaysia.

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Current prevalence of chronic hepatitis B and C virus infection in the general population and other low-risk populations of the EU/EEA: a systematic review

10.26226/morressier.57fe118cd462b8028d890793 ◽

2016 ◽

Author(s):

Sanne Hofstraat

Keyword(s):

Systematic Review ◽

Chronic Hepatitis ◽

General Population ◽

Virus Infection ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Low Risk ◽

Current Prevalence ◽

The Eu

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Prevalence of hepatitis delta virus among chronic hepatitis B carriers in a large tertiary center in the Netherlands

Journal of Clinical Virology ◽

10.1016/j.jcv.2021.104870 ◽

2021 ◽

pp. 104870

Author(s):

Boris J.B. Beudeker ◽

Jolanda J.C. Voermans ◽

Corine.H. GeurtsvanKessel ◽

Robert J. de Knegt ◽

Tamara Kuhlemann ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B ◽

The Netherlands ◽

Chronic Hepatitis B ◽

Hepatitis Delta Virus ◽

Hepatitis Delta ◽

Tertiary Center ◽

Delta Virus

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Estimated burden of chronic hepatitis B among first generation migrants in Germany, Hungary, The Netherlands, Italy, Spain and United Kingdom

European Journal of Public Health ◽

10.1093/eurpub/ckt123.190 ◽

2013 ◽

Vol 23 (suppl_1) ◽

Author(s):

A Ahmad ◽

I Veldhuijzen ◽

A Falla ◽

A Bechini ◽

R Reintjes

Keyword(s):

Chronic Hepatitis ◽

United Kingdom ◽

Hepatitis B ◽

The Netherlands ◽

Chronic Hepatitis B ◽

First Generation ◽

First Generation Migrants

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Association of STAT3 and STAT4 polymorphisms with susceptibility to chronic hepatitis B virus infection and risk of hepatocellular carcinoma: a meta-analysis

Bioscience Reports ◽

10.1042/bsr20190783 ◽

2019 ◽

Vol 39 (6) ◽

Cited By ~ 4

Author(s):

Han Shi ◽

Hongyan He ◽

Suvash Chandra Ojha ◽

Changfeng Sun ◽

Juan Fu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Chronic Hepatitis ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Meta Analysis ◽

Hbv Infection ◽

Chronic Hbv Infection ◽

B Virus ◽

Chronic Hbv

Abstract Background: It has been reported that polymorphisms of signal transducer and activator of transcription (STAT) 3 and STAT4 might be associated with susceptibility to hepatitis B virus (HBV) infection and risk of chronic hepatocellular carcinoma (HCC). Owing to limitation of sample size and inconclusive results, we conducted a meta-analysis to clarify the association. Methods: We identified relevant studies by a systematic search of Medline/PubMed, Embase, Web of Science and the Cochrane Library up to 20 February 2019. The strength of the association measured by odds ratios (OR) with 95% confidence intervals (CIs) was studied. All the statistical analyses were conducted based on Review Manager 5.3 software. Results: A total of 5242 cases and 2717 controls from five studies were included for the STAT3 polymorphism, 5902 cases and 7867 controls from nine studies for the STAT4 polymorphism. Our results suggested that STAT3 rs1053004 polymorphism was a significant risk factor of chronic HBV infection (C vs. T: OR = 1.17, 95% CI: 1.07–1.29, PA=0.0007; CC + CT vs. TT: OR = 1.38, 95% CI: 1.09–1.76, PA=0.008). Validation with all the genetic models revealed that rs7574865 polymorphism of STAT4 gene was closely associated with chronic HBV infection (PA<0.01) and chronic hepatitis B (CHB)-related HCC (PA<0.05). Meanwhile, the authenticity of the above meta-analysis results was confirmed by trial sequential analysis (TSA). Conclusions: The meta-analysis showed that STAT3 rs1053004 polymorphism may be the risk for developing chronic HBV infection but not associated with HCC. The present study also indicates that STAT4 rs7574865 polymorphism increased the risk of chronic HBV infection and HCC.

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