scholarly journals Dementia with Lewy bodies

1997 ◽  
Vol 7 (2) ◽  
pp. 163-170 ◽  
Author(s):  
J Allardyce ◽  
IG McKeith
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
The Elderly ◽  
Common Cause ◽  
Autopsy Series ◽  
Cortical Lewy Bodies

Dementia with Lewy bodies (DLB) is being increasingly recognized as a common cause of progressive cognitive decline in the elderly, with hospital-based autopsy series demonstrating rates of between 7% and 25% of all cases of dementia, second only in frequency to Alzheimer's disease (AD). Although DLB has only recently been described, it is unlikely to be a newly occurring disease but one which has become identifiable as a result of advances in neuropathological techniques which make cortical Lewy bodies (LBs) easier to detect.

scholarly journals A systematic review of cognitive decline in dementia with Lewy bodies versus Alzheimer’s disease

2014 ◽  
Vol 6 (5-8) ◽  
Author(s):  
Monica H Breitve ◽  
Luiza J Chwiszczuk ◽  
Minna J Hynninen ◽  
Arvid Rongve ◽  
Kolbjørn Brønnick ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

scholarly journals Comparison of cognitive decline between dementia with Lewy bodies and Alzheimer's disease: a cohort study

BMJ Open ◽  
2012 ◽  
Vol 2 (1) ◽  
pp. e000380 ◽  
Author(s):  
Zuzana Walker ◽  
Ian McKeith ◽  
Joanne Rodda ◽  
Tarik Qassem ◽  
Klaus Tatsch ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cohort Study ◽  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

Sleep-related behaviors in Alzheimer’s disease and dementia with Lewy bodies

2015 ◽  
Vol 26 (1) ◽  
Author(s):  
Alberto Raggi ◽  
Walter Neri ◽  
Raffaele Ferri
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Circadian Rhythm ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
The Elderly ◽  
Narrative Review ◽  
Clinical Approach ◽  
Prevalence Studies

AbstractPrevalence studies suggest that Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) are the most common dementing illnesses in the elderly. The aim of this narrative review was to provide data on sleep-related behaviors in AD and DLB. This paper contains arguments, with a clinical approach, on both circadian rhythm changes and dissociated states of wakefulness and sleep in these two conditions.

scholarly journals Kynurenic Acid Levels in Cerebrospinal Fluid from Patients with Alzheimer's Disease or Dementia with Lewy Bodies

2014 ◽  
Vol 7 ◽  
pp. IJTR.S13958 ◽  
Author(s):  
Malin Wennström ◽  
Henrietta M Nielsen ◽  
Funda Orhan ◽  
Elisabet Londos ◽  
Lennart Minthon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cognitive Decline ◽  
Cognitive Functions ◽  
Dementia With Lewy Bodies ◽  
Kynurenic Acid ◽  
Lewy Bodies ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1

Kynurenic acid (KYNA) is implicated in cognitive functions. Altered concentrations of the compound are found in serum and cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). Further studies to determine whether KYNA serves as a biomarker for cognitive decline and dementia progression are required. In this study, we measured CSF KYNA levels in AD patients (n = 19), patients with dementia with Lewy bodies (DLB) (n = 18), and healthy age-matched controls (Ctrls)) (n = 20) to further explore possible correlations between KYNA levels, cognitive decline, and well-established AD and inflammatory markers. Neither DLB patients nor AD patients showed significantly altered CSF KYNA levels compared to Ctrls. However, female AD patients displayed significantly higher KYNA levels compared to male AD patients, a gender difference not seen in the Ctrl or DLB group. Levels of KYNA significantly correlated with the AD-biomarker P-tau and the inflammation marker soluble intercellular adhesion molecule-1 (sICAM-1) in the AD patient group. No associations between KYNA and cognitive functions were found. Our study shows that, although KYNA was not associated with cognitive decline in AD or DLB patients, it may be implicated in AD-related hyperphosphorylation of tau and inflammation. Further studies on larger patient cohorts are required to understand the potential role of KYNA in AD and DLB.

scholarly journals A longitudinal study of anxiety and cognitive decline in dementia with Lewy bodies and Alzheimer’s disease

2016 ◽  
Vol 8 (1) ◽  
Author(s):  
Monica H. Breitve ◽  
Minna J. Hynninen ◽  
Kolbjørn Brønnick ◽  
Luiza J. Chwiszczuk ◽  
Bjørn H. Auestad ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

Rates of Cognitive Decline in Alzheimer’s Disease and Dementia with Lewy Bodies

2003 ◽  
Vol 15 (2) ◽  
pp. 67-71 ◽  
Author(s):  
Edward Helmes ◽  
John V. Bowler ◽  
Harold Merskey ◽  
David G. Munoz ◽  
Vladimir C.I. Hachinski
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

scholarly journals ALZHEIMER’S DISEASE: TYPICAL AND ATYPICAL. PART II

2018 ◽  
Vol 4 (3-4) ◽  
pp. 9-16
Author(s):  
Richard Camicioli
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Family Physicians ◽  
Cognitive Domain ◽  
Common Cause ◽  
Insidious Onset ◽  
Number Of Patients

The article describes typical and atypical forms of Alzheimer’s disease (AD), risk factors, clinical features, diagnosis and treatment. There are 35.6 million people worldwide with AD, and the number of patients will double in the next 30 years. AD is a common problem seen by neurologists, family physicians, geriatrics and psychiatrists who all should be familiar the diagnosis and course in order to best advise families. AD is the most common cause of dementia, in which memory is affected and at least one other cognitive domain. The disease has an insidious onset and gradual progression. Donepezil, rivastigmine, galantamine, and memantine are used to treat dementia in AD. Key words: Alzheimer’s disease, dementia, mild cognitive impairment, vascular dementia, dementia with Lewy bodies.

Association of Butyrylcholinesterase-K Allele and Apolipoprotein E ɛ4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer’s Disease

2016 ◽  
Vol 50 (2) ◽  
pp. 567-576 ◽  
Author(s):  
Swetha Vijayaraghavan ◽  
Taher Darreh-Shori ◽  
Arvid Rongve ◽  
Guro Berge ◽  
Sigrid B. Sando ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Apolipoprotein E ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
E4 Allele
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