scholarly journals Cortisol levels among older people with and without depression and dementia

2018 ◽  
Vol 31 (04) ◽  
pp. 597-601 ◽  
Author(s):  
Maria Lage Barca ◽  
Rannveig S. Eldholm ◽  
Karin Persson ◽  
Guro Hanevold Bjørkløf ◽  
Tom Borza ◽  
...  

ABSTRACTCortisol dysregulation has been reported in dementia and depression. Cortisol levels and its associates were investigated among older people living at home and in nursing homes, in a cross-sectional study. A sample of 650 older people, from the community (home and nursing homes) and specialized care (memory clinics and old age psychiatry wards), mean age 76.8 (SD = 10.3) (dementia n = 319, depression, n = 154, dementia plus depression n = 53, and reference group n = 124), was included. Assessment included the Mini Mental State Examination (MMSE), Cornell scale for depression in dementia, activities of daily living scales, and salivary cortisol. Number of drugs was registered. The results showed that the cortisol ratio was highest among patients with dementia and co-morbid depression in comparison to those with either depression or dementia and the reference group. Characteristics significantly associated with cortisol levels were higher MMSE score (in patients with dementia and co-morbid depression), male gender (in people with dementia), and number of medications (in the reference group). We conclude that the cortisol ratio was highest among patients with dementia and co-morbid depression in comparison to those with either depression or dementia and the reference group. The association of cortisol level with MMSE score among patients with dementia and depression could further indicate that increased stress is related to cognitive function.

Author(s):  
Phanit Leecharoen ◽  
Linchong Pothiban ◽  
Rojanee Chintanawat ◽  
Totsaporn Khampolsiri

Gerontology ◽  
2021 ◽  
pp. 1-5
Author(s):  
Anton De Spiegeleer ◽  
Jordi Van Migerode ◽  
Antoon Bronselaer ◽  
Evelien Wynendaele ◽  
Milan Peelman ◽  
...  

<b><i>Background:</i></b> Statins are progressively accepted as being associated with reduced mortality. However, few real-world statin studies have been conducted on statin use in older people and especially the most frail, that is, the nursing home residents. <b><i>Objective:</i></b> The aim of this study was to evaluate the impact of statin intake in nursing home residents on all-cause mortality. <b><i>Method:</i></b> This is a cross-sectional study of 1,094 older people residing in 6 nursing homes in Flanders (Belgium) between March 1, 2020 and May 30, 2020. We considered all residents who were taking statins for at least 5 days as statin users. All-cause mortality during the 3 months of data collection was the primary outcome. Propensity score overlap-weighted logistic regression models were applied with age, sex, functional status, diabetes, and cardiac failure/ischemia as potential confounders. <b><i>Results:</i></b> 185 out of 1,094 residents were on statin therapy (17%). The statin intake was associated with decreased all-cause mortality: 4% absolute risk reduction; adjusted odds ratio 0.50; CI 0.31–0.81, <i>p</i> = 0.005. <b><i>Conclusions:</i></b> The statin intake was associated with decreased all-cause mortality in older people residing in nursing homes. More in-depth studies investigating the potential geroprotector effect of statins in this population are needed.


BMC Nursing ◽  
2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Denise Wilfling ◽  
Martin N. Dichter ◽  
Diana Trutschel ◽  
Sascha Köpke

Abstract Background Sleep disturbances are common in people with dementia. In nursing homes, this is frequently associated with residents’ challenging behavior and potentially with nurses’ burden. This study examined nurses’ burden associated with nursing home residents’ sleep disturbances. Methods A multicenter cross-sectional study was conducted. Nurses’ burden associated with residents’ sleep disturbances was assessed using the Sleep Disorder Inventory (SDI). Additionally, the proportion of nurses’ total burden associated with sleep disturbances of residents with dementia was assessed. A linear mixed regression model was used to investigate the association with nurses’, residents’ and institutional characteristics. Results One hundred eleven nurses from 38 nursing homes were included. 78.4% stated to be regularly confronted with residents’ sleep disturbances during nightshifts, causing distress. The mean proportion of nurses‘ total burden caused by residents‘ sleep disturbances was 23.1 % (SD 18.1). None of the investigated characteristics were significantly associated with nurses’ total burden. Conclusions Nurses report burden associated with sleep disturbances as common problem. There is a need to develop effective interventions for sleep problems and to train nurses how to deal with residents’ sleep disturbances.


BMJ Open ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. e022549 ◽  
Author(s):  
Sarah Voss ◽  
Janet Brandling ◽  
Hazel Taylor ◽  
Sarah Black ◽  
Marina Buswell ◽  
...  

ObjectivesAn increasing number of older people are calling ambulances and presenting to accident and emergency departments. The presence of comorbidities and dementia can make managing these patients more challenging and hospital admission more likely, resulting in poorer outcomes for patients. However, we do not know how many of these patients are conveyed to hospital by ambulance. This study aims to determine: how often ambulances are called to older people; how often comorbidities including dementia are recorded; the reason for the call; provisional diagnosis; the amount of time ambulance clinicians spend on scene; the frequency with which these patients are transported to hospital.MethodsWe conducted a retrospective cross-sectional study of ambulance patient care records (PCRs) from calls to patients aged 65 years and over. Data were collected from two ambulance services in England during 24 or 48 hours periods in January 2017 and July 2017. The records were examined by two researchers using a standard template and the data were extracted from 3037 PCRs using a coding structure.ResultsResults were reported as percentages and means with 95% CIs. Dementia was recorded in 421 (13.9%) of PCRs. Patients with dementia were significantly less likely to be conveyed to hospital following an emergency call than those without dementia. The call cycle times were similar for patients regardless of whether or not they had dementia. Calls to people with dementia were more likely to be due to injury following a fall. In the overall sample, one or more comorbidities were reported on the PCR in over 80% of cases.ConclusionRates of hospital conveyance for older people may be related to comorbidities, frailty and complex needs, rather than dementia. Further research is needed to understand the way in which ambulance clinicians make conveyance decisions at scene.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Thamara Tapia Muñoz ◽  
Andrea Slachevsky ◽  
María O. León-Campos ◽  
Michel Madrid ◽  
Alejandra Caqueo-Urízar ◽  
...  

Author(s):  
Verlita Evelyn Susanto ◽  
Adji Prayitno Setiadi ◽  
Bobby Presley ◽  
Steven Victoria Halim ◽  
Eko Setiawan

Frailty and drug related problems (DRPs) are common among elderly who lives in the nursing home. There is currently limited information available regarding the profile of frailty and DRPs among elderly living in the nursing homes in Indonesia. This project aims to describe the profile of frailty and DRPs among nursing home residents in Surabaya. This cross-sectional study was conducted in three nursing homes in Surabaya. Integrated Systematic Care for older People (ISCOPE) questionnaire was used to identify the frailty profile among participants. Beers Criteria, screening tool of older person’s prescriptions (STOPP), geriatric dosage handbook and drug interactions analysis and management were used as tools to identify and analyse drug related problems in this study. Several DRPs were identified in this study including inappropriate drug choices, drugs interaction, and inappropriate dose of drugs. In total, 68 elderly were recruited in this study and 41.18% of them were classified as frail older people. There was no drugs interaction with “clinical significance” being identified, however, inappropriate dose of drugs and potentially inappropriate drug choices were found in 58.82% and 19.12% of nursing home residents, respectively. Findings regarding the profile of frailty and DRPs among elderly may indicate the needs to implement an appropriate intervention strategic in order to optimize the use of medications among nursing homes-dwelling elderly people.


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