Perioperative care of the newborns with CHDs in the time of COVID-19

AbstractCoronavirus disease 2019 (COVID-19), caused by a novel betacoronavirus (SARS-CoV-2), has led to an unexpected outbreak affecting people of all ages. The first data showed that COVID-19 could cause severe pulmonary disease, cardiac injury, and death in adults, especially the elderly and those with concomitant diseases. Currently, it was demonstrated that severe COVID-19 may also develop in neonatal age, although rarely. Newborns with CHD are known to be at high risk for increased morbidity from viral lower respiratory tract infections because of underlying anatomical cardiac lesions. There are limited data on the implications of COVID-19 on patients with cardiovascular disease, especially for those with CHD. Herein, we aimed to summarise the COVID-19-specific perioperative management issues for newborns with CHD by combining available data from the perspectives of neonatology and paediatric cardiovascular surgery.

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Empirical antibiotic therapy (ABT) of lower respiratory tract infections (LRTI) in the elderly: Application of artificial neural network (ANN). Preliminary results

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2011.09.006 ◽

2012 ◽

Vol 55 (2) ◽

pp. 499-503 ◽

Cited By ~ 6

Author(s):

Nicolò Gueli ◽

Andrea Martinez ◽

Walter Verrusio ◽

Adele Linguanti ◽

Paola Passador ◽

...

Keyword(s):

Neural Network ◽

Artificial Neural Network ◽

Respiratory Tract ◽

Lower Respiratory Tract ◽

Respiratory Tract Infections ◽

The Elderly ◽

Empirical Antibiotic Therapy ◽

Lower Respiratory Tract Infections ◽

Artificial Neural Network Ann ◽

Tract Infections

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Animal Models of Pneumococcal pneumonia

International Journal of Molecular Sciences ◽

10.3390/ijms20174220 ◽

2019 ◽

Vol 20 (17) ◽

pp. 4220 ◽

Cited By ~ 3

Author(s):

Borsa ◽

Pasquale ◽

Restrepo

Keyword(s):

Animal Models ◽

Pneumococcal Disease ◽

Pneumococcal Pneumonia ◽

Respiratory Tract Infections ◽

Bacterial Pathogen ◽

The Elderly ◽

Lower Respiratory Tract Infections ◽

Bacterial Inoculation ◽

Pneumococcal Infections ◽

Tract Infections

Streptococcus pneumoniae remains the most common bacterial pathogen causing lower respiratory tract infections and is a leading cause of morbidity and mortality worldwide, especially in children and the elderly. Another important aspect related to pneumococcal infections is the persistent rate of penicillin and macrolide resistance. Therefore, animal models have been developed to better understand the pathogenesis of pneumococcal disease and test new therapeutic agents and vaccines. This narrative review will focus on the characteristics of the different animal pneumococcal pneumonia models. The assessment of the different animal models will include considerations regarding pneumococcal strains, microbiology properties, procedures used for bacterial inoculation, pathogenesis, clinical characteristics, diagnosis, treatment, and preventive approaches.

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