Impact of pulmonary hypertension and congenital heart disease with hemodynamic repercussion on the severity of acute respiratory infections in children under 5 years of age at a pediatric referral center in Colombia, South America

2020 ◽  
Vol 30 (12) ◽  
pp. 1866-1873
Author(s):  
Diego A. Lozano-Espinosa ◽  
Victor M. Huertas-Quiñones ◽  
Carlos E. Rodríguez-Martínez
Keyword(s):  
Congenital Heart Disease ◽  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Congenital Heart ◽  
Respiratory Infections ◽  
Syncytial Virus ◽  
The Impact ◽  
Children Under 5

AbstractBackground:Acute respiratory infection is one of the main causes of morbidity in children. Some studies have suggested that pulmonary hypertension and congenital heart disease with haemodynamic repercussion increase the severity of respiratory infections, but there are few publications in developing countries.Methods:This was a prospective cohort study evaluating the impact of pulmonary hypertension and congenital heart disease (CHD) with haemodynamic repercussion as predictors of severity in children under 5 years of age hospitalised for acute respiratory infection.Results:Altogether, 217 children hospitalised for a respiratory infection who underwent an echocardiogram were evaluated; 62 children were diagnosed with CHD with haemodynamic repercussion or pulmonary hypertension. Independent predictors of admission to intensive care included: pulmonary hypertension (RR 2.14; 95% CI 1.06–4.35, p = 0.034), respiratory syncytial virus (RR 2.52; 95% CI 1.29–4.92, p = 0.006), and bacterial pneumonia (RR 3.09; 95% CI 1.65–5.81, p = 0.000). A significant difference was found in average length of hospital stay in children with the cardiovascular conditions studied (p = 0.000).Conclusions:Pulmonary hypertension and CHD with haemodynamic repercussion as well as respiratory syncytial virus and bacterial pneumonia were predictors of severity in children with respiratory infections in this study. Early recognition of cardiovascular risks in paediatric populations is necessary to lessen the impact on respiratory infections.

IMPACT OF ZINC SUPPLEMENTATION ON MORBIDITY FROM DIARRHEA NAD ACUTE RESPIRATORY INFECTIONS AMONG MALNOURISHED CHILDREN AGED UNDER 5 YEARS AT HUONG HO COMMUNNE, HUONG TRA DISTRICT, THUA THIEN HUE PROVINCE

2011 ◽  
pp. 91-98
Author(s):  
Thu Cu Nguyen
Keyword(s):  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Respiratory Infections ◽  
Control Group ◽  
Study Group ◽  
Study Methods ◽  
Zinc Supplement ◽  
And Control ◽  
The Impact ◽  
Children Under 5

Tittle: study the impact of Zinc supplement on acute respiratory infection and diarrhea in children under 5 yrs at Huong ho commune, Huong tra district, Thua Thien Hue province. Background: diarhea and pneumonia are two common diseases in malnutrition children. The studies showed that zinc is a microsubstance to improve the immune capacicty of children. Many studies showed that malnutrition children gone with zinc deficiency. The study is aim to assess the impact of zinc supplement on malnutrition children with diarrhea and acute respiratory infection (ARI). Population and study methods: Population: 129 malnutrition children under 5 yrs living at Huong ho commune, Huong tra district, Thua Thien Hue province. Study methods: intervene at community with control group. 2 groups of children have the similarity of age, sex, level of malnutrition, avarage weight. Study group: supplement with Zinc 10 mg/day x 30 days. Control group: no zinc supplement. Both groups were followed up about diarrhea and ARI every week in 6 months. Result: In 6 months, there was 24,6% of children in study group has the diseases while in control group was 43,7% (p<0,05). Avarage time of diarrhea per period in study group was shorter significantly than in control group (4,1±0,8 vs 6,0±1,4) (p<0,01). There was no diferrence in average diarrhea period, incidence of diarrhea between study group and control group. There still did not find out the difference in ARI period, incidence of ARI between study group and control group. Conclusion: Zinc supplement for malnutrition children is to reduce the general acquired rate of diarrhea and ARI, especially to reduce the time of diarrhea period. This study did not find out the improvement of acquired ARI in study group with zince supplement. Keywords: Malnutrition, zinc, diarrhea

scholarly journals Impact of hygienic and social distancing measures against SARS-CoV-2 on respiratory infections caused by other viruses

2021 ◽  
Author(s):  
Jordi Reina ◽  
◽  
Ricardo M. Arcay ◽  
María Busquets ◽  
Herminia Machado
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Respiratory Infections ◽  
Respiratory Viruses ◽  
Contact Material ◽  
Rt Pcr ◽  
Social Distancing ◽  
Syncytial Virus ◽  
The Impact

Introduction. To control the pandemic caused by SARS-CoV-2, the implementation of social and hygienic confinement measures was determined in all countries. These measures reduce the circulation of most respiratory viruses that are transmitted preferentially by air and contact. Material and methods. The impact of these measures on non-Covid respiratory viruses during the period August-December 2020 and 2019 has been comparatively analyzed. To all nasopharyngeal aspirates that were negative against SARS-CoV-2 by RT-PCR and the suspicion of acute respiratory infection persisted, were subjected to a new RT-PCR that simultaneously and differentially amplifies 21 different respiratory viruses. Results. In the year of the pandemic, a 36.6% decrease was detected in the number of respiratory samples studied and 66% in their positivity in relation to 2019. All viruses showed reduction percentages of between 40-100%. The only viruses that circulated during and after national lockdown were rhinovirus (74.1%), adenovirus (10.1%), and enterovirus (9.6%). Conclusion. The measures used to control the SARS-CoV-2 infection have also affected the community circulation of most respiratory viruses including influenza and respiratory syncytial virus.

scholarly journals Acute Lower Respiratory Infections Associated With Respiratory Syncytial Virus in Children With Underlying Congenital Heart Disease: Systematic Review and Meta-analysis

2019 ◽  
Vol 222 (Supplement_7) ◽  
pp. S613-S619 ◽  
Author(s):  
Pa Saidou Chaw ◽  
Stephanie Wen Lan Wong ◽  
Steve Cunningham ◽  
Harry Campbell ◽  
Rafael Mikolajczyk ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Respiratory Syncytial Virus ◽  
Congenital Heart ◽  
Respiratory Infections ◽  
Meta Analysis ◽  
Case Fatality ◽  
Viral Pathogen ◽  
Acute Lower Respiratory Infections ◽  
Syncytial Virus

Abstract Background Respiratory syncytial virus (RSV) is the most common viral pathogen associated with acute lower respiratory infections (ALRIs), with significant childhood morbidity and mortality worldwide. Estimates reporting RSV-associated ALRI (RSV-ALRI) severity in children with congenital heart disease (CHD) are lacking, thus warranting the need to summarize the available data. We identified relevant studies to summarize the findings and conducted a meta-analysis of available data on RSV-associated ALRI hospitalizations in children aged &lt;5 years, comparing those with underlying CHD to those without CHD. Methods We conducted a systematic search of existing relevant literature and identified studies reporting hospitalization of children aged &lt;5 years with RSV-ALRI with underlying or no CHD. We summarized the data and conducted (where possible) a random-effects meta-analysis to compare the 2 groups. Results We included 18 studies that met our strict eligibility criteria. The risk of severe RSV-ALRI (odds ratio, 2.2; 95% confidence interval [CI], 1.6–2.8), the rate of hospitalization (incidence rate ratio, 2.8; 95% CI, 1.9–4.1), and the case-fatality ratio (risk ratio [RR], 16.5; 95% CI, 13.7–19.8) associated with RSV-ALRI was higher among children with underlying CHD as compared to those without no CHD. The risk of admission to the intensive care unit (RR, 3.9; 95% CI, 3.4–4.5), need for supplemental oxygen therapy (RR, 3.4; 95% CI, .5–21.1), and need for mechanical ventilation (RR, 4.1; 95% CI, 2.1–8.0) was also higher among children with underlying CHD. Conclusion This is the most detailed review to show more-severe RSV-ALRI among children aged &lt;5 years with underlying CHD, especially hemodynamically significant underlying CHD, as compared those without CHD, supporting a need for improved RSV prophylactics and treatments that also have efficacy in children older than 1 year.

scholarly journals Reappraisal of the Subtropical Guidelines on Palivizumab Prophylaxis in Congenital Heart Disease

2022 ◽  
Vol 9 ◽  
Author(s):  
Shuenn-Nan Chiu ◽  
Ching-Chia Wang ◽  
Ming-Tai Lin ◽  
Chun-An Chen ◽  
Chun-Wei Lu ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Care Center ◽  
Tertiary Care ◽  
The Novel ◽  
Genetic Syndromes ◽  
Syncytial Virus ◽  
The Impact ◽  
Associated Abnormalities

Objective: To define the impact of associated abnormalities on the efficacy of the novel subtropical guidelines for palivizumab prophylaxis on respiratory syncytial virus (RSV)-related hospitalizations in patients with hemodynamically significant congenital heart disease (hsCHD).Method: This prospective study enrolled every patient seen at a tertiary care center for hsCHD, who was born between 2014 and 2018 and received at least 1 dose of palivizumab, according to the subtropical guidelines. The patients were followed until the age of 2 years.Results: A total of 772 patients (49% male) were enrolled. Cyanotic CHD was seen in 46% of patients, of whom 23% had associated abnormalities. Lung/airway abnormalities (14%) were the most common followed by the genetic syndromes associated with CHD (7.3%). Among the 772 patients, RSV-related hospitalizations occurred in 3.2 and 2.2% children aged ≤ 12 and 13–24 months, respectively. Most of the RSV infections occurred in patients no longer satisfying the criteria for palivizumab prophylaxis. The patients with associated abnormalities but not the type of CHD, patient age, and patient sex were risk factors for RSV-related hospitalizations. The rates of RSV-related hospitalizations, admission to the intensive care unit, and endotracheal intubation were higher for patients with associated anomalies than for other patients before 24 months of age (10.2 vs. 4.0%, 67 vs. 33%, and 39 vs. 4.2%, p = 0.004, 0.06, 0.013, respectively).Conclusion: Children with abnormalities, especially genetic syndromes and lung/airway problems associated with CHD, are at high risk for RSV-related hospitalization. Our current subtropical guidelines for palivizumab prophylaxis in patients with hsCHD, should be revised to include the results of this study.

The impact of medical interventions on admission characteristics in children with congenital heart disease and cardiomyopathy

2020 ◽  
pp. 1-8
Author(s):  
Rohit S. Loomba ◽  
Jacqueline Rausa ◽  
Vincent Dorsey ◽  
Ronald A. Bronicki ◽  
Enrique G. Villarreal ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Length Of Stay ◽  
Congenital Heart ◽  
Unit Length ◽  
Channel Blockers ◽  
Regression Analyses ◽  
Converting Enzyme Inhibitors ◽  
Medical Interventions ◽  
The Impact

Abstract Introduction: Children with congenital heart disease and cardiomyopathy are a unique patient population. Different therapies continue to be introduced with large practice variability and questionable outcomes. The purpose of this study is to determine the impact of various medications on intensive care unit length of stay, total length of stay, billed charges, and mortality for admissions with congenital heart disease and cardiomyopathy. Materials and methods: We identified admissions of paediatric patients with cardiomyopathy using the Pediatric Health Information System database. The admissions were then separated into two groups: those with and without inpatient mortality. Univariate analyses were conducted between the groups and the significant variables were entered as independent variables into the regression analyses. Results: A total of 10,376 admissions were included these analyses. Of these, 904 (8.7%) experienced mortality. Comparing patients who experienced mortality with those who did not, there was increased rate of acute kidney injury with an odds ratio (OR) of 5.0 [95% confidence interval (CI) 4.3 to 5.8, p < 0.01], cardiac arrest with an OR 7.5 (95% CI 6.3 to 9.0, p < 0.01), and heart transplant with an OR 0.3 (95% CI 0.2 to 0.4, p < 0.01). The medical interventions with benefit for all endpoints after multivariate regression analyses in this cohort are methylprednisolone, captopril, enalapril, furosemide, and amlodipine. Conclusions: Diuretics, steroids, angiotensin-converting enzyme inhibitors, calcium channel blockers, and beta blockers all appear to offer beneficial effects in paediatric cardiomyopathy admission outcomes. Specific agents within each group have varying effects.

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