scholarly journals The impact of vascular comorbidities on qualitative error analysis of executive impairment in Alzheimer’s disease

2009 ◽  
Vol 16 (1) ◽  
pp. 77-83 ◽  
Author(s):  
MELISSA LAMAR ◽  
DAVID J. LIBON ◽  
ANGELA V. ASHLEY ◽  
JAMES J. LAH ◽  
ALLAN I. LEVEY ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Error Analysis ◽  
Vascular Diseases ◽  
Zero Point ◽  
Adult Intelligence Scale ◽  
Wechsler Adult Intelligence Scale ◽  
Caregiver Education ◽  
Wechsler Adult Intelligence ◽  
The Impact

AbstractRecent evidence suggests that patients with Alzheimer’s disease (AD) and vascular comorbidities (VC) perform worse across measures of verbal reasoning and abstraction when compared to patients with AD alone. We performed a qualitative error analysis of Wechsler Adult Intelligence Scale-III Similarities zero-point responses in 45 AD patients with varying numbers of VC, including diabetes, hypertension, and hypercholesterolemia. Errors were scored in set if the answer was vaguely related to how the word pair was alike (e.g., dog-lion: “they can be trained”) and out of set if the response was unrelated (“a lion can eat a dog”). AD patients with 2–3 VC did not differ on Similarities total score or qualitative errors from AD patients with 0–1 VC. When analyzing the group as a whole, we found that increasing numbers of VC were significantly associated with increasing out of set errors and decreasing in set errors in AD. Of the vascular diseases investigated, it was only the severity of diastolic blood pressure that significantly correlated with out of set responses. Understanding the contribution of VC to patterns of impairment in AD may provide support for directed patient and caregiver education concerning the presentation of a more severe pattern of cognitive impairment in affected individuals. (JINS, 2010, 16, 77–83.)

Discrepancies between Premorbid and Current IQ as a Function of Progressive Mental Deterioration

2005 ◽  
Vol 100 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Francis McCarthy ◽  
William J. Burns ◽  
Alfred H. Sellers
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Reading Tests ◽  
Adult Intelligence Scale ◽  
Wechsler Adult Intelligence Scale ◽  
Wide Range Achievement Test ◽  
Wide Range ◽  
Adult Reading ◽  
Severity Of The Disease ◽  
Wechsler Adult Intelligence

The declining cognitive functioning typically found in patients with Alzheimer's disease presents an opportunity to study that decline. The changing magnitude of ever widening discrepancies between premorbid estimators of IQ and observed IQ increases as severity of the disease increases. Premorbid IQs estimated by these scores (the National Adult Reading Test–Revised, the reading tests of the Revised and Third Editions of the Wide Range Achievement Test, and a demographically based regression index for the Wechsler Adult Intelligence Scale–Revised) had relatively similar discrepancies from obtained WAIS–R Full Scale IQs in samples of normal elderly ( n = 30), and elderly patients diagnosed with mild ( n = 30) and moderate Alzheimer's disease ( n = 30) dementia. The discrepancies became larger, regardless of premorbid estimator, as disease severity progressed from none to mild to moderate across the samples.

scholarly journals ACCURACY OF NEUROPSYCHOLOGICAL TESTS IN PATIENTS WITH BIOLOGICAL DIAGNOSIS OF ALZHEIMER’S DISEASE

2021 ◽  
Author(s):  
Patrícia Peles ◽  
Larissa Salvador ◽  
Luciano Mariano ◽  
Viviane Carvalho ◽  
Clarisse Frieldlaender ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuropsychological Tests ◽  
Rating Scale ◽  
Digit Span ◽  
Verbal Learning ◽  
High Sensitivity ◽  
High Specificity ◽  
Adult Intelligence Scale ◽  
Wechsler Adult Intelligence Scale

Background: Neuropsychological tests are important tools for the diagnosis of mild cognitive impairment or dementia due to Alzheimer’s disease (AD). Objective: To investigate the accuracy of common neuropsychological tests used in the clinical setting for AD diagnosis. Methods: Forty two patients with diagnosis of AD continuum [A+T+/-(N)+/-] and 32 non-AD [A-T+/-(N)+/-]. All participants were submitted to a thorough neuropsychological assessment with the following instruments: Mattis Dementia Rating Scale (DRS), Rey’s Auditory Verbal Learning Test (RAVLT), Boston naming-Consortium to Establish a Registry for Alzheimer’s Disease, a reduced version of the CERAD, Digit Span Forward (DSF), Digit Span Backward (DSB) and Cubes from The Wechsler Adult Intelligence Scale (WAIS), verbal fluency – animals (VF-A), and FAS. Results: Memory (MEM) and Initiation/Perseveration (I/P) subscales of the DRS, FAS, Digit Span Backward (DSB) and Boston naming displayed good discrimination between AD and non-AD patients. The MEM subscale of the DRS, RAVLT A6 and FAS presented high sensitivity (90% or more) for AD diagnosis, while DSF displayed high specificity. Non-AD patients had greater difficulty in FAS, DSB and in Boston naming. Conclusion: Performance of patients with biological diagnosis of AD on MEM and I/P of DRS, and RAVLT A7 was significantly different from that of non-AD subjects.

Geschlechtseffekte bei Intelligenz- und Gedächtnisleistungen

2015 ◽  
Vol 26 (1) ◽  
pp. 5-16 ◽  
Author(s):  
Anja C. Lepach ◽  
Wiebke Reimers ◽  
Franz Pauls ◽  
Franz Petermann ◽  
Monika Daseking
Keyword(s):  
Adult Intelligence Scale ◽  
Intelligence Scale ◽  
Wechsler Adult Intelligence Scale ◽  
Adult Intelligence ◽  
Wechsler Memory Scale ◽  
Wechsler Adult Intelligence

Diese Studie untersucht die Zusammenhänge von Intelligenz- und Gedächtnisleistungen in der Wechsler Adult Intelligence Scale-IV und der Wechsler Memory Scale-IV unter Berücksichtigung des Geschlechts (N = 137 Gesunde, 63 w/74 m). Ein Vorteil der weiblichen Testpersonen im verbalen episodischen Gedächtnis sowie in einzelnen Aufgaben zur Verarbeitungsgeschwindigkeit konnte beobachtet werden. Die männlichen Testpersonen schnitten in den Untertests Allgemeines Wissen und Visuelle Puzzles besser ab. Wie gut Gedächtnisleistungen Intelligenzleistungen erklären beziehungsweise vorhersagen, ist aufgrund unserer Ergebnisse nicht nur abhängig von den Aufgaben, sondern auch vom Geschlecht.

Analyse von Querschnittsdaten zur Intelligenzentwicklung im Erwachsenenalter: eine Studie zur deutschsprachigen Version der WAIS-IV

2013 ◽  
Vol 24 (3) ◽  
pp. 149-160 ◽  
Author(s):  
Monika Daseking ◽  
Franz Petermann
Keyword(s):  
Fourth Edition ◽  
Adult Intelligence Scale ◽  
Intelligence Scale ◽  
Wechsler Adult Intelligence Scale ◽  
Adult Intelligence ◽  
Wechsler Adult Intelligence ◽  
Deutschsprachige Version

Im vorliegenden Beitrag wird der Datensatz (N = 1664), aus dem auch die Normstichprobe für die deutschsprachige Version der Wechsler Adult Intelligence Scale – Fourth Edition (WAIS-IV) gezogen wurde, nach altersabhängigen Veränderungen kognitiver Fähigkeiten analysiert. Die niedrigsten Rohwertmittelwerte werden in der ältesten Altersgruppe erreicht, die Leistungsspitzen finden sich überwiegend im Altersbereich zwischen 20 und 29 Jahren. In den Untertests der Indizes Wahrnehmungsgebundenes Logisches Denken und Verarbeitungsgeschwindigkeit kommt es zu einer bedeutsamen Leistungsabnahme mit zunehmendem Alter: In der ältesten Altersgruppe werden nur noch zwischen 50 und 60 % der Rohwertmittelwerte der leistungsstärksten Altersgruppe erreicht. Gleichzeitig nimmt die Heterogenität in der Rohwertverteilung zu. Für die Indizes Sprachverständnis und Arbeitsgedächtnis fallen beide Effekte deutlich niedriger aus.

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