Intakes of magnesium, calcium and risk of fatty liver disease and prediabetes

AbstractObjectiveObesity and insulin resistance play important roles in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Mg intake is linked to a reduced risk of metabolic syndrome and insulin resistance; people with NAFLD or alcoholic liver disease are at high risk of Mg deficiency. The present study aimed to investigate whether Mg and Ca intakes were associated with risk of fatty liver disease and prediabetes by alcohol drinking status.DesignWe analysed the association between Ca or Mg intake and fatty liver disease, prediabetes or both prediabetes and fatty liver disease in cross-sectional analyses.SettingThird National Health and Nutrition Examination Survey (NHANES III) follow-up cohort of US adults.SubjectsNationally representative sample of US adults in NHANES (n 13 489).ResultsAfter adjusting for potential confounders, Mg intake was associated with approximately 30 % reduced odds of fatty liver disease and prediabetes, comparing the highest intake quartile v. the lowest. Mg intake may only be related to reduced odds of fatty liver disease and prediabetes in those whose Ca intake is less than 1200 mg/d. Mg intake may also only be associated with reduced odds of fatty liver disease among alcohol drinkers.ConclusionsThe study suggests that high intake of Mg may be associated with reduced risks of fatty liver disease and prediabetes. Further large studies, particularly prospective cohort studies, are warranted to confirm the findings.

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Frequency of pre-diabetes, diabetes mellitus in non-alcoholic fatty liver disease.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.08.4617 ◽

2020 ◽

Vol 27 (08) ◽

pp. 1703-1709

Author(s):

Rakhshinda Jabeen ◽

Ahsan Mobin ◽

Khalid Mehmood ◽

Syed Tajammul Ali

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Control Group ◽

Metabolic Parameter ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Objectives: To determine the prevalence of diabetes mellitus and pre-diabetes among patients with NAFLD having BMI ≥ 25 kg/m2and compare it with the control group with non-fatty liver with same BMI. Study Design: Prospective, Analytical and Cross-sectional study. Setting: Department of Medicine, Civil Hospital Karachi. Period: January 2015 to October 2016. Material & Methods: The study was conducted among two groups of patients, one with non-alcoholic fatty liver disease (NAFLD), having BMI of ≥25kg/m2and they were compared with a control group having BMI≥25kg/m2 but without fatty liver on ultrasound. Result: Out of 201 NAFLD participants, 82.08% had pre-diabetes and diabetes mellitus, while 82.51% of participants from non-NAFLD (n=101) had pre-diabetes or diabetes mellitus. Insulin resistance was more common among non-NAFLD group than NAFLD group. Most of the metabolic parameter analysed in the study among two groups having slight difference, and they were statistically significant. Conclusion: Pre-diabetes and diabetes mellitus is a frequently reported problem among NAFLD and overweight/obese patients. Insulin resistance was found to be a significant predictor of diabetes mellitus.

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Abstract P141: Non-alcoholic Fatty Liver Disease, Insulin Resistance, and the Risk of Incident Ischemic Heart Disease and Stroke - The Kangbuk Samsung Health Study

Circulation ◽

10.1161/circ.131.suppl_1.p141 ◽

2015 ◽

Vol 131 (suppl_1) ◽

Author(s):

Yoosoo Chang ◽

Seungho Ryu ◽

Juhee Cho ◽

Sanjay Rampal ◽

Yiyi Zhang ◽

...

Keyword(s):

Insulin Resistance ◽

Heart Disease ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Health Study ◽

Model Assessment ◽

Alcoholic Fatty Liver ◽

Hazard Ratios

Objective: Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance (IR) and with other metabolic abnormalities, but the association of NAFLD with the risk of clinical cardiovascular disease (CVD) is controversial. Furthermore, the risk associated with the combination of NAFLD and IR has not been evaluated in prospective studies. The aim of this study was to evaluate the association of NAFLD with or without IR on the incidence of coronary heart disease (CHD) and stroke. Methods: We performed a cohort study in 166,126 adults without CVD at baseline who underwent a health checkup exam during 2008 - 2011 and were followed-up through December 31, 2012 (average follow-up of 3.2 years). NAFLD was defined as hepatic steatosis on ultrasonography in the absence of excessive alcohol use or other identifiable causes. IR was defined as a homeostasis model assessment of IR (HOMA-IR) value ≥ 2.5. Incident hospitalizations for CHD events and strokes were ascertained through data linkage with the Korean Health Insurance Review and Assessment Service (HIRA) database. Results: At baseline, the prevalence of NAFLD and of IR were 25.1 and 6.3%, respectively. During follow-up, 831 participants developed CHD and 582 subjects developed stroke. After adjusting for age, sex, center, year of screening exam, BMI, smoking, alcohol intake, physical activity, family history of CVD, and education, the hazard ratios (95 % confidence intervals) for CHD comparing NAFLD without IR, IR without NAFLD, and NAFLD with IR vs. no NAFLD without IR were 1.07 (0.91 - 1.27), 1.19 (0.74 - 1.91) and 1.55 (1.18 - 2.03), respectively. The corresponding hazard ratios for stroke were 0.93 (0.75 - 1.16), 1.40 (0.83 - 2.35) and 1.82 (1.32 - 2.52), respectively. The P-values for the interaction of NAFLD and IR for CHD and stroke were 0.48 and 0.28, respectively. These associations did not differ by clinically relevant subgroups. Conclusions: The combination of NAFLD and IR was associated with an increased incidence of CHD and of stroke, but this was not observed in those with either NAFLD or IR alone. The combination of NAFLD and IR may identify individuals at high cardiometabolic risk who may need to receive more intensive preventive intervention.

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Relationship between non-alcoholic fatty liver disease, metabolic syndrome and insulin resistance in Korean adults: A cross-sectional study

Clinica Chimica Acta ◽

10.1016/j.cca.2016.03.018 ◽

2016 ◽

Vol 458 ◽

pp. 12-17 ◽

Cited By ~ 7

Author(s):

Ji Young Kim ◽

Choae Lee ◽

Minsuk Oh ◽

Jee-Aee Im ◽

Ji-Won Lee ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Glucose intolerance and insulin resistance in non-alcoholic fatty liver disease: A Hospital-based Cross-sectional Study from Southern Karnataka, India

Journal of Diabetology ◽

10.4103/jod.jod_12_17 ◽

2017 ◽

Vol 8 (3) ◽

pp. 68

Author(s):

Sudha Vidyasagar ◽

Thomas Mathew ◽

MuralidharDantuluru Varma ◽

B Nandakrishna ◽

AvinashManjunath Holla ◽

...

Keyword(s):

Insulin Resistance ◽

Liver Disease ◽

Fatty Liver ◽

Glucose Intolerance ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Non-Alcoholic Fatty Liver Disease in Overweight Children and its Relationship with Retinol Serum Levels

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.78.1.27 ◽

2008 ◽

Vol 78 (1) ◽

pp. 27-32 ◽

Cited By ~ 15

Author(s):

Suano de Souza ◽

Silverio Amancio ◽

Saccardo Sarni ◽

Sacchi Pitta ◽

Fernandes ◽

...

Keyword(s):

Insulin Resistance ◽

Liver Disease ◽

Fatty Liver ◽

Lipid Profile ◽

Fatty Liver Disease ◽

Thiobarbituric Acid ◽

Serum Levels ◽

Control Group ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Objectives: To evaluate the frequency of non-alcoholic fatty liver disease, the retinol serum levels, lipid profile, and insulin resistance in overweight/obese children. To relate these biochemical variables with the risk of this disease in the population studied. Methods: The study was cross-sectional and prospective, with 46 overweight/obese school children (28 female, 18 male; mean age 8.6 years). The control group consisted of 45 children, paired by age and gender. Hepatic steatosis, evaluated by ultrasound, was classified as normal, mild, moderate, or severe. Also evaluated were serum retinol levels; thiobarbituric acid reactive substances; lipid profile; and fasting glucose and serum insulin levels, used for the calculation of the Homeostasis Model Assessment. Results: Hepatic ultrasound alterations were found in 56.5% and 48,9% of the overweight/obese and control group children, respectively. Presence of obesity was associated with high levels of triglycerides (OR = 4.6; P = 0.002). In the studied children, the risk of steatosis was related to a trend to a higher percentage of retinol inadequacy (OR = 2.8; p = 0.051); there was no association with thiobarbituric acid reactive substances, lipid profile, or insulin resistance. Conclusions: The high frequency of non-alcoholic fatty liver disease in both groups, evaluated by hepatic ultrasound, in low-socioeconomic level children, independent of nutritional condition and without significant association with insulin resistance, emphasizes that especially in developing countries, other risk factors such as micronutrient deficiencies (e.g. vitamin A) are involved.

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