Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk

2020 ◽  
pp. 1-8
Author(s):  
Ju Eun Seol ◽  
Jeongseon Kim ◽  
Bong-Hwa Lee ◽  
Dae-Yong Hwang ◽  
Jinyoung Jeong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Alcohol Intake ◽  
Case Control Study ◽  
Case Control ◽  
Potential Interaction ◽  
University Hospitals ◽  
Logistic Regression Models ◽  
Asian Populations ◽  
Control Study

Abstract Objective: There is limited evidence on the interaction by alcohol dehydrogenase 2 (ADH1B) (rs1229984) and aldehyde dehydrogenase 2 (ALDH2) (rs671) regarding the associations of alcohol and a methyl diet (low folate and high alcohol intake) with cancer risk, partly because of rare polymorphisms in Western populations. Design: In a case–control study, we estimated the ORs and 95 % CIs to evaluate the associations of ADH1B and ALDH2 genotypes with colorectal cancer (CRC) and the joint association between methyl diets and ADH1B and ALDH2 polymorphisms with CRC risk using logistic regression models. Setting: A hospital-based case–control study. Participants: In total, 1001 CRC cases and 899 cancer-free controls admitted to two university hospitals. Results: We found that alcohol intake increased the risk of CRC; OR (95 % CI) was 2·02 (1·41, 2·87) for ≥60 g/d drinkers compared with non-drinkers (Ptrend < 0·001). The associations for two polymorphisms with CRC were not statistically significant. However, we found a potential interaction of ALDH2 with methyl diets and CRC. We observed a 9·08-fold (95 % CI 1·93, 42·60) higher risk of CRC for low-methyl diets compared with high-methyl diets among individuals with an A allele of ALDH2, but the association was not apparent among those with ALDH2 GG (Pinteraction = 0·02). Conclusions: Our data support the evidence that gene–methyl diet interactions may be involved in CRC risk in East Asian populations, showing that a low-methyl diet increased the risk of CRC among individuals with an A allele of ALDH2.

scholarly journals High consumption of vegetable and fruit colour groups is inversely associated with the risk of colorectal cancer: a case–control study

2015 ◽  
Vol 113 (7) ◽  
pp. 1129-1138 ◽  
Author(s):  
Wei-Ping Luo ◽  
Yu-Jing Fang ◽  
Min-Shan Lu ◽  
Xiao Zhong ◽  
Yu-Ming Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Vegetable Intake ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Fruit Colour ◽  
Logistic Regression Models ◽  
Orange Yellow ◽  
Control Study

The colour of the edible portion of vegetables and fruit reflects the presence of specific micronutrients and phytochemicals. No existing studies have examined the relationship between the intake of vegetable and fruit colour groups and the risk of colorectal cancer. The present study, therefore, aimed to investigate these associations in a Chinese population. A case–control study was conducted between July 2010 and July 2014 in Guangzhou, China, in which 1057 consecutively recruited cases of colorectal cancer were frequency-matched to 1057 controls by age (5-year interval), sex and residence (rural/urban). A validated FFQ was used to collect dietary information during face-to-face interviews. Vegetables and fruit were classified into four groups according to the colour of their primarily edible parts: green; orange/yellow; red/purple; white. Unconditional logistic regression models were used to estimate the OR and 95 % CI. A higher consumption of orange/yellow, red/purple and white vegetables and fruit was inversely associated with the risk of colorectal cancer, with adjusted OR of 0·16 (95 % CI 0·12, 0·22) for orange/yellow, 0·23 (95 % CI 0·17, 0·31) for red/purple and 0·53 (95 % CI 0·40, 0·70) for white vegetables and fruit when the highest and lowest quartiles were compared. Total vegetable intake and total fruit intake have also been found to be inversely associated with colorectal cancer risk. However, the intake of green vegetable and fruit was not associated with colorectal cancer risk. The results of the present study, therefore, suggest that a greater intake of orange/yellow, red/purple and white vegetables and fruit is inversely associated with the risk of colorectal cancer.

scholarly journals REPRODUCTIVE FACTORS AND COLORECTAL CANCER RISK. Case - control study.

2014 ◽  
Vol 21 (1) ◽  
pp. 694-698
Author(s):  
Adriana Ruseva ◽  
◽  
Radka Lazarova ◽  
Ilko Kosturkov ◽  
Vesselina Ianachkova ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Reproductive Factors ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Control Study

scholarly journals Diabetes Mellitus and Site-specific Colorectal Cancer Risk in Korea: A Case-control Study

2015 ◽  
Vol 49 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Hyeongtaek Woo ◽  
Jeeyoo Lee ◽  
Jeonghee Lee ◽  
Ji Won Park ◽  
Sungchan Park ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Site Specific ◽  
Control Study

scholarly journals 0058 Colorectal cancer risk and shift work in a population-based case-control study in Spain (MCC-Spain)

2014 ◽  
Vol 71 (Suppl 1) ◽  
pp. A5.3-A6 ◽  
Author(s):  
Kyriaki Papantoniou ◽  
Manolis Kogevinas ◽  
Vicente Martin Sanchez ◽  
Victor Moreno ◽  
Marina Pollan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Shift Work ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Control Study

scholarly journals Association between shiftwork and the risk of colorectal cancer in females: a population-based case–control study

2018 ◽  
Vol 75 (5) ◽  
pp. 344-350 ◽  
Author(s):  
Wa Mwenga Walasa ◽  
Renee N Carey ◽  
Si Si ◽  
Lin Fritschi ◽  
Jane S Heyworth ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Early Morning ◽  
Population Based ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Adverse Health Outcomes ◽  
Increased Risk ◽  
Control Study

ObjectiveResearch indicates that shiftwork may be associated with increased risks of adverse health outcomes, including some cancers. However, the evidence of an association between shiftwork and colorectal cancer risk is limited and inconclusive. Further, while several possible pathways through which shiftwork might result in cancer have been proposed, few studies have taken these factors into account. We investigated the association between two types of shiftwork (graveyard shiftwork and early-morning shiftwork) and six mechanistic shiftwork variables (including light at night and phase shift) and the risk of colorectal cancer among females in an Australian population-based case–control study. Graveyard shiftwork was the primary exposure of interest.MethodsParticipants (350 cases and 410 controls) completed a lifetime occupational history, and exposure to each of the eight shiftwork variables was assigned to participants through a job exposure matrix. We used logistic regression to calculate odds ratios (OR) and corresponding 95% confidence intervals (CI) for the association between different shiftwork variables and the risk of colorectal cancer, adjusting for potential demographic, lifestyle and medical confounders.ResultsWorking in an occupation involving long-term exposure (>7.5 years) to graveyard shiftwork was not associated with colorectal cancer risk (adjusted OR 0.95, 95% CI 0.57 to 1.58). Similarly, no increased risks of colorectal cancer were seen for any of the other seven shiftwork variables examined.ConclusionsNo evidence of an increased risk of colorectal cancer among females who had worked in occupations involving shiftwork was observed in this study.

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