Long-term outcome after gamma knife radiosurgery of advanced jugulotympanic glomus tumour: a case report

AbstractAimJugulotympanic glomus tumours (JTGT) are highly vascular neoplasms composed of paraganglionic tissue of neural crest origin. Because of the neoplasm’s slow growth potential, any claimed efficacy associated with applied treatment must be supported by long-term effects observed in patients.MethodologyThis report presents a case of advanced stage JTGT in a 66-year-old woman treated by γ knife radiosurgery (GKRS).ResultsSustained tumour control with preservation of lower cranial nerve function was observed for more than 10 years after completion of treatment.ConclusionGKRS even with large intracranial extension of JTGT in patients may help to achieve long-term disease control with minimal morbidity.

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Long-Term Outcome after Aggressive Surgical Resection of Clival Chordomas and Gamma Knife Radiosurgery for Recurrences

Skull Base ◽

10.1055/s-2007-983997 ◽

2007 ◽

Vol 17 (S 1) ◽

Author(s):

Kiyoshi Saito ◽

Tetsuya Nagatani ◽

Yuri Aimi ◽

Masahiro Ichikawa ◽

Jun Yoshida

Keyword(s):

Surgical Resection ◽

Gamma Knife ◽

Gamma Knife Radiosurgery ◽

Term Outcome ◽

Long Term Outcome

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Residual hip dysplasia: is there a place for hip shelf operation?

Journal of Children s Orthopaedics ◽

10.1302/1863-2548.12.180042 ◽

2018 ◽

Vol 12 (4) ◽

pp. 358-363 ◽

Cited By ~ 3

Author(s):

T. Terjesen

Keyword(s):

Periacetabular Osteotomy ◽

Developmental Dysplasia ◽

Hip Pain ◽

Older Children ◽

Long Term Effects ◽

Term Outcome ◽

Long Term Outcome ◽

Shelf Procedure ◽

Shelf Operation

Purpose After modern acetabular osteotomies were introduced, hip shelf operations have become much less commonly used. The aims of this study were to assess the short-term and long-term outcome of a modified Spitzy shelf procedure and to compare the results with those of periacetabular osteotomy (PAO). Methods In all, 44 patients (55 hips) with developmental dysplasia of the hip and residual dysplasia had a modified Spitzy shelf operation. Mean age at surgery was 13.2 years (8 to 22). Indication for surgery was a centre-edge angle < 20° with or without hip pain. Outcome was evaluated using duration of painless period and survival analysis with conversion to total hip arthroplasty (THA) as endpoints. Results Preoperative hip pain was present in 46% of the hips and was more common in patients ≥ 12 years at surgery (p < 0.001). One year postoperatively, 93% of the hips were painless. Analysis of pain in hips with more than ten years follow-up showed a mean postoperative painless period of 20.0 years (0 to 49). In all, 44 hips (80%) had undergone THA at a mean patient age of 50.5 years (37 to 63). Mean survival of the shelf procedure (time from operation to THA) was 39.3 years (21 to 55). Conclusions The Spitzy operation had good short and long-term effects on hip pain and a 30-year survival (no THA) of 72% of the hips. These results compare favourably with those of PAO and indicate that there is still a place for the shelf procedure in older children and young adults.

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Management and Long-term Outcome of Adenoid Cystic Carcinoma with Intracranial Extension: A Neurosurgical Perspective

Neurosurgery ◽

10.1097/00006123-199606000-00008 ◽

1996 ◽

Vol 38 (6) ◽

pp. 1105-1113 ◽

Cited By ~ 5

Author(s):

William B. Gormely ◽

Laligam N. Sekhar ◽

Donald C. Wright ◽

Micheal Olding ◽

Ivo P. Janecka ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Intracranial Extension ◽

Term Outcome ◽

Long Term Outcome ◽

Adenoid Cystic

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Evaluation of long-term outcome and prognostic factors of feline squamous cell carcinomas treated with photodynamic therapy using liposomal phosphorylated meta-tetra(hydroxylphenyl)chlorine

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x17752196 ◽

2018 ◽

Vol 20 (12) ◽

pp. 1100-1104 ◽

Cited By ~ 2

Author(s):

Irene Flickinger ◽

Eva Gasymova ◽

Simona Dietiker-Moretti ◽

Alexander Tichy ◽

Carla Rohrer Bley

Keyword(s):

Photodynamic Therapy ◽

Prognostic Factors ◽

Squamous Cell ◽

Tumour Response ◽

Dose Intensity ◽

Treatment Intensity ◽

Term Outcome ◽

Long Term Outcome ◽

Tumour Control

Objectives The aim of this study was to evaluate the efficacy, long-term outcome and prognostic factors of feline squamous cell carcinoma (SCC) treated with photodynamic therapy (PDT). Methods Cats with histologically verified SCC of the head and neck received an intravenous injection of liposomal phosphorylated meta-tetra(hydroxylphenyl)chlorine (mTHPC) and 4 h later 652 nm light was delivered by a diode laser. One group received ⩽10 J/cm2, the other 20 J/cm2. Tumour response and duration were analysed with stage, tumour diameter, location and treatment intensity as prognostic factors. Results In total, 63 lesions in 38 cats underwent treatment with ⩽10 J/cm2 (n = 22) and 20 J/cm2 (n = 41). Overall response rate was 84% (complete remission 61%, partial remission 22%) with a mean progression-free interval of 35 months (median not reached) and a median overall survival time of 40 months (95% confidence interval 33–47). With regard to tumour stage, invasiveness yielded a highly significant worse outcome ( P <0.017). All patients with invasive tumours showed progression at less than 6 months. Larger lesions were associated with inferior control and treatment intensity, and tumour location did not influence response and duration. Conclusions and relevance PDT using a systemic photosensitiser leads to excellent long-term tumour control in the majority of cats. However, invasive and large tumours had a clearly inferior outcome, even if treated with the higher-dose intensity. This suggests that advanced lesions are not indications for PDT.

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Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis

The British Journal of Psychiatry ◽

10.1192/bjp.bp.113.127753 ◽

2014 ◽

Vol 205 (2) ◽

pp. 88-94 ◽

Cited By ~ 278

Author(s):

Matti Penttilä ◽

Erika Jääskeläinen ◽

Noora Hirvonen ◽

Matti Isohanni ◽

Jouko Miettunen

Keyword(s):

Negative Symptoms ◽

Meta Analysis ◽

Hospital Treatment ◽

Duration Of Untreated Psychosis ◽

Long Term Effects ◽

Term Outcome ◽

Long Term Outcome ◽

Positive Effects ◽

Early Intervention In Psychosis

BackgroundDuration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear.AimsTo analyse the associations between DUP and long-term outcomes of schizophrenia.MethodA systematic literature search was performed using seven electronic databases and manual searches. Random effects weighted meta-analysis with correlation coefficients was used to pool the results.ResultsWe identified 3493 unique publications, from which 33 samples met our predefined selection criteria. Long DUP correlated statistically significantly with poor general symptomatic outcome, more severe positive and negative symptoms, lesser likelihood of remission and poor social functioning and global outcome (correlations 0.13–0.18). Long DUP was not associated with employment, quality of life or hospital treatment.ConclusionsThe small but mostly consistent correlation between long DUP and poor outcome indicates that early intervention in psychosis may have at least subtle positive effects on the long-term course of illness.

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Long term outcome of Gamma Knife radiosurgery for metastatic brain tumors

Journal of Clinical Neuroscience ◽

10.1016/j.jocn.2014.05.015 ◽

2014 ◽

Vol 21 (12) ◽

pp. 2122-2128 ◽

Cited By ~ 2

Author(s):

Shyamal C. Bir ◽

Sudheer Ambekar ◽

Anil Nanda

Keyword(s):

Brain Tumors ◽

Gamma Knife ◽

Gamma Knife Radiosurgery ◽

Metastatic Brain Tumors ◽

Term Outcome ◽

Long Term Outcome

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Long-Term Outcome of Gamma Knife Radiosurgery for Symptomatic Brainstem Cavernous Malformation

World Neurosurgery ◽

10.1016/j.wneu.2018.05.164 ◽

2018 ◽

Vol 116 ◽

pp. e1054-e1059 ◽

Cited By ~ 2

Author(s):

Kawngwoo Park ◽

Jin Wook Kim ◽

Hyun-Tai Chung ◽

Sun Ha Paek ◽

Dong Gyu Kim

Keyword(s):

Gamma Knife ◽

Cavernous Malformation ◽

Gamma Knife Radiosurgery ◽

Term Outcome ◽

Long Term Outcome ◽

Brainstem Cavernous Malformation

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Long-Term Effects of the Treatment of Depressive Female Inpatients in a Naturalistic Study: Is Early Improvement a Valid Predictor of Outcome?

Depression Research and Treatment ◽

10.1155/2014/780237 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8

Author(s):

Elian Zuercher-Huerlimann ◽

Martin grosse Holtforth ◽

Ernst Hermann

Keyword(s):

Binary Logistic Regression ◽

Inpatient Setting ◽

Long Term Effects ◽

Term Outcome ◽

Long Term Outcome ◽

Early Improvement ◽

Valid Predictor ◽

Short And Long Term

Objectives.To examine the predictive value of early improvement for short- and long-term outcome in the treatment of depressive female inpatients and to explore the influence of comorbid disorders (CD).Methods.Archival data of a naturalistic sample of 277 female inpatients diagnosed with a depressive disorder was analyzed assessing the BDI at baseline, after 20 days and 30 days, posttreatment, and after 3 to 6 months at follow-up. Early improvement, defined as a decrease in the BDI score of at least 30% after 20 and after 30 days, and CD were analyzed using binary logistic regression.Results.Both early improvement definitions were predictive of remission at posttreatment. Early improvement after 30 days showed a sustained treatment effect in the follow-up phase, whereas early improvement after 20 days failed to show a persistent effect regarding remission at follow-up. CD were not significantly related neither at posttreatment nor at follow-up. At no time point CD moderated the prediction by early improvement.Conclusions.We show that early improvement is a valid predictor for short-term remission and at follow-up in an inpatient setting. CD did not predict outcome. Further studies are needed to identify patient subgroups amenable to more tailored treatments.

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