Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

Genetic and epigenetic changes alter gene expression, contributing to cancer. Epigenetic changes in cancer arise from alterations in DNA and histone modifications that lead to tumour suppressor gene silencing and the activation of oncogenes. The acetylation status of histones and non-histone proteins are determined by the histone deacetylases and histone acetyltransferases that control gene transcription. Organoselenium compounds have become promising contenders in cancer therapeutics. Apart from their anti-oxidative effects, several natural and synthetic organoselenium compounds and metabolites act as histone deacetylase inhibitors, which influence the acetylation status of histones and non-histone proteins, altering gene transcription. This review aims to summarise the effect of natural and synthetic organoselenium compounds on histone and non-histone protein acetylation/deacetylation in cancer therapy.

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Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni

Molecular and Biochemical Parasitology ◽

10.1016/j.molbiopara.2009.06.001 ◽

2009 ◽

Vol 168 (1) ◽

pp. 7-15 ◽

Cited By ~ 69

Author(s):

Florence Dubois ◽

Stéphanie Caby ◽

Frédérik Oger ◽

Céline Cosseau ◽

Monique Capron ◽

...

Keyword(s):

Schistosoma Mansoni ◽

Histone Deacetylase ◽

Gene Transcription ◽

Histone Deacetylase Inhibitors ◽

Histone Hyperacetylation

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Histone Deacetylase Inhibitors Upregulate Natriuretic Peptide Receptor‐A Gene Transcription via Histone Modifications and Sp1 Acetylation

The FASEB Journal ◽

10.1096/fasebj.27.1_supplement.550.10 ◽

2013 ◽

Vol 27 (S1) ◽

Author(s):

Prerna Kumar ◽

Smitha Neerukonda ◽

Vickie Nguyen ◽

Kailash N Pandey

Keyword(s):

Histone Deacetylase ◽

Natriuretic Peptide ◽

Gene Transcription ◽

Histone Modifications ◽

Histone Deacetylase Inhibitors ◽

Natriuretic Peptide Receptor ◽

Peptide Receptor ◽

Natriuretic Peptide Receptor A

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Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells

Frontiers in Immunology ◽

10.3389/fimmu.2021.690207 ◽

2021 ◽

Vol 12 ◽

Author(s):

Yudan Cui ◽

Jingshan Cai ◽

Wenxin Wang ◽

Shengjun Wang

Keyword(s):

Tumor Microenvironment ◽

Tumor Cells ◽

Histone Deacetylase ◽

Gene Transcription ◽

Histone Deacetylase Inhibitors ◽

Suppressor Cells ◽

Antitumor Drugs ◽

Clinical Settings ◽

Myeloid Derived Suppressor Cells ◽

Regulatory Effects

Histone deacetylase inhibitors (HDACIs) are antitumor drugs that are being developed for use in clinical settings. HDACIs enhance histone or nonhistone acetylation and promote gene transcription via epigenetic regulation. Importantly, these drugs have cytotoxic or cytostatic properties and can directly inhibit tumor cells. However, how HDACIs regulate immunocytes in the tumor microenvironment, such as myeloid-derived suppressor cells (MDSCs), has yet to be elucidated. In this review, we summarize the effects of different HDACIs on the immunosuppressive function and expansion of MDSCs based on the findings of relevant studies.

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