The Colorado Twin Registry: 2019 Update

2019 ◽  
Vol 22 (6) ◽  
pp. 707-715 ◽  
Author(s):  
Robin P. Corley ◽  
Chandra A. Reynolds ◽  
Sally J. Wadsworth ◽  
Sally-Ann Rhea ◽  
John K. Hewitt
Keyword(s):  
Human Genetics ◽  
Longitudinal Research ◽  
Population Based ◽  
Twin Research ◽  
Research Opportunities ◽  
Twin Registry ◽  
History Of ◽  
Population Based Registry ◽  
School Records

AbstractThe Colorado Twin Registry (CTR) is a population-based registry formed from birth and school records including twins born between 1968 and the present. Two previous reports on the CTR [Rhea et al., (2006). Twin Research and Human Genetics, 9, 941–949; Rhea et al., (2013).Twin Research and Human Genetics, 16, 351–357] covered developments in the CTR through 2012. This report briefly summarizes previously presented material on ascertainment and recruitment and the relationships between samples and studies, discusses developments since 2012 for four previously described twin samples, describes two new samples and their complementary studies and expands on two subjects briefly mentioned in the last report: a history of genotyping efforts involving CTR samples, and a survey of collaborations and consortia in which CTR twins have been included. The CTR remains an active resource for both ongoing, longitudinal research and the recruitment of new twin samples for newly identified research opportunities.

An Update of Twin Research in Spain: The Murcia Twin Registry

2019 ◽  
Vol 22 (6) ◽  
pp. 667-671 ◽  
Author(s):  
Juan R. Ordoñana ◽  
Eduvigis Carrillo ◽  
Lucía Colodro-Conde ◽  
Francisco J. García-Palomo ◽  
Francisca González-Javier ◽  
...  
Keyword(s):  
Population Based ◽  
Short Term ◽  
Public Health Perspective ◽  
Twin Research ◽  
Main Research ◽  
Twin Registry ◽  
Adult Participants ◽  
Health Related ◽  
Population Based Registry

AbstractThe Murcia Twin Registry (MTR) is the only population-based registry in Spain. Created in 2006, the registry has been growing more than a decade to become one of the references for twin research in the Mediterranean region. The MTR database currently comprises 3545 adult participants born between 1940 and 1977. It also holds a recently launched satellite registry of university students (N = 204). Along five waves of data collection, the registry has gathered questionnaire and anthropometric data, as well as biological samples. The MTR keeps its main research focus on health and health-related behaviors from a public health perspective. This includes lifestyle, health promotion, quality of life or environmental conditions. Future short-term development points to the expansion of the biobank and the continuation of the collection of longitudinal data.

Cocaine use, abuse and dependence in a population-based sample of female twins

1998 ◽  
Vol 173 (4) ◽  
pp. 345-350 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Carol A. Prescott
Keyword(s):  
Cocaine Abuse ◽  
Genetic Factors ◽  
Model Fitting ◽  
Population Based ◽  
Cocaine Use ◽  
Past Half Century ◽  
History Of ◽  
Population Based Registry ◽  
Twin Resemblance

BackgroundAlthough cocaine use in women has increased substantially over the past half-century, we understand little about the aetiology in women of cocaine use and abuse, and know almost nothing about the role of genetic factors.MethodWe obtained by telephone interview a history of lifetime cocaine use, abuse and dependence from 1934 individual twins from female–female pairs ascertained through a population-based registry, including both members of 485 monozygotic (MZ) and 335 dizygotic (DZ) pairs.ResultsThe prevalence of lifetime cocaine use, abuse and dependence were 14.0%, 3.3% and 2.3%. Probandwise concordance rates, in MZ and DZ twins, respectively, were: cocaine use 54% and 42%; cocaine abuse 47% and 8% and cocaine dependence 35% and 0%. In MZ and DZ twins, odds ratios were: cocaine use 14.2 and 6.7 and cocaine abuse 40.8 and 2.7. Biometrical model-fitting suggested that twin resemblance for liability to cocaine use was due to both genetic and familial–environmental factors while twin resemblance for cocaine abuse and symptoms of dependence was due solely to genetic factors. Estimated heritabilities were: cocaine use 0.39, cocaine abuse 0.79 and symptoms of dependence 0.65.ConclusionsThe vulnerability to cocaine use and particularly cocaine abuse and dependence in women is substantially influenced by genetic factors.

scholarly journals The NAS-NRC Twin Registry and Duke Twins Study of Memory in Aging: An Update

2019 ◽  
Vol 22 (6) ◽  
pp. 757-760 ◽  
Author(s):  
Margaret Gatz ◽  
Brenda L. Plassman ◽  
Caroline M. Tanner ◽  
Samuel M. Goldman ◽  
Gary E. Swan ◽  
...  
Keyword(s):  
World War Ii ◽  
Human Genetics ◽  
White Male ◽  
National Research Council ◽  
Armed Forces ◽  
National Archive ◽  
Population Based ◽  
National Academy Of Sciences ◽  
Twin Registry ◽  
Academy Of Sciences

AbstractThe National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry is one of the oldest, national population-based twin registries in the USA. It comprises 15,924 White male twin pairs born in the years 1917–1927 (N = 31.848), both of whom served in the armed forces, chiefly during World War II. This article updates activities in this registry since the most recent report in Twin Research and Human Genetics (Page, 2006). Records-based data include information from enlistment charts and Veterans Administration data linkages. There have been three major epidemiologic questionnaires and an education and earnings survey. Separate data collection efforts with the NAS-NRC registry include the National Heart, Lung, and Blood Institute (NHLBI) subsample, the Duke Twins Study of Memory in Aging and a clinically based study of Parkinson’s disease. Progress has been made on consolidating the various data holdings of the NAS-NRC Twin Registry. Data that had been available through the National Academy of Sciences are now freely available through National Archive of Computerized Data on Aging (NACDA).

The Mid-Atlantic Twin Registry, Revisited

2012 ◽  
Vol 16 (1) ◽  
pp. 424-428 ◽  
Author(s):  
Emily C. H. Lilley ◽  
Judy L. Silberg
Keyword(s):  
South Carolina ◽  
Developmental Psychopathology ◽  
Human Microbiome ◽  
Population Based ◽  
Data Set ◽  
Twin Registry ◽  
Children Of Twins ◽  
Scientific Disciplines ◽  
Sleep Homeostasis ◽  
Population Based Registry

The Mid-Atlantic Twin Registry (MATR) is a population-based registry of more than 56,000 twins primarily born or living in Virginia, North Carolina, and South Carolina. The MATR employs several methods of ascertaining twins, and devotes considerable resources to tracking and maintaining communication with MATR participants. Researchers may utilize the MATR for administration of research services including study recruitment, collection of DNA, archival data set creation, as well as data collection through mailed, phone, or online surveys. In addition, the MATR houses the MATR Repository, with over 1,200 blood samples available for researchers interested in DNA genotyping. For over 35 years MATR twins have participated in research studies with investigators from diverse scientific disciplines and various institutions. These studies, which have resulted in numerous publications, have covered a range of topics, including the human microbiome, developmental psychopathology, depression, anxiety, substance use, epigenetics of aging, children of twins, pre-term birth, social attitudes, seizures, eating disorders, as well as sleep homeostasis. Researchers interested in utilizing twins are encouraged to contact the MATR to discuss potential research opportunities.

Colorado Twin Registry

2006 ◽  
Vol 9 (6) ◽  
pp. 941-949 ◽  
Author(s):  
Sally-Ann Rhea ◽  
Andy A. Gross ◽  
Brett C. Haberstick ◽  
Robin P. Corley
Keyword(s):  
Reading Ability ◽  
Behavioral Genetics ◽  
Early Reading ◽  
Population Based ◽  
Demographic Information ◽  
Early Reading Development ◽  
University Of Colorado ◽  
Executive Cognitive Function ◽  
Twin Registry ◽  
Population Based Registry

AbstractThe Colorado Twin Registry (CTR) is a population-based registry housed at the Institute for Behavioral Genetics, University of Colorado. Recruited subjects' birth years date from 1968. Four samples comprise the CTR: the Community Twin Sample, Infant Twin Sample, Longitudinal Twin Sample, and the Early Reading Development Sample. Criteria for enrollment, recruitment strategies, demographic information and zygosity assignment are explained for each sample. In addition, 8 studies in which CTR twins have participated are highlighted. These include studies of early cognition, early reading ability, executive cognitive function, and vulnerability to substance abuse and antisocial behavior. Goals, measures, and brief results are provided for each study. The development of the CTR is an ongoing and evolving process, and it has proved to be a valuable resource, relatively representative of the population from which it was drawn.

scholarly journals The Italian Twin Registry: An Update at 18 Years From Its Inception

2019 ◽  
Vol 22 (6) ◽  
pp. 572-578
Author(s):  
Emanuela Medda ◽  
Virgilia Toccaceli ◽  
Corrado Fagnani ◽  
Lorenza Nisticò ◽  
Sonia Brescianini ◽  
...  
Keyword(s):  
Age Groups ◽  
Population Based ◽  
International Studies ◽  
Questionnaire Data ◽  
Twin Registry ◽  
Health Related ◽  
Research Initiatives ◽  
Population Based Registry ◽  
Age Range ◽  
Research Period

AbstractThe Italian Twin Registry (ITR), established in 2001, is a population-based registry of voluntary twins. To date, it consists of approximately 29,000 twins who gave their consent to participate in the studies proposed by the ITR research group. The database comprises 11,500 monozygotic and 16,700 dizygotic twins resident throughout the country and belonging to a wide age range (from 0 to 95 years, mean 36.8 years). This article provides an overview of the recruitment strategies along with the major phenotypes investigated during an 18 years’ research period. Over the years, several self-reported questionnaire data were collected, together with saliva/blood samples and measurements taken during in-person interviews or outpatient clinical examinations. Mental and behavioral phenotypes as well as atherosclerotic traits were studied in depth across different age groups. A birth cohort of twins was established and followed up. Novel research hypotheses are also being tested in ongoing projects. The ITR is involved in international studies in collaboration with other twin registries and represents a valuable resource for national and international research initiatives regarding a broad spectrum of health-related characteristics.

scholarly journals The Washington State Twin Registry: 2019 Update

2019 ◽  
Vol 22 (6) ◽  
pp. 788-793 ◽  
Author(s):  
Glen E. Duncan ◽  
Ally R. Avery ◽  
Eric Strachan ◽  
Eric Turkheimer ◽  
Siny Tsang
Keyword(s):  
Human Genetics ◽  
Washington State ◽  
Future Research ◽  
Special Issue ◽  
Twin Research ◽  
Construction Methods ◽  
Twin Registry ◽  
Future Research Directions ◽  
Current Special Issue

AbstractIt has been over 5 years since the last special issue of Twin Research and Human Genetics on ‘Twin Registries Worldwide: An Important Resource for Scientific Research’ was published. Much progress has been made in the broad field of twin research since that time, and the current special issue is a follow-up to update the scientific community about twin registries around the globe. The present article builds upon our 2013 Registry description by summarizing current information on the Washington State Twin Registry (WSTR), including history and construction methods, member characteristics, available data, and major research goals. We also provide a section with brief summaries of recently completed studies and discuss the future research directions of the WSTR. The Registry has grown in terms of size and scope since 2013; highlights include recruitment of youth pairs under 18 years of age, extensive geocoding work to develop environmental exposures that can be linked to survey and administrative health data such as death records, and expansion of a biobank with specimens collected for genotyping, DNA methylation, and microbiome based-studies.

scholarly journals Colorado Twin Registry: An Update

2012 ◽  
Vol 16 (1) ◽  
pp. 351-357 ◽  
Author(s):  
Sally-Ann Rhea ◽  
Andy A. Gross ◽  
Brett C. Haberstick ◽  
Robin P. Corley
Keyword(s):  
Behavioral Genetics ◽  
Early Reading ◽  
Population Based ◽  
Learning Ability ◽  
Demographic Information ◽  
Early Reading Development ◽  
University Of Colorado ◽  
Twin Registry ◽  
The University ◽  
Population Based Registry

The Colorado Twin Registry (CTR) is a population-based registry housed at the Institute for Behavioral Genetics at the University of Colorado. Recruitment began in 1982 and includes twins born from 1968 to the present. Four samples are currently drawn from the CTR: The Community Twin Sample, the Longitudinal Twin Sample, the Early Reading Development Sample, and the Colorado Learning Sample. Criteria for enrollment, recruitment strategies, demographic information, and zygosity assignment are explained for each sample. In addition, five studies in which CTR twins are now participating are highlighted. These include studies of cognition, learning ability, and vulnerability to substance abuse and antisocial behavior. The development of the CTR is an ongoing and evolving process, and it has proven to be a valuable registry, relatively representative of the population from which it was drawn.

scholarly journals The Michigan State University Twin Registry (MSUTR): 15 Years of Twin and Family Research

2019 ◽  
Vol 22 (6) ◽  
pp. 741-745 ◽  
Author(s):  
S. Alexandra Burt ◽  
Kelly L. Klump
Keyword(s):  
Family Environment ◽  
Large Scale ◽  
Population Based ◽  
Future Research ◽  
Buccal Swab ◽  
Michigan State University ◽  
Childhood And Adolescence ◽  
State University ◽  
Twin Registry ◽  
Population Based Registry

AbstractThe primary aim of the Michigan State University Twin Registry (MSUTR) is to examine developmental differences in genetic, environmental, neural, epigenetic, and neurobiological influences on psychopathology and resilience, particularly during childhood and adolescence. The MSUTR has two broad components: a large-scale, population-based registry of child, adolescent, and adult twins and their families (current N ~30,000) and a series of more focused and in-depth studies drawn from the registry (projected N ~7200). Participants in the population-based registry complete a family health and demographic questionnaire via mail. Families can then be recruited for one or more of the intensive, in-person studies from the population-based registry, using any one of several recruitment strategies (e.g., population-based, based on their answers to the registry questionnaire). These latter studies target a variety of biological, genetic, and environmental phenotypes, including multi-informant measures of psychiatric and behavioral phenotypes, functional and structural neuroimaging, comprehensive measures of the twin family environment (e.g., census and neighborhood informant reports of twin neighborhood characteristics, videotaped interactions of child twin families), buccal swab and salivary DNA samples, and/or assays of adolescent and adult steroid hormone levels. This article provides an overview of the MSUTR and describes current and future research directions.

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