Screening Assay of Very Long Chain Fatty Acids in Human Plasma with Multiwalled Carbon Nanotube-Based Surface-Assisted Laser Desorption/Ionization Mass Spectrometry

2010 ◽  
Vol 82 (16) ◽  
pp. 6814-6820 ◽  
Author(s):  
Wei-Yi Hsu ◽  
Wei-De Lin ◽  
Wuh-Liang Hwu ◽  
Chien-Chen Lai ◽  
Fuu-Jen Tsai
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acids ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Long Chain Fatty Acids ◽  
Laser Desorption Ionization ◽  
Screening Assay ◽  
Multiwalled Carbon ◽  
Desorption Ionization ◽  
Long Chain

scholarly journals Analysis of fatty acids and triacylglycerides by Pd nanoparticle-assisted laser desorption/ionization mass spectrometry

2015 ◽  
Vol 7 (9) ◽  
pp. 3701-3707 ◽  
Author(s):  
Yuliya E. Silina ◽  
Claudia Fink-Straube ◽  
Heiko Hayen ◽  
Dietrich A. Volmer
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Pd Nanoparticle ◽  
Rapid Technique ◽  
Desorption Ionization

In this study, we propose a simple and rapid technique for characterization of free fatty acids and triacylglycerides (TAG) based on palladium nanoparticular (Pd-NP) surface-assisted laser desorption/ionization (SALDI) mass spectrometry (MS).

Analysis of Free Fatty Acids by Ultraviolet Laser Desorption Ionization Mass Spectrometry Using Insect Wings as Hydrophobic Sample Substrates

2014 ◽  
Vol 86 (21) ◽  
pp. 10763-10771 ◽  
Author(s):  
Alexander Pirkl ◽  
Martin Meier ◽  
Yulia Popkova ◽  
Matthias Letzel ◽  
Andreas Schnapp ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Ultraviolet Laser ◽  
Desorption Ionization ◽  
Insect Wings

scholarly journals Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 610
Author(s):  
Mariann Inga Van Meter ◽  
Salah M. Khan ◽  
Brynne V. Taulbee-Cotton ◽  
Nathan H. Dimmitt ◽  
Nathan D. Hubbard ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Active Pharmaceutical Ingredients ◽  
Laser Desorption Ionization ◽  
Over The Counter ◽  
Pharmaceutical Ingredients ◽  
Desorption Ionization

Agglomeration of active pharmaceutical ingredients (API) in tablets can lead to decreased bioavailability in some enabling formulations. In a previous study, we determined that crystalline APIs can be detected as agglomeration in tablets formulated with amorphous acetaminophen tablets. Multiple method advancements are presented to better resolve agglomeration caused by crystallinity in standard tablets. In this study, we also evaluate three “budget” over-the-counter headache medications (subsequently labeled as brands A, B, and C) for agglomeration of the three APIs in the formulation: Acetaminophen, aspirin, and caffeine. Electrospray laser desorption ionization mass spectrometry imaging (ELDI-MSI) was used to diagnose agglomeration in the tablets by creating molecular images and observing the spatial distributions of the APIs. Brand A had virtually no agglomeration or clustering of the active ingredients. Brand B had extensive clustering of aspirin and caffeine, but acetaminophen was observed in near equal abundance across the tablet. Brand C also had extensive clustering of aspirin and caffeine, and minor clustering of acetaminophen. These results show that agglomeration with active ingredients in over-the-counter tablets can be simultaneously detected using ELDI-MS imaging.

Analysis of microbial lipids deposited on Mars Global Simulant (MGS-1) by geomatrix-assisted laser desorption/ionization-mass spectrometry

2021 ◽  
pp. 1-7
Author(s):  
Alef dos Santos ◽  
Edson Rodrigues-Filho ◽  
Manoel Gustavo Petrucelli Homem
Keyword(s):  
Mass Spectrometry ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Organic Substances ◽  
Microbial Lipids ◽  
Desorption Ionization ◽  
Martian Soil ◽  
Planetary Missions

Abstract Lipids are among the organic substances that can work as biosignatures, indicating life in an environment. We present an experimental investigation concerning analysis of lipids from a microbial source deposited on the Mars Global Simulant (MGS-1) regolith by geomatrix-assisted laser desorption/ionization-mass spectrometry (GALDI-MS). Our results indicate that lipids from intact microbial cells of a black yeast strain can be detected in these mimetic samples of Martian soil. These lipid molecules are predominantly associated with the occurrence of adducts in the GALDI-MS spectra. The results can be helpful in the planning of future planetary missions.

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